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Effect of diets supplemented with linseed alone or combined with vitamin E and selenium or with plant extracts,on Longissimus thoracis transcriptome in growing-finishing Italian Large White pigs

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Journal of Animal Science and Biotechnology 2019年第1期10卷 159-171页

作者： Rubina Sirri Marika Vitali Paolo Zambonelli Giulia Giannini Martina Zappaterra Domenico Pietro Lo Fiego dalal sami Roberta Davoli Interdepartmental Centre for Industrial Agrifood Research (CIRI- AGRO) University of Bologna Department of Agricultural and Food Sciences (DISTAL) University of Bologna Department of Life Sciences University of Modena and Reggio Emilia Interdepartmental Research Centre for Agri-Food Biological Resources Improvement and Valorisation (BIOGEST-SITEIA) University of Modena and Reggio Emilia

Background: Supplementing farm animals diet with functional ingredients may improve the nutritional quality of meat *** composition has been also demonstrated to influence the gene expression with effect on biological processes and ***,the knowledge on the effect of nutrients at the molecular level is *** particular,studies on the effects of antioxidants and polyphenols dietary supplementation have been investigated mainly in rodents,and only scarcely in farm animals so ***-Seq with next-generation sequencing is increasingly the method of choice for studying changes in the transcriptome and it has been recently employed also in pig nutrigenomics studies to identify diet-induced changes in gene *** present study aimed to investigate the effect of diets enriched with functional ingredients(linseed,vitamin E and plant extracts) on the transcriptome of pig Longissimus thoracis to elucidate the role of these compounds in influencing genes involved in muscle physiology and metabolism compared to a standard ***: Eight hundred ninety-three significant differentially expressed genes(DEGs)(FDR adjusted P-value ≤ 0.05)were detected by RNA-Seq analysis in the three diet comparisons(D2-D1,D3-D1,D4-D1).The functional analysis of DEGs showed that the diet enriched with n-3 PUFA from linseed(D2) mostly downregulated genes in pathways and biological processes(BPs) related to muscle development,contraction,and glycogen metabolism compared to the standard *** diet supplemented with linseed and vitamin E/Selenium(D3) showed to mostly downregulate genes linked to oxidative *** few genes involved in extracellular matrix(ECM)organization were upregulated by the ***,the comparison D4-D1 showed that the diet supplemented with linseed and plant extracts(D4) upregulated the majority of genes compared to D1 that were involved in a complex network of pathways and BPs all connected by hub *** particular,IGF2 wa

关键词： Diet supplementation Functional analysis Gene expression Linseed Muscle transcriptome n-3 PUFA Pigs Plant extracts Polyphenols Vitamin E

Co-seismic surface displacement of the June 21, 2022 M_(W)6 Khōst,Afghanistan earthquake from InSAR observations

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Geodesy and Geodynamics 2024年第3期15卷 201-208页

作者： Prohelika dalal Batakrushna Senapati Bhaskar Kundu Department of Earth and Atmospheric Sciences National Institute of TechnologyRourkelaOdisha 769008India

A robust estimation of the earthquake location, seismic moment, and fault geometry is essential for objective seismic hazard assessment. Seismic events in a remote location, specifically in the absence of seismic and GNSS networks, can be investigated effectively using the In SAR-based technique. This study adopts the Differential Interferometric SAR(DIn SAR) technique to quantify the co-seismic surface displacement caused by the June 21, 2022, Khōst M_(W)6 earthquake that occurred along the western plate boundary between the Indian and Eurasian plate. The interferograms show that the maximum surface deformation occurred on the northwest and southwest of the fault line. From coherence, the Line of Sight(LOS) displacement, and the co-seismic surface displacement analysis, it has been observed that surface deformation was most pronounced in the southwest region of the fault line, and the surface has moved to the opposite direction along the fault line, which indicates a sinistral slightly oblique strike-slip movement. This In SAR-based observation appears consistent with the seismic waveforms derived from co-seismic surface displacements. Further, it has been argued that the slip deficit accumulated during the period of the last about 48 years along the frontal region of the northward extension of the Suleiman range and associated fault zone is qualitatively estimated at about 1.5 m, which is consistent with the seismic waveforms derived finite slip model.

关键词： Seismic hazard Khōst earthquake DInSAR Slip deficit LOS displacement Finite slip model

On the Enhanced Power Graph of a Semigroup

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Algebra Colloquium 2024年第1期31卷 83-96页

作者： Sandeep dalal Jitender Kumart Siddharth Singh Department of Mathematics Birla Institute of Technology and Science Pilani PilaniIndia

The enhanced power graph P_(E)(S)of a semigroup S is a simple graph whose vertex set is S and two vertices a,y∈S are adjacent if and only if c,y∈(z)for some z∈S,where(z)is the subsemigroup generated by *** this paper,we first describe the structure of P_(E)(S)for an arbitrary semigroup S,and then discuss the connectedness of P_(E)(S).Further,we characterize the semigroup S in the cases when P_(E)(S)is separately a complete,bipartite,regular,tree and null *** planarity,together with the minimum degree and independence number,of P_(E)(S)is also *** chromatic number of a spanning subgraph,i.e.,the cyclic graph,of P_(E)(S)is proved to be *** the final part of this paper,we construct an example of a semigroup S such that the chromatic number of P_(E)(S)need not be countable.

关键词： monogenic semigroup completely regular semigroup planar graph enhanced powergraph

The Impact of an Evidence-Based Bundle on Cesarean Section-Related Surgical Site Infections:A Randomized Clinical Trial

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Maternal-Fetal Medicine 2024年第2期6卷 70-77页

作者： Aditya Gan Romana Khursheed Mahadevi Savanur Anita dalal Arif Maldar Department of Obstetrics and Gynecology Jawaharlal Nehru Medical CollegeKLE Academy of Higher Education and ResearchBelagaviKarnataka 590009India Department of Medicine Jawaharlal Nehru Medical CollegeKLE Academy of Higher Education and ResearchBelagavi 590010India

Objective:To compare the effectiveness of an evidence-based bundle in minimizing cesarean section(CS)-related surgical site infections(SSIs)with that of standard routine ***:This was a single-center,parallel,and randomized clinical trial conducted at KAHER’s *** Kore Charitable Hospital,Belagavi,India,from January 2021 to December 31,*** hundred twenty women undergoing CS delivery were selected and allocated into two groups(1:1)using simple randomization with fixed *** evidence-based surgical bundle(a combination of more than three perioperative interventions)was used for the intervention group,whereas the control group received routine standard perioperative *** primary outcome was the incidence of SSI(superficial,deep,and organ or space SSIs)within 6 weeks postpartum in both *** and continuous data were analyzed using appropriate statistical tests with a significance threshold set at P<***:In this study,16 and 17 participants each from the control and intervention groups,respectively,were lost to follow-up,resulting in a total of 144 and 143 study participants included in the respective ***-eight(19.4%)and 14(9.8%)women developed SSI in the control and intervention groups,respectively(P=0.02).Methicillin-resistantStaphylococcus aureus was the most common cause of SSI in both groups(63.6%(7/11)and 100%(3/3)in the control and intervention groups,respectively).Conclusion:The use of the evidence-based bundle for CS-related SSI prevention effectively decreased the incidence of SSI by half compared to standard routine *** the use of this bundle in routine perioperative care will reduce the cost of CS and improve health outcomes in CS.

关键词： Cesarean section Bundle approach Infection prevention bundle Surgical site infections Evidence-based bundle

Deciphering the Hidden Secrets between the Early Skin Wrinkling & the Metabolic (X) Syndrome with the Possible Reversal of This Process at the Molecular Level

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Journal of Cosmetics, Dermatological Sciences and Applications 2024年第1期14卷 45-68页

作者： dalal Alsaadoun Dermatology Department King Faisal University Hofuf Kingdom of Saudi Arabia

The aging process is a group of degenerative changes that physiologically occur in most of the people in the elderly. This affects one or more of the human body systems. The treatment of diseases related to the aging process has a huge impact on the economy of all nations. Aging of the skin comes on the top and despite that, the results of the already present lines of treatment are not always satisfactory. This acts as a stimulus for us to dig deeper to discover the root causes of the premature aging of the skin. This was simply caused by the accumulation of repeated minute damage to the internal structure skin. In other words, if the degree of minute damage is more than the capacity of the skin to repair, the repeated micro-damage is presented in the long run as a skin wrinkling. Moreover, the skin acts as a mirror that reflects the internal structures of the human body. Thus, the more degenerative changes in the human body systems, the more the skin could become wrinkled. Our strategy to prevent or at least slow down the aging process of the skin depends on 2 main steps;the 1st is to reduce the micro-damage as can as possible, and the 2nd is to enhance the capacity of tissue regeneration to be able to reverse the already present damaged skin. As the 2 processes are synchronized with each other, this strategy would be considered the ideal for prevention of skin wrinkling especially premature ones. This not only reverses premature skin wrinkling but also protects it from future wrinklings. This review sharply pointed out the role of the functional collagen of the dermal layer of the skin in the prevention of skin wrinklings. Therefore, it would be the target to study how collagen works in the complex machinery of the dermal layer of the skin. This concept deeply believes that the recovery of dermal collagen has a much better effect than simply ingesting collagen or receiving a topical collagen booster. .

关键词： Collagen Skin Wrinkling Glycation Hyper-Insulinemia Hidden Obesity Vis-ceral Fat Inflammatory Cytokines

Paradiplomacy for Non-recognized States:Case of Palestine

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International Relations and Diplomacy 2024年第1期12卷 34-39页

作者： dalal Iriqat Arab American University of Palestine RamallahPalestine

This paper endeavours to elucidate the intricacies of Palestinian Paradiplomacy,focusing in the political impetus pioneered by its principle actors,namely the Palestine Liberation Organisation(PLO)and subsequently,the establishment of the Palestinian National Authority(PNA).Additionally,attention will be directed towards the creation of the Palestinian Ministry of Foreign Affairs(PMOFA)and its subsidiary,the Palestinian International Cooperation Agency(PICA),albeit briefly *** inspiration from Alexander ***’s seminal work“Theory and Practice of Paradiplomacy:Subnational Governments in International Affairs”(2015),this paper tries to scrutinize the trajectory of Palestinian paradiplomacy and its evolutionary course over *** it comes to activity and growth,Palestinian paradiplomacy has a unique *** way in which topics pertaining to nations are not yet recognized has a great deal of bearing on current discussions and academic research about urgent political concerns like the right to self-determination and human *** analysis of de facto states via the prism of paradiplomacy naturally arises from the dominant state recognition procedures in international politics.

关键词： PLO nationalism non-state actors self-determination paradiplomacy Palestine foreign affairs

Gas Chromatographic Method for Identification and Quantification of Commonly Used Residual Solvents in Pharmaceuticals Products

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American Journal of Analytical Chemistry 2024年第8期15卷 241-252页

作者： Sreekanta Nath dalal Pranab Kumar Das Department of Applied Chemistry & Chemical Engineering Faculty of Engineering & Technology University of Dhaka Dhaka Bangladesh Department of Applied Chemistry & Chemical Engineering Faculty of Engineering University of Rajshahi Rajshahi Bangladesh

Background: Impurities are not expected in the final pharmaceutical products. All impurities should be regulated in both drug substances and drug products in accordance with pharmacopeias and ICH guidelines. Three different types of impurities are generally available in the pharmaceutical’s product specification: organic impurities, inorganic impurities, and residual solvents. Residual solvents are organic volatile chemicals used or generated during the manufacturing of drug substances or drug products. Purpose: The aim of this study is to develop a cost-effective gas chromatographic method for the identification and quantification of some commonly used solvents—methanol, acetone, isopropyl alcohol (IPA), methylene chloride, ethyl acetate, tetrahydrofuran (THF), benzene, toluene, and pyridine—in pharmaceutical product manufacturing. This method will be able to identify and quantify the multiple solvents within a single gas chromatographic procedure. Method: A gas chromatography (GC) equipped with a headspace sampler and a flame ionization detector, and a column DB 624, 30-meter-long × 0.32-millimeter internal diameter, 1,8 μm-thick, Brand-Agilent was used to develop this method. The initial GC oven temperature was 40°C and held for 5 minutes. It was then increase to 80˚C at a rate of 2˚C per minute, followed by a further increase to 225˚C at a rate of 30˚C per minute, with a final hold at 225˚C for 10 minutes. Nitrogen was used as a carrier gas at a flow rate of 1.20 mL per minute. Dimethyl sulfoxide (DMSO) was selected as sample solvent. Results: The developed method is precise and specific. The percent RSD for the areas of six replicate injections of this gas chromatographic method was within 10.0 and the recovery result found within 80.0% to 120.0%.

关键词： Method Development Gas Chromatography Compendial Method GDP Specificity Recovery

Hemoperitonium: Atypical Presentation Caused by Spontaneous Rupture of Hepatocellular Carcinoma in an Undiagnosed Patient

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Open Journal of Emergency Medicine 2024年第3期12卷 77-84页

作者： Youssef Abboud Lalarukh Burki dalal Abdalkarim Department of Emergency Medicine Fakeeh University Hospital Dubai United Arab Emirates

Introduction : Acute hemoperitoneum due to the spontaneous rupture of hepatocellular carcinoma (HCC) is a rare case of non-traumatic intra-abdomen bleeding that requires a high index of suspicion to approach, especially if no known history of HCC. It can mislead the physicians when the patient presents in an atypical way. Case Presentation : In this case report, we describe a fortuitous rupture of hepatocellular carcinoma in a 58-year-old male who was not previously diagnosed as having HCC and who came with atypical symptoms and signs of hemoperitoneum. He was then treated by trans-arterial embolectomy. Discussion : Diagnosis of hemoperitoneum in a case with bradycardia and hypotension is uncommon, as it goes more towards cardiogenic shock than hypovolemic shock, especially in a patient who is previously not symptomatic and has no risk factor for hepatocellular carcinoma. Conclusion : physicians should be alert to the possibility of encountering a hemorrhagic shock, although no trauma injury in any hypotensive patient with no clear reason for his condition.

关键词： Hepatocellular Carcinoma Rupture of HCC Trans-Arterial Embolectomy Hemoperitoneum Liver Cancer

AMachine Learning Approach to Cyberbullying Detection in Arabic Tweets

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Computers, Materials & Continua 2024年第7期80卷 1033-1054页

作者： Dhiaa Musleh Atta Rahman Mohammed Abbas Alkherallah Menhal Kamel Al-Bohassan Mustafa Mohammed Alawami Hayder Ali Alsebaa Jawad Ali Alnemer Ghazi Fayez Al-Mutairi May Issa Aldossary dalal A.Aldowaihi Fahd Alhaidari Department of Computer Science College of Computer Science and Information TechnologyImam Abdulrahman Bin Faisal UniversityP.O.Box 1982Dammam31441Saudi Arabia Department of Computer Information Systems College of Computer Science and Information TechnologyImam Abdulrahman Bin Faisal UniversityP.O.Box 1982Dammam31441Saudi Arabia Department of Networks and Communications College of Computer Science and Information TechnologyImam Abdulrahman Bin Faisal UniversityP.O.Box 1982Dammam31441Saudi Arabia

With the rapid growth of internet usage,a new situation has been created that enables practicing *** has increased over the past decade,and it has the same adverse effects as face-to-face bullying,like anger,sadness,anxiety,and *** the anonymity people get on the internet,they tend to bemore aggressive and express their emotions freely without considering the effects,which can be a reason for the increase in cyberbullying and it is the main motive behind the current *** study presents a thorough background of cyberbullying and the techniques used to collect,preprocess,and analyze the ***,a comprehensive review of the literature has been conducted to figure out research gaps and effective techniques and practices in cyberbullying detection in various languages,and it was deduced that there is significant room for improvement in the Arabic *** a result,the current study focuses on the investigation of shortlisted machine learning algorithms in natural language processing(NLP)for the classification of Arabic datasets duly collected from Twitter(also known as X).In this regard,support vector machine(SVM),Naive Bayes(NB),Random Forest(RF),Logistic regression(LR),Bootstrap aggregating(Bagging),Gradient Boosting(GBoost),Light Gradient Boosting Machine(LightGBM),Adaptive Boosting(AdaBoost),and eXtreme Gradient Boosting(XGBoost)were shortlisted and investigated due to their effectiveness in the similar ***,the scheme was evaluated by well-known performance measures like accuracy,precision,Recall,and ***,XGBoost exhibited the best performance with 89.95%accuracy,which is promising compared to the state-of-the-art.

关键词： Supervised machine learning ensemble learning cyberbullying Arabic tweets NLP