Value of adipokines in predicting the severity of acute pancreatitis:Comprehensive review

作     者：Andrius Karpavicius Zilvinas Dambrauskas Audrius Sileikis Dalius Vitkus Kestutis Strupas 

作者机构：Clinic of GastroenterologyNephrologyUrology and SurgeryFaculty of MedicineVilnius UniversityLT-01513 VilniusLithuania Center of Abdominal SurgeryVilnius University Hospital "Santariskiu klinikos"LT-08661 VilniusLithuania Department of SurgeryMedical AcademyLithuanian University of Health SciencesLT-50009 KaunasLithuania Institute for Research of Digestive SystemMedical AcademyLithuanian University of Health SciencesLT-50009 KaunasLithuania Department of PhysiologyBiochemistryMicrobiologyand Laboratory MedicineFaculty of MedicineVilnius UniversityLT-01513 VilniusLithuania 

出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)

年 卷 期：2012年第18卷第45期

页      面：6620-6627页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

主　　题：重症急性胰腺炎 细胞因子 严重程度 预测值 高脂肪 急性坏死性胰腺炎 审查 价值 

摘      要：AIM:To analyze the prognostic value of adipokines in predicting the course,complications and fatal outcome of acute pancreatitis(AP).METHODS:We performed the search of PubMed database and the systemic analysis of the literature for both experimental and human studies on prognostic value of adipokines in AP for period *** the papers that described the use of adipokines for prediction of severity and/or complications of AP were selected for further *** article had to contain information about the levels of measured adipokines,diagnosis and verification of AP,to specify presence of pancreatic necrosis,organ dysfunction and/or mortality *** the very beginning,study was carried out adhering to the PRISMA checklist and flowchart for systemic *** assess quality of all included human studies,the Quality Assessment of Diagnostic Accuracy Studies tool was *** of the high heterogeneity between the studies,it was decided to refrain from the statistical processing or meta-analysis of the available ***:Nine human and three experimental studies were included into *** experimental studies significant differences between leptin concentrations at 24 and 48 h in control,acute edematous and acute necrotizing pancreatitis groups were found(P = 0.027 and P 0.001).In human studies significant differences between leptin and resitin concentrations in control and acute pancreatitis groups were found.1-3 d serum adiponectin threshold of 4.5 μg/mL correctly classified the severity of 81% of patients with *** threshold yielded a sensitivity of 70%,specificity 85%,positive predictive value 64%,negative predictive value88%(area under curve 0.75).Resistin and visfatin concentrations differ significantly between mild and severe acute pancreatitis groups,they correlate with severity of disease,need for interventions and *** adipokines are good markers for parapancreatic necrosis and the cut-off values of 11.9 ng/mL and 1.8 ng/