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Comparison of methods for deriving phenotypes from incomplete observation data with an application to age at puberty in dairy cattle

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Journal of Animal Science and Biotechnology 2024年第2期15卷 535-545页

作者： Melissa A.Stephen Chris R.Burke Jennie E.Pryce Nicole M.Steele Peter R.Amer Susanne Meier Claire v.C.Phyn dorian J.Garrick dairyNZ Ltd 605 Ruakura RoadHamilton 3240New Zealand AL Rae Centre for Genetics and Breeding-massey University RuakuraHamilton 3214New Zealand Agriculture victoria Research AgriBioCentre for AgriBioscienceBundooraVictoria 3083Australia School of Applied Systems Biology La Trobe UniversityBundooraVictoria 3083Australia AbacusBio DunedinNew Zealand

Background many phenotypes in animal breeding are derived from incomplete measures,especially if they are challenging or expensive to measure *** include time-dependent traits such as reproductive status,or *** measures for these traits result in phenotypes that are subject to left-,interval-and rightcensoring,where phenotypes are only known to fall below an upper bound,between a lower and upper bound,or above a lower bound *** we compare three methods for deriving phenotypes from incomplete data using age at first elevation(>1 ng/mL)in blood plasma progesterone(AGEP4),which generally coincides with onset of puberty,as an example *** We produced AGEP4 phenotypes from three blood samples collected at about 30-day intervals from approximately 5,000 Holstein–Friesian or Holstein–Friesian×Jersey cross-bred dairy heifers managed in 54 seasonal-calving,pasture-based herds in New *** used these actual data to simulate 7 different visit scenarios,increasing the extent of censoring by disregarding data from one or two of the three *** methods for deriving phenotypes from these data were explored:1)ordinal categorical variables which were analysed using categorical threshold analysis;2)continuous variables,with a penalty of 31 d assigned to right-censored phenotypes;and 3)continuous variables,sampled from within a lower and upper bound using a data augmentation *** Credibility intervals for heritability estimations overlapped across all methods and visit scenarios,but estimated heritabilities tended to be higher when left censoring was *** sires with at least 5 daughters,the correlations between estimated breeding values(EBvs)from our three-visit scenario and each reduced data scenario varied by method,ranging from 0.65 to *** estimated breed effects also varied by method,but breed differences were smaller as phenotype censoring *** Our results indicate that using

关键词： Cattle Gibbs sampler markov-chain Monte Carlo(MCMC) Puberty

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矿岩冲击斜溜井底板位置及其影响因素分析

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矿业研究与开发 2024年第7期44卷 36-41页

作者：马强英陈锡勇路增祥王薪荣马驰辽宁科技大学矿业工程学院辽宁鞍山市114051 海南矿业股份有限公司海南昌江黎族自治县572700 北京科技大学土木与资源工程学院北京100083

为揭示斜溜井内矿岩运动对溜井底板的冲击损伤规律,基于运动学原理,研究了矿岩块在斜溜井中的运动规律及其影响因素,建立了矿岩块的运动轨迹方程,明确了矿岩块与斜溜井底板发生碰撞的条件,得到了矿岩块首次碰撞溜井底板的位置计算公式... 详细信息

为揭示斜溜井内矿岩运动对溜井底板的冲击损伤规律,基于运动学原理,研究了矿岩块在斜溜井中的运动规律及其影响因素,建立了矿岩块的运动轨迹方程,明确了矿岩块与斜溜井底板发生碰撞的条件,得到了矿岩块首次碰撞溜井底板的位置计算公式。研究结果表明:矿岩块进入主斜溜井时的初始速度v_(0)及其方向角α、主斜溜井倾角β及其顶底板距离d是影响矿岩块与斜溜井底板碰撞的主要因素;v_(0)越小,α、d与β越大,碰撞位置距矿岩块进入斜溜井时的垂直距离h_(1)越大,反之h_(1)越小;当v_(0)和α一定时,d与β越大,h_(1)越大,且d较β对碰撞位置的影响更大。提出斜溜井设计与管理思路,即降低矿岩块进入斜溜井时的初始速度,选择合理的主斜溜井的倾角及其顶底板距离,降低主斜溜井空井高度,能有效降低发生碰撞的概率,减小斜溜井底板受冲击破坏的程度。

关键词：矿岩冲击斜溜井底板运动轨迹碰撞位置

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Evidence-Based Complementary and Alternative Medicine Effects of Capybara Oil on Cardiac Remodeling of C57bl/6 Mice

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Journal of Biosciences and Medicines 2024年第5期12卷 213-232页

作者： Rafael M. Almeida Wagner d. Giannetti Guilherme R. Silveira Carolina R. Castilho Renata v. Lisboa Bianca T. Ciambarella Rodrigo N. Ferreira Jorge José de Carvalho Laboratory of Ultrastructure and Tissue Biology Institute of Biology State University of Rio de Janeiro Rio de Janeiro Brazil Higher Education Center of valenç a Dom Andr&#233 Arcoverde Educational Foundation Valen&#231a Brazil

Cardiovascular diseases are the main cause of morbidity and mortality in the world, and obesity and the metabolic syndrome are risk factors for its development. One of the therapies to reduce cardiovascular risk is the use of polyunsaturated fatty acids. In Brazil, a source of such acid is the oil extracted from the fat of the capybara. The objective of this work is to study the effects of the capybara oil on lipid and glucose metabolism, as well as its effects on the adipose tissue and cardiac remodeling. We assessed the effects of capybara oil treatment on body mass, lipid and carbohydrate metabolism, systolic blood pressure, adipose tissue and cardiac remodeling, and performed an ultrastructural evaluation of the myocardium in C57Bl/6 mice treated with high-fat diet. Treatment with capybara oil reduced total cholesterol and triglyceride levels, systolic blood pressure, visceral and subcutaneous adipose tissue, and adipocyte diameter. In addition, cardiac remodeling was attenuated, preserving cardiomyocytes, increasing vascularization, reducing cardiomyocyte hypertrophy and the extracellular matrix, and preserving the morphological integrity of mitochondria. Capybara oil has several beneficial effects on the cardiovascular and metabolic system, and further studies are needed to better understand its role in the prevention or treatment of cardiovascular diseases.

关键词： Capybara Oil Cardiac Remodeling Polyunsaturated Fatty Acids Obesity Metabolic Syndrome

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Higher Grain-Filling Rate in Inferior Spikelets of Tolerant Rice Genotype Offset Grain Yield Loss under Post-Anthesis High Night Temperatures

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Rice science 2024年第5期31卷 572-586,I0059-I0061页

作者： Nitin SHARma Bhupinder SINGH Subbaiyan Gopala KRISHNAN Haritha BOLLINEdI Pranab Kumar maNdAL Milan Kumar LAL Prakash Kumar JHA P.v.vara PRASAd Anjali ANANd division of Plant Physiology Indian Council of Agricultural Research(ICAR)-Indian Agricultural Research Institute(IARI)New Delhi 110012India division of Environment Science ICAR-IARINew Delhi 110012India division of Genetics ICAR-IARINew Delhi 110012India ICAR-National Institute for Plant Biotechnology New Delhi 110012India division of Crop Physiology and Biochemistry ICAR-National Rice Research InstituteCuttack 753006India department of Plant and Soil Sciences Mississippi State UniversityStarkvilleMS 39762USA Feed the Future Innovation Lab for Collaborative Research on Sustainable Intensification Kansas State UniversityManhattanKS 66506USA department of Agronomy Kansas State UniversityManhattanKS 66506USA

Increased nighttime respiratory losses decrease the amount of photoassimilates available for plant growth and yield. We hypothesized that the increased respiratory carbon loss under high night temperatures(HNT) could be compensated for by increased photosynthesis during the day following HNT exposure. Two rice genotypes, vandana(HNT-sensitive) and Nagina 22(HNT-tolerant), were exposed to HNT(4 ℃ above the control) from flowering to physiological maturity. They were assessed for alterations in the carbon balance of the source(flag leaf) and its subsequent impact on grain filling dynamics and the quality of spatially differentiated sinks(superior and inferior spikelets). Both genotypes exhibited significantly higher night respiration rates. However, only Nagina 22 compensated for the high respiration rates with an increased photosynthetic rate, resulting in a steady production of total dry matter under HNT. Nagina 22 also recorded a higher grain-filling rate, particularly at 5 and 10 d after flowering, with 1.5- and 4.0-fold increases in the translocation of ^(14)C sugars to the superior and inferior spikelets, respectively. The ratio of photosynthetic rate to respiratory rate on a leaf area basis was negatively correlated with spikelet sterility, resulting in a higher filled spikelet number and grain weight per plant, particularly for inferior grains in Nagina 22. Grain quality parameters such as head rice recovery, high-density grains, and gelatinization temperature were maintained in Nagina 22. An increase in the rheological properties of rice flour starch in Nagina 22 under HNT indicated the stability of starch and its ability to reorganize during the cooling process of product formation. Thus, our study showed that sink adjustments between superior and inferior spikelets favored the growth of inferior spikelets, which helped to offset the reduction in grain weight under HNT in the tolerant genotype Nagina 22.

关键词： high night temperature inferior grain pasting property radiolabeled sugar superior grain

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manipulation of Na_(3)v_(2)(PO_(4))_(2)F_(3) via aluminum doping to alter local electron states toward an advanced cathode for sodiumion batteries

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Rare Metals 2024年第9期43卷 4253-4262页

作者： Shi-Min Wang Jin-Qi Li Li Xu Meng-Jiao Sun Wen-Jin Huang Qing Liu Fu-Tong Ren Yong-Jiang Sun Ling-Yan duan Hang ma Hong Guo International Joint Research Center for Advanced Energy materials of Yunnan Province Yunnan Key Laboratory of Carbon Neutrality and Green Low-Carbon TechnologiesSchool of Materials and EnergyYunnan UniversityKunming 650091China College of Environmental and Chemical Engineering Metallurgy CollegeKunming 650033China R&d Center Yunnan Yuntianhua Co.LtdKunming 650228China Southwest United Graduate School Kunming 650091China

With its unique 3d skeleton structure and exceptional cyclic stability,the Na^(+)superionic conducto(NASICON)-type Na_(3)v_(2)(PO_(4))_(2)F_(3)(NvPF)has been con sidered as a competitive cathode material for advanced Na ion ***,the release of fluorine during th heat treatment leads to the formation of an additional phas Na_(3)v_(2)(PO_(4))_(3)(NvP),which results in a low-voltage plateau and compromises the energy ***,we modulat the local electronic states of the v site by aluminum sub stitution to strengthen the stability of *** results confirm that the aluminum introduction not only changes the loca electron states of v sites,significantly reducing the for mation of NvP by-product from 6.71 wt%to 1.01 wt%but also effectively reduces the band gap,improving th electronic conductivity of *** optimized Na_(3)v_(1.9)Al_(0.1)(PO_(4))_(2)F_(3)exhibits higher energy density of 340 Wh·kg^(-1)and excellent rate performance of 106.7 mah·g^(-1)at 10C compared with the pristine cathode.

关键词： Sodium-ion energy storage batteries Cathode NASICON doping Electrochemistry

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Surface heterojunction based on n-type low-dimensional perovskite film for highly efficient perovskite tandem solar cells

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National Science Review 2024年第05期11卷 244-253页

作者： Xianyuan Jiang Qilin Zhou Yue Lu Hao Liang Wenzhuo Li Qi Wei Mengling Pan Xin Wen Xingzhi Wang Wei Zhou danni Yu Hao Wang Ni Yin Hao Chen Hansheng Li Ting Pan Mingyu ma Gaoqi Liu Wenjia Zhou Zhenhuang Su Qi Chen Fengjia Fan Fan Zheng Xingyu Gao Qingqing Ji Zhijun Ning School of Physical Science and Technology Shanghai Tech University department of Modern Physics University of Science and Technology of China i-Lab CAS Key Laboratory of Nanophotonic Materials and Devices Suzhou Institute of Nano-Tech and Nano-Bionics Shanghai Synchrotron Radiation Facility (SSRF) Shanghai Advanced Research InstituteChinese Academy of Sciences

Enhancing the quality of junctions is crucial for optimizing carrier extraction and suppressing recombination in semiconductor devices. In recent years, metal halide perovskite has emerged as the most promising next-generation material for optoelectronic devices. However, the construction of high-quality perovskite junctions, as well as characterization and understanding of their carrier polarity and density,remains a challenge. In this study, using combined electrical and spectroscopic characterization techniques,we investigate the doping characteristics of perovskite films by remote molecules, which is corroborated by our theoretical simulations indicating Schottky defects consisting of double ions as effective charge *** a post-treatment process involving a combination of biammonium and monoammonium molecules, we create a surface layer of n-type low-dimensional perovskite. This surface layer forms a heterojunction with the underlying 3d perovskite film, resulting in a favorable doping profile that enhances carrier extraction. The fabricated device exhibits an outstanding open-circuit voltage(vOC) up to 1.34 v and achieves a certified efficiency of 19.31% for single-junction wide-bandgap（1.77 ev） perovskite solar cells, together with significantly enhanced operational stability, thanks to the improved separation of carriers. Furthermore, we demonstrate the potential of this wide-bandgap device by achieving a certified efficiency of 27.04% and a vOCof 2.12 v in a perovskite/perovskite tandem solar cell configuration.

关键词： perovskite solar cells field effect transistors heterojunction

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Synthesis of Pharmaceutical Intermediates by Toluene Benzylation over Heteropoly Acids on different Support

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Journal of Natural Gas Chemistry 2007年第2期16卷 186-192页

作者： v. v. Bokade G. d. Yadav Catalysis division National Chemical LaboratoryPune 411008India University Institute of Chemical TechnologyMumbai-19India University Institute of Chemical Technology Mumbai-19India

Selective formation of pharmaceutical intermediates like diphenylmethane, dimethyldiphenylmethane, benzyl toluene and benzoic acid by liquid phase, toluene benzylation with benzyl chloride as a benzylating agent, was systematically studied over plane clay （K-10, montmorillonite）, plane H-Beta, plane MFI structured titanosilicate （TS-1） and heteropoly acids [HPA, namely dodecatungstophosphoric acid [H3PO4.12WOa-xH2O] （TPA）, dodeca-molybdo phosphoric acid ammonium salt hydrate [H12Mo12N3040P＋aq] （dmaA）, sodium tungstate hydrated purified [Na12WO4.2H2O] （STH）] supported on clay, H-beta and TS-1. The 20%TPA/Clay, 30%TPA/H-Beta and 30%TPA/TS-1, were observed to be the best catalyst samples over plane clay, plane H-Beta and plane TS-1. The catalyst samples are compared with respect to benzyl chloride conversion and selectivities for diphenylmethane, dimethyl-diphenylmethane, benzyl toluene and benzoic acid. The reaction follows the pseudo-first order rate power law model. The apparent rate constants are calculated and compared with the reported ones.

关键词： toluene benzylation benzyl chloride heteropolyacid diphenylmethane dimethyl-diphenyl methane benzyl toluene benzoic acid

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On the Theory of Fragmentation Process with Initial Particle volume

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Communications in Theoretical Physics 2017年第8期67卷 269-271页

作者： d.v.Alexandrov department of Theoretical and mathematical Physics Laboratory of Multi-Scale Mathematical Modeling Ural Federal University

The problem of fragmentation(disintegration) process is theoretically studied with allowance for the initial particle volume. An exact analytical solution of integro-differential model governing the fragmentation phenomenon is obtained. The key role of a finite initial volume of particles leading to substantial changes of the particle-size distribution function is demonstrated.

关键词： Iphase transitions particle-size distribution fragmentation

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排卵期女性用自然周期、改良自然周期或人工子宫内膜制剂进行一次冷冻胚胎移植后活产率的临床研究

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中国临床药理学杂志 2024年第16期40卷 2456-2456页

作者： HO v N A PHAM T d NGUYEN N T 孟海峰

本研究为一项随机、开放标签研究,研究对象为18~45岁的排卵期女性,受试者按照1:1:1的比例被随机分为自然周期组、改良自然周期组或人工周期组。由于研究干预措施的性质特殊,故本试验不设盲。自然周期组不使用雌激素、孕酮或人绒毛膜促... 详细信息

本研究为一项随机、开放标签研究,研究对象为18~45岁的排卵期女性,受试者按照1:1:1的比例被随机分为自然周期组、改良自然周期组或人工周期组。由于研究干预措施的性质特殊,故本试验不设盲。自然周期组不使用雌激素、孕酮或人绒毛膜促性腺激素(hCG);改良自然周期组使用hCG来触发排卵;人工周期组使用口服戊酸雌二醇(从月经第2~4天开始,每天8mg)和阴道孕酮(从子宫内膜厚度≥7mm开始,每天800mg)。

关键词：人工周期戊酸雌二醇子宫内膜厚度活产率自然周期冷冻胚胎移植排卵期孕酮

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面向多场景辅助服务的大规模电动汽车聚合可调度容量建模

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电力系统自动化 2024年第7期48卷 103-115页

作者：王杨洋茆美琴杨铖周堃杜燕 Nikos d.HATZIARGYRIOU 教育部光伏系统工程研究中心合肥工业大学安徽省合肥市230009 国网安徽省电力有限公司安徽省合肥市230000 国网安徽省电动汽车服务有限公司安徽省合肥市230000 雅典国立理工大学希腊雅典15780

大规模电动汽车聚合可调度容量是含电动汽车的虚拟电厂参与多层级多场景电力平衡辅助服务的重要技术指标之一。然而,现有电动汽车聚合可调度容量模型难以适应大规模电动汽车与省级电力调度中心互动场景。为此,文中从面向电力系统调峰、... 详细信息

大规模电动汽车聚合可调度容量是含电动汽车的虚拟电厂参与多层级多场景电力平衡辅助服务的重要技术指标之一。然而,现有电动汽车聚合可调度容量模型难以适应大规模电动汽车与省级电力调度中心互动场景。为此,文中从面向电力系统调峰、调频和调压多级多场景调控新视角,提出了数据驱动和机器学习相结合的双层聚类电动汽车聚合可调度容量建模方法。该方法通过构建电动汽车-充电桩广义储能单元的个体可调度容量模型,结合基于密度空间的聚类算法和改进的自组织映射深度聚类算法,有效地融合了电动汽车电量的时间分布和充电桩的空间分布特性,构建了面向调峰、调频和调压多场景调控的聚合可调度容量模型。采用了某省实际充电记录数据对提出的方法进行了验证,获得了“早间型”“中午型”“晚间型”等多种充电画像类型,实现了时空分布各异的电动汽车广义储能系统的自主聚合和省市级规模电动汽车参与电网不同辅助服务潜能的评估,并为聚合可调度容量的预测奠定了数据基础。

关键词：电动汽车辅助服务数据驱动广义储能系统电动汽车与电网互动可调度容量聚合模型双层聚类

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