Molecular insights into colorectal cancer stem cell regulation by environmental factors
Molecular insights into colorectal cancer stem cell regulation by environmental factors作者机构：Department of Gastroenterological SurgeryGraduate School of Medical ScienceKumamoto University1-1-1 HonjoKumamoto 860-8556Japan Cancer and Stem Cell BiologyDuke-NUS Graduate Medical School Singapore169857 Singapore.
出 版 物：《Journal of Cancer Metastasis and Treatment》 (癌症转移与治疗（英文版）)
年 卷 期：2015年第1卷第1期
页 面：156-162页
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
主 题：Cancer stem cells markers colorectal cancer stem cell nutrient obesity tumor microenvironment
摘 要：Colorectal cancer remains a signifi cant cause of cancer-related mortality worldwide,mainly because of tumor relapse and *** stem cells(CSCs)are considered to be the main cause of resistance to chemotherapeutic agents,as well as being responsible for distant *** CSCs themselves possess innate abilities for self-renewal and differentiation,the environment surrounding CSCs provides oxygen,nutrients and secreted factors,and also supports angiogenesis,thus it s responsible for maintaining their CSC ***,extensive investigations have revealed that obesity,accompanied by excess visceral adipose tissue,induces chronic infl ammation,and is linked to the risk and progression of several gastrointestinal cancers,through modulating the capacities of the *** review presents the evidence linking colorectal CSCs and their environment and summarizes our current understanding of the molecular mechanisms underlying this relationship.
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