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designing a medical ethics curriculum in ophthalmology

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Annals of Eye Science 2024年第1期9卷 4-9页

作者： Matthew d.Gearinger Flaum Eye Institute University of Rochester Medical CenterRochesterNYUSA

Ethical principles form a bedrock to medical practice in any specialty,guiding physicians to appropriate attitudes and behaviors.A formal ethics curriculum can be difficult to generate de novo in an ophthalmology training program.A number of barriers exist in most ophthalmology departments:trainees may think ethics is of secondary importance compared to core basic and clinical science topics;most ophthalmology faculty have no formal degree in medical ethics;there is limited didactic time with competing academic,clinical,and surgical priorities;work-hours regulations may limit the time available to deliver“para-professional”lectures;and there is a belief that the medical ethics lectures during medical school is a sufficient amount of coursework to last through a physician’s career with no need for continuing professional *** four pillars of medical ethics are beneficence,non-maleficence,autonomy,and *** addition,morals,ethics,and professionalism are important aspects of sound medical practice.A curriculum specific to medical ethics in ophthalmology can be developed in any of our sub-specialties and include lectures,curated readings,case rounds,and clinic wrap-up *** considerations are part of everyday clinical practice,and a structured ethics curriculum can be incorporated into ophthalmology training *** concept of backward design can be used to structure the curriculum,starting with the expected outcome,then designing authentic assessments,and finally putting together a learning plan that has students actively involved in ethical *** paper will provide a guide to developing an ethics curriculum for an ophthalmology training program utilizing the concept of backwards design and guide the reader through the process of developing expected learning outcomes,authentic assessments,and a unified learning plan.

关键词： Medical ethics curriculum design medical education

Global patterns and ecological drivers of taxonomic and phylogenetic endemism in angiosperm genera

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Plant diversity 2024年第2期46卷 149-157页

作者： Hong Qian Brent d.Mishler Jian Zhang Shenhua Qian Research and Collections Center Illinois State Museum1011 East Ash StreetSpringfieldIL 62703USA University and Jepson Herbaria Department of Integrative BiologyUniversity of CaliforniaBerkeleyCA 94720-2465USA Center for Global Change and Complex Ecosystems Zhejiang Tiantong Forest Ecosystem National Observation and Research StationSchool of Ecological and Environmental SciencesEast China Normal UniversityShanghai 200241China Shanghai Institute of Pollution Control and Ecological Security Shanghai 200092China Key Laboratory of the Three Gorges Reservoir Region's Eco-Environment Ministry of EducationChongqing UniversityChongqing 400045China

Endemism of lineages lies at the core of understanding variation in community composition among geographic regions because it reflects how speciation,extinction,and dispersal have influenced current ***,we investigated geographic patterns and ecological drivers of taxonomic and phylogenetic endemism of angiosperm genera across the *** identify centers of paleo-endemism and neo-endemism of angiosperm genera,and show that they are mostly located in the Southern Hemisphere in tropical and subtropical regions,particularly in Asia and *** categories of phylogenetic endemism centers can be differentiated using current climate *** climate,historical climate change,and geographic variables together explained~80%of global variation in taxonomic and phylogenetic endemism,while 42-46%,1%,and 15%were independently explained by these three types of variables,*** our findings show that past climate change,current climate,and geography act together in shaping endemism,which are consistent with the findings of previous studies that higher temperature and topographic heterogeneity promote *** study showed that many centers of phylogenetic endemism of angiosperms,including regions in Amazonia,Venezuela,and west-central tropical Africa that have not previously been identified as biodiversity hotspots,are missed by taxon-based measures of endemism,indicating the importance of including evolutionary history in biodiversity assessment.

关键词： Angiosperm Current climate Endemism Historical climate change Topographic heterogeneity

Advancing Wound Filling Extraction on 3d Faces:An Auto-Segmentation and Wound Face Regeneration Approach

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Computer Modeling in Engineering & Sciences 2024年第5期139卷 2197-2214页

作者： duong Q.Nguyen Thinh d.Le Phuong d.Nguyen Nga T.K.Le H.Nguyen-Xuan department of Mathematics and Statistics Quy Nhon UniversityQuy Nhon City55100Viet Nam Applied Research Institute for Science and Technology Quy Nhon UniversityQuy Nhon City55100Viet Nam CIRTECH Institute HUTECH UniversityHo Chi Minh City72308Viet Nam

Facial wound segmentation plays a crucial role in preoperative planning and optimizing patient outcomes in various medical *** this paper,we propose an efficient approach for automating 3d facial wound segmentation using a two-stream graph convolutional *** method leverages the Cir3d-FaIR dataset and addresses the challenge of data imbalance through extensive experimentation with different loss *** achieve accurate segmentation,we conducted thorough experiments and selected a high-performing model from the *** selectedmodel demonstrates exceptional segmentation performance for complex 3d facial ***,based on the segmentation model,we propose an improved approach for extracting 3d facial wound fillers and compare it to the results of the previous *** method achieved a remarkable accuracy of 0.9999993% on the test suite,surpassing the performance of the previous *** this result,we use 3d printing technology to illustrate the shape of the wound *** outcomes of this study have significant implications for physicians involved in preoperative planning and intervention *** automating facial wound segmentation and improving the accuracy ofwound-filling extraction,our approach can assist in carefully assessing and optimizing interventions,leading to enhanced patient ***,it contributes to advancing facial reconstruction techniques by utilizing machine learning and 3d bioprinting for printing skin tissue *** source code is available at https://***/SIMOGroup/WoundFilling3d.

关键词： 3d printing technology face reconstruction 3d segmentation 3d printed model

Comparing Fine-Tuning, Zero and Few-Shot Strategies with Large Language Models in Hate Speech detection in English

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Computer Modeling in Engineering & Sciences 2024年第9期140卷 2849-2868页

作者： Ronghao Pan JoséAntonio García-díaz Rafael Valencia-García departamento de Informática y Sistemas Universidad de MurciaCampus de EspinardoMurcia30100Spain

Large Language Models(LLMs)are increasingly demonstrating their ability to understand natural language and solve complex tasks,especially through text *** of the relevant capabilities is contextual learning,which involves the ability to receive instructions in natural language or task demonstrations to generate expected outputs for test instances without the need for additional training or gradient *** recent years,the popularity of social networking has provided a medium through which some users can engage in offensive and harmful online *** this study,we investigate the ability of different LLMs,ranging from zero-shot and few-shot learning to *** experiments show that LLMs can identify sexist and hateful online texts using zero-shot and few-shot approaches through information ***,it is found that the encoder-decoder model called Zephyr achieves the best results with the fine-tuning approach,scoring 86.811%on the Explainable detection of Online Sexism(EdOS)test-set and 57.453%on the Multilingual detection of Hate Speech Against Immigrants and Women in Twitter(HatEval)***,it is confirmed that the evaluated models perform well in hate text detection,as they beat the best result in the HatEval task *** error analysis shows that contextual learning had difficulty distinguishing between types of hate speech and figurative ***,the fine-tuned approach tends to produce many false positives.

关键词： Hate speech detection zero-shot few-shot fine-tuning natural language processing

Small molecules to target tau amyloid aggregation

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Neural Regeneration Research 2024年第3期19卷 509-511页

作者： Zoe Manglano-Artuñedo Samuel Peña-díaz Salvador Ventura Institut de Biotecnologia i Biomedicina Universitat Autònoma de BarcelonaBellaterraSpain

Protein aggregation has been linked with many neurodegenerative diseases,such as Alzheimer’s disease(Ad)or Parkinson’s *** belongs to a group of heterogeneous and incurable neurodegenerative disorders collectively known as *** comprise frontotemporal dementia,Pick’s disease,or corticobasal degeneration,among *** symptomatology varies with the specific tau protein variant involved and the affected brain region or cell ***,they share a common neuropathological hallmark-the formation of proteinaceous deposits named neurofibrillary *** tangles,primarily composed of aggregated tau(Zhang et al.,2022),disrupt normal neuronal functions,leading to cell death and cognitive decline.

关键词： tau degeneration aggregation

The effect of Common Cuckoo parasitism on the annual productivity of a host population

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Avian Research 2024年第2期15卷 287-291页

作者： Alfred Trnka department of Biology University of TrnavaPriemyselna 491843TrnavaSlovakia

Avian interspecific brood parasitism is an excellent system for studying coevolutionary processes in nature because brood parasites directly affect host reproductive *** research on avian brood parasitism has,therefore,focused primarily on specific host anti-parasite behaviours and parasite ***,the population-level consequences of brood parasitism for host species are poorly *** study investigated the effect of Common Cuckoo(Cuculus canorus)parasitism on the productivity of a local population of the Great Reed Warbler(Acrocephalus arundinaceus)host in south-western Slovakia.A total of 495 females nesting at the studied site successfully fledged 1321 of their own young and 63 young of the Common Cuckoo over the course of 15 years(2008-2022),and the annual rate of successful parasitism ranged from 18% to 44% over this *** predicted,higher rates of successful cuckoo parasitism significantly reduced the annual productivity of the local Great Reed Warbler population,and its contribution to decreased host reproductive success was at about the same rate as overall nest failure caused by predation and other environmental *** a heavily parasitized population was probably maintained by immigrants from other populations and density-dependent selection,which is also consistent with source-sink ***,further long-term studies monitoring parasitized populations are required to confirm these findings.

关键词： Acrocephalus arundinaceus Cuculus canorus Great Reed Warbler Population growth Reproductive success

Prescribed-Time Nash Equilibrium Seeking for Pursuit-Evasion Game

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IEEE/CAA Journal of Automatica Sinica 2024年第6期11卷 1518-1520页

作者： Lei Xue Jianfeng Ye Yongbao Wu Jian Liu d.C.Wunsch Key Laboratory of Measurement and Control of Complex Systems of Engineering Ministry of EducationNanjing 210096 School of Automation Southeast UniversityNanjing 210096China department of Electrical and Computer Engineering Missouri University of Science and TechnologyRollaMO 65409 USA IEEE

dear Editor,This letter is concerned with prescribed-time Nash equilibrium(PTNE)seeking problem in a pursuit-evasion game(PEG)involving agents with second-order *** order to achieve the prior-given and user-defined convergence time for the PEG,a PTNE seeking algorithm has been developed to facilitate collaboration among multiple pursuers for capturing the evader without the need for any global ***,it is theoretically proved that the prescribedtime convergence of the designed algorithm for achieving Nash equilibrium of ***,the effectiveness of the PTNE method was validated by numerical simulation results.A PEG consists of two groups of agents:evaders and *** pursuers aim to capture the evaders through cooperative efforts,while the evaders strive to evade *** is a classic noncooperative *** has attracted plenty of attention due to its wide application scenarios,such as smart grids[1],formation control[2],[3],and spacecraft rendezvous[4].It is noteworthy that most previous research on seeking the Nash equilibrium of the game,where no agent has an incentive to change its actions,has focused on asymptotic and exponential convergence[5]-[7].

关键词： seeking prescribed convergence

differentiating rhythmic high-amplitude delta with superimposed(poly)spikes from extreme delta brushes:limitations of standardized nomenclature and implications for patient management

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World Journal of Pediatrics 2024年第8期20卷 764-773页

作者： Rene Andrade-Machado Elham Abushanab Namrata d.Patel Avantika Singh Children’s Hospital of Wisconsin Wauwatosa:Milwaukee 8915 W Connell CtMilwaukeeWI53226USA

Background Following the standardized nomenclature proposed by the American Clinical Neurophysiology Society(ACNS),rhythmic high-amplitude delta activity with superimposed spikes(RHAdS)can be reported as an extreme delta brush(EdB).The clinical implications of similar electrographic patterns being reported as RHAdS versus EdB are important to *** aim to review the electrographic characteristics of RHAdS,evaluate whether RHAdS is seen in other neurological disorders,and identify the similar and unique characteristics between RHAdS and EdB to ultimately determine the most accurate way to differentiate and report these *** believe that the differentiation of RHAdS and EdB is important as there is a vast difference in the diagnostic approach and the medical management of associated underlying *** source We conducted an extensive search on MEdLINE and Pubmed utilizing various combinations of *** for“gamma polymerase and EEG”,or“RHAdS”or“Alpers syndrome and EEG”or“EEG”ANd“Alpers–Huttenlocher syndrome”.Results Three articles were found to be focused on the description of“RHAdS”pattern in Alpers *** publication to date were found when searching for the terms“EdB”ANd“children”,ANd“infant”ANd“adolescent”excluding“encephalitis”and“neonate”.Although RHAdS and EdB appear as similar EEG patterns,meticulous analysis can differentiate *** is not exclusive to patients with Alpers–Huttenlocher syndrome and may manifest in regions beyond the posterior head *** to eye-opening and response to anesthesia can be two other elements that help in the differentiation of these *** RHAdS is not exclusive to patients with AHS and may manifest in regions beyond the posterior head *** to eye-opening and response to anesthesia are features that help in the differentiation of these patterns.

关键词： Alpers-Huttenlocher syndrome Autoimmune encephalitis Extreme delta brush Neurological disorder Polyspike Rhythmic delta activity Rhythmic high-amplitude delta activity Seizure

Autonomous Vehicle Platoons In Urban Road Networks:A Joint distributed Reinforcement Learning and Model Predictive Control Approach

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IEEE/CAA Journal of Automatica Sinica 2024年第1期11卷 141-156页

作者： Luigi d’Alfonso Francesco Giannini Giuseppe Franzè Giuseppe Fedele Francesco Pupo Giancarlo Fortino IEEE the department of Computer Engineering ModelingElectronics and SystemsUniversitàdella CalabriaVia Pietro BucciCubo 42-CRende(CS)87036Italy the department of Mechanical Engineering Energy Engineering and ManagementUniversitàdella CalabriaVia Pietro BucciCubo 42-CRende(CS)87036Italy

In this paper, platoons of autonomous vehicles operating in urban road networks are considered. From a methodological point of view, the problem of interest consists of formally characterizing vehicle state trajectory tubes by means of routing decisions complying with traffic congestion criteria. To this end, a novel distributed control architecture is conceived by taking advantage of two methodologies: deep reinforcement learning and model predictive control. On one hand, the routing decisions are obtained by using a distributed reinforcement learning algorithm that exploits available traffic data at each road junction. On the other hand, a bank of model predictive controllers is in charge of computing the more adequate control action for each involved vehicle. Such tasks are here combined into a single framework:the deep reinforcement learning output(action) is translated into a set-point to be tracked by the model predictive controller;conversely, the current vehicle position, resulting from the application of the control move, is exploited by the deep reinforcement learning unit for improving its reliability. The main novelty of the proposed solution lies in its hybrid nature: on one hand it fully exploits deep reinforcement learning capabilities for decisionmaking purposes;on the other hand, time-varying hard constraints are always satisfied during the dynamical platoon evolution imposed by the computed routing decisions. To efficiently evaluate the performance of the proposed control architecture, a co-design procedure, involving the SUMO and MATLAB platforms, is implemented so that complex operating environments can be used, and the information coming from road maps(links,junctions, obstacles, semaphores, etc.) and vehicle state trajectories can be shared and exchanged. Finally by considering as operating scenario a real entire city block and a platoon of eleven vehicles described by double-integrator models, several simulations have been performed with the a

关键词： distributed model predictive control distributed reinforcement learning routing decisions urban road networks