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Successful embolization of an intrahepatic portosystemic shunt using balloon-occluded retrograde transvenous obliteration:A case report

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World Journal of Clinical Cases 2022年第6期10卷 2023-2029页

作者： Hidemasa Saito Satoru Murata Fumie Sugihara Tatsuo Ueda daisuke Yasui izumi Miki Hiromitsu Hayashi Shin-Ichiro Kumita Department of Radiology Nippon Medical SchoolTokyo 113-8602Japan Center for Interventional Radiology Teikyo University Chiba Medical CenterChiba 299-0011Japan

BACKGROUND A congenital intrahepatic portosystemic shunt(IPSVS)is a rare vascular abnormality that is characterized by an anomalous intrahepatic venous tract that connects the intrahepatic portal vein with the hepatic venous *** encephalopathy is an indication for IPSVS embolization,which is technically challenging because rapid blood flow through shunts can induce the migration of embolization material to systemic *** case report discusses the efficacy of percutaneous balloon-occluded retrograde transvenous obliteration for treating patients with *** SUMMARY A 75-year-old woman presented with a six-month history of repeated hepatic encephalopathy due to an IPSVS without liver *** successfully embolized the IPSVS using percutaneous balloon-occluded retrograde transvenous obliteration with interlocking detachable *** the procedure,the patient exhibited no symptoms of hepatic encephalopathy for 14 *** Balloon-occluded retrograde transvenous obliteration with detachable coils can be effective for the endovascular treatment of an IPSVS.

关键词： Hepatic veins Portal vein Hepatic encephalopathy Endovascular procedures Embolization Therapeutic Case report

Characteristic pathological findings and effects of ecabet sodium in rat reflux esophagitis

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World Journal of Gastroenterology 2009年第28期15卷 3480-3485页

作者： daisuke Asaoka Akihito Nagahara Masako Oguro Yuko izumi Akihiko Kurosawa Taro Osada Masato Kawabe Mariko Hojo Michiro Otaka Sumio Watanabe Department of Gastroenterology Juntendo University School of Medicine

AIM： To explore the pathological findings in the entire esophagus in rats with reflux esophagitis, and the effects of ecabet sodium （ES）. METHODS： A rat model of chronic acid reflux esophagitis was used. In the treatment group, ES was administered after surgery （n = 16）. No drug was administered postoperatively to the esophagitis group （n = 9）. Shamoperated rats were used as a control group （n = 5）. Rats were sacrificed on day 7 after the operation. The epithelial thickness and leukocyte infiltration were examined in the upper, middle and lower areas of the esophagus. The survival rate, incidence of esophageal ulcer, and mean surface area and number of esophageal ulcers were determined in the esophagitis and ES groups. Esophageal histology was assessed in all three groups. RESULTS： Leukocyte infiltration in the esophagitis group was 26.3 ± 22.0 in the middle esophagus and 8.2 ± 4.9 in the upper esophagus, which was significantly greater than that in the controls （1.3 ± 1.1 and 1.4 ±1.0, respectively）（P 〈 0.05）. The thickness of the epithelium in the esophagitis group was 210.8 ± 47.7 μm in the lower esophagus and 204.2 ± 60.1 μm in the middle esophagus, which was significantly greater than that in the controls （26.0 ± 5.5 and 21.0 ± 6.5 μm, respectively）（P 〈 0.05）. The mean number of ulcers per animal in the ES group in the entire esophagus was 5.4 =1= 2.5, which was significantly less than that in the esophagitis group （9.0 ± 3.5）（P 〈 0.05）. The epithelial thickness in the ES group was 97.5 ± 32.2 μm in the lower esophagus, which was decreased compared with that in the esophagitis group （210.8 ± 47.7 μm）（P 〈 0.05）. CONCLUSION： Mucosal inflammation extended to the upper esophagus close to the hypopharynx. Our study suggested that ES may have a useful defensive role in reflux esophagitis.

关键词： Gastroesophageal reflux disease Upperesophagus Laryngopharyngeal reflux disease Extraesophageal syndrome

Evaluation of the relationship between hepatocellular carcinoma location and transarterial chemoembolization efficacy

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World Journal of Gastroenterology 2017年第35期23卷 6437-6447页

作者： izumi Miki Satoru Murata Fumio Uchiyama daisuke Yasui Tatsuo Ueda Fumie Sugihara Hidemasa Saito Hidenori Yamaguchi Ryusuke Murakami Chiaki Kawamoto Eiji Uchida Shin-ichiro Kumita Department of Radiology Center of Advanced MedicineNippon Medical School Department of Radiology Ebina-Sogo Hospital Department of Radiology Tamanagayama HospitalNippon Medical School Division of Gastroenterology and Hepatology Department of Internal MedicineNippon Medical School Department of Gastrointestinal and Hepato-Biliary-Pancreatic Surgery Nippon Medical School

AIM To evaluate the relationship between the location of hepatocellular carcinoma(HCC) and the efficacy of transarterial chemoembolization(TACE).METHODS We evaluated 115 patients(127 nodules), excluding recurrent nodules, treated with TACE between January 2011 and June 2014. TACE efficacy was evaluated according to m RECIST. The HCC location coefficient was calculated as the distance from the central portal portion to the HCC center(mm)/liver diameter(mm) on multiplanar reconstruction images rendered(MPR) to visualize bifurcation of the right and left branches of the portal vein and HCC center. The HCC location coefficient was compared between complete response(CR) and non-CR groups in Child-Pugh grade A and B *** The median location coefficient of HCC among all nodules, the right lobe, and the medial segment was significantly higher in the CR group than in the non-CR group in the Child-Pugh grade A patients(0.82 vs 0.62, P 0.05). On the other hand, in the Child-Pugh grade B patients, the HCC median location coefficient in each lobe and segment was not significantly different between in the CR and in the non-CR *** Improved TACE efficacy may be obtained for HCC in the peripheral zone of the right lobe and the medial segment in Child-Pugh grade A patients.

关键词： Hepatocellular carcinoma location Transarterial chemoembolization efficacy Child-Pugh Modified response evaluation criteria in solid tumors Central zone Peripheral zone

Contrast-Induced Nephropathy in Patients with Hepatocellular Carcinoma Undergoing Transcatheter Arterial Chemoembolization

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Open Journal of Radiology 2016年第3期6卷 243-249页

作者： Ryusuke Murakami Hidemasa Saito izumi Miki daisuke Yasui Fumie Sugihara Tatsuo Ueda Satoru Murata Hiromitsu Hayashi Shinichiro Kumita Department of Radiology Nippon Medical School Tokyo Japan

Purpose: The purpose of this retrospective study was to assess the incidence and the risk factors of contrast-induced nephropathy (CIN) following transcatheter arterial chemoembolization (TACE) in patients with hepatocellular carcinoma (HCC). Materials and Methods: We performed a retrospective review of 186 sessions of TACE in 122 patients with HCC. We examined the incidence and factors associated with risk of CIN, defined as an increase of at least 0.5 mg/dl (44.2 μmol/l) or 25% of the baseline serum creatinine level between 48 and 72 hours after TACE. Results: CIN developed in 14 (7.5%) of the 186 sessions after TACE. A univariate analysis showed that the Child-Pugh class B or C [10/14 (71%) vs. 70/172 (41%), P = 0.046], a low albumin level (3.0 ± 0.5 vs. 3.4 ± 0.6, P = 0.018), and a low hemoglobin level (10.6 ± 2.0 vs. 11.8 ± 2.0, P = 0.035) were significantly associated with the development of CIN. Multivariate analysis revealed that the hemoglobin value was associated with CIN [odds ratio (OR) 1.6;P = 0.038]. Conclusions: CIN after TACE is closely associated with the severity of liver cirrhosis, and with low levels of albumin and hemoglobin. Effective preventive methods remain to be considered in patients with HCC and advanced LC who are undergoing TACE.

关键词： Contrast Induced Nephropathy Hepatocellular Carcinoma Transcatheter Arterial Chemoembolization Contrast Media

Holographic augmented reality display with conical holographic optical element for wide viewing zone

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Light(Advanced Manufacturing) 2022年第1期3卷 166-174页

作者： Yusuke Sando Kazuo Satoh daisuke Barada Toyohiko Yatagai Osaka Research Institute of Industrial Science and Technology 2-7-1 AyuminoIzumiOsaka 594-1157Japan. Center for Optical Research&Education Utsunomiya University7-1-2 YotoUtsunomiyaTochigi 321-8585Japan. Graduate School of Engineering Utsunomiya University7-1-2 YotoUtsunomiyaTochigi 321-8585Japan

In this study, we propose a holographic augmented reality (AR) display with a wide viewing zone realized by using a special-designed reflective optical element. A conical holographic optical element (HOE) is used as such a reflective optical element. This conical HOE was implemented to reconstruct a diverging spherical wave with a wide spread angle. It has a sharp wavelength selectivity by recording it as a volume hologram, enabling augmented reality (AR) representation of real and virtual 3D objects. The quality of the generated spherical wave and the spectral reflectivity of the fabricated conical HOE were investigated. An optical superimposition between real and virtual 3D objects was demonstrated, thereby enhancing the validity of our proposed method. A horizontal viewing zone of 140° and a vertical viewing zone of 30° were experimentally confirmed. The fabrication procedure for the conical HOE is presented, and the calculation method of the computer-generated hologram (CGH) based on Fermat’s principle is explained in detail.

关键词： Holographic 3D display Holographic optical element Conical hologram Wide viewing zone

Characteristics of Small Pancreatic Carcinoma: Neural Invasion is Associated with Tumor Recurrence

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Journal of Cancer Therapy 2017年第12期8卷 1125-1134页

作者： Hideki izumi Hisamichi Yoshii Masaya Mukai Eiji Nomura Naoki Yazawa daisuke Furukawa Yoshihito Masuoka Misuzu Yamada Taro Mashiko Takuma Tajiri Toshio Nakagohri Hiroyasu Makuuchi Department of Gastrointestinal Surgery Tokai University Hachioji Hospital Tokyo Japan Department of Gastrointestinal Surgery School of Medicine Tokai University Kanagawa Japan Department of Pathology Tokai University Hachioji Hospital Tokyo Japan

Background: Pancreatic carcinoma has a poor prognosis. It is important to focus on early detection and treatment for improvement of the prognosis. Understanding the characteristics of TS1 pancreatic carcinoma (≤2 cm) could improve the treatment outcome of pancreatic carcinoma. Methods: Among 444 patients with conventional pancreatic carcinoma who underwent surgery at our facility, the study targeted 65 (14.6%) with a histopathological diagnosis of TS1 pancreatic carcinoma. We examined 65 cases of TS1 pancreatic carcinoma in reason for hospital visit, examination findings, histopathological findings, and treatment outcomes. Results: The detection rate of TS1 pancreatic carcinoma by ultrasonography was 83.1% for visualization of the tumor mass and 96.9% for main pancreatic duct dilatation. The corresponding rates for endoscopic ultrasound were 92.9% and 100%. With regard to postoperative outcome, 43.1% of patients had a recurrence;the site of recurrence was local in 24.6% and hepatic in 9.2%. On multivariate analysis, intrapancreatic neural invasion was an independent risk factor for recurrence (odds ratio, 6.333;95% confidence interval, 1.834 - 21.872;p = 0.004). Conclusions: To screen for TS1 pancreatic carcinoma, the study first examined for main pancreatic duct dilatation by ultrasonography and then conducted a detailed examination with endoscopic ultrasound. Patients with pancreatic neural invasion require careful attention for local recurrence.

关键词： Early Detection Recurrence Factor Small Pancreatic Carcinoma