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Geography and Sustainability 2023年第1期4卷 29-38页

作者： d.daniel Trimo Pamudji Al djono Widya Prihesti Iswarani department of Health Behavior Environmentand Social MedicineFaculty of MedicinePublic Health and NursingUniversitas Gadjah MadaIndonesia Sekolah Tinggi Teknologi Sapta Taruna Indonesia Environmental Science for Sustainable Energy and Technology(ESSET) School of Life Sciences and Environmental Technology(ATGM/ALST)Avans University of Applied SciencesThe Netherlands

This study used multinomial logistic regression and Bayesian belief networks(BBN)to analyze factors influenc-ing the functionality of the community-based rural drinking water supply and sanitation program(PAMSIMAS)in Indonesia.28,936 PAMSIMAS projects in 33 provinces in Indonesia were *** data indicates that 85.4%of the water supply systems were fully functioning,9.1%were partially functioning,and 5.5%were not *** the regression analysis,good management is positively associated with functionality and a high investment per capita is negatively associated with the *** latter suggests the need for comprehen-sive economic analysis in the feasibility study in scattered housing sites and remote-undeveloped *** also found that high community participation at the beginning of the project was associated with the not functioning system,while women’s participation was positively associated with the ***,the household connection is more likely to be functioning than communal *** analysis shows if the beneficiaries do not pay for water,the probability of not functioning systems is 20 times higher than systems with fee ***,the combination of strong management,strong financial status,and household connection rather than communal connection increases the probability of fully functioning to 98%.Improvement of data collection is also necessary to monitor the current conditions of all PAMSIMAS systems in *** study offers a country-level perspective for better implementation of the community-based rural water supply and sanitation program in developing countries.

关键词： Rural water supply PAMSIMAS Functionality Indonesia Bayesian belief networks Logistic regression

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出露于美国西南部的一条中地壳拉伸性剪切带

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世界地质 1993年第1期 87-88页

作者： Jeffrey A.Grambing Christopher d.daniel 洪景鹏

在新墨西哥北部山区（地形起伏超过2km）出露一条低角度的韧性剪切带,它将上覆的中地壳岩石和下伏的下地壳岩石分开。在该带上已填制了15000km2的地质图。该带是古生代变质作用过程中发展起来的,似乎代表了一条中地壳的拉伸性断裂。这... 详细信息

在新墨西哥北部山区（地形起伏超过2km）出露一条低角度的韧性剪切带,它将上覆的中地壳岩石和下伏的下地壳岩石分开。在该带上已填制了15000km2的地质图。该带是古生代变质作用过程中发展起来的,似乎代表了一条中地壳的拉伸性断裂。这一拉伸系统的上部构造片体保留了变形和变质作用的历史,其中有部分事件发生在拉伸之前,这段历史以在高绿片岩相一低角闪岩相P-T条件下的北西向倾斜的逆掩作用

关键词：西南部拉伸性片体中地壳岩石深成岩体岩石侵入体矿物上部构造角闪石链状硅酸盐矿物矽线石硅线石岛状硅酸盐矿物形变体红柱石美国美利坚合众国北美洲

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反垄断与规制大数据

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经济法论丛 2019年第2期34卷 3-48页

作者： d.daniel Sokol Roisin Comerford 管泽亚(译) 臧俊恒(校) 佛罗里达大学威尔逊·桑西尼·古奇·罗沙迪律师事务所中国政法大学法学院

目次引言一既有学术研究成果二大数据是否会产生促进竞争的效益?(一)数据货币化为消费者提供免费产品补贴(二)提高质量和创新能力(三)大数据的经济特征可以抵御竞争损害三大数据是否会对竞争产生影响?(一)质量和创新的损失(二)对隐私的... 详细信息

目次引言一既有学术研究成果二大数据是否会产生促进竞争的效益?(一)数据货币化为消费者提供免费产品补贴(二)提高质量和创新能力(三)大数据的经济特征可以抵御竞争损害三大数据是否会对竞争产生影响?(一)质量和创新的损失(二)对隐私的侵犯(三)数据驱动的合并和数据驱动的防御(四)已感知到的关于规模、网络效应和准入壁垒的力量.

关键词：反垄断数据问题反托拉斯法消费者保护法反垄断法

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Amyloid-β-induced disruption of axon-initial-segment mitochondria localization:consequences for TAU missorting in Alzheimer's disease pathology

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Neural Regeneration Research 2025年第5期20卷 1407-1408页

作者： daniel Adam Felix Langerscheidt Hans Zempel Institute of Human Genetics University Hospital CologneCologneGermany Center for Molecular Medicine Cologne(CMMC) University of CologneCologneGermany

TAU is a neuronal microtubule-associated protein preferentially located in *** a battery of neurodegenerative diseases termed"tauopathies,"including Alzheimer's disease (Ad),TAU is missorted and abnormally phosphorylated,leading to filamentous accumulations of hyperphosphorylated TAU,a pathological hallmark and potential disease driver of Ad and related tauopathies (Zempel,2024).

关键词： Alzheimer tau diseases

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Vascular endothelial growth factor:a double-edged sword in the development of white matter lesions

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Neural Regeneration Research 2025年第1期20卷 191-192页

作者： Narek Manukjan daniel Fulton Zubair Ahmed WMatthijs Blankesteijn Sébastien Foulquier department of Pharmacology and Toxicology Maastricht UniversityMaastrichtThe Netherlands CARIM-School for Cardiovascular diseases Maastricht UniversityMaastrichtThe Netherlands Neuroscience and Ophthalmology Institute of Inflammation and AgeingUniversity of BirminghamEdgbastonBirminghamUK Centre for Trauma Sciences Research University of BirminghamEdgbastonBirminghamUK MHeNs-School for Mental Health and Neuroscience Maastricht UniversityMaastrichtThe Netherlands department of Neurology Maastricht University Medical CenterMaastrichtThe Netherlands

As the population ages,the burden of age-related diseases becomes ***,over 55 million people suffer from dementia worldwide,with Alzheimer’s disease being the most common ***,it is becoming clearer that underlying vascular pathology such as cerebral small vessel disease(cSVd)may be a more detrimental cause for dementia(Cuadrado-Godia et al.,2018).It is estimated that 10%-30%of the elderly population and 35%-90%of all dementia patients exhibit signs of *** term cSVd refers to pathology affecting the small vessels of the brain,which can lead to lacunar cerebral infarcts,enlarged perivascular spaces,and cortical hemorrhages(Cuadrado-Godia et al.,2018).CSVd is often associated with cognitive decline,gait problems,and dementia(Cuadrado-Godia et al.,2018).

关键词： pathology becoming white

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Complement-dependent neuroinflammation in spinal cord injury:from pathology to therapeutic implications

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Neural Regeneration Research 2025年第5期20卷 1324-1335页

作者： Hassan Saad Bachar El Baba Ali Tfaily Firas Kobeissy Juanmarco Gutierrez Gonzalez daniel Refai Gerald R.Rodts Christian Mustroph david Gimbel Jonathan Grossberg daniel L.Barrow Matthew F.Gary Ali M.Alawieh department of Neurosurgery Emory University School of MedicineAtlantaGAUSA department of Neurology Yale UniversityNew HavenCTUSA Center for Neurotrauma Multiomics&Biomarkers(CNMB)Morehouse School of MedicineAtlantaGAUSA

Spinal cord injury remains a major cause of disability in young adults,and beyond acute decompression and rehabilitation,there are no pharmacological treatments to limit the progression of injury and optimize recovery in this *** the thorough investigation of the complement system in triggering and propagating cerebral neuroinflammation,a similar role for complement in spinal neuroinflammation is a focus of ongoing *** this work,we survey the current literature investigating the role of complement in spinal cord injury including the sources of complement proteins,triggers of complement activation,and role of effector functions in the *** study relevant data demonstrating the different triggers of complement activation after spinal cord injury including direct binding to cellular debris,and or activation via antibody binding to damage-associated molecular *** effector functions of complement have been implicated in spinal cord injury,and we critically evaluate recent studies on the dual role of complement anaphylatoxins in spinal cord injury while emphasizing the lack of pathophysiological understanding of the role of opsonins in spinal cord *** this pathophysiological review,we systematically review the different translational approaches used in preclinical models of spinal cord injury and discuss the challenges for future translation into human *** review emphasizes the need for future studies to dissect the roles of different complement pathways in the pathology of spinal cord injury,to evaluate the phases of involvement of opsonins and anaphylatoxins,and to study the role of complement in white matter degeneration and regeneration using translational strategies to supplement genetic models.

关键词： complement neuroinflammation neuroplasticity regeneration spinal cord injury targeted therapy

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Regulator of G protein signaling 6 mediates exercise-induced recovery of hippocampal neurogenesis,learning,and memory in a mouse model of Alzheimer’s disease

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Neural Regeneration Research 2025年第10期20卷 2969-2981页

作者： Mackenzie M.Spicer Jianqi Yang daniel Fu Alison N.deVore Marisol Lauffer Nilufer S.Atasoy deniz Atasoy Rory A.Fisher department of Neuroscience and Pharmacology University of Iowa Carver College of MedicineIowa CityIAUSA Iowa Neuroscience Institute University of Iowa Carver College of MedicineIowa CityIAUSA Interdisciplinary Graduate Program in Molecular Medicine University of Iowa Carver College of MedicineIowa CityIAUSA Neural Circuits and Behavior Core University of Iowa Carver College of MedicineIowa CityIAUSA

Hippocampal neuronal loss causes cognitive dysfunction in Alzheimer’s *** hippocampal neurogenesis is reduced in patients with Alzheimer’s *** stimulates adult hippocampal neurogenesis in rodents and improves memory and slows cognitive decline in patients with Alzheimer’s ***,the molecular pathways for exercise-induced adult hippocampal neurogenesis and improved cognition in Alzheimer’s disease are poorly ***,regulator of G protein signaling 6(RGS6)was identified as the mediator of voluntary running-induced adult hippocampal neurogenesis in ***,we generated novel RGS6fl/fl;APP_(SWE) mice and used retroviral approaches to examine the impact of RGS6 deletion from dentate gyrus neuronal progenitor cells on voluntary running-induced adult hippocampal neurogenesis and cognition in an amyloid-based Alzheimer’s disease mouse *** found that voluntary running in APP_(SWE) mice restored their hippocampal cognitive impairments to that of control *** cognitive rescue was abolished by RGS6 deletion in dentate gyrus neuronal progenitor cells,which also abolished running-mediated increases in adult hippocampal *** hippocampal neurogenesis was reduced in sedentary APP_(SWE) mice versus control mice,with basal adult hippocampal neurogenesis reduced by RGS6 deletion in dentate gyrus neural precursor ***6 was expressed in neurons within the dentate gyrus of patients with Alzheimer’s disease with significant loss of these RGS6-expressing ***,RGS6 mediated voluntary running-induced rescue of impaired cognition and adult hippocampal neurogenesis in APP_(SWE) mice,identifying RGS6 in dentate gyrus neural precursor cells as a possible therapeutic target in Alzheimer’s disease.

关键词： adult hippocampal neurogenesis Alzheimer’s disease dentate gyrus exercise learning/memory neural precursor cells regulator of G protein signaling 6(RGS6)

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AddRESSING EQUITY ISSUE IN MULTI-ACTOR POLICYMAKING VIA A SYSTEM-OF-SYSTEMS APPROACH:AVIATION EMISSIONS REdUCTION CASE STUdY

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Journal of Systems Science and Systems Engineering 2011年第1期20卷 1-24页

作者： d.Buyung AGUSdINATA daniel A.dELAURENTIS System-of-Systems Laboratory(SoSL) College of EngineeringPurdue University School of Aeronautics and Astronautics Purdue University

Finding equitable policy solutions is critical for developing sustainable energy *** paper presents a system-of-systems(SoS) formalism for addressing the equity issue in multi-actor *** a SoS,the control of the overall system performance is shared among a network of *** contrast to a single optimal solution that aggregates objectives of actors,the solution concept of iso-performance is formulated and employed to illuminate multiple solutions and hence the ’space’ for actors to *** specifically accounting for the equity issue,the level of sacrifice each actor makes for each iso-performance solution is *** demonstrate the approach,a case study is presented about policymaking to reduce fuel life cycle aviation emissions in the United States based on the year 2020 reduction target,involving government,airlines,jet fuel refinery companies,and aircraft and engine manufacturers.A resource allocation mixed integer programming model is employed to calculate carbon emissions resulting from airlines’ deployment of aircraft fleet to meet changing air transport *** paper discusses three iso-performance solutions;each of them requires a different level of sacrifice from each *** an insight can inform policymaking in determining the magnitude of compensation required when a particular solution is pursued.

关键词： System-of-systems equity multi-actor policymaking iso-performance solutions aviation emissions.

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Vitamin d and calcium signaling in epidermal stem cells and their regeneration

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World Journal of Stem Cells 2020年第7期12卷 604-611页

作者： Yuko Oda daniel d Bikle department of Medicine University of California San FranciscoCA 94158United States Endocrine Research Veterans Affairs Medical Center San FranciscoCA 94158United States

Epidermal stem cells(SCs)residing in the skin play an essential role for epidermal regeneration during cutaneous wound *** injury,distinct epidermal SCs residing in the interfollicular epidermis and/or hair follicles are activated to ***,SCs and progeny migrate,differentiate and restore the *** review a role of the vitamin d signaling through its receptor of vitamin d receptor(Vdr)in these *** conditional knockout(cKO)mouse skin experiences a delay in wound re-epithelialization under low dietary calcium conditions,stimulating our efforts to examine a cooperative role of Vdr with calcium signaling through the calcium sensing receptor in the *** review the role of vitamin d and calcium signaling in different processes essential for injury induced epidermal regeneration during cutaneous wound ***,we discuss their roles in self-renewal of epidermal SCs through β-catenin ***,we describe epidermal remodeling,in which SCs and progeny migrate and differentiate to restore the epidermis,events controlled by the Ecadherin mediated adherens junction ***,we discuss the potential mechanisms for vitamin d and calcium signaling to regulate injury induced epidermal regeneration mutually and interdependently.

关键词： Vitamin d Calcium Stem cells Epidermis Regeneration Wound healing

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Glial cell line-derived neurotrophic factor as a treatment after spinal cord injury

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Neural Regeneration Research 2018年第10期13卷 1733-1734页

作者： stephen d.ortmann daniel j.hellenbrand department of neurological surgery university of wisconsinmadisonwiusa

Spinal cord injury（SCI）is a devastating trauma that currently affects 54 people out of every million,which is approximately 270,000people in the United States（National Spinal Cord Injury Statistical Center,2013）.The effects of such an injury can cause a loss of both motor and sensory function below the injury site,normally leaving the patient unable to care for themselves entirely and relying on family and friends to provide personal *** there are no.

关键词： Glial cell line-derived neurotrophic factor as a treatment after spinal cord injury GFR SCI

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