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单宁酸改性互穿网络水凝胶促进断裂跟腱术后的组织重塑

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中国组织工程研究 2025年第4期29卷 721-729页

作者：张博张振江东北京大学第三医院运动医学科北京市100191

背景:跟腱断裂术后的再生与重塑是临床治疗的难点,组织工程水凝胶材料为促进跟腱修复提供了可能。目的:探究单宁酸改性互穿网络水凝胶对大鼠断裂跟腱组织再生与重塑的作用。方法:①通过蓝光照射及CaSO4溶液浸泡交联制备单宁酸改性互穿... 详细信息

背景:跟腱断裂术后的再生与重塑是临床治疗的难点,组织工程水凝胶材料为促进跟腱修复提供了可能。目的:探究单宁酸改性互穿网络水凝胶对大鼠断裂跟腱组织再生与重塑的作用。方法:①通过蓝光照射及CaSO4溶液浸泡交联制备单宁酸改性互穿网络水凝胶,表征水凝胶的微观形貌、力学性能、黏附性能、体外释药性能与生物相容性。②取30只SD大鼠,采用随机数字表法分为假手术组、手术组与水凝胶组,每组10只,后2组建立右后肢跟腱断裂模型,手术组采用改良Kessler法将断裂跟腱重新缝合,水凝胶组采用相同术式缝合断裂跟腱后将单宁酸改性互穿网络水凝胶贴片完全缠绕包裹于断端接合处。术后4周,对断裂跟腱进行影像学检查、组织学评价、生物力学测试及炎症因子水平检测。结果与结论:①扫描电镜下可见单宁酸改性互穿网络水凝胶呈多孔微观结构,孔径为3-10μm,并且水凝胶具备良好的体外释药性能、黏附强度与拉伸强度;CCK-8检测与活/死染色显示,该水凝胶对大鼠骨髓间充质干细胞增殖活性无明显影响,具备良好的生物相容性。②MRI成像显示,与手术组比较,水凝胶组大鼠跟腱呈均一低信号,跟腱前后径厚度减小,与周围组织分界更为明确,表现更接近假手术组。苏木精-伊红与Masson染色显示,手术组大鼠跟腱纤维排列松散混乱,细胞密度增加且排布杂乱,伴有明显炎性细胞浸润,部分区域出现腱内骨化;水凝胶组大鼠跟腱纤维排列有序,细胞密度降低且排布规整,炎性细胞浸润明显减少。手术组大鼠跟腱的拉伸强度低于假手术组(P<0.05),水凝胶组大鼠跟腱的拉伸强度高于手术组(P<0.05)。与假手术组比较,手术组大鼠跟腱中白细胞介素1β、白细胞介素6及肿瘤坏死因子α质量浓度及mRNA表达升高(P<0.05);与手术组比较,水凝胶组3种炎症因子水平及mRNA表达降低。③结果表明,单宁酸改性互穿网络水凝胶可显著抑制局部炎症反应、促进断裂跟腱组织重塑。

关键词：单宁酸水凝胶互穿网络跟腱断裂组织重塑组织再生

基于2018-2022年国家自然科学基金结题项目分析干细胞研究现状

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中国组织工程研究 2025年第19期29卷 4145-4150页

作者：蒋君张玢中国医学科学院医学信息研究所北京市100005

背景:目前大多数研究从国家自然科学基金资助论文和项目申请角度出发,对干细胞某一方面进行深入分析,或者验证某种评价方法,缺乏对干细胞领域国家自然科学基金已结题项目的全面分析。目的:了解2018-2022年干细胞领域国家自然科学基金结... 详细信息

背景:目前大多数研究从国家自然科学基金资助论文和项目申请角度出发,对干细胞某一方面进行深入分析,或者验证某种评价方法,缺乏对干细胞领域国家自然科学基金已结题项目的全面分析。目的:了解2018-2022年干细胞领域国家自然科学基金结题项目资助情况及研究热点,为后续研究提供参考。

关键词：干细胞国家自然科学基金聚类分析研究热点文献计量学

Unraveling the mechanism of action of Shangxia Liangji formula for treating insomnia:a metabolomics and network pharmacology approach

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Traditional Medicine Research 2025年第2期10卷 16-29页

作者： Xia-Jie Quan Hao Liang Yong-Hong Tang Li jiang Xiong-Ying Ji Feng-Ying zhang Ping zhang Bo Ouyang Department of Information The Affiliated Nanhua HospitalHengyang Medical SchoolUniversity of South ChinaHengyang 421002China Department of Neurology The Affiliated Nanhua HospitalHengyang Medical SchoolUniversity of South ChinaHengyang 421002China Department of Gastroscopy The Affiliated Nanhua HospitalHengyang Medical SchoolUniversity of South ChinaHengyang 421002China Department of Traditional Chinese Medicine The Affiliated Nanhua HospitalHengyang Medical SchoolUniversity of South ChinaHengyang 421002China

Background:Insomnia is a prevalent clinical condition and Shangxia Liangji formula(SXLJF)is a well-established method of ***,the specific mechanism of action of SXLJF remains ***:The mouse model of insomnia was established by intraperitoneal injection of ***-two mice were randomly divided into a negative control group,model group,SXLJF group(18.72 g/kg/day),and positive control group(diazepam,2 mg/kg)and treated with the corresponding drugs for 7 consecutive *** open field test and pentobarbital-induced sleeping test were ***-MS-based untargeted metabolomics and network pharmacology were applied to explore the potential targets of SXLJF for treating ***,key targets were validated using ***:Behavioral tests demonstrated that SXLJF reduced the total distance,average velocity,central distance,and sleep latency,and prolonged sleep *** and network pharmacology revealed potential targets,signaling pathways,metabolic pathways,and metabolites associated with the anti-insomnia effects of ***,tyrosine hydroxylase(TH)and tyrosine metabolism emerged as crucial metabolic pathways and targets,***-qPCR results supported the role of TH in the mechanism of SXLJF in treating ***:In conclusion,TH and tyrosine metabolism may represent significant targets and pathways for SXLJF in treating insomnia.

关键词： Shangxia Liangji formula insomnia metabolomics network pharmacology tyrosine hydroxylase tyrosine metabolism

Electro-optic tuning in ferroelectric capacitor with photonic crystal nanobeam cavity

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Science China(Information Sciences) 2025年

作者： Tongtong WANG Yong zhang danyang YAO Zhi jiang Dongxin TAN Jie WEN Qiyu YANG Xuetao GAN Yan LIU Yue HAO Genquan HAN State Key Discipline Laboratory of Wide Band Gap Semiconductor Technology School of MicroelectronicsXidian University Key Laboratory of Light Field Manipulation and Information Acquisition Ministry of Industry and Information TechnologyShaanxi Key Laboratory of Optical Information Technology School of Physical Science and TechnologyNorthwestern Polytechnical University Hangzhou Institute of Technology Xidian University

Silicon photonics has provided a platform for the convergency of photonic devices and electronic circuits, facilitating the development of optical telecommunications and optical interconnects on chip[1]. As the basic building block of optical communication systems, electro-optic tuning is expected to be more compact, high bandwidth, energy efficient, and allow for CMOS-compatible fabrication in the future[2]. Resonator-based electro-optic tuning has attracted more and more interest due to the small footprint, enhanced light-matter interactions and high energy efficiency. Compared with microring and microdisk resonators, photonic crystal nanobeam cavities （PCNBCs） realize higher quality factors, stronger light-matter interactions, ultrasmall mode volume and a much larger free spectral range （FSR）[3].

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日粮中添加枯草芽孢杆菌对高氧气调包装猪肉蛋白质和脂质氧化的影响

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食品科学 2025年第1期46卷 142-148页

作者：张悦于江刘飞张玉玉张一敏毛衍伟山东农业大学食品科学与工程学院山东泰安271018 山东省农业科学院畜牧兽医研究所农业农村部畜禽生物组学重点实验室山东济南250100

为探究日粮添加枯草芽孢杆菌对猪肉抗氧化能力以及高氧气调包装贮藏期间猪肉肉色、蛋白质氧化、脂质氧化和感官品质的影响,选取对照组(只饲喂基础日粮)和处理组(基础日粮添加枯草芽孢杆菌)的三元杂交(杜洛克×长白×大约克)猪各6只,屠... 详细信息

为探究日粮添加枯草芽孢杆菌对猪肉抗氧化能力以及高氧气调包装贮藏期间猪肉肉色、蛋白质氧化、脂质氧化和感官品质的影响,选取对照组(只饲喂基础日粮)和处理组(基础日粮添加枯草芽孢杆菌)的三元杂交(杜洛克×长白×大约克)猪各6只,屠宰后取背最长肌测定抗氧化酶活性,其余背最长肌样品进行高氧气调包装,4℃冷库贮藏,分别在0、5、10、15、20?d测定肉色、丙二醛(malondialdehyde,Mda)、羰基和巯基含量,并进行感官评价。结果表明:与对照组相比,处理组能够显著提高超氧化物歧化酶、谷胱甘肽过氧化物酶和过氧化氢酶活性(Pda含量(P<0.05),抑制高氧气调包装猪肉的脂肪氧化;日粮中添加枯草芽孢杆菌能够显著抑制高氧气调包装猪肉的蛋白质氧化、羰基的生成和巯基损失(P<0.05),同时显著提高猪肉打开包装前的颜色和打开包装后的总体喜爱度评分(P<0.05)。综上,在日粮中添加枯草芽孢杆菌可提高猪肉的抗氧化能力、改善猪肉在高氧气调包装中的肉色、抑制蛋白质和脂质氧化,提高猪肉的食用品质。

关键词：枯草芽孢杆菌猪肉抗氧化能力脂质氧化蛋白质氧化

Roles of Synoptic to Quasi-Monthly Disturbances in Generating Two Pre-Summer Heavy Rainfall Episodes over South China

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Advances in Atmospheric Sciences 2020年第2期37卷 211-228页

作者： Zhina jiang da-Lin zhang Hongbo LIU State Key Laboratory of Severe Weather Chinese Academy of Meteorological SciencesBeijing 100081China Department of Atmospheric and Oceanic Science University of MarylandCollege ParkMaryland 20742-2425USA LASG Institute of Atmospheric PhysicsChinese Academy of SciencesBeijing 100029China

In this study,power spectral analysis and bandpass filtering of daily meteorological fields are performed to explore the roles of synoptic to quasi-monthly disturbances in influencing the generation of pre-summer heavy rainfall over South *** heavy rainfall episodes are selected during the months of April-June 2008-15,which represent the collaboration between the synoptic and quasi-biweekly disturbances and the synoptic and quasi-monthly disturbances,*** show that the first heavy rainfall episode takes place in a southwesterly anomalous flow associated with an anticyclonic anomaly over the South China Sea(SCS)at the quasi-biweekly scale with 15.1%variance contributions,and at the synoptic scale in a convergence zone between southwesterly and northeasterly anomalous flows associated with a southeastward-moving anticyclonic anomaly on the leeside of the Yungui Plateau and an eastwardpropagating anticyclonic anomaly from higher latitudes with 35.2%variance *** contrast,the second heavy rainfall episode takes place in southwest-to-westerly anomalies converging with northwest-to-westerly anomalies at the quasi-monthly scale with 23.2%variance contributions to the total rainfall variance,which are associated with an anticyclonic anomaly over the SCS and an eastward-propagating cyclonic anomaly over North China,*** the synoptic scale,it occurs in south-to-southwesterly anomalies converging with a cyclonic anomaly on the downstream of the Yungui Plateau with 49.3%variance *** both cases,the lower-tropospheric mean south-to-southwesterly flows provide ample moisture supply and potentially unstable conditions;it is the above synoptic,quasi-biweekly or quasimonthly disturbances that determine the general period and distribution of persistent heavy rainfall over South China.

关键词： synoptic scale pre-summer rainfall quasi-biweekly scale quasi-monthly disturbances

Galvanic Effect Between Galvanized Steel and Carbon Fiber Reinforced Polymers

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Acta Metallurgica Sinica(English Letters) 2017年第4期30卷 342-351页

作者： Chi zhang da-jiang Zheng Guang-Ling Song Center for Marine Materials Corrosion and Protection State Key Laboratory of Physical Chemistry of Solid SurfaceCollege of MaterialsXiamen University School of Mechanical and Mining Engineering The University of Queensland

The galvanic corrosion behavior of carbon fiber reinforced polymers （CFRPs） GM-CFRP and Tepex-CFRP in contact with a Zn-coated DP590 steel in solution containing 0.9 wt% NaCl＋ 0.1 wt% CaCl2 ＋ 0.075 wt% NaHCO3 was investigated. The results showed that the GM-CFRP/steel couple was initially more resistant to galvanic corrosion, but its galvanic corrosion activity gradually became higher than the Tepex-CFRP/steel couple. The different galvanic behaviors of these two couples were discussed based on the electrochemical performance of GM-CFRP, Tepex-CFRP and DP590 coupons in the testing solution.

关键词： Carbon fiber reinforced polymer (CFRP) Composite Carbon fiber Steel Galvanic effect

Advances and applications in single-cell and spatial genomics

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Science China Life Sciences 2025年

作者： Jingjing Wang Fang Ye Haoxi Chai Yujia jiang Teng Wang Xia Ran Qimin Xia Ziye Xu Yuting Fu Guodong zhang Hanyu Wu Guoji Guo Hongshan Guo Yijun Ruan Yongcheng Wang Dong Xing Xun Xu Zemin zhang Beijing Advanced Innovation Center for Genomics (ICG) Peking University Guangdong Provincial Key Laboratory of Genome Read and Write BGI Research Bone Marrow Transplantation Center of the First Affiliated Hospital & Liangzhu Laboratory Zhejiang University School of Medicine Life Sciences Institute and The Second Affiliated Hospital Zhejiang University BGI Research Biomedical Pioneering Innovation Center (BIOPIC) and School of Life Sciences Peking University Academy for Advanced Interdisciplinary Studies Peking University Institute of Hematology Zhejiang University Department of Laboratory Medicine of The First Affiliated Hospital & Liangzhu Laboratory Zhejiang University School of Medicine Center for Stem Cell and Regenerative Medicine Zhejiang University School of Medicine Zhejiang Provincial Key Lab for Tissue Engineering and Regenerative Medicine Dr.Li Dak Sum & Yip Yio Chin Center for Stem Cell and Regenerative Medicine

The applications of single-cell and spatial technologies in recent times have revolutionized the present understanding of cellular states and the cellular heterogeneity inherent in complex biological systems. These advancements offer unprecedented resolution in the examination of the functional genomics of individual cells and their spatial context within tissues. In this review, we have comprehensively discussed the historical development and recent progress in the field of single-cell and spatial genomics. We have reviewed the breakthroughs in single-cell multi-omics technologies, spatial genomics methods, and the computational strategies employed toward the analyses of singlecell atlas data. Furthermore, we have highlighted the advances made in constructing cellular atlases and their clinical applications,particularly in the context of disease. Finally, we have discussed the emerging trends, challenges, and opportunities in this rapidly evolving field.

关键词：

生物可降解聚乳酸共衣康酸丁二醇酯/纳米二氧化硅包装材料对发酵酸奶贮藏品质及活菌数的影响

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食品与发酵工业 2025年第1期51卷 108-115页

作者：蒋伟陈钟生张元董同力嘎内蒙古农业大学食品科学与工程学院内蒙古呼和浩特010018

探讨不同阻隔性的聚乳酸共衣康酸丁二醇酯/纳米二氧化硅共聚物薄膜[poly(L-lactic-co-butanediol itaconate)nano-silica copolymer films,PLBI-SiO_(2)]包装对发酵酸奶贮藏效果,并对贮藏期间酸奶的理化指标和活菌数进行测定。结果表明:... 详细信息

探讨不同阻隔性的聚乳酸共衣康酸丁二醇酯/纳米二氧化硅共聚物薄膜[poly(L-lactic-co-butanediol itaconate)nano-silica copolymer films,PLBI-SiO_(2)]包装对发酵酸奶贮藏效果,并对贮藏期间酸奶的理化指标和活菌数进行测定。结果表明:在4℃贮藏0~21 d期间,所有包装组的pH都呈现下降趋势,PLBI-SiO_(2)0.5%包装组与对照(市售)组在贮藏后期pH下降得到减缓;在贮藏期间,PLBI-SiO_(2)0.5%包装组与对照(市售)组能有效维持酸奶的质构特性与持水能力,同时也保持良好的感官评价与表观黏度;所有包装组的活菌数在整个贮藏期间都呈现逐渐降低的趋势,但随包装阻隔性的提高,下降幅度得到减缓,PLBI-SiO_(2)0.5%包装组与对照组在贮藏21 d时,保加利亚乳杆菌与嗜热链球菌都保持在10~7 CFU/mL以上。综合各项指标,PLBI-SiO_(2)0.5%包装组在贮藏21 d可以维持酸奶贮藏品质并几近于市售包装组,这为酸奶及其他发酵乳替代包装材料提供了一定的理论基础。

关键词：酸奶贮藏纳米二氧化硅聚乳酸共衣康酸丁二醇酯纳米二氧化硅共聚物阻隔性