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耗流仅8μA的频率比较器

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电子设计技术 1997年第10期 64-64页

作者： dalius baranauskas Lithuania Semiconductor Physics Institute Vilnius

图1所示电路包括了构成一个简单的低功耗频率比较器必需的所有元件。电路的核心是IC;。它由一个放大器、一个比较器和一个电压基准组合而成。

关键词：频率比较器带通滤波器中心频率

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Value of adipokines in predicting the severity of acute pancreatitis:Comprehensive review

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World Journal of Gastroenterology 2012年第45期18卷 6620-6627页

作者： Andrius Karpavicius Zilvinas Dambrauskas Audrius Sileikis dalius Vitkus Kestutis Strupas Clinic of Gastroenterology NephrologyUrology and SurgeryFaculty of MedicineVilnius UniversityLT-01513 VilniusLithuania Center of Abdominal Surgery Vilnius University Hospital "Santariskiu klinikos"LT-08661 VilniusLithuania Department of Surgery Medical AcademyLithuanian University of Health SciencesLT-50009 KaunasLithuania Institute for Research of Digestive System Medical AcademyLithuanian University of Health SciencesLT-50009 KaunasLithuania Department of Physiology BiochemistryMicrobiologyand Laboratory MedicineFaculty of MedicineVilnius UniversityLT-01513 VilniusLithuania

AIM:To analyze the prognostic value of adipokines in predicting the course,complications and fatal outcome of acute pancreatitis(AP).METHODS:We performed the search of PubMed database and the systemic analysis of the literature for both experimental and human studies on prognostic value of adipokines in AP for period *** the papers that described the use of adipokines for prediction of severity and/or complications of AP were selected for further *** article had to contain information about the levels of measured adipokines,diagnosis and verification of AP,to specify presence of pancreatic necrosis,organ dysfunction and/or mortality *** the very beginning,study was carried out adhering to the PRISMA checklist and flowchart for systemic *** assess quality of all included human studies,the Quality Assessment of Diagnostic Accuracy Studies tool was *** of the high heterogeneity between the studies,it was decided to refrain from the statistical processing or meta-analysis of the available ***:Nine human and three experimental studies were included into *** experimental studies significant differences between leptin concentrations at 24 and 48 h in control,acute edematous and acute necrotizing pancreatitis groups were found(P = 0.027 and P < 0.001).In human studies significant differences between leptin and resitin concentrations in control and acute pancreatitis groups were found.1-3 d serum adiponectin threshold of 4.5 μg/mL correctly classified the severity of 81% of patients with *** threshold yielded a sensitivity of 70%,specificity 85%,positive predictive value 64%,negative predictive value88%(area under curve 0.75).Resistin and visfatin concentrations differ significantly between mild and severe acute pancreatitis groups,they correlate with severity of disease,need for interventions and *** adipokines are good markers for parapancreatic necrosis and the cut-off values of 11.9 ng/mL and 1.8 ng/

关键词：重症急性胰腺炎细胞因子严重程度预测值高脂肪急性坏死性胰腺炎审查价值

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Plasma Nogo-A and placental growth factor levels are associated with portal hypertension in patients with liver cirrhosis

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World Journal of Gastroenterology 2019年第23期25卷 2935-2946页

作者： Sigita Gelman Violeta Salteniene Andrius Pranculis Jurgita Skieceviciene Romanas Zykus dalius Petrauskas Limas Kupcinskas Ali Canbay Alexander Link Juozas Kupcinskas Department of Gastroenterology Medical AcademyLithuanian University of Health SciencesKaunas 44307Lithuania Institute for Digestive Research Medical AcademyLithuanian University of Health SciencesKaunas 44307Lithuania Department of Radiology Medical AcademyLithuanian University of Health SciencesKaunas 44307Lithuania Institute for Digestive Research and Department of Gastroenterology Medical AcademyLithuanian University of Health SciencesKaunas 44307Lithuania Department of Gastroenterology Hepatology and Infectious Diseases Otto-von-Guericke UniversityMagdeburg 39106Germany

BACKGROUND Clinically significant portal hypertension(CSPH) and severe portal hypertension(SPH) increase the risk for decompensation and life-threatening complications in liver cirrhosis. Pathologic angiogenesis might contribute to the formation of these conditions. Placental growth factor(PlGF) and Nogo-A protein are biomarkers of pathological angiogenesis, but data on their role in liver cirrhosis and portal hypertension is *** To determine plasma levels of PlGF and Nogo-A in patients with liver cirrhosis,CSPH, SPH and potential to predict portal *** A cohort of 122 patients with hepatitis C virus and/or alcohol-induced liver cirrhosis with characterized hepatic venous pressure gradient(HVPG) were included in the study. Demographic data, medical history, Child-Turcotte-Pugh and Model of End Stage liver disease score, clinical chemistry, liver stiffnessvalues were recorded on the day of the procedure prior HVPG measurement. The degree of portal hypertension was determined by the invasive HVPG measurement. Nogo-A and PlGF plasma levels were evaluated using enzyme linked immunosorbent assay. The control group consisted of 30 healthy age-and sex-matched *** Peripheral PlGF levels were higher and Nogo-A levels were lower in patients with liver cirrhosis(23.20 vs 9.85;P < 0.0001 and 2.19 vs 3.12;P = 0.004 respectively). There was a positive linear correlation between peripheral levels of PlGF and HVPG(r = 0.338, P = 0.001) and negative linear correlation between the peripheral Nogo-A levels and HVPG(r =-0.267, P = 0.007). PlGF levels were higher in CSPH and SPH(P = 0.006;P < 0.0001) whereas Nogo-A levels were lower(P = 0.01;P < 0.033). Area under the curve for the diagnosis of CSPH for PlGF was 0.68(P = 0.003) and for Nogo-A-0.67(P = 0.01);for SPH 0.714(P <0.0001) and 0.65(P = 0.014) respectively. PlGF levels were higher and Nogo-A levels were lower in patients with esophageal varices(P < 0.05). PlGF cut-off value of 25 pg/mL dist

关键词： Liver cirrhosis Portal hypertension Angiogenesis Placental growth factor Nogo-A Hepatic venous pressure gradient

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Disease-specific health-related quality of life and its determinants in liver cirrhosis patients in Lithuania

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World Journal of Gastroenterology 2006年第48期12卷 7792-7797页

作者： Jolanta Sumskiene Linas Sumskas dalius Petrauskas Limas Kupcinskas Department of Gastroenterology Kaunas University of Medicine A.Mickeviciaus street 9 Kaunas LT-44307 Lithuania Institute for Biomedical Research of Kaunas University of Medicine Eiveniu street 4 Kaunas LT-50009 Lithuania

AIM: To evaluate disease-specific quality of life (QOL) in liver cirrhosis patients and to compare it with those of a healthy population. Also an important objective was to assess whether QOL in liver cirrhosis patients differs by age and gender, by type and severity of disease. METHODS: The case group of 131 liver cirrhosis patients was selected. The control group of 262 was enrolled from a healthy population according to the scheme of case-control study. Clinical, demographic, laboratory data were collected. QOL was measured with a specific chronic liver disease questionnaire (CLDQ), which was translated and validated in Lithuanian. QOL scores were compared between groups by age, gender, type and severity of disease. Cronbach’s alpha statistics calculation was used for evaluation of internal consistency reliability. Student’s t test or ANOVA were used for evaluation hypothesis about probability equation. RESULTS: QOL was significantly lower in liver cirrhosis patients than in healthy population (59.5 ± 18.3 vs 85.3 ± 12.3, P < 0.001). The significant QOL differences between case and control groups were observed in domains of worry and abdominal symptoms, the smaller differences-in emotional functions and systematic symptom domains. Significantly worse QOL was in observed patients with increased clinical severity of the disease measured by Child-Pugh class. Age, gender and etiology of disease had an insignificant effect on QOL in cirrhotic patients. CONCLUSION: QOL was significantly impaired in all CLDQ domains in liver cirrhosis patients. Increase in severity of disease was the major factor associated with poorer QOL.

关键词：生活质量立陶宛肝硬化病理机制

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多重互动——上海Kik公园

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中国建筑装饰装修 2013年第2期 144-147页

作者： Nicole Ni Francesco Negri dalius Ripley Michele Ruju Muavii Sun Charles Mariambourg Shen Qiang 3Gatti事务所

Kik公园位于近年来专为附近复旦大学和同济大学的学生建造的创智坊八口处，作为一块位置显赫的城市空地，居然在快速的城市营造中成了漏网之鱼，这令Francesco Gatti大为惊讶。自从这位意大利建筑师将他的部分业务活动转移到中国以来，... 详细信息

Kik公园位于近年来专为附近复旦大学和同济大学的学生建造的创智坊八口处，作为一块位置显赫的城市空地，居然在快速的城市营造中成了漏网之鱼，这令Francesco Gatti大为惊讶。自从这位意大利建筑师将他的部分业务活动转移到中国以来，他一直对此类罅隙空间的设计可能性饶有兴趣。

关键词：公园上海多重同济大学复旦大学建筑师意大利城市

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