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Complex Regulation of Prolyl-4-Hydroxylases Impacts Root Hair Expansion

Molecular Plant 2015年第5期8卷 734-746页

作者： Silvia M. Velasauez Martiniano M. Ricardi Christian Peter Poulsen Ai Oikawa Adiphol dilokpimol Adnan Halim Silvina Mangano Silvina Paola denita Juarez Eliana Marzol Juan d. Salgado Salter Javier Gloazzo dorosz Cecilia Borassi Svenning Rune Moller Rafael Buono Yukiko Ohsawa Ken Matsuoka Marisa S. Otegui Henrik V. Scheller Naomi Geshi Bent Larsen petersen Norberto d. lusem Jose M. Estevez Instituto de Fisiologfa Biologia Molecular y Neurociencias (IFIBYNE-CONICET) Facultad de Ciencias Exactas y Naturales Universidad de Buenos AiresBuenos Aires C1428EGA Argentina VKR Research Centre Department of Plant and Environmental Sciences University of Copenhagen DK-1871 Frededksberg C Denmark Joint BioEnergy Institute Feedstocks Division Lawrence Berkeley National Laboratory 5885 Hollis Street Emeryville CA 94608 USA Copenhagen Center for Glycomios Department of Cellular and Molecular Faculty of Health and Medical Sciences University of CopenhagenDK-2200 Copenhagen N Denmark department of Botany University of Wisconsin Madison WI 53706 USA RIKEN Plant Science Center Tsurumi-ku Yokohama 230-0045 Japan Laboratory of Plant Nutrition Faculty of Agriculture Kyushu University Hakozaki 6-10-1 Higashi-ku Fukuoka 812-8581 Japan departamento de Fisiologia Biologia Molecular y Celular Facultad de Ciencias Exactas y Naturales Universidad de Buenos Aires Buenos Aires C1428EGAArgentina These authors contributed equally to the article. Present address: Fungal Physiology CBS-KNAW Fungal Biodiversity Center Uppsalalaan 8 Utrecht 3584 CT The Netherlands Present address: The danish Stem Cell Center The Panum Institute Blegdamsvej 3B DK-2200 Copenhagen Denmark

Root hairs are single cells that develop by tip growth, a process shared with pollen tubes, axons, and fungal hyphae. However, structural plant cell walls impose constraints to accomplish tip growth. In addition to polysaccharides, plant cell walls are composed of hydroxyproline-rich glycoproteins （HRGPs）, which include several groups of O-glycoproteins, including extensins （EXTs）. Proline hydroxylation, an early post-translational modification （PTM） of HRGPs catalyzed by prolyl 4-hydroxylases （P4Hs）, defines their subsequent O-glycosylation sites. In this work, our genetic analyses prove that P4H5, and to a lesser extent P4H2 and P4H13, are pivotal for root hair tip growth. Second, we demonstrate that P4H5 has in vitro preferred specificity for EXT substrates rather than for other HRGPs. Third, by P4H promoter and protein swapping approaches, we show that P4H2 and P4H13 have interchangeable functions but cannot replace P4H5. These three P4Hs are shown to be targeted to the secretory pathway, where P4H5 forms dimers with P4H2 and P4H13. Finally, we explore the impact of deficient proline hydroxylation on the cell wall architec- ture. Taken together, our results support a model in which correct peptidyl-proline hydroxylation on EXTs, and possibly in other HRGPs, is required for proper cell wall self-assembly and hence root hair elongation in Arabidopsis thaliana.

关键词： enzymology cell expansion cell walls protein targeting proline hydroxylation root hairs

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根据南加州的背景地震活动性估计地震危险性

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世界地震译丛 2008年第3期39卷 1-11页

作者： M.d.petersen M.S.Reichle 张力方中国地震局地壳应力研究所

通过分析南加州的历史地震活动性,找到了一种用6.5级或小于6.5级的背景地震活动性计算地震危险性的合理方法。该方法的基本假设是:未来地震在空间上将群集在4级或4级以上历史主震震中附近。通过分析加州去群集的地震目录,计算每个网格... 详细信息

通过分析南加州的历史地震活动性,找到了一种用6.5级或小于6.5级的背景地震活动性计算地震危险性的合理方法。该方法的基本假设是:未来地震在空间上将群集在4级或4级以上历史主震震中附近。通过分析加州去群集的地震目录,计算每个网格内的地震发生率,并对该发生率进行空间光滑处理,以预测未来地震的空间分布。为了寻找合适的空间光滑函数,我们研究了南加州地震震级与距离(r)的相关性,发现其遵循1/rμ幂次率关系,其中μ随着震级增大而增大。我们的研究结果表明,较大的地震在空间上比较小地震更群集。假设地震活动性遵从古登堡-里克特震级分布关系,我们计算了50年超越概率10%的地面峰值加速度。南加州大部分地区的峰值地面加速度值在0.25g至0.35g(g=10m/s2)之间。所得地震动水平一般比用全部震源模型(包括地质和大地测量资料)所得结果的一半还要小。我们还用蒙特卡罗方法计算了危险性图的总体不确定性,发现该地区大多数区域的变化系数为0.24±0.01。

关键词：地震危险性不确定性光滑函数背景地震活动地震动地震活动性小地震南加州危险性区划震级上限

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非退行性和非血管性痴呆的发病率和病因:一项人群研究

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世界核心医学期刊文摘（神经病学分册） 2006年第6期2卷 13-14页

作者： Knopman d.S. petersen R.C. 郭俊 department of Neurology Mayo Clinic 200 First St SW Rochester MN 55905 United States Dr.

Background: Information on the incidence of nondegenerative and nonvascular dementia is limited. design: We used the records-linkage system of the Rochester Epidemiology Project to ascertain incident cases of dementia in Rochester, Minn, from January 1, 1990, through december 31, 1994. To define causes of dementia, we reviewed all diagnoses, imaging study results, laboratory test results, and clinical courses, as recorded historically in the patient dossier. Results: We found 560 incident cases of dementia, and 60 of them (10.7%) had onset before the age of 70 years (younger-onset group). Forty-three cases (7.7%) were due to nondegenerative nonvascular causes and represented 30.0%of the total in the you nger-onset group, but only 5.0%of the total in the older-onset group (aged 70 -99 years). The most common nondegenerative nonvascular causes were cancer with or without brain metastases (n=13), chronic alcoholism (n=7), and chronic menta l illness (n=11). There were no cases of dementia due to normal-pressure hydroc ephalus, subdural hematoma, hypothyroidism, vitamin B12 deficiency, or neurosyph ilis. There were 2 individuals with acute confusion due to subdural hematoma and 1 with hypothyroidism whose cognition normalized with therapy. Conclusions: Non degenerative nonvascular causes were more common than expected in patients with a younger onset of dementia. None of the patients with dementia reverted to norm al with treatment of the putative reversible cause.

关键词：血管性痴呆发病率退行性人群研究甲状腺功能减退正常压力性脑积水维生素B12缺乏硬膜下血肿病例档案病因

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Percutaneous transluminal angioplasty balloons for endoscopic ultrasound-guided pancreatic duct interventions

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World Journal of Gastrointestinal Endoscopy 2022年第8期14卷 487-494页

作者： Jad P AbiMansour Barham K Abu dayyeh Michael J Levy Andrew C Storm John A Martin Bret T petersen Ryan J Law Mark d Topazian Vinay Chandrasekhara department of Gastroenterology and Hepatology Mayo ClinicRochesterMN 55905United States

BACKGROUNd Endoscopic ultrasound(EUS)-guided main pancreatic duct(Pd)access may be used when conventional endoscopic retrograde cholangiopancreatography(ERCP)techniques *** use of a percutaneous transluminal angioplasty balloon(PTAB),originally developed for vascular interventions,can be used to facilitate transmural(e.g.,transgastric)Pd access and to dilate high-grade pancreatic *** To describe the technique,efficacy,and safety of PTABs for EUS-guided Pd *** Patients who underwent EUS with use of a PTAB from March 2011 to August 2021 were retrospectively identified from a tertiary care medical center supply *** included 3-4 French angioplasty catheters with 3-4 mm balloons designed to use over a 0.018-inch *** primary outcome was technical *** outcomes included incidence of adverse events(AEs)and need for early *** A total of 23 patients were identified(48%female,mean age 55.8 years).Chronic pancreatitis was the underlying etiology in 13(56.5%)patients,surgically altered anatomy(SAA)with stricture in 7(30.4%),and SAA with post-operative leak in 3(13.0%).Technical success was achieved in 20(87%)*** AE rate was 26%(n=6).All AEs were mild and included 1 pancreatic duct leak,2 cases of post-procedure pancreatitis,and 3 admissions for post-procedural *** patients required early *** EUS-guided use of PTABs for Pd access and/or stricture management is feasible with an acceptable safety profile and can be considered in patients when conventional ERCP cannulation fails.

关键词： dilating balloon Pancreatic duct intervention Chronic pancreatitis Anastomotic stricture

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冠状动脉搭桥术并非痴呆或阿尔茨海默病的危险因素

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世界核心医学期刊文摘(神经病学分册) 2006年第2期 41-42页

作者： Knopman d.S. petersen R.C. 赵天智 department of Neurology Mayo Clinic 200 First Street SW Rochester MN 55905 United States.Dr

Objective: To study coronary artery bypass grafting (CABG) as a risk factor for dementia and Alzheimer disease (Ad) using a case-control design. Methods: The authors used the records-linkage system of the Rochester Epidemiology Project to ascertain incident cases of dementia in Rochester, MN, for the 5-year period 1990 to 1994. The authors defined dementia and Ad using the criteria of the diagnostic and Statistical Manual of Mental disorders, fourth edition (dSM-IV). Each case was individually matched by age (±1 year) and sex to a person drawn randomly from the same population, and free of dementia in the index year (year of onset of dementia in the matched case). Results: Among 557 dementia cases, 24 (4.3%) had undergone a CABG prior to the onset of dementia with a median lag time of 5.5 years (range = 0.1 to 15.9). Among 557 controls, 28 subjects (5.0%) had undergone a CABG prior to the index year with a median lag time 3.9 years (rang e = 0.1 to 12.3); OR = 0.85 (95%CI = 0.49 to 1.49; p = 0.57) for dementia and O R = 0.78 (95%CI = 0.39 to 1.56; p = 0.48) for Ad. The findings did not change a fter adjustment for education. The perioperative courses of cases and controls w ere comparable. Analyses including only the 481 cases of dementia with presumed neurodegenerative or cerebrovascular etiology were also negative. Conclusions: T his population-based case-control study suggests that coronary artery bypass g rafting is not a major risk factor for dementia overall, or for Alzheimer diseas e.

关键词：搭桥术危险因素危险隐患阿尔茨海默病冠状动脉

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Thermo-mechanical dynamics of nanoimprinting anti-reflective structures onto small-core mid-IR chalcogenide fibers [Invited]

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Chinese Optics Letters 2021年第3期19卷 46-52页

作者： Christian R.petersen Mikkel B.Lotz Christos Markos Getinet Woyessa david Furniss Angela B.Seddon Rafael J.Taboryski O.Bang dTU Fotonik Technical University of DenmarkDK-2800 Kgs.LyngbyDenmark dTU Nanolab Technical University of DenmarkDK-2800 Kgs.LyngbyDenmark NORBLIS DK-2830 VirumDenmark Mid-Infrared Photonics Group University of NottinghamNottingham NG72RDUK NKT Photonics DK-3460 Bi「ke「0dDenmark

Thermal nanoimprinting is a fast and versatile method for transferring the anti-reflective properties of subwavelength nanostructures onto the surface of highly reflective substrates, such as chalcogenide glass optical fiber end faces. In this paper, the technique is explored experimentally on a range of different types of commercial and custom-drawn optical fibers to evaluate the influence of geometric design, core/cladding material, and thermo-mechanical properties. Up to32.4% increased transmission and 88.3% total transmission are demonstrated in the 2–4.3 μm band using a mid-infrared(IR) supercontinuum laser.

关键词： nanoimprint lithography anti-reflection hot imprint chalcogenide glass optical fiber mid-infrared supercontinuum

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玉米、玉米副产品和面包副产品饲喂生长猪的氨基酸消化率

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饲料工业 2013年第18期34卷 59-64页

作者： F.N.Almeida G.I.petersen H.H.Stein 尔巴那市伊利诺伊大学动物科学系 il61801 美国薜瑞登市联合JBS公司 in460691113

文章旨在测定面包副产品、玉米蛋白粉、玉米糠麸饲料、玉米胚芽粕和玉米麸的粗蛋白(CP)和氨基酸(AA)的表观回肠消化率(AId)和标准回肠消化率(SId),并将这些值与玉米和玉米干酒精糟及可溶物(ddGS)的粗蛋白和氨基酸表观回肠消化率和标准... 详细信息

文章旨在测定面包副产品、玉米蛋白粉、玉米糠麸饲料、玉米胚芽粕和玉米麸的粗蛋白(CP)和氨基酸(AA)的表观回肠消化率(AId)和标准回肠消化率(SId),并将这些值与玉米和玉米干酒精糟及可溶物(ddGS)的粗蛋白和氨基酸表观回肠消化率和标准回肠消化率进行比较。8头生长阉公猪[初始体重(82.5±5.5)kg],随机分配,按照8×8的拉丁方设计,8种日粮和8个阶段。日粮分别以玉米、ddGS、面包副产品、玉米蛋白粉、玉米糠麸饲料、玉米胚芽粕和玉米麸作为唯一的蛋白和氨基酸来源。使用无氮日粮测定氨基酸和蛋白质的基础内源性损失。试验日粮分成8个阶段饲喂给试验猪只,每个阶段7 d,每个阶段的第6和第7 d收集回肠食糜。结果显示,玉米蛋白粉的赖氨酸SId(78.7%)高于(PddGS、面包副产品、玉米胚芽粕和玉米麸的赖氨酸SId(分别为46.0%、48.4%、68.4%和58.8%)。面包副产品和ddGS的必需氨基酸(除精氨酸、亮氨酸和蛋氨酸外)的SId没有差异。玉米糠麸饲料的精氨酸、组氨酸、亮氨酸和蛋氨酸的SId比玉米的低(Pd,玉米糠麸饲料和玉米没有显著差异。然而,对于大多数的必需氨基酸而言,玉米糠麸饲料和ddGS的SId没有差异。除精氨酸、组氨酸、亮氨酸和蛋氨酸外,玉米胚芽粕的必需氨基酸SId和玉米的必需氨基酸SId没有差异。同样地,除精氨酸、亮氨酸和赖氨酸外,玉米胚芽粕的必需氨基酸SId和ddGS的必需氨基酸SId没有差异。玉米麸的异亮氨酸、蛋氨酸、苯丙氨酸和缬氨酸SId低于玉米的(Pd玉米麸和玉米没有差异。除精氨酸和赖氨酸外,玉米麸的所有其他必需氨基酸的SId和ddGS的必需氨基酸的SId没有差异,玉米麸的精氨酸和赖氨酸的SId高于(PddGS的精氨酸和赖氨酸的SId。总之,面包副产品的大多数氨基酸的SId低于玉米的,但是,玉米蛋白粉的大多数氨基酸的SId高于玉米、面包副产品和玉米副产品的氨基酸SId。

关键词：氨基酸消化率面包副产品玉米胚芽粕玉米糠麸饲料玉米蛋白粉玉米麸

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气垫船动力学ACVSIM模型的初步验证(一)

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橡塑资源利用 2021年第2期 32-38页

作者： W.Milewski B.Connell B.petersen d.Kring 孙新(编译) Applied Physical Sciences Corporation Flight Safety Technologies Inc. 不详

人们对改进气垫载具的耐波性动力学预测能力重新产生了兴趣。这导致了第一原理数值模拟模型ACVSIM(Milewski等人,2007)的发展,该模型集成了气垫和裙摆动力学模型与基于高阶样条的流体动力学边界元模型。本文概述了ACVSIM最近的改进,以... 详细信息

人们对改进气垫载具的耐波性动力学预测能力重新产生了兴趣。这导致了第一原理数值模拟模型ACVSIM(Milewski等人,2007)的发展,该模型集成了气垫和裙摆动力学模型与基于高阶样条的流体动力学边界元模型。本文概述了ACVSIM最近的改进,以及使用2007年秋季获得的基线深裙作为模型尺度的LCAC进行初始验证研究的结果。该仿真工具提供了研究设计修改的影响的能力,以及模型载具缩放问题与多耦合物理系统的问题。

关键词：模型集成第一原理物理系统流体动力学气垫船耐波性数值模拟模型 ACV

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delaying Postpartum Supplementation in Cows Consuming Low-Quality Forage does Not Alter Cow and Calf Productivity

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Agricultural Sciences 2016年第9期7卷 642-649页

作者： J. Travis Mulliniks Jason E. Sawyer Richard C. Waterman Mark K. petersen department of Animal Science University of Tennessee Knoxville TN USA department of Animal Science Texas A&M University College Station TX USA USdA-ARS Fort Keogh Livestock & Range Research Laboratory Miles City MT USA

Reducing the amount of supplemental feed postpartum without affecting productivity may enhance profitability of cow-calf operations. Therefore, sixteen 2-yr-old fall calving cows were used to evaluate effects of delaying postpartum supplementation on milk production, serum metabolites, and cow and calf BW change. Cows were stratified by calving date and randomly assigned to one of two treatments: 908 g/d of a 46% CP supplement beginning 5 d postpartum (Supp5, n = 7);or 908 g/d of the same supplement beginning 30 d postpartum (Supp30, n = 9). Supplements were formulated to provide 425 g/d of CP with 225 g coming from ruminally undegradable protein (RUP), and were fed twice weekly. Cows were daily fed 8.2 kg chopped sudangrass hay (5.5% CP, 74% NdF, OM basis) during lactation. Cows and calves were weighed before feeding on two consecutive days on d 0, d 30, and d 80 postpartum. Milk production and constituents were evaluated on d 90. Cow BW was not different at d 0 (P = 0.21) and 80 (P = 0.12) between treatment groups. Cows receiving supplement starting on d 5 postpartum were heavier (P = 0.04) than Supp30 cows on d 30. However, no differences (P ≥ 0.17) were found in BW change or AdG during the duration of the study. Milk production was similar (P = 0.99) for postpartum supplementation treatments. No differences (P ≥ 0.27) were observed in milk fat, lactose, protein, or solids-non-fat. However, there was a tendency (P = 0.09) for milk urea nitrogen to be greater for cows receiving supplement on d 5 than d 30 of lactation. Serum urea nitrogen was greater (P = 0.02) in cows receiving Supp5 than cows receiving Supp30. Serum non-esterified fatty acid (NEFA) and glucose concentrations were not different (P ≥ 0.40) between treatment groups. Calf BW and average daily gain (AdG) was not influenced (P ≥ 0.81) by timing of initial postpartum supplementation. These results indicate that withholding supplementation during the first 30 d postpartum may change pattern of cow BW lo

关键词： Beef Heifers Postpartum Supplementation

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初始不可切除IIIB期非小细胞肺癌免疫联合化疗后的根治性微创手术

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中国肺癌杂志 2022年第11期25卷 835-840页

作者： Hongsheng dENG Jun LIU Xiuyu CAI Jiawei CHEN Gaetano ROCCO Rene' Horsleben petersen Alessandro BRUNELLI Calvin S.H.NG Thomas A.d'AMICO Wenhua LIANG Jianxing HE 雷杰 department of Thoracic Surgery and Oncology the First Affiliated Hospital of Guangzhou Medical University State Key Laboratory of Respiratory Disease National Clinical Research Center for Respiratory Disease Guangzhou Institute of Respiratory Health department of General Internal Medicine Sun Yat-sen University Cancer Centre State Key Laboratory of Oncology in South China Collaborative Innovation Centre for Cancer Medicine department of Surgery Memorial Sloan Kettering Cancer Center department of Cardiothoracic Surgery University Hospital of CopenhagenRigshospitalet department of Thoracic Surgery St. James's University Hospital division of Cardiothoracic Surgery Department of Surgery Prince of Wales Hospital the Chinese University of Hong Kong division of Thoracic Surgery Department of Surgery Duke University Medical Center 空军军医大学第二附属医院胸腔外科

背景新辅助免疫治疗在局部晚期非小细胞肺癌（non-small cell lung cancer, NSCLC）的应用仍存在争议。因此，本研究旨在报道通过免疫联合化疗将初始不可切除c IIIB期NSCLC患者转化为根治性微创手术的系列病例，评估手术效果和术后的生... 详细信息

背景新辅助免疫治疗在局部晚期非小细胞肺癌（non-small cell lung cancer, NSCLC）的应用仍存在争议。因此，本研究旨在报道通过免疫联合化疗将初始不可切除c IIIB期NSCLC患者转化为根治性微创手术的系列病例，评估手术效果和术后的生存获益。方法回顾性分析2018年5月-2020年8月期间接受程序性细胞死亡受体1(programmed cell death-1,Pd-1)抑制剂联合含铂双药化疗的51例c IIIB期NSCLC患者。收集入组患者手术相关数据和肿瘤相关数据。结果31例患者最终接受手术治疗，其中23例（74.2%）患者行肺叶切除术，1例（3.2%）患者行全肺切除术，5例（16.1%）患者行袖状肺叶切除术，2例（6.5%）患者行双肺叶切除术。中位手术时间为205 min（范围100-520），平均失血量为185 m L（范围10-1100）。15例患者出现致密粘连或纤维化。术后平均住院时间为6 d（范围3-13）。无手术相关死亡，仅5例（16.1%）患者发生术后并发症（无3级以上并发症）。10例（32.3%）患者达到主要病理缓解，22/31例（71.0%）患者出现纵隔病变降期。中位随访15.4个月，31例手术患者的中位无进展生存期/无病生存期（progression-free survival/disease-free survival, PFS/dFS）相对于未进行手术的无缓解或缓解的患者（分别为27.5个月vs 4.7个月vs 16.7个月）更长。结论初始不可切除的IIIB期NSCLC接受免疫联合化疗治疗后行根治性手术相对安全，手术相关死亡率和并发症发病率较低，与未手术患者相比dFS/PFS更长。

关键词：免疫联合化疗新辅助治疗初始不可切除非小细胞肺癌手术切除

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