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Relationship of plasminogen activator inhibitor 1 gene 4G/5G polymorphisms to hypertension in Korean women

Chinese Medical Journal 2012年第7期125卷 1249-1253页

作者： Kyu-nam kim Kwang-min kim Bom-taeck kim Nam-seok Joo Doo-yeoun Cho Duck-joo Lee Department of Family Practice and Community Health Ajou University School of MedicineSuwonRepublic of Korea

Background Hypertension （HTN） is a major determinant of various cardiovascular events. Plasma levels of plasminogen activator inhibitor 1 （PAl-l） modulate this risk. A deletion/insertion polymorphism within the PAl-1 loci （4G/4G, 4G/5G, 5G/5G） affects the expression of this gene. The present study investigated the association between PAl-1 loci polymorphisms and HTN in Korean women. Methods Korean women （n=1312） were enrolled in this study to evaluate the association between PAl-1 4G/5G gene polymorphisms and HTN as well as other metabolic risk factors. PAl-1 loci polymorphisms were investigated using polymerase chain reaction amplification and single-strand conformation polymorphism analysis. Results The three genotype groups differed with respect to systolic blood pressure （P=0.043）, and diastolic blood pressure （P=0.009） but not with respect to age, body mass index, total cholesterol, low or high density lipoprotein cholesterol, triglycerides, or fasting blood glucose. Carriers of the PAl-1 4G allele had more hypertension significantly （PAl-1 4G/5G vs. PAl-1 5G/5G, P=0.032; PAl-1 4G/4G vs. PAl-1 5G/5G, P=0.034）. When stratified according to PAl-1 4G/5G polymorphism, there was no significant difference in all metabolic parameters among PAl-1 genotype groups in patients with HTN as well as subjects with normal blood pressure. The estimated odds ratio of the 4G/4G genotype and 4G/5G for HTN was 1.7 （P=0.005）, and 1.6 （P=0.015）, respectively. Conclusion These findings might indicate that PAl-1 loci polymorphisms independently contribute to HTN and that gene-environmental interaction may be not associated in Korean women.

关键词： hypertension plasminogen activator inhibitor 1 polymorphism

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Gain enhancement of perovskite nanosheets by a patterned waveguide:excitation and temperature dependence of gain saturation

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Light(Science & Applications) 2023年第12期12卷 2688-2699页

作者： Inhong kim Ga Eul Choi Ming Mei Min Woo kim Minju kim Young Woo Kwon Tae-In Jeong Seungchul kim Suck Won Hong Kwangseuk Kyhm Robert A.Taylor Department of Opto&Cogno Mechatronics Engineering RCDAMPPusan National UniversityBusan 46241Republic of Korea Department of Nano-Fusion Technology Pusan National UniversityBusan 46241Republic of Korea Clarendon Laboratory Department of PhysicsUniversity of OxfordOxford OX13PUUK

Optical gain enhancement of two-dimensional CsPbBr3 nanosheets was studied when the amplified spontaneous emission is guided by a patterned structure of *** the uncertainties and pitfalls in retrieving a gain coefficient from the variable stripe length method,a gain contour g((h))ω.x)was obtained in the plane of spectrum energy(hω)and stripe length(x),whereby an average gain was obtained,and gain saturation was *** and temperature dependence of the gain contour show that the waveguide enhances both gain and thermal stability due to the increased optical confinement and heat dissipation,and the gain origins were attributed to the two-dimensional excitons and the localized states.

关键词： waveguide saturation contour

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Web of Cell体系——适应未来智能电网发展的新理念

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电力系统自动化 2017年第15期41卷 1-9页

作者：宋蕙慧于国星曲延滨 Hak-Man kim 哈尔滨工业大学(威海)信息与电气工程学院山东省威海市264209 韩国仁川国立大学工学院

针对未来大量分布式发电并网需求,以智能电网为背景阐释了一种全新的电力系统控制体系——Web of Cell体系。首先,诠释该体系的概念并总结归纳出其特点,通过对比Web of Cell体系与集中控制体系及Cell与微电网和主动配电网间的差异,剖析... 详细信息

针对未来大量分布式发电并网需求,以智能电网为背景阐释了一种全新的电力系统控制体系——Web of Cell体系。首先,诠释该体系的概念并总结归纳出其特点,通过对比Web of Cell体系与集中控制体系及Cell与微电网和主动配电网间的差异,剖析了该体系在未来电力系统中的优势和可行性。随后,对该体系调压调频的控制结构和运行方式进行了分析并指出应重点关注的技术问题。最后,对该体系的进一步发展和研究方向进行了展望,以期为中国电网智能化发展提供参考和借鉴。

关键词：智能电网 Web of Cell体系集中控制体系微电网(微网) 调压调频

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Medially based de-epithelialized flap for nasal base narrowing and nostril sill augmentation in a cleft lip nasal deformity

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Plastic and Aesthetic Research 2016年第1期3卷 291-295页

作者： Kun Hwang Jong Hwan Choi Hun kim dae Joong kim Department of Plastic Surgery Inha University School of MedicineIncheon 400-711South Korea Department of Plastic Surgery Inha University HospitalIncheon 400-711South Korea Department of Anatomy Inha University School of MedicineIncheon 400-711South Korea

Aim:The authors observed the nostril floor in a gross cadaver specimen histologically and innovated a medially based de-epithelialized flap for nasal base narrowing and nostril sill ***:In cadaver,fully thick section was taken from the nostril sill at the midpoint of the columella base and ala base,and stained with *** eight patients,circumferential incision along the nostril sill and alar base freed the alar base from the upper *** the columellar base,fresh epithelium was shaved on the medial side of the incision *** widened scar on the upper lip was *** de-epithelialized tip of the columellar base was pulled under the medial tip of the alar base flap and sutured *** anthropometric distances were measured preoperatively and ***:Histologically the nostril sill was composed of thickened *** below the dermis,the depressor septi nasi muscle ran obliquely,augmenting the nostril *** nostril floor width,alar distance,and alar curvature distance decreased on the cleft side after the ***:A medially based de-epithelialized flap narrows the alar base and augments the nostril sill simultaneously,since the de-epithelialized part of the excess skin augments the depressed nostril sill.

关键词： Cleft lip nose deformities acquired surgical flaps dermis

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Neuroprotective effects of ischemic preconditioning on hippocampal CA1 pyramidal neurons through maintaining calbindin D28k immunoreactivity following subsequent transient cerebral ischemia

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Neural Regeneration Research 2017年第6期12卷 918-924页

作者： In Hye kim Yong Hwan Jeon Tae-Kyeong Lee Jeong Hwi Cho Jae-Chul Lee Joon Ha Park Ji Hyeon Ahn Bich-Na Shin Yang Hee kim Seongkweon Hong Bing Chun Yan Moo-Ho Won Yun Lyul Lee Department of Neurobiology School of Medicine Kangwon National University Department of Radiology School of Medicine Kangwon National University Department of Biomedical Science Research Institute of Bioscience and Biotechnology Hallym University Department of Physiology College of Medicine Hallym University Department of Surgery School of Medicine Kangwon National University Institute of Integrative Traditional & Western Medicine Medical College Yangzhou University

Ischemic preconditioning elicited by a non-fatal brief occlusion of blood flow has been applied for an experimental therapeutic strategy against a subsequent fatal ischemic insult. In this study, we investigated the neuroprotective effects of ischemic preconditioning（2-minute transient cerebral ischemia） on calbindin D28k immunoreactivity in the gerbil hippocampal CA1 area following a subsequent fatal transient ischemic insult（5-minute transient cerebral ischemia）. A large number of pyramidal neurons in the hippocampal CA1 area died 4 days after 5-minute transient cerebral ischemia. Ischemic preconditioning reduced the death of pyramidal neurons in the hippocampal CA1 area. Calbindin D28k immunoreactivity was greatly attenuated at 2 days after 5-minute transient cerebral ischemia and it was hardly detected at 5 days post-ischemia. Ischemic preconditioning maintained calbindin D28 k immunoreactivity after transient cerebral ischemia. These findings suggest that ischemic preconditioning can attenuate transient cerebral ischemia-caused damage to the pyramidal neurons in the hippocampal CA1 area through maintaining calbindin D28k immunoreactivity.

关键词： hippocampal subsequent minute pyramidal maintaining attenuated hippocampus neuronal occlusion fatal

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Management Performance Evaluation Model of Korean Construction Firms

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Journal of Building Construction and Planning Research 2013年第2期1卷 27-38页

作者： Donghoon Lee Manki kim Sunkuk kim Department of Architectural Engineering Kyung Hee University Seoul Republic of Korea

Corporate management performance evaluation currently focuses on financial aspects;however, it is necessary to identify and manage elements that contribute to increased economic values in the long run. When it comes to construction firms, most previous research did not cover weighting and estimation approaches for non-financial elements that ultimately influence financial status. In this research, the objective is to develop a management performance evaluation model for Korean construction firms. The model includes financial factors and non-financial factors. This research investigated actual data from Korean construction firmsandclassifiedtheir characteristics. This study is performed in two steps. First, this study derives KPIs for performance measurement techniques and weights the KPIs. And then, it applies the performance data of construction firms to the technique. The findings of this study show that Korean construction firms consider customers to be the foremost priority, converse to previous research which argued that the internal business process was the top priority. The performance measurement results can be fed back into strategies and plans to shed light on issues, reflect on management plans for subsequent years and modify mid to long-term strategies. Therefore, the developed model can help decision-makers effectively revise their management plans.

关键词： Management Performance Evaluation Key Performance Indicators Balanced Scorecard AHP Fuzzy

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Three-dimensional Analysis of Prestressed Concrete Offshore Wind Turbine Structure Under Environmental and 5-MW Turbine Loads

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Journal of Marine Science and Application 2018年第4期17卷 625-637页

作者： Bum-Joon kim Pasin Plodpradit Ki-Du kim Hyun-Gi kim Department of Civil and Environmental Plant Engineering Konkuk University Department of Energy Plant Engineering Catholic Kwangdong University

A concrete gravity base structure may not be suitable for offshore weak soil because of its heavy weight. Therefore, a conceptual model for a concrete offshore wind turbine structure suitable for weak soils is proposed. The proposed model is composed of a prestressed concrete(PSC) supported by a pile foundation. For a three-dimensional analysis of the large concrete structure, wave pressures based on the diffraction wave theory are developed using a three-dimensional solid finite element method. Static and dynamic analyses were performed to achieve the conceptual model of a PSC structure subjected to ocean environmental loads and a 5-MW turbine load on southwest coast in Korea. From the analysis, the maximum displacement and stresses of the proposed model did not exceed the allowable values from design standard, and the first mode of natural frequency of the structure was in a safe range to avoid resonance. The proposed model has enough structural stability to withstand external loads, and it is expected to be used in locations suitable for concrete gravity structures.

关键词： Prestressed concrete offshore wind turbine structure Morison equation Diffraction theory Static analysis Natural frequency analysis

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Gold nanoparticle-assisted delivery of brain-derived neurotrophic factor to cerebral organoids

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Nano Research 2022年第4期15卷 3099-3105页

作者： Sung Bum Park Hye-Jin Cho Sang Rin Moon Kyoung Jin Choi Won Hoon Jung Ki Young kim Byumseok Koh Therapeutics and Biotechnology Division Korea Research Institute of Chemical Technology141 Gajeong-roYuseong-guDaejeon 34114Republic of Korea Chemical Platform Technology Division Korea Research Institute of Chemical Technology141 Gajeong-roYuseong-guDaejeon 34114Republic of Korea

Gold nanoparticle(AuNP)-assisted delivery of proteins/drugs to cells or in vivo systems has long been ***,their interaction with in vivo mimicking organoids is still largely ***,we conjugated brain-derived neurotropic factor(BDNF)to the AuNP surface and monitored how AuNP-BDNF interacts with cerebral *** suggest that AuNP-BDNF can successfully enter cerebral organoids and can be found up to 15.21μm inside cerebral ***-BDNF does not induce significant cytotoxicity to cerebral organoids at concentrations up to 2 nM and increases the expression of 75 genes compared to control cerebral *** data suggest the successful delivery of BDNF through AuNP-BDNF conjugation in cerebral organoids,and the conjugation can affect its differentiation.

关键词： gold nanoparticles cerebral organoids delivery penetration differentiation viability

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Effect of gadolinium incorporation on optical characteristics of YNbO_4:Eu^(3+) phosphors for lamp applications

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Journal of Rare Earths 2012年第3期30卷 205-209页

作者： Sung Hwan Choi G. Anoop Dong Wook Suh Kyung Pil kim Hyun Ju Lee Jae Soo Yoo Display Materials Laboratory School of Chemical Engineering and Materials Science Chung-Ang University

Eu3＋-doped （Y,Gd）NbO4 phosphor was synthesized by solid-state reaction for possible application in cold cathode fluorescent lamps. A broad absorption band with peak maximum at 272 nm was observed which was due to the charge transfer between Eu3＋ ions and neighboring oxygen anions. A deep red emission at the peak wavelength of 612 nm was observed which could be attributed to the 5D0→7F2 transition in Eu3＋ ions. The highest luminance for Y1-x-yGdyNbO4：Eux3＋ under 254 nm excitation was achieved at Eu3＋ concentration of 18 mol.% （x=0.18） and Gd3＋ concentration of 8.2 mol.% （y=0.082）. The luminance of Y0.738Gd0.082NbO4：Eu3＋0.18 was higher than that of a typical commercial phosphor Y2O3：Eu3＋ and the CIE chromaticity coordinate was （0.6490, 0.3506）, which was deeper than that of Y2O3：Eu3＋. The particle size of the synthesized phosphors was controlled by the NaCl flux and particle size as high as 8 μm with uniform size distribution of particles was obtained.

关键词： YNbO4:Eu oxide phosphors rare earths

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Interface properties and phase formation between surface coated SKD61 and aluminum alloys

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中国有色金属学会会刊：英文版 2009年第4期19卷 875-878页

作者： Se-Weon CHOI Young-Chan kim Se-Hun CHANG Ik-Hyun OH Joon-Sik PARK Chang-Seog KANG Automotive Components Center Korea Institute of Industrial Technology Division of Advanced Materials Engineering Hanbat National University

The intermediate phase formation and surface protection effects between SKD61 die mold alloys and aluminum alloys were investigated during a simulated die-casting *** surface coatings of SKD61 alloy were carried out via Si pack cementation coatings at 900 ℃ for 10 h and the ε-FeSi phase *** the coated SKD61 alloy was dipped in the liquid aluminum alloy(ALDC12),the surface coated SKD61 alloys showed better surface properties compared with uncoated SKD61 alloys,i.e.,the intermediate phases(FeSiAl compound) were not produced for the coated SKD61 *** coating layer of ε-FeSi served as a diffusion barrier for the formation of FeSiAl compounds.

关键词：表面涂层铝合金接口特性表面合金涂层表面保护合金生产化合物中间相

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