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Polymeric micelle nanocarriers in cancer research

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Frontiers of Chemical Science and Engineering 2016年第3期10卷 348-359页

作者： dae hwan shin Yu Tong Tam Glen S. Kwon School of Pharmacy University of Wisconsin Madison WI 53705 USA

Amphiphilic block copolymers （ABCs） assem- ble into a spherical nanoscopic supramolecular core/shell nanostructure termed a polymeric micelle that has been widely researched as an injectable nanocarrier for poorly water-soluble anticancer agents. The aim of this review article is to update progress in the field of drug delivery towards clinical trials, highlighting advances in polymeric micelles used for drug solubilization, reduced off-target toxicity and tumor targeting by the enhanced permeability and retention （EPR） effect. Polymeric micelles vary in stability in blood and drug release rate, and accordingly play different but key roles in drug delivery. For intravenous （IV） infusion, polymeric micelles that disas- semble in blood and rapidly release poorly water-soluble anticancer agent such as paclitaxel have been used for drug solubilization, safety and the distinct possibility of toxicity reduction relative to existing solubilizing agents, e.g., Cremophor EL. Stable polymeric micelles are long- circulating in blood and reduce distribution to non-target tissue, lowering off-target toxicity. Further, they participate in the EPR effect in murine tumor models. In summary, polymeric micelles act as injectable nanocarriers for poorly water-soluble anticancer agents, achieving reduced toxi- city and targeting tumors by the EPR effect.

关键词： nanomedicine parenteral poly(ethylene glycol) poly(lactic acid) reformulation

An Experimental Study of Condensation Heat Transfer in Sub-Millimeter Rectangular Tubes

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Journal of Thermal Science 2004年第4期13卷 350-357页

作者： Jeong Seob shin Moo hwan KIM Department of Mechanical Engineering POSTECH Pohang KoreaDepartment of Mechanical Engineering POSTECH Pohang Korea

The characteristics of local heat transfer and pressure drops were experimentally investigated using condensing R134a two-phase flow, in single rectangular tubes, with hydraulic diameter of 0.494, 0.658, and 0.972 mm. New experimental techniques were used to measure the in-tube condensation heat transfer coefficient especially for the low heat and mass flows. Tests were performed for a mass flux of 100, 200, 400, and 600 kg/m2s, a heat flux of 5 to 20 kW/m2, and a saturation temperature of 40℃. In this study, effect of heat flux, mass flux, vapor qualities, and hydraulic diameter on flow condensation were investigated and the experimental local condensation heat transfer coefficients and frictional pressure drop are shown. The experimental data of condensation Nusselt number are compared with previous correlations, most of which are proposed for the condensation of pure refrigerant in a relatively large inner diameter round tubes.

关键词： condensation hydraulic diameter rectangular in-tube multiphase flow.

Understanding of the Relationship between the Properties of Cu(In,Ga)Se_(2) Solar Cells and the Structure of Ag Network Electrodes

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Energy & Environmental Materials 2024年第6期7卷 246-253页

作者： Hyesun Yoo Hoang Van Quy Inpyo Lee Seung Taek Jo Tae Ei Hong JunHo Kim dae-hwang Yoo Jinwook shin Walter Commerell dae-hwan Kim Jong Wook Roh Regional Leading Research Center(RLRC)of Smart Energy System Kyungpook National UniversityGyeongsangbuk-do 37224Korea Division of Energy Technology DaeguGyeongbuk Institute of Science and Technology(DGIST)Daegu 42988Korea Department of Hydrogen and Renewable Energy Kyungpook National UniversityDaegu 47922Korea Nano Photoelectronic Device Lab Department of PhysicsIncheon National UniversityIncheon 22012Korea Institute for Energy and Drive Technology Technische Hochschule Ulm(THU)Ulm 89081Germany Department of Nano&Advanced Materials Science and Engineering Kyungpook National UniversityGyeongsangbuk-do 37224Korea

The relation between the structure of the silver network electrodes and the properties of Cu(In,Ga)Se_(2)(CIGS)solar cells is systemically *** Ag network electrode is deposited onto an Al:ZnO(AZO)thin film,employing a self-forming cracked *** control over the cracked template's structure is achieved through careful adjustment of temperature and *** Ag network electrodes with different coverage areas and network densities are systemically applied to the CIGS solar *** is revealed that predominant fill factor(FF)is influenced by the figure of merit of transparent conducting electrodes,rather than sheet resistance,particularly when the coverage area falls within the range of 1.3–5%.Furthermore,a higher network density corresponds to an enhanced FF when the coverage areas of the Ag networks are *** utilizing a thinner AZO film,CIGS solar cells with a surface area of 1.0609 cm^(2)exhibit a notable performance improvement,with efficiency increasing from 10.48%to 11.63%.This enhancement is primarily attributed to the increase in FF from 45%to 65%.These findings underscore the considerable potential for reducing the thickness of the transparent conductive oxide(TCO)in CIGS modules with implications for practical applications in photovoltaic technology.

关键词： CIGS large-area solar cell metal mesh metallic network transparent electrode

Direct interaction of DNMT inhibitors to PrP^C suppresses pathogenic process of prion

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Acta Pharmaceutica Sinica B 2019年第5期9卷 952-959页

作者： dae-hwan Kim Chunyan Ren Chongsuk Ryou Jiaojie Li Institute of Pharmaceutical Science and Technology Hanyang UniversityAnsan15588Republic of Korea School of Undergraduate Studies College of Transdisciplinary StudiesDaegu Gyeongbuk Institute of Science and TechnologyDaegu42988Republic of Korea Boston Children’s Hospital Harvard Medical SchoolBostonMA02115USA Department of Pharmacy Hanyang UniversityAnsan15588Republic of Korea Department of Chemistry Gwangju Institute of Science and TechnologyGwangju61005Republic of Korea

The conversion of the normal cellular prion protein(PrP^C) to the misfolded pathogenic scrapie prion protein(Pr PSc) is the biochemical hallmark of prion replication. So far, various chemical compounds that inhibit this conformational conversion have been identified. Here, we report the novel anti-prion activity of SGI-1027 and its meta/meta analogue(M/M), previously known only as potent inhibitors of DNA methyltransferases(DNMTs). These compounds effectively decreased the level of Pr PSc in cultured cells with permanent prion infection, without affecting PrP^Cat the transcriptional or translational levels. Furthermore, SGI-1027 prevented effective prion infection of the cells. In a Pr P aggregation assay, both SGI-1027 and M/M blocked the formation of misfolded Pr P aggregates, implying that binding of these compounds hinders the Pr P conversion process. A series of binding and docking analyses demonstrated that both SGI-1027 and M/M directly interacted with the C-terminal globular domain of PrP^C, but only SGI-1027 bound to a specific region of PrP^C with high affinity, which correlates with its potent antiprion efficacy. Therefore, we report SGI-1027 and related compounds as a novel class of potential antiprion agents that preferentially function through direct interaction with PrP^C.

关键词： Prion DNMT Therapeutic compounds PrP^C Epigenetic regulation

Identifying the relationships between subsurface absorber defects and the characteristics of kesterite solar cells

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Carbon Energy 2023年第8期5卷 42-54页

作者： dae-Ho Son Dong-hwan Jeon dae-hwan Kim Jin-Kyu Kang Shi-Joon Sung Jaebaek Lee Taeseon Lee Enkhjargal Enkhbayar JunHo Kim Kee-Jeong Yang Division of Energy Technology DGISTDaeguRepublic of Korea Research Center for Thin Film Solar Cells DGISTDaeguRepublic of Korea Department of Physics Incheon National UniversityIncheonRepublic of Korea

Understanding the defect characteristics that occur near the space-charge regions(SCRs)of kesterite(CZTSSe)solar cells is important because the recombination loss at the CZTSSe/CdS interface is considered the main cause of their low *** surfaces with different elemental compositions were formed without polishing(C00)and with polishing for 20 s(C20)and 60 s(C60).For C60,a specific region near the SCR was excessively Cu-rich and Zn-poor compared to C00 and *** charged defects formed where the elemental variation was *** the main deep acceptor defect energy level(E_(a2))near the SCR increased,the efficiency,open-circuit voltage deficit,and current density degraded,and this phenomenon was especially rapid for large E_(a2) *** the E_(a2) near the SCR became deep,the carrier diffusion length decreased more for the CZTSSe solar cells with a low carrier mobility than for the CuInGaSe_(2)(CIGSe)solar *** large amplitude of the electrostatic potential fluctuation in the CZTSSe solar cells induced a high carrier recombination and a short carrier ***,the properties of the CZTSSe solar cells were more strongly degraded by defects with deep energy levels near the SCR than those of the CIGSe solar cells.

关键词： defect density defect energy level elemental variation kesterite space charge region

Solitary Peutz-Jeghers-type appendiceal hamartomatous polyp growing into the terminal ileum

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World Journal of Gastroenterology 2014年第16期20卷 4822-4826页

作者： Chang In Choi dae hwan Kim Tae Yong Jeon Dong Heon Kim Na Ri shin Do Youn Park Department of Surgery Medical Research InstitutePusan National University HospitalSeo-GuBusan 602-739South Korea Department of Pathology Medical Research InstitutePusan National University HospitalSeo-GuBusan 602-739South Korea

Solitary Peutz-Jeghers type hamartomatous polyp is *** is considered to be related to a variant PeutzJeghers syndrome(PJS)and may be a separate disease entity.A 50-year-old man was referred to our hospital with a diagnosis of intussusception in the terminal ileum and underwent segmental ileal resection with *** identified a 3.5-cm diameter polyp arising from the appendix with ingrowth into the terminal *** polyp was confirmed to be a hamartomatous polyp of Peutz-Jeghers-type,***,the patient had no characteristic manifestations of PJS such as mucocutaneous pigmentation and family *** are few reports of appendiceal hamartomatous polyp in PJS patients and solitary appendiceal hamartomatous polyp is even ***,rather than telescoping,ours is the first reported intussuscepted lesion,to the best of our knowledge.

关键词： Peutz-Jeghers syndrome Hamartomatous intestinal polyposis Neoplasms Intussusception Intestinal obstruction

Do we have enough evidence for expanding the indications of ESD for EGC?

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World Journal of Gastroenterology 2011年第21期17卷 2597-2601页

作者： Hang Lak Lee Chang hwan Choi dae Young Cheung Department of Internal Medicine Hanyang University College of Medicine Department of Internal Medicine ChungAng University College of Medicine Division of Gastroenterology Department of Internal MedicineYeouido St.Mary's Hospitalthe Catholic University of Korea College of Medicine

Endoscopic submucosal dissection(ESD) is the most advanced and representative technique in the field of therapeutic endoscopy and has been used for the treatment of gastrointestinal neoplasms,including early gastric *** major difference and advantage of ESD compared to existing endoscopic resection techniques,such as endoscopic mucosal resection(EMR) and polypectomy,are the width and depth of the *** developed cutting devices,distal attachable endoscopic accessories,and an advanced electrosurgical unit have helped to overcome the limitations of therapeutic endoscopy in terms of lesion size,location,presence of fibrotic scarring,and accompanying *** a result,the indications for ESD have been expanded from the classical indication for EMR and polypectomy,and there is now support for a further expansion of ESD *** present,the most critical factor to consider in the decision of whether to perform ESD is the probability of unexpected lymph node *** guidelines for ESD are continually being updated and *** this review,we discuss the strengths and weaknesses of the expanded guidelines,based on evidence found in the literature.

关键词： Endoscopic submucosal dissection Endoscopic mucosal resection Early gastric cancer Indications

Vertical plane depth-resolved surface potential and carrier separation characteristics in flexible CZTSSe solar cells with over 12% efficiency

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Carbon Energy 2024年第3期6卷 36-52页

作者： dae-Ho Son Ha Kyung Park dae-hwan Kim Jin-Kyu Kang Shi-Joon Sung dae-Kue hwang Jaebaek Lee Dong-hwan Jeon Yunae Cho William Jo Taeseon Lee JunHo Kim Sang-Hoon Nam Kee-Jeong Yang Division of Energy Technology DGISTDaeguRepublic of Korea Research Center for Thin Film Solar Cells DGISTDaeguRepublic of Korea Department of Physics Ewha Womans UniversitySeoulRepublic of Korea Department of Physics Incheon National UniversityIncheonRepublic of Korea Department of Mechanical Engineering Massachusetts Institute of TechnologyCambridgeMassachusettsUSA

Cu2ZnSn(S,Se)4(CZTSSe)solar cells have resource distribution and economic *** main cause of their low efficiency is carrier loss resulting from recombination of photo-generated electron and *** overcome this,it is important to understand their electron-hole behavior *** determine the carrier separation characteristics,we measured the surface potential and the local current in terms of the absorber *** elemental variation in the intragrains(IGs)and at the grain boundaries(GBs)caused a band edge shift and bandgap(Eg)*** the absorber surface and subsurface,an upward Ec and Ev band bending structure was observed at the GBs,and the carrier separation was *** the absorber center,both upward Ec and Ev and downward Ec-upward Ev band bending structures were observed at the GBs,and the carrier separation was *** improve the carrier separation and suppress carrier recombination,an upward Ec and Ev band bending structure at the GBs is desirable.

关键词： carrier separation CZTSSe flexible solar cell local current surface potential

Numerical study on the performance of nozzle flow for supersonic chemical oxygen-iodine lasers

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Acta Mechanica Sinica 2008年第2期24卷 133-142页

作者： Zongmin Hu Junming Lā Zonglin Jiang Rho-shin Myong Tae-hwan Cho LHD Institute of MechanicsCAS Beijing 100080 China Research Center for Aircraft Parts Technology Geyongsang National University Jinju 660-701 South Korea

Laser performance is greatly dependent on its operating conditions due to the strong coupling among multi- physics such as gas-dynamics, chemical reaction kinetics and optics in the mixing nozzle of COIL. In this paper, 3D CFD technology is used to simulate the mixing and reactive flow of subsonic cross jet scheme at different conditions. Results obtained show that the jet penetration depth plays a dominant role in the spatial distribution of small signal gains. In the case of over-penetration, unsteady flow structures are induced by impinging between the opposing jets. The optimum spatial distribution of the chemical performance cannot be obtained even if the full penetration condition is achieved through the subsonic transverse jet mixing scheme in the COIL nozzle flow.

关键词： Chemical oxygen-iodine laser (COIL) Numerical simulation Small signal gains Unsteady structures