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分流漩涡型灌水器结构设计及其优化

节水灌溉 2024年第10期 41-48页

作者：李海洋魏立山于东平杨帅杨越王亚林德州市水利局山东德州253000 山东省水利勘测设计院有限公司济南250000 德州市水利工程施工与维修中心山东德州253000 三峡大学水利与环境学院湖北宜昌443000

分流漩涡型灌水器是一种先分流再产生漩涡从而达到消能目的的灌水器。为研究灌水器流道结构参数对水力特性和抗堵塞性能的影响,选取分水体与流道边壁的距离、分水体与阻水体头部的距离、阻水体齿倾斜角度和阻水体齿到流道边壁的距离4个... 详细信息

分流漩涡型灌水器是一种先分流再产生漩涡从而达到消能目的的灌水器。为研究灌水器流道结构参数对水力特性和抗堵塞性能的影响,选取分水体与流道边壁的距离、分水体与阻水体头部的距离、阻水体齿倾斜角度和阻水体齿到流道边壁的距离4个特征参数研究其水力性能,选取粒径为0.125 mm、密度为2500 kg/m3的泥沙颗粒研究其抗堵塞性能。结果表明,灌水器流态指数为0.4812~0.5068,分水体与流道边壁的距离对流态指数影响最大;灌水器流量系数为2.2093~3.2906,分水体与流道边壁的距离和阻水体齿端到流道边壁的距离均对流量系数有影响。研究发现主漩涡区是易堵塞区域,在多数情况下流态指数与颗粒滞留时间呈负相关规律。最后对该结构进行了优化设计,以提高其水力性能和抗堵塞性能,可为分流漩涡型灌水器水力性能评估和结构优化提供技术支撑。

关键词：水力性能分流漩涡结构参数局部水头损失颗粒轨迹灌水器流道结构设计优化抗堵塞

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麻醉苏醒期间不同吸入氧浓度对腹腔镜胃癌根治术患者术后肺不张的影响

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广东医学 2024年第2期45卷 194-199页

作者：蔡信杰郭文雅汪洋李云安徽医科大学第二附属医院麻醉与围术期医学科安徽合肥230601

目的探讨麻醉苏醒期间不同吸入氧浓度对腹腔镜胃癌根治术患者术后肺不张的影响。方法选择行择期腹腔镜下胃癌根治术的老年患者68例,随机分为两组:高吸入氧浓度组(C组)和低吸入氧浓度组(L组),每组34例。在麻醉苏醒期间,L组采用40%吸入氧... 详细信息

目的探讨麻醉苏醒期间不同吸入氧浓度对腹腔镜胃癌根治术患者术后肺不张的影响。方法选择行择期腹腔镜下胃癌根治术的老年患者68例,随机分为两组:高吸入氧浓度组(C组)和低吸入氧浓度组(L组),每组34例。在麻醉苏醒期间,L组采用40%吸入氧浓度,C组采用100%吸入氧浓度。采用床旁肺超声评估患者12个区域(左肺和右肺各6个区域)的肺超声评分(LUS)。记录入室时(T_(0))、术后30min(T_(4))的LUS评分及术后肺不张的发生率。记录入室(T_(0))、气腹结束时(T_(1))、拔管时(T_(2))、出PACU时(T_(3))的心率(HR)、平均动脉压(maP),血气分析记录血氧分压(PaO_(2)),计算氧合指数(Oi)。记录拔管后在PACU中SpO_(2)d(d_(0))和术后1d(d_(1))、3d(d_(2))、5d(d_(3))测定第1秒用力呼气容积(FEV_(1))、用力肺活量(FVC)、1秒率(FEV_(1)/FVC)。记录术后1d临床肺部感染评分(CPiS)和术后7d肺部并发症的发生情况。结果L组和C组从气腹结束至拔管时间分别为(36.4±5.2)min和(37.3±4.2)min(P>0.05)。与C组相比,L组在T4时的肺超声评分及肺不张发生率明显降低(Pi均明显升高(Pd_(0)时比较,d_(1-3)两组患者的FEV_(1)、FVC、FEV_(1)/FVC均明显降低(Pd_(1)时FEV_(1)、FVC、FEV_(1)/FVC均明显升高(PdCPiS评分和术后7d肺部并发症发生率两组无明显差异(P>0.05)。结论麻醉苏醒期间低吸入氧浓度能降低老年患者腹腔镜胃癌根治术术后肺不张的发生率及严重程度,改善术后早期肺功能。

关键词：吸入氧浓度麻醉苏醒期肺部超声老年胃癌肺功能

基于PkCβⅡ/NOX2/ROS信号通路探讨柴胡三参胶囊对心肌缺血再灌注损伤大鼠的保护作用

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中国中药杂志 2024年第5期49卷 1361-1368页

作者：胡雅琪孙丽李雪珂卢圣花袁恒佑王伟松刘建和湖南中医药大学第一附属医院湖南长沙410007 国家中医心血管病临床医学研究中心分中心湖南长沙410007

基于氧化应激介导的程序性细胞死亡探讨心肌缺血再灌注损伤的发病机制,及基于PkCβⅡ/NOX2/ROS信号通路探讨柴胡三参胶囊调节心肌缺血再灌注损伤的机制及作用靶点。结扎左前降支建立心肌缺血再灌注损伤大鼠模型,随机分为6组:假手术组,... 详细信息

基于氧化应激介导的程序性细胞死亡探讨心肌缺血再灌注损伤的发病机制,及基于PkCβⅡ/NOX2/ROS信号通路探讨柴胡三参胶囊调节心肌缺血再灌注损伤的机制及作用靶点。结扎左前降支建立心肌缺血再灌注损伤大鼠模型,随机分为6组:假手术组,模型组,柴胡三参胶囊临床等效、高剂量组,N-乙酰半胱氨酸(N-acetylcysteine)组,蛋白激酶C抑制剂(CGP53353)组。柴胡三参胶囊各剂量组连续给药7 d后,检测各组大鼠心肌梗死面积;苏木精-伊红(HE)染色观察大鼠心肌组织病理形态;TUNEL染色观察大鼠心脏组织凋亡情况;酶联免疫吸附(enzyme-linked immunosorbent assay,ELiSA)法检测大鼠心肌损伤指标和氧化应激相关指标;流式细胞仪检测心脏组织中活性氧(ROS)水平;蛋白免疫印迹法(Western blot)及实时荧光定量聚合酶链式反应(real-time quantitative PCR,RT-qPCR)检测大鼠心脏组织相关蛋白及mRNA相对表达水平。结果显示,与假手术组比较,模型组大鼠心肌梗死面积明显,心肌结构紊乱、间质水肿及出血,可见大量空泡,心肌损伤标志物及心肌凋亡水平明显升高,ROS及丙二醛(MdA)水平明显升高,超氧化物歧化酶(Sod)水平明显下降,心肌组织中蛋白激酶C(PkCβⅡ)、烟酰胺腺嘌呤二核苷酸磷酸氧化酶2(NOX2)、半胱氨酸蛋白酶3(caspase-3)、长链脂酰辅酶A合成酶4(ACSL4)蛋白及mRNA表达水平明显升高。与模型组比较,柴胡三参胶囊可改善大鼠心肌梗死面积和心脏组织病理形态,改善心肌损伤标志物和氧化应激相关指标,减少心肌组织凋亡水平,降低心肌组织中PkCβⅡ、NOX2、caspase-3、ACSL4蛋白及mRNA的表达。结果表明,柴胡三参胶囊可通过调控PkCβⅡ/NOX2/ROS信号通路,抑制氧化应激和程序性细胞死亡(凋亡、铁死亡),从而减轻心肌缺血再灌注损伤。

关键词：心肌缺血再灌注损伤柴胡三参胶囊氧化应激程序性细胞死亡

A functional hyperbranched binder enabling ultra-stable sulfur cathode for high-performance lithium-sulfur battery

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Journal of Energy Chemistry 2020年第11期29卷 63-72页

作者： Xiang Luo Xianbo Lu Xiaodong Chen ya Chen Chunyang Yu dawei Su Guoxiu Wang Lifeng Cui School of materials Science and Engineering Dongguan University of TechnologyDongguan 523808GuangdongChina Center for Clean Energy Technology School of Mathematical and Physical ScienceFaculty of ScienceUniversity of Technology SydneyNSW 2007Australia R&d Center Shanghai Kingfa Sci.&Tech.Co.Ltd.Shanghai 201714China department of Applied Chemistry School of ScienceXi'an Jiaotong UniversityXi'an 710049ShaanxiChina School of Physical Science and Technology ShanghaiTech UniversityShanghai 201210China School of Chemistry&Chemical Engineering Shanghai Jiao Tong UniversityShanghai 200240China

Binders are of vital importance in stabilizing the cathodes to enhance the cycling stability of lithiumsulfur(Li-S) batteries. However, conventional binders are typically confronted with the drawback of inability for adsorbing lithium polysulfide(Li PS), thus resulting in severe active material losing and rapid capacity fading. Herein, a novel water-soluble hyperbranched poly(amidoamine)(HPAA) binder with controllable hyperbranched molecular structure and abundant amino end groups for Li-S battery is designed and fabricated, which can improve efficient adsorption for Li PS and stability of the sulfur cathodes. Besides, the strong intermolecular hydrogen bonds in HPAA binder can contribute to the structural stability of S cathode and integration of the conductive paths. Therefore, the Li-S battery with this functional binder exhibits excellent cycle performance with a capacity retention of 91% after 200 cycles at 0.1 *** at a high sulfur loading of 5.3 mg cm-2, a specific capacity of 601 ma h g-1 can also be *** functional theory(dFT) calculation further demonstrates that the enhanced electrochemical stability derives from the high binding energy between amino groups and LiP S and the wide electrochemical window(6.87 e V) of HPAA molecule. Based on the above all, this functional polymer will lighten a new species of binders for eco-friendly sulfur cathodes and significantly promote the practical applications of high-performance Li-S batteries.

关键词： Functional binder Hyperbranched polymer Sulfur cathode Polysulfide adsorption Lithium-sulfur battery

Parasitism-induced effects on host growth and metabolic efficiency in Plutella xylostella larvae parasitized by Cotesia vestalis or diadegma semiclausum

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insect Science 2008年第3期15卷 237-243页

作者： Fang Huang ting-ting Cao Min Shi ya-Feng Chen Xue-xin Chen institute of insect Sciences Zhejiang University Hangzhou China

The nutritional physiology of the diamondback moth, Plutella xylostella, larvae was examined after parasitization by the solitary endoparasitoids Cotesia vestalis or diadegma semiclausum. Examinations were performed in two phases, one was examined at the time point of 24 h post-parasitization, and the other was done at the end of the 4th instar larvae of host. Rates of growth, food consumption, assimilation, excretion, and respiration were calculated as well as approximate digestibility and the rate ratios ECi （percent efficiency of conversion of ingested food to body substance）, and ECd （percent efficiency of conversion of digested food to body substance）. Parasitization by C. vestalis resulted in significant decrease in the rates of growth, feeding, excretion, assimilation, and respiration, but the final dry rate of respiration at the end of last larval stadium was elevated. The ECi and ECd were also reduced as the result of parasitization, but digestibility was increased. All these parameters in the larvae parasitized by d. semiclausum at 24 h post-parasitization were also significantly changed compared to the control; however, these differences were quantitatively, but not qualitatively before pupation, similar to those resulted from parasitization by C. vestalis. in spite of the similarities of the parasitism-induced effects caused by these endoparasitoids, the final metabolic rate, that is, the rate of intake of nutrients required to compensate for metabolism, was much lower in the larvae parasitized by C. vestalis than that of the larvae parasitized by d. semiclausum. All of the results discussed here will contribute toward explaining the different ways these two wasps regulate the parasitoid-host relationship.

关键词： approximate digestibility Cotesia vestalis diadegma semiclausum foodconsumption Plutella xylostella

Bear Bile Powder inhibits Growth of Hepatocellular Carcinoma via Suppressing STAT3 Signaling Pathway in Mice

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Chinese Journal of integrative Medicine 2020年第5期26卷 370-374页

作者： CHEN Hong-wei SHEN A-ling LiU Li-ya PENG Jun CHU Jian-feng Academy of integrative Medicine Fujian University of Traditional Chinese MedicineFuzhou(350122)China Fujian key Laboratory of integrative Medicine on Geriatrics Fujian University of Traditional Chinese MedicineFuzhou(350122)China

Objective: To evaluate the inhibitory effect of bear bile powder(BBP) on hepatocellular carcinoma(HCC) growth in vivo and investigate the underlying mechanisms. Methods: A HCC xenograft mouse model was developed by producing with huh7 cells. After 5 days following xenograft implantation, ten HCC xenograft mice were given intra-gastric administration with 10 mg/(kg·d) dose of BBP or saline for 3 weeks. Tumor growth in HCC xenograft mice was evaluated by measuring the tumor weight and volume. Cell apoptosis, proliferation or tumor angiogenesis were examined via immunohistochemical(iHC) staining for transferase-mediated deoxyuridine triphosphate-biotin nick end labeling(TUNEL), proliferating cell nuclear antigen(PCNA) or cluster of differentiation 31(Cd31), respectively. Phosphorylation of signal transducer and activator of transcription 3(STAT3) were determined by Western blot. The m RNA and protein expressions of Bcl-2, Bax, Cyclin d1 and Cyclin-dependent kinase 4(Cdk4) in HCC tumor tissues were respectively determined by reverse transcription polymerase chain reaction(RT-PCR) and Western blot. The protein expression of vascular endothelial growth factor A(VEGF-A) in tumor tissues was examined by iHC staining. Results: BBP treatment led to a significant decrease on tumor volume and tumor weight in HCC mice(Pd had no effect on the change of body weight. in addition, BBP profoundly promoted cell apoptosis, inhibited cell proliferation and intratumoral microvessel density in HCC tumor tissues(Pmarkably suppressed the STAT3 phosphorylation and modulated the expression of critical target genes including Bcl-2, Bax, Cyclin d1, Cdk4 and VEGF-A in HCC mice. Conclusion: BBP exerts its anti-cancer activities via suppressing STAT3 signaling pathway and affecting multiple intracellular targets.

关键词： bear bile powder Chinese medicine hepatocellular carcinoma signal transducer and activator of transcription 3 pathway

四子散热奄包外敷联合运动疗法在胃癌根治术后化疗期间的应用研究

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中国疗养医学 2024年第9期33卷 37-41页

作者：黄娅琳李唯媛李丽丽河南省肿瘤医院中西医结合二病区河南郑州450000

目的探讨四子散热奄包联合运动疗法在胃癌根治术后化疗患者中的应用价值。方法本研究是一项随机对照试验,入选河南省肿瘤医院2021年1月至2023年1月收治的92例腹腔镜胃癌d2根治术后患者,采用随机数字表进行分组,分为试验组和对照组各46... 详细信息

目的探讨四子散热奄包联合运动疗法在胃癌根治术后化疗患者中的应用价值。方法本研究是一项随机对照试验,入选河南省肿瘤医院2021年1月至2023年1月收治的92例腹腔镜胃癌d2根治术后患者,采用随机数字表进行分组,分为试验组和对照组各46例。对照组化疗期间采用运动干预,试验组联合四子散热奄包外敷,干预至化疗结束时进行效果评价。评价指标包括化疗相关恶心呕吐(CiNV)、癌因性疲乏、生活质量。结果化疗期间,试验组延迟期、全程期CiNV发生率45.65%、28.26%低于对照组67.39%、52.17%,差异有统计学意义(PiNV频率6.00(5.00,7.00)次,严重程度3.00(3.00,4.00)分均低于对照组7.00(6.00,8.00)次、5.00(4.00,5.00)分,差异有统计学意义(PiNV发生频率,减轻CiNV和癌因性疲乏程度,从而提高患者生活质量。

关键词：胃癌辅助化疗四子散热奄包运动疗法

Science Letters:Hydrothermal production of formic and acetic acids from syringol

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2010年第8期11卷 613-618页

作者： Lu-ting PAN Zheng SHEN Lei WU ya-lei ZHANG Xue-fei ZHOU Fang-ming JiN MOE Key Laboratory of Yangtze River Water Environment State Key Laboratory of Pollution Control and Resources Reuse College of Environmental Science and Engineering Tongji University Shanghai 200092 China

The production of formic and acetic acids （or salts） by hydrothermal oxidation of syringol, a model compound for lignin, was investigated using a batch reactor. Results show that the highest yields of formic and acetic acids were, respectively, 59.6% and 11.3% at the reaction condition of 0.5 mol/L NaOH, 120% H2O2 supply and 280 ℃. These results will inform studies aiming to develop more enviromnental friendly lignin conversion processes by obtaining products beyond a CO2 end product.

关键词： Lignin Syringol Formic acid. Acetic acid. Hvdrothermal process

Therapeutic effects of herbal formula Huangqisan on metabolic disorders via SREBF1,SCd1 and AMPk signaling pathway

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Journal of integrative Medicine 2021年第2期19卷 167-176页

作者： ya-lei Liu Zhen-yu Zhou Min Gao Guang Ji Cheng Huang Sheng-jie Fan School of Pharmacy Shanghai University of Traditional Chinese MedicineShanghai 201203China College of Pharmacy Shanxi Medical UniversityTaiyuan 030001Shanxi ProvinceChina institute of digestive diseases Longhua HospitalShanghai University of Traditional Chinese MedicineShanghai 200032China

Objective:Metabolic syndrome is a complex medical condition that has become an alarming epidemic,but an effective therapy for this disease is still *** use of the herbal formula Huangqisan(HQS)to treat diabetes is documented in the Chinese medical literature as early as 1117 A.d.;however,its therapeutic effects and underlying mechanisms remain ***:To investigate the beneficial effects of HQS on metabolic disorders,high-fat diet-induced obesity(diO),leptin receptor dysfunction(db/db)and low-density lipoprotein receptor-knockout(LdLR^(-/-))mice were *** mice were treated with either HQS or ***,liver tissue,white fat tissue and brown adipose tissue were harvested at the end of the *** disease-related parameters were evaluated to test effects of HQS against diabetes,obesity and *** arches from LdLR^(-/-)mice were analyzed to investigate the effects of HQS on ***-sequence,quantitative real-time polymerase chain reaction and Western blot were performed to investigate the mechanisms of HQS against metabolic ***:HQS lowered body weight,fasting blood glucose and serum lipid levels and improved glucose tolerance and insulin sensitivity in diO mice and db/db mice(Pked atherosclerotic plaque formation in LdLR^(^(-/-)) *** suppressed de novo lipid synthesis by reducing the expression of messenger RNA for sterol regulatory element-binding factor 1,stearyl coenzyme A desaturase 1 and fatty acid synthase,and enhancing adenosine 5’-monophosphate-activated protein kinase signaling in both in vivo and in vitro experiments,indicating potential mechanisms for HQS’s activity against ***:HQS is effective for reversing metabolic disorder and has the potential to be used as therapy for metabolic syndrome.

关键词： Tradition Chinese medicine diabetes Hyperlipidemia Obesity Atherosclerosis