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Chinese Journal of Integrative Medicine 2019年第7期25卷 483-489页

作者： LIU Wen-bin LI Sai YU Xiao-ling dai tie-ying GAO Rui-lan Institute of Hematology Research The First Affiliated Hospital of Zhejiang Chinese Medical University

Chronic primary immune thrombocytopenia(CITP) is the most common acquired autoimmune disease that seriously threaten the physical and mental health of patients. Compared with Western medicine treatment, the intervention and treatment of Chinese medicine(CM) has shown certain therapeutic advantages. This paper reviewed the new pathogenesis progress on T cell immune abnormality in CITP, and CM studies on interferes effects of cellular immune regulation of CITP in recent years. Qi deficiency failing to control blood and internal obstruction of blood stasis are the two common types of CM syndromes in CITP patients, the corresponding treatments include invigorating Pi(Spleen), supplementing qi, activating blood, as well as tonifying qi and activating yang, regulating Gan(Liver) to invigorate Pi. The authors also mentioned the problems in the research field of CM for CTIP treatment, and put forward new ideas for the research in the future.

关键词： chronic immune thrombocytopenia cellular immunity Chinese medicine

Pure Total Flavonoids from Citrus paradisi Macfad InduceLeukemia Cell Apoptosis In Vitro

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Chinese Journal of Integrative Medicine 2017年第5期23卷 370-375页

作者： dai tie-ying WANG Bo LIN Sheng-yun JIANG Jian-ping WU Li-qiang QIAN Wen-bing Department of Hematology the First Hospital Affiliated to Zhejiang University of Traditional Chinese Medicine Department of Hematology the First Affiliated Hospital of Medical School of Zhejiang University

Objective： To investigate the potential effect of pure total flavonoids from Citrus paradisi Macfad peel（PTFC） on the proliferation and apoptosis of human myeloid leukemia cells Kasumi-1, HL-60 and K562, and the underlying mechanisms. Methods： PTFC was extracted from Citrus paradisi Macfad peel and was identified by high performance liquid chromatography. The effect of PTFC on the proliferation and apoptosis of leukemia cells were determined by 3-（4,5-dimethylthiazol-2-yl）-2,5-diphenyltetrazolium bromide, fluorescent microscopy and flow cytometry, respectively. The effect of PTFC on the expression levels of apoptosis-related regulators was determined by Western blot assay. Results： Treatment with PTFC inhibited leukemia cell proliferation in a dose-and time-dependent manner and triggered Kasumi-1 cell apoptosis. Treatment with PTFC significantly increased the levels of activated poly adenosine diphosphate-ribosepolymerase and caspase-3/-9, but reduced the levels of Mcl-1 expression in Kasumi-1 cells. However, PTFC did not obviously induce HL-60 cell apoptosis. Conclusion： PTFC inhibited leukemia cell proliferation and induced their apoptosis by modulating apoptosisrelated regulator expression in leukemia cells in vitro.

关键词： total flavonoids from Citrus paradisi Macfad human myeloid leukemia cells growth inhibition apoptosis Chinese medicine

Chinese Medicine Treatment on Graft-Versus-Host Disease after Allogeneic Hematopoietic Stem Cell Transplantation

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Chinese Journal of Integrative Medicine 2020年第5期26卷 324-329页

作者： WU Xiao-long ZHUANG Hai-feng ZHAO Yan-na YU Xiao-ling dai tie-ying GAO Rui-lan Institute of Hematology Research the First Affiliated Hospital of Zhejiang Chinese Medical UniversityHangzhou(310006)China

Graft-versus-host disease(GVHD)is the most common complication after allogeneic hematopoietic stem cell transplantation,and also an important factor affecting the survival and quality of life in patients after ***,immunosuppressive therapy is commonly used for GVHD,but the curative effect is not *** to effectively prevent and treat GVHD is one of the difficulties to be solved urgently in the field of *** this paper,we summarize the latest progress in pathogenesis,prevention and treatment of GVHD with Chinese medicine(CM).We hope it will provide ideas and methods for exploring the mechanism and establishing a new comprehensive therapy for GVHD with CM.

关键词： Chinese medicine hematopoietic stem cell transplantation graft-versus-host disease

Effect Evaluation of Strychnos nux-vomica *** Integrative Methods for Bortezomib-Induced Peripheral Neuropathy in Multiple Myeloma Patients:A Self-Controlled Clinical Trial

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Chinese Journal of Integrative Medicine 2021年第2期27卷 131-136页

作者： dai tie-ying CHEN Chu-chu HONG Li-li Ge Hang-ping PEI Jun LYU Wen-qi YANG Xue SHEN Jian-ping HU Zhi-ping Department of Hematology the First Hospital Affiliated to Zhejiang University of Traditional Chinese MedicineHangzhou(310006)China

Objective:To explore the clinical effect and adverse reactions of Strychnos nux-vomica in bortezomib-induced peripheral neuropathy(BIPN)of patients with multiple myeloma(MM).Methods:A total of 19 MM patients with BIPN were enrolled and Nux Vomica Capsule(NVC,0.4 g,thrice daily)were orally administrated for 30 *** analysis on parameters between pre-and post-therapy,including peripheral neuropathy(PN)grade,neurotoxicity score,Chinese medicine(CM)syndrome score,total neuropathy score(TNS),coagulation function,and serum nerve growth factor(NGF)levels were *** adverse events were ***:In BIPN of MM patients who received NVC,PN grade was lowered,neurotoxicity score was obviously decreased(P 0.01),and both CM syndrome score and TNS were remarkably decreased(P0.05).No evident adverse reactions were observed during the course of ***:Strychnos nux-vomica *** significantly effect with a good safety in treatment of BIPN in MM patients.

关键词： bortezomib-induced peripheral neuropathy grilled nux vomica total neuropathy score Chinese medicine syndrome score nerve growth factor

Panaxdiol Saponins Component Promotes Hematopoiesis and Modulates T Lymphocyte Dysregulation in Aplastic Anemia Model Mice

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Chinese Journal of Integrative Medicine 2019年第12期25卷 902-910页

作者： ZHENG Zhi-yin YU Xiao-ling dai tie-ying YIN Li-ming ZHAO Yan-na XU Min ZHUANG Hai-feng Chong Beng Hock GAO Rui-lan Institution of Hematology Research the First Affiliated Hospital of Zhejiang Chinese Medical UniversityHangzhou(310006)China Department of Hematology St George HospitalSt George Clinical SchoolUniversity of New South WalesKogarah(NSW 2217)Australia

Objective: To investigate the potential efficacy of panaxadiol saponins component(PDS-C) in the treatment of aplastic anemia(AA) model mice. Methods: Totally 70 mice were divided into 7 groups as follows: normal, model, low-, medium-, high-dose PDS-C(20, 40, 80 mg/kg, namely L-, M-, H-PDS-C), cyclosporine(40 mg/kg), and andriol(25 mg/kg) groups, respectively. An immune-mediated AA mouse model was established in BALB/c mice by exposing to 5.0 Gy total body irradiation at 1.0 Gy/min, and injecting with lymphocytes from DBA mice. On day 4 after establishment of AA model, all drugs were intragastrically administered daily for 15 days, respectively, while the mice in the normal and model groups were administered with saline solution. After treatment, the peripheral blood counts, bone marrow pathological examination, colony forming assay of bone marrow culture, T lymphocyte subpopulation analysis, as well as T-bet, GATA-3 and Fox P3 proteins were detected by flow cytometry and Western blot. Results: The peripheral blood of white blood cell(WBC), platelet, neutrophil counts and hemoglobin(Hb) concentration were significantly decreased in the model group compared with the normal group(all P<0.01). In response to 3 dose PDS-C treatment, the WBC, platelet, neutrophil counts were significantly increased at a dose-dependent manner compared with the model group(all P<0.01). The myelosuppression status of AA was significantly reduced in M-, H-PDS-C groups, and hematopoietic cell quantity of bone marrow was more abundant than the model group. The colony numbers of myeloid, erythroid and megakaryocytic progenitor cells in the model group were less than those of the normal mice in bone marrow culture, while, PDS-C therapy enhanced proliferation of hematopoietic progenitor cells by significantly increasing colony numbers(all P<0.01). Furthermore,PDS-C therapy increased peripheral blood CD3^+ and CD3^+CD4^+ cells and reduced CD3^+CD8^+ cells(P<0.05 or P<0.01). Meanwhile, PDS-C treatme

关键词： Panaxadiol saponins component aplastic anemia hematopoiesis T lymphocyte

Biohythane production from two-stage anaerobic digestion of food waste:A review

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Journal of Environmental Sciences 2024年第5期139卷 334-349页

作者： Xiaona An ying Xu Xiaohu dai State Key Laboratory of Pollution Control and Resource Reuse School of Environmental Science and EngineeringTongji UniversityShanghai 200092China Shanghai Institute of Pollution Control and Ecological Security Shanghai 200092China

The biotransformation of food waste(FW)to bioenergy has attracted considerable research attention as a means to address the energy crisis and waste disposal *** this end,a promising technique is two-stage anaerobic digestion(TSAD),in which the FW is transformed to biohythane,a gaseous mixture of biomethane and *** review summarises the main characteristics of FW and describes the basic principle of ***,the factors influencing the TSAD performance are identified,and an overview of the research status;economic aspects;and strategies such as pre-treatment,co-digestion,and regulation of microbial consortia to increase the biohythane yield from TSAD is ***,the challenges and future considerations associated with the treatment of FW by TSAD are *** paper can provide valuable reference for the improvement and widespread implementation of TSAD-based FW treatment.

关键词： Two-stage anaerobic digestion(TSAD) Food waste(FW) Methane production Hydrogen production

Neighborhood predictors of short sleep duration and bedtime irregularity among children in the United States: results from the 2019-2020 National Surveyof Children's Health

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World Journal of Pediatrics 2024年第1期20卷 73-81页

作者： ying dai Jianghong Liu School of Nursing University of Pennsylvania418 Curie Blvd.Room 426Claire M.Fagin HallPhiladelphiaPA19104-6096USA

Background Environmental factors may contribute to short sleep duration and irregular bedtime in *** factors and children's sleep duration and bedtime regularity remain a less investigated *** aim of this study was to investigate the national and state-level proportions of children with short sleep duration and irregular bedtime and their neighborhood *** A total of 67,598 children whose parents completed the National Survey of Children's Health in 2019-2020 were included in the ***-weighted Poisson regression was used to explore the neighborhood predictors of children's short sleep duration and irregular *** The prevalence of short sleep duration and irregular bedtime among children in the United States(US)was 34.6%[95%confidence interval(CI)=33.8%-35.4%]and 16.4%(95%CI=15.6%-17.2%)in 2019-2020,*** neighborhoods,supportive neighborhoods,and neighborhoods with amenities were found to be protective factors against children's short sleep duration,with risk ratios ranging between 0.92 and 0.94,Pties and short *** Insufficient sleep duration and irregular bedtime were highly prevalent among US children.A favorable neighborhood environment can decrease children's risk of short sleep duration and irregular *** the neighborhood environment has implications for children's sleep health,especially for children from minority racial/ethnic groups.

关键词： Child National Survey of Children's Health Neighborhood.Sleep Social determinants of health

Securing Forwarding Layers from Eavesdropping Attacks Using Proactive Approaches

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Computers, Materials & Continua 2024年第4期79卷 563-580页

作者： Jiajun Yan ying Zhou Anchen dai Tao Wang School of Electronics and Communication Engineering Sun Yat-sen UniversityShenzhen518107China

As an emerging network paradigm,the software-defined network(SDN)finds extensive application in areas such as smart grids,the Internet of Things(IoT),and edge *** forwarding layer in software-defined networks is susceptible to eavesdropping *** hopping is amoving target defense(MTD)technology that is frequently employed to resist eavesdropping *** the traditional route hopping technology,both request and reply packets use the same hopping *** an eavesdropping attacker monitors the nodes along this path,the risk of 100%data leakage becomes *** this paper,we present an effective route hopping approach,called two-day different path(TDP),that turns communication paths into untraceable moving *** technology minimizes the probability of data leakage by transmitting request data and reply data through different ***,a brief introduction to the network model and attack model involved in this paper is ***,the algorithm and processingmethod of the TDP are ***,the paper proposes three differentmetrics tomeasure the effectiveness of the proposed ***,theoretical analysis and simulation results show that the TDP can effectively reduce the percentage of data exposure,decrease eavesdropping attack success probability,and improve the unpredictability of the path.

关键词： Route hopping moving target defense software-defined network two-way different path metrics

Asymmetric copolyimide membranes fabricated by nonsolvent-induced phase separation for He/CH_(4) and He/N_(2) separation

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Frontiers of Chemical Science and Engineering 2024年第4期18卷 97-106页

作者： ying Li Lu Wang Junyan Xie Yong dai Xuehong Gu Xuerui Wang State Key Laboratory of Materials-Oriented Chemical Engineering College of Chemical EngineeringNanjing Tech UniversityNanjing 211816China Quzhou Membrane Material Innovation Institute Quzhou 324000China

Membrane gas separation is considered an energy-saving technique to extract He from natural gas due to no phase change and room temperature ***,the membrane performance was strongly limited by the trade-off between permeance and ***,novel 4,4′-(hexafluoroisopropylidene)diphthalic anhydride(6FDA)-2,2′-bis(3-amino-4-hydroxyphenyl)hexafluoropropane(APAF)-5-amino-2-(4-aminobenzene)benzimidazole(BIA)asymmetric membranes with a thickness of 300 nm were successfully prepared by the non-solvent induced phase separation *** membrane performance was modulated by regulating dope solution compositions(e.g.,tetrahydrofuran and polymer concentration).The ideal He/CH_(4) selectivity was 124 and the optimized He permeance reached 87 GPU,beyond the current upper ***/CH_(4) selectivity was 75 and He permeance was 73 GPU for the binary mixture feed containing 0.2 mol%*** membrane showed good resistance to CO_(2) and C_(2)H_(6),which are the typical impurities in natural *** 6FDA-APAF-BIA membranes have good stability(>160 h),which can provide great potential in He extraction from natural gas.

关键词： He separation membrane natural gas copolyimide

Revealing the stability origins of 596 days-humidity-stable semitransparentperovskite solar cells

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Journal of Energy Chemistry 2024年第7期94卷 208-216页

作者： Tian Chen ying Yang Congtan Zhu Weihuang Lin Qilin dai Xueyi Guo School of Metallurgy and Environment Central South UniversityChangsha 410083HunanChina Department of Chemistry Physics and Atmospheric SciencesJackson State UniversityJacksonMS 39217USA

Hybrid organic-inorganic perovskites(HOIPs)hold promise in the field of optoelectronics due to their excellent photoelectric conversion ***,the ion migration and hygroscopicity of these perovskite solar cells need to be ***,we presented semitransparent perovskite solar cells(ST-PSCs)using hole transport layer(HTL)combined with polyaniline(PANI)to stabilize HTL/perovskite interface,achieving a humidity durability(RH,50%-90%)for 596 days(14304 h)without ***,the decrease in hydrolysis products(LiF)showed the interaction between PANI with the addi-tives in HTL dramatically inhibited the water uptake and corrosion on MAPbI_(3),*** PANI modified samples had a higher I/Pb ratio and lower trap state density,which indicated the passivation effect of PANI on the uncoordinated Pb^(2+)and iodine ***,PANI successfully stabilized the interface and perovskite by inhibiting the formation of Pb^(0) and Au migration as long period *** work presented an interfacial design to develop HOiP in air with high humidity stability.

关键词： HTL/perovskite interface Polyaniline-passivation Humidity-degradation mechanism lon migration