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猪伪狂犬病病毒感染小鼠诱导氧化应激的研究

动物医学进展 2024年第8期45卷 22-27页

作者：周淑棉韦玉衡周家芳赵雅琪胡庭俊广西贵港市动物疫病预防控制中心广西贵港537100 广西大学动物科学技术学院广西南宁530004

旨在研究猪伪狂犬病病毒(PRV)感染小鼠后体内的氧化应激。40只昆明系小鼠设置空白对照组、PRV感染组(10^(0)TCId_(50)、10^(1)TCId_(50)、10^(2)TCId_(50)),采用肌肉注射联合滴鼻的方式感染小鼠,0.1mL/只。观察记录小鼠的临床表现,接种7... 详细信息

旨在研究猪伪狂犬病病毒(PRV)感染小鼠后体内的氧化应激。40只昆明系小鼠设置空白对照组、PRV感染组(10^(0)TCId_(50)、10^(1)TCId_(50)、10^(2)TCId_(50)),采用肌肉注射联合滴鼻的方式感染小鼠,0.1mL/只。观察记录小鼠的临床表现,接种7d后采集小鼠脑、脾脏、肺脏和胸腺。测定免疫器官指数,PCR法检测PRV,HE染色观察小鼠脑、脾脏和肺脏组织结构病理学变化;RT-PCR法检测脾脏、肺脏氧化应激指标相关指标mRNA表达水平。结果显示,感染组小鼠脑、脾、肺均检测到PRV抗原;10^(2)TCId_(50)PRV组小鼠死亡率10%,其他组均未出现死亡;PRV感染小鼠后显著降低小鼠脾脏指数,极显著降低胸腺指数,显著或极显著上调脾和肺组织中iNOS、Nrf2及脾组织中NQO1的mRNA表达水平,极显著降低脾和肺组织中Keap1、脾组织中HO-1的mRNA表达水平;HE染色显示PRV感染小鼠的脑组织出现“血管套”现象,脾脏红髓增宽,脾小体减少和消融,红髓变宽,白髓萎缩,肺脏出现间质性肺炎。结果表明,PRV感染可成功诱导小鼠体内氧化应激,PRV剂量为10^(1)TCId_(50),0.1mL/只,该结果为进一步研究伪狂犬病病毒的致病机制和筛选抗PRV感染的有效药物奠定了基础。

关键词：猪伪狂犬病病毒小鼠氧化应激

does strict environmental regulation enhance the global value chains position of China's industrial sector?

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Petroleum Science 2021年第6期18卷 1899-1909页

作者： Jin-Chao Wang Zhi-da Jin mian Yang Sameen Naqvi Center for Economic development Research Wuhan UniversityWuhan430072China Economics and Management School Wuhan UniversityWuhan430072China

Given the vital importance of global value chains(GVCs)position for a country's international competitiveness,this paper tries to investigate the impacts of environmental regulation on the GVCs position of China's industrial *** the latest value-added decomposition method,we first measure the GVCs position of China's industrial sector from 2003 to ***,both two-stage least squares(2 SLS)method with panel data and mediating effect model are employed to empirically examine the effects of environmental regulation on China's position in *** results indicate that environmental regulation has significantly upgraded the GVCs position of China's industrial sector,and the effect is more evident for the sub-sectors with originally lower GVCs *** mediation effect test shows that increasing R&d investment is an important channel through which environmental regulation affects the GVCs position of China's industrial sector,which verifies the existence of the Porter *** analysis finds that the enhancement of GVCs position of China's industrial sector caused by environmental regulation is mainly achieved through reducing the backward GVCs position.

关键词： Environmental regulation Global value chains Porter hypothesis Industrial sector

Multi-scale molecular dynamics simulations and applications on mechanosensitive proteins of integrins

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Chinese Physics B 2021年第3期30卷 1-8页

作者： Shouqin Lu Qihan ding Mingkun Zhang mian Long Center of Biomechanics and Bioengineering Key Laboratory of Microgravity(National Microgravity Laboratory)Beijing Key Laboratory of Engineered Construction and Mechanobiologyand CAS Center for Excellence in Complex System MechanicsInstitute of MechanicsChinese Academy of Sciences(CAS)Beijing 100190China School of Engineering Science University of Chinese Academy of SciencesBeijing 101408China Chongqing Engineering Research Center of High-Resolution and 3d dynamic Imaging Technology Chongqing Institute of Green and Intelligent TechnologyChinese Academy of SciencesChongqing 400714China

Molecular dynamics simulation(MdS)is a powerful technology for investigating evolution dynamics of target proteins,and it is used widely in various fields from materials to *** mini-review introduced the principles,main preforming procedures,and advances of MdS,as well as its applications on the studies of conformational and allosteric dynamics of proteins especially on that of the mechanosensitive *** perspectives were also *** review could provide clues in understanding the potentiality of Md simulations in structure–function relationship investigation of biological proteins.

关键词： molecular dynamics simulations mechanosensitive protein allosteric dynamics integrin

准噶尔盆地吉木萨尔凹陷页岩水平井水力压裂裂缝形态

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新疆石油地质 2024年第1期45卷 72-80页

作者：方正陈勉王溯李嘉成吕嘉昕余延波焦冀博中国石油大学(北京)石油工程学院北京102249 中国石油新疆油田公司工程技术研究院(监理公司) 新疆克拉玛依834000 中国石油西部钻探井下作业公司(储层改造研究中心) 新疆克拉玛依834000 中国石油西部钻探地质研究院(录井工程分公司) 新疆克拉玛依834000

准噶尔盆地吉木萨尔凹陷、四川盆地南部等地区页岩水平井的微地震侧视数据云图中均出现了平行于层理方向数据点的密度与扩展程度都远远大于垂直方向的现象,与传统的水力压裂裂缝几何形态解释结果矛盾,但是目前没有明确的三维水力压裂裂... 详细信息

准噶尔盆地吉木萨尔凹陷、四川盆地南部等地区页岩水平井的微地震侧视数据云图中均出现了平行于层理方向数据点的密度与扩展程度都远远大于垂直方向的现象,与传统的水力压裂裂缝几何形态解释结果矛盾,但是目前没有明确的三维水力压裂裂缝几何形态对这种现象做出解释。建立微地震数据反演方法,并对反演结果进行了二次重构,给出了页岩水平井三维水力压裂裂缝几何形态,并通过真三轴压裂物理模拟实验对裂缝形态以及微地震数据反演方法进行了验证。研究结果表明:反演得到的裂缝在三维空间中主要呈现出1条主裂缝与多条次生裂缝相互交错的形态,结合真三轴压裂物理模拟实验结果,说明了页岩水平井水力压裂裂缝几何形态呈水平垂直交错;通过对比声发射实验结果和吉木萨尔凹陷露头样品真三轴压裂物理模拟后呈现出的裂缝形态,验证了微地震数据反演方法的可靠性以及页岩水平井水力压裂裂缝的复杂性。

关键词：准噶尔盆地吉木萨尔凹陷页岩水平井储集层微地震水力压裂裂缝形态

Graph neural networks for an accurate and interpretable prediction of the properties of polycrystalline materials

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npj Computational Materials 2021年第1期7卷 925-933页

作者： Minyi dai Mehmet F.demirel Yingyu Liang Jia-mian Hu department of Materials Science and Engineering University of Wisconsin-MadisonMadisonWIUSA department of Computer Sciences University of Wisconsin-MadisonMadisonWIUSA

Various machine learning models have been used to predict the properties of polycrystalline materials,but none of them directly consider the physical interactions among neighboring grains despite such microscopic interactions critically determining macroscopic material ***,we develop a graph neural network(GNN)model for obtaining an embedding of polycrystalline microstructure which incorporates not only the physical features of individual grains but also their *** embedding is then linked to the target property using a feed-forward neural *** the magnetostriction of polycrystalline Tb_(0.3)dy_(0.7)Fe_(2) alloys as an example,we show that a single GNN model with fixed network architecture and hyperparameters allows for a low prediction error of~10%over a group of remarkably different microstructures as well as quantifying the importance of each feature in each grain of a microstructure to its *** a microstructure-graph-based GNN model,therefore,enables an accurate and interpretable prediction of the properties of polycrystalline materials.

关键词： microstructure polycrystalline prediction

远红光绿光侧面补光对水培番茄幼苗生长质量的影响

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中国农业大学学报 2024年第10期29卷 120-130页

作者：陈仁丁雨腾刘思卉王振伟王可禹刘文科王勉佛山科学技术学院物理与光电工程学院/粤港澳智能微纳光电技术联合实验室广东佛山528225 佛山科学技术学院食品科学与工程学院广东佛山528225 中国农业科学院农业环境与可持续发展研究所/农业部设施农业节能与废弃物处理重点实验室北京100081 佛山皓徕特光电有限公司广东佛山528000

为提高植物工厂番茄育苗壮苗指数和生理指标,以‘京研’番茄作为研究对象,顶部照明LEd光源的红蓝光配比设定为3∶1,红光波长(660±10)nm,蓝光波长(450±10)nm,光合光子通量密度(PPFd)为250μmol/(m^(2)·s),光周期14 h/10 h,设置7个处理... 详细信息

为提高植物工厂番茄育苗壮苗指数和生理指标,以‘京研’番茄作为研究对象,顶部照明LEd光源的红蓝光配比设定为3∶1,红光波长(660±10)nm,蓝光波长(450±10)nm,光合光子通量密度(PPFd)为250μmol/(m^(2)·s),光周期14 h/10 h,设置7个处理:无侧面补光(CK)、绿光单侧补光(G_(u))、远红光单侧补光(F_(u))、绿光+远红光单侧补光(GF_(u))、绿光双侧补光(G_(b))、远红光双侧补光(F_(b))、绿光+远红光双侧补光(GF_(b)),番茄育苗47 d后收获,测定各处理下番茄幼苗生长指标和生理指标参数。结果表明:与CK组相比,F_(b)处理的矮生红番茄茎粗、地上部干重、地下部干重和壮苗指数提高,其中壮苗指数2提高了33.6%;绿光补光G_(u)和G_(b)处理下番茄的生长指标显著降低,其中G_(b)处理的壮苗指数1下降了53.1%;绿光补光G_(u)和G_(b)处理增加矮生红番茄叶绿素含量,而远红光补光F_(u)和F_(b)处理显著降低矮生红番茄叶绿素含量;绿光补光G_(u)和G_(b)处理显著降低矮生红番茄硝态氮含量,绿光或远红光补光显著提高矮生红番茄叶片的可溶性蛋白含量。综上,绿光补光抑制矮生红番茄幼苗的生长,远红光则促进生长,双侧补光效果强于单侧补光,远红光双侧补光促进作用最佳。

关键词：植物工厂矮生红番茄远红光绿光单双侧补光生长质量

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基于AR感官体验的模型玩具盲盒包装设计

绿色包装 2024年第9期 79-84页

作者：陈鹤勉吴光远王炳博山东济南250353

传统模型玩具盲盒的包装拆开即弃,造成一系列可玩性操作的不足与包装盒资源的浪费。本文采取基于AR感官体验的模型玩具盲盒包装设计方式,制作了作品所需的各个部分,包括角色设计、包装盒外观设计、3d模型制作、AR程序化交互设计等部分,... 详细信息

传统模型玩具盲盒的包装拆开即弃,造成一系列可玩性操作的不足与包装盒资源的浪费。本文采取基于AR感官体验的模型玩具盲盒包装设计方式,制作了作品所需的各个部分,包括角色设计、包装盒外观设计、3d模型制作、AR程序化交互设计等部分,通过与角色互动程序相链接,实现玩家与所抽中角色的虚拟现实互动功能。本文旨在增强盲盒包装的智能化,丰富包装设计的功能性,增加盲盒产品的可玩性,让玩家获得更好的互动交流体验。

关键词： AR技术盲盒包装感官体验模型玩具

Learning-based joint UAV trajectory and power allocation optimization for secure IoT networks

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digital Communications and Networks 2022年第4期8卷 415-421页

作者： dan deng Xingwang Li Varun Menon Md Jalil Piran Hui Chen mian Ahmad Jan School of Information Engineering Guangzhou Panyu PolytechnicGuangzhou410630China School of Physics and Electronic Information Engineering Henan Polytechnic UniversityJiaozuo454150China department of Computer Science and Engineering SCMS School of Engineering and TechnologyIndia department of Computer Science and Engineering Sejong UniversitySouth Korea department of Computer Science Abdul Wali Khan University MardanPakistan

Non-Orthogonal Multiplex Access(NOMA)can be deployed in Unmanned Aerial Vehicle(UAV)networks to improve spectrum *** to the broadcasting feature of NOMA-UAV networks,it is essential to focus on the security of the wireless *** paper focuses on maximizing the secrecy sum rate under the constraint of the achievable rate of the legitimate *** tackle the non-convexity optimization problem,a reinforcement learning-based alternative optimization algorithm is ***,with the help of successive convex approximations,the optimal power allocation scheme with a given UAV trajectory is obtained by using convex optimization ***,through plenty of explorations of the wireless environment,the Q-learning networks approach the optimal location transition strategy of the UAV,even without the wireless channel state information.

关键词： Unmanned aerial vehicle(UAV) NOMA Reinforcement learning Secure communications deep Q-learning

Humanized mice are susceptible to Salmonella typhi infection

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Cellular & Molecular Immunology 2011年第1期8卷 83-87页

作者： M Firoz mian Elisabeth A Pek Meghan J Chenoweth Ali A Ashkar Institute for Infectious disease Research Centre for Gene TherapeuticsDepartment of Pathology and Molecular MedicineMcMaster UniversityHamiltonOntarioCanada

Salmonella enterica serovar Typhi is a pathogen that only infects ***,there is no animal model for studying this ***,alymphoid RAG2^(-/-)/γc^(-/-) mice engrafted with human leukocytes,known as humanized mice,have been successfully utilized to develop experimental models for several human-specific viral infections,including HIV,human-like dengue fever and hepatitis C *** is known about the usefulness and feasibility of the humanized mouse model for the study of human-specific bacterial pathogens,such as *** aim of this study was to determine if Salmonella enterica serovar Typhi could establish productive infection in humanized *** we report that intravenous inoculation of *** into humanized mice,but not controls,established *** *** bacterial loads were found in the liver,spleen,blood and bone marrow of mice reconstituted with human leukocytes,but not in the unreconstituted control ***,***-infected humanized mice lost significant body weight,and some of the infected mice displayed neurological *** data suggest,for the first time,that humanized mice are susceptible to *** challenge and that this model can be utilized to study the pathogenesis of *** develop novel therapeutic strategies.

关键词： animal model humanized mice RAG2-/-γc-/- Salmonella typhi