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Efficacy and safety of yangxinshi tablet for chronic heart failure:A systematic review and meta-analysis

World Journal of Clinical Cases 2024年第13期12卷 2218-2230页

作者： Sheng-Hua Lu Yun-Feng Yu Si-Si dai ya-Qi Hu Jian-He Liu The First Clinical College of Chinese Medicine Hunan University of Chinese MedicineChangsha 410007Hunan ProvinceChina Branch of National Clinical Research Center for Chinese Medicine Cardiology The First Hospital of Hunan University of Chinese MedicineChangsha 410007Hunan ProvinceChina

BACkGROUNd The specific benefits of yangxinshi tablet(YXST)in the treating chronic heart failure(CHF)remain *** To systematically evaluate the efficacy and safety of YXST in the treatment of *** Randomized controlled trials(RCTs)investigating YXST for CHF treatment were retrieved from eight public databases up to November ***-analyses of the included clinical studies were conducted using Review manager *** Twenty RCTs and 1845 patients were *** meta-analysis results showed that the YXST combination group,compared to the conventional drug group,significantly increased the clinical efficacy rate by 23%[relative risk(RR)=1.23,95%Ci:1.17-1.29],(Picular ejection fraction by 6.69%[mean difference(Md)=6.69,95%Ci:4.42-8.95,Pd 6-min walk test by 49.82 m(Md=49.82,95%C:38.84-60.80,Pd reduced N-terminal pro-Btype natriuretic peptide by 1.03 ng/L[standardized Md(SMd)=-1.03,95%Ci:-1.32 to-0.74,Pin natriuretic peptide by 80.95 ng/L(Md=-80.95,95%Ci:-143.31 to-18.59,P=0.01),left ventricular end-diastolic diameter by 3.92 mm(Md=-3.92,95%Ci:-5.06 to-2.78,Pd left ventricular endsystolic diameter by 4.34 mm(Md=-4.34,95%Ci:-6.22 to-2.47,Pding safety,neither group reported any serious adverse events during treatment(RR=0.54,95%Ci:0.15-1.90,P=0.33).in addition,Egger's test results indicated no significant publication bias(P=0.557).CONCLUSiON YXST effectively improves clinical symptoms and cardiac function in patients with CHF while maintaining a favorable safety profile,suggesting its potential as a therapeutic strategy for CHF.

关键词： yangxinshi tablet Chronic heart failure Cardiac function Systematic evaluation Meta-analysis

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i-dCGAN and TOPSiS-iFP:A simulation generation model for radiographic flaw detection images in light alloy castings and an algorithm for quality evaluation of generated images

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China Foundry 2024年第3期21卷 239-247页

作者： Ming-jun Hou Hao dong Xiao-yuan Ji Wen-bing Zou Xiang-sheng Xia Meng Li ya-jun Yin Bao-hui Li Qiang Chen Jian-xin Zhou State key Laboratory of materials Processing and die&Mould Technology Huazhong University of Science and TechnologyWuhan 430074China Xinjiang Technology(Jiangsu)Co. Ltd.Nantong 226100JiangsuChina Southwest Technique and Engineering Research institute Chongqing 400039China Shanghai Spaceflight Precision machinery institute Shanghai 201600China

The intelligent detection technology driven by X-ray images and deep learning represents the forefront of advanced techniques and development trends in flaw detection and automated evaluation of light alloy ***,the efficacy of deep learning models hinges upon a substantial abundance of flaw *** existing research on X-ray image augmentation for flaw detection suffers from shortcomings such as poor diversity of flaw samples and low reliability of quality *** this end,a novel approach was put forward,which involves the creation of the interpolation-deep Convolutional Generative Adversarial Network(i-dCGAN)for flaw detection image generation and a comprehensive evaluation algorithm named TOPSiS-iFP.i-dCGAN enables the generation of high-resolution,diverse simulated images with multiple appearances,achieving an improvement in sample diversity and quality while maintaining a relatively lower computational ***-iFP facilitates multi-dimensional quality evaluation,including aspects such as diversity,authenticity,image distribution difference,and image distortion *** results indicate that the X-ray radiographic images of magnesium and aluminum alloy castings achieve optimal performance when trained up to the 800th and 600th epochs,*** TOPSiS-iFP value reaches 78.7%and 73.8%similarity to the ideal solution,*** to single index evaluation,the TOPSiS-iFP algorithm achieves higher-quality simulated images at the optimal training *** approach successfully mitigates the issue of unreliable quality associated with single index *** image generation and comprehensive quality evaluation method developed in this paper provides a novel approach for image augmentation in flaw recognition,holding significant importance for enhancing the robustness of subsequent flaw recognition networks.

关键词： light alloy casting flaw detection image generator discriminator comprehensive evaluation index

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UWLPiPE:Ultra-wide Bandwidth Low-frequency Pulsar data Processing Pipeline

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Research in Astronomy and Astrophysics 2024年第7期24卷 145-157页

作者： ya-Zhou Zhang Hai-Long Zhang Jie Wang Jian Li Xin-Chen Ye Shuang-Qiang Wang Xu du Han Wu ting Zhang Shao-Cong Guo Xinjiang Astronomical Observatory Chinese Academy of SciencesUrumqi 830011China University of Chinese Academy of Sciences Beijing 100049China key Laboratory of Radio Astronomy Chinese Academy of SciencesNanjing 210008China National Astronomical data Center Beijing 100101China Southeast University Nanjing 211189China

For real-time processing of ultra-wide bandwidth low-frequency pulsar baseband data,we designed and implemented an ultra-wide bandwidth low-frequency pulsar data processing pipeline(UWLPiPE)based on the shared ringbuffer and GPU parallel *** runs on the GPU cluster and can simultaneously receive multiple 128 MHz dual-polarization VdiF data packets preprocessed by the front-end *** aligning the dual-polarization data,multiple 128M subband data are packaged into PSRdAdA baseband data or multi-channel coherent dispersion filterbank data,and multiple subband filterbank data can be spliced into wideband data after time *** used the Nanshan 26 m radio telescope with the L-band receiver at964~1732 MHz to observe multiple ***,we processed the data using dSPSR software,and the results showed that each subband could correctly fold out the pulse profile,and the wideband pulse profile accumulated by multiple subbands could be correctly aligned.

关键词： (stars)pulsars general-methods data analysis-techniques miscellaneous

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Shuxuening injection inhibits Apoptosis and Reduces Myocardial ischemia-Reperfusion injury in Rats through Pi3k/AkT Pathway

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Chinese Journal of integrative Medicine 2024年第5期30卷 421-432页

作者： YUE Tong-tong CAO Ying-jie CAO ya-xuan Li Wei-xia WANG Xiao-yan Si Chun-ying XiA Han ZHU Ming-jun TANG Jin-fa WANG He The First Clinical Medical College of Henan University of Chinese Medicine Zhengzhou 450046China department of Pharmacy the First Affiliated Hospital of Henan University of Chinese MedicineZhengzhou 451200China department of Cardiovascular diseases the First Affiliated Hospital of Henan University of Chinese MedicineZhengzhou 451200China

Objective: To investigate the main components and potential mechanism of Shuxuening injection(SXNi) in the treatment of myocardial ischemia-reperfusion injury(MiRi) through network pharmacology and in vivo research. Methods: The Traditional Chinese Medicine Systems Pharmacology(TCMSP) and Pharm mapper databases were used to extract and evaluate the effective components of Ginkgo biloba leaves, the main component of SXNi. The Online Mendelian inheritance in man(OMiM) and Gene Cards databases were searched for disease targets and obtain the drug target and disease target intersections. The active ingredient-target network was built using Cytoscape 3.9.1 software. The STRiNG database, Metascape online platform, and R language were used to obtain the key targets and signaling pathways of the anti-MiRi effects of SXNi. in order to verify the therapeutic effect of different concentrations of SXNi on MiRi in rats, 60 rats were first divided into 5 groups according to random number table method: the sham operation group, the model group, SXNi low-dose(3.68 mg/kg), medium-dose(7.35 mg/kg), and high-dose(14.7 mg/kg) groups, with 12 rats in each group. Then, another 60 rats were randomly divided into 5 groups: the sham operation group, the model group, SXNi group(14.7 mg/kg), SXNi+LY294002 group,and LY294002 group, with 12 rats in each group. The drug was then administered intraperitoneally at body weight for 14 days. The main biological processes were validated using in vivo testing. Evans blue/triphenyltetrazolium chloride(TTC) double staining, hematoxylin-eosin(HE) staining, terminal deoxynucleotidyl transferase d UTP nick end labeling(TUNEL) assay, enzyme-linked immunosorbent assay(ELiSA), and Western blot analysis were used to investigate the efficacy and mechanism of SXNi in MiRi rats. Results: Eleven core targets and 30 kyoto Encyclopedia of Genes and Genomes(kEGG) pathways were selected. Among these, the phosphoinositide 3-kinase(Pi3k)/protein kinase B(AkT) pathway was

关键词： myocardial ischemia reperfusion injury Pi3k/AkT signaling pathway Shuxuening injection apoptosis Ginkgo biloba leaves

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芍药苷调控血管内皮生长因子对小鼠宫颈癌组织病理变化的影响

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中国临床药理学杂志 2024年第19期40卷 2875-2879页

作者：程亚高伟王钟辉商丘医学高等专科学校病理教研室

目的探讨芍药苷通过靶向调控血管内皮生长因子（VEGF）对宫颈癌移植瘤小鼠肿瘤组织病理变化的影响。方法将小鼠随机分为模型组（构建宫颈癌移植瘤小鼠模型）、芍药苷组(建模后给予100 mg·kg-1芍药苷)、Vector组(建模后给予100 mg·k... 详细信息

目的探讨芍药苷通过靶向调控血管内皮生长因子（VEGF）对宫颈癌移植瘤小鼠肿瘤组织病理变化的影响。方法将小鼠随机分为模型组（构建宫颈癌移植瘤小鼠模型）、芍药苷组(建模后给予100 mg·kg-1芍药苷)、Vector组(建模后给予100 mg·kg-1芍药苷+瘤体注射Vector质粒)、VEGF组(建模后给予100 mg·kg-1芍药苷+瘤体注射过表达VEGF质粒),建模成功后每隔7 d测量肿瘤体积，用免疫组化法检测肿瘤微血管密度（MVd）,用蛋白质印迹法检测肿瘤组织增殖、凋亡及转移相关蛋白的表达水平，用原位末端转移酶标记法检测肿瘤组织的细胞凋亡率。结果模型组、芍药苷组、Vector组和VEGF组建模成功后第28天的肿瘤体积分别为（1 025.50±81.38）、（722.89±49.67）、（720.36±64.01）和（946.79±89.77） mm3,Cd34-MVd水平分别为118.92±6.93、71.67±7.45、72.14±5.55和86.74±8.86,VEGF蛋白相对表达水平分别为1.08±0.09、0.56±0.09、0.54±0.06和0.88±0.13,细胞周期蛋白d1（Cyclin d1）蛋白相对表达水平分别为0.93±0.14、0.44±0.03、0.46±0.07和0.81±0.09,基质金属蛋白9（MMP-9）蛋白相对表达水平分别为1.17±0.12、0.62±0.07、0.64±0.08和0.90±0.07,细胞凋亡率分别为（4.13±0.47）%、（22.16±2.84）%、（21.24±3.42）和（8.60±0.96）%;芍药苷组的上述指标与VEGF组和模型组比较，在统计学上差异均有统计学意义（均P<0.01）。结论芍药苷可能通过调节VEGF的表达来抑制血管生成，改变肿瘤组织病理学变化，抑制肿瘤生长，从而缓解小鼠宫颈癌进程。

关键词：芍药苷宫颈癌血管内皮生长因子组织病理抗血管生成

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Ganoderma lucidum spore oil enhances the effect of paclitaxel,improves the tolerance to paclitaxel and prolongs the survival in Lewis tumor-bearing mice

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Cancer Advances 2024年第12期7卷 1-6页

作者： Hong-Fei Cai Zhao-Jian Jiang Cheng Yuan Lin Cao Qin Wang ya-Ming Han Qin Zhang Jing Li Wen-dong Xu Ju-yan Liu Guangzhou HanFang Pharmaceutical Company Limited National Engineering Research Center of Pharmaceutical Processing Technology of Traditional Chinese Medicine and Drug InnovationGuangdong Provincial Key Laboratory of Medicinal LipidsGuangzhou 510240China Nanchang Research institute Sun Yat-Sen UniversityNanchang 330096China Guangzhou Pharmaceutical Holdings Limited Guangzhou 510130China

Purpose:This study aims to investigate whether Ganoderma lucidum spore oil(GLSO)could enhance the effect of paclitaxel(PTX),improve the tolerance to PTX and prolong the overall survival of Lewis tumor-bearing mice,which has never been reported ***:The tumor,spleen,and thymus were weighed at the end of the *** blood was collected for hematological index analysis,and the intact femur was removed to determine the bone marrow nucleated cell count(BMN).The percentage of lymphocytes in the spleen of mice was detected by flow cytometry,the activity of Nk cells was detected by LdH assay,and the proliferation index of lymphocytes was determined by CCk-8 *** overall and mean survival time and life extension rate were calculated using SPSS ***:Our data showed that GLSO could enhance the anti-tumor effect of PTX and prolong the survival of *** underlying mechanisms of the above effects might be related to the toxic reduction effect of GLSO by relieving hematotoxicity,myelosuppression and ***,GLSO could increase the number of blood cells and bone marrow cells,alleviate the thymic index,and elevate the number and activity of Nk cells in mice treated with ***:GLSO may enhance the efficacy of PTX by boosting the activity of immune Nk cells and prolong survival by counteracting PTX-induced bone marrow alterations and improving *** findings suggested the promising role of GLSO in combination with PTX to extend the survival and increase the tolerance of patients in clinical chemotherapy of lung cancer.

关键词： Ganoderma lucidum spore oil Traditional Chinese Medicine lung cancer paclitaxel tolerance survival

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Understanding and modifications on lithium deposition in lithium metal batteries

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Rare Metals 2022年第8期41卷 2800-2818页

作者： Qin-ya yang Zhao Yu yao Li Wang Zhang Hao-Wen Yuan Hong-Jie Li Wei ma Shen-Min Zhu Sa Li State key Laboratory of Metal matrix Composites School of Materials Science and EngineeringShanghai Jiao Tong UniversityShanghai200240China School of materials Science and Engineering Tongji UniversityShanghai201804China

Lithium metal has been considered as an ultimate anode choice for next-generation secondary batteries due to its low density,superhigh theoretical specific capacity and the lowest voltage ***,uncontrollable dendrite growth and consequently large volume change during stripping/plating cycles can cause unsatisfied operation efficiency and serious safety concern,restraining its commercial use for the last 40 *** widely used lithium-ion battery is approaching its theoretical limit at present,it is increasingly urgent to develop new energy storage equipment with sufficient practical ***,two important processes of lithium deposition,nucleation and growth on lithium metal anode are *** three-dimensional(3 d)porous anodes with unique structure and dynamic surface conditions,as one of the most efficient designs on dendrites suppression,are specifically discussed in terms of their beneficial adjustment on the dendrite *** on current designs and prospects on future advanced porous anode are explored in the end.

关键词： Lithium metal batteries Lithium nucleation dendrites growth Porous anodes

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珠江口潜水镭同位素时空特征及其对海底地下水排泄通量测算的影响研究

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矿物岩石地球化学通报 2024年第3期43卷 541-552页

作者：吴才华张泽彬王亚周永章朱雅敏赵新锋李清洋李镇雄中山大学地球科学与工程学院广东珠海519082 南方海洋科学与工程广东省实验室(珠海) 广东珠海519082 广东省地质过程与矿产资源探查重点实验室广州510275 广东省珠海生态环境监测站广东珠海519070 自然资源部珠海海洋中心广东珠海519015

准确选取具有代表性的地下水端元是采用镭同位素示踪法量化海底地下水排泄(SGd)通量的关键。本研究分析了珠江三角洲潜水^(224)Ra与^(223)Ra的时空分布特征,评估了其对SGd通量计算的影响。结果表明,从潮间带近端至远端,潮间带潜水盐度... 详细信息

准确选取具有代表性的地下水端元是采用镭同位素示踪法量化海底地下水排泄(SGd)通量的关键。本研究分析了珠江三角洲潜水^(224)Ra与^(223)Ra的时空分布特征,评估了其对SGd通量计算的影响。结果表明,从潮间带近端至远端,潮间带潜水盐度和镭活度总体上表现为先下降后升高;相近盐度下,不同潮滩潮间带潜水镭活度无量级差别,仅随盐度上升的变化趋势略有差异;河口内外潮间带潜水的^(224)Ra活度最大相差(1986.8±94.5)dpm/100L,导致测算的SGd差异可达(25.2±9.6)×10^(8)m^(3)/d;以砂质潮滩为例,测算的旱、雨季SGd通量差异可达(2.3±1.6)×10^(8)m^(3)/d。SGd通量对潜水端元取值的敏感性分析显示,盐度影响最大,季节影响次之,潮滩性质影响最小。因此选择镭同位素趋近解吸平衡的高盐度潮间带潜水作为代表性潜水端元进行SGd通量测算较为合理。

关键词：镭同位素镭质量平衡模型盐度潜水端元潮间带潜水

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调补肺肾三法对慢性阻塞性肺疾病大鼠肾损伤的影响

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中国病理生理杂志 2024年第9期40卷 1688-1699页

作者：范正媛韩迪李亚韩冰洋李素云河南中医药大学第一附属医院中药药理(呼吸)实验室河南省呼吸病防治中医药重点实验室河南郑州450000 河南中医药大学第一附属医院呼吸科河南郑州450000 河南中医药大学呼吸疾病中医药防治省部共建协同创新中心河南郑州450046

目的:探讨调补肺肾三法对慢性阻塞性肺疾病(chronic obstructive pulmonary disease,COPd)大鼠肾损伤的影响及机制。方法:将SPF级Sd大鼠随机分为对照(control)组、COPd组、吡咯烷二硫代甲酸铵(pyrrolidinedithiocarbamate ammonium,PdTC)组、补肺健脾方(Bufei-Jianpi formula,BJF)组、补肺益肾方(Bufei-Yishen formula,BYF)组、益气滋肾方(Yiqi-Zishen formula,YZF)组、BJF联合PdTC(BJF+PdTC)组、BYF联合PdTC组(BYF+PdTC)和YZF联合PdTC(YZF+PdTC)组。采用香烟烟雾暴露联合细菌感染的方法建立COPd稳定期大鼠模型,筛选COPd肾损伤大鼠进行后续治疗。第16周末取材观察大鼠肺、肾功能;HE染色观察肺、肾病理形态学;检测24 h尿量和尿生化指标;免疫组化检测水通道蛋白(aquaporins,AQPs)水平;取支气管肺泡灌洗液(bronchoalveolar lavage fluid,BALF)进行细胞分类计数;测定血清炎症因子水平及肾组织ikk和NF-κB的mRNA和蛋白表达变化。结果:与control组比较,COPd大鼠肺功能指标用力肺活量(forced expiratory vital capacity,FVC)、第0.1秒用力呼气容积(forced expiratory volume in 0.1 second,FEV_(0.1))及FEV_(0.1)/FVC显著降低(Ptinine,Cr)、血尿素氮(blood urea nitrogen,BUN)及血清胱抑素C(cystatin C,Cys-C)水平显著升高(Pd-氨基葡萄糖苷酶水平显著升高(PiL-6、iL-13、iL-1β和TGF-β1水平显著升高(Pikk和NF-κB的mRNA和蛋白表达水平显著升高(Pd组比较,各治疗组干预后大鼠上述症状及指标均有不同程度的改善,其中BJF、BYF和YZF组表现出与PdTC相似的作用效果,BJF+PdTC、BYF+PdTC和YZF+PdTC组改善效果优于对应的中药组。结论:调补肺肾三法能缓解COPd大鼠气道和全身炎症反应,改善肾功能,减轻肾组织损伤,其机制可能与抑制NF-κB信号通路有关。

关键词：调补肺肾三法慢性阻塞性肺疾病肾损伤水通道蛋白 NF-κB信号通路

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寿胎丸对先兆流产肾虚证模型小鼠母胎界面糖酵解关键蛋白和凋亡相关因子表达的影响

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中国中药杂志 2024年第8期49卷 2169-2177页

作者：宋亚静李丹丹吕竞芳蒋敏杜惠兰河北中医药大学中西医结合研究所河北石家庄050091 河北省中西医结合生殖疾病协同创新中心河北石家庄050091 河北省中西医结合肝肾病证研究重点实验室河北石家庄050091

探究寿胎丸治疗先兆流产的作用机制。按照随机数字表法将iCR雌性小鼠随机分为4组,分别为正常组、模型组、寿胎丸组和地屈孕酮组,每组15只。每日9:00正常组和模型组灌胃生理盐水,寿胎丸组灌胃寿胎丸混悬液,地屈孕酮组灌胃地屈孕酮溶解剂... 详细信息

探究寿胎丸治疗先兆流产的作用机制。按照随机数字表法将iCR雌性小鼠随机分为4组,分别为正常组、模型组、寿胎丸组和地屈孕酮组,每组15只。每日9:00正常组和模型组灌胃生理盐水,寿胎丸组灌胃寿胎丸混悬液,地屈孕酮组灌胃地屈孕酮溶解剂,每日16:00正常组用等体积蒸馏水灌胃,模型组、寿胎丸组、地屈孕酮组灌胃氢化可的松溶液,连续4 d。将动情前期或动情期的iCR雌鼠与雄鼠按2∶1合笼。自妊娠第1天,按照之前给药方式继续给药,连续给药5 d。第6天灌胃米非司酮,复制肾虚流产模型。各组在妊娠第6天时随机选择10只iCR雌性小鼠,取连胎子宫,HE染色观察母胎界面滋养细胞病理形态学改变;Western blot及免疫荧光法检测糖酵解的关键酶己糖激酶2(hexokinase 2,Hk2)、烯醇化酶1(enolase 1,ENO1)、丙酮酸激酶M2(pyruvate kinase M2,PkM2)以及乳酸脱氢酶A(lactate dehydrogenase A,LdHA)的蛋白表达,Western blot及实时荧光定量PCR法检测胚胎组织凋亡相关因子caspase-3、Bax、Bcl-2的表达,TUNEL法检测滋养细胞凋亡;剩余5只雌鼠孕14 d时采用台盼蓝染法计算胚胎丢失率。妊娠第14天时,正常组胚胎丢失率为5.00%,模型组与正常组相比胚胎丢失率升高,为27.78%(Pk2、ENO1、PkM2、LdHA表达显著降低(Pk2、ENO1、PkM2、LdHA蛋白表达均显著升高(P<0.05),凋亡因子Bcl-2表达显著升高(P<0.05),caspase-3、Bax表达显著降低(P<0.05)。TUNEL染色显示,与正常组相比,模型组细胞凋亡率显著升高(P<0.05);与模型组相比,地屈孕酮组及寿胎丸组滋养细胞凋亡率显著降低(P<0.05)。综上,寿胎丸能降低胚胎丢失率,发挥保胎作用,其机制可能是通过提高先兆流产模型小鼠母胎界面有氧糖酵解水平,抑制滋养细胞凋亡实现的。

关键词：寿胎丸先兆流产糖酵解凋亡

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