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Additive neurorestorative effects of exercise and docosahexaenoic acid intake in a mouse model of Parkinson’s disease

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Neural Regeneration Research 2025年第2期20卷 574-586页

作者： Olivier Kerdiles Méryl-Farelle Oye Mintsa Mi-mba Katherine Coulombe Cyntia Tremblay VincentÉmond Martine Saint-Pierre Clémence Rouxel Line Berthiaume Pierre Julien Francesca Cicchetti Frédéric Calon Facultéde pharmacie UniversitéLaval1050 Avenue de la MédecineQuebecQCCanada Axe Neuroscience Centre de recherche du CHU de Québec-UniversitéLaval(Pavillon CHUL)2705 Boulevard LaurierQuebecQCCanada Institute of Nutrition and Functional Foods QuebecQCCanada Optinutribrain International Associated Laboratory(NutriNeuro FranceINAFCanada)QuebecQCCanada Axe Endocrinologie et Néphrologie Centre de recherche du CHU de Québec-UniversitéLavalQuebecQCCanada département de Médecine Facultéde MédecineUniversitéLavalQuebecQCCanada département de Psychiatrie et Neurosciences Facultéde MédecineQuebecQCCanada

There is a need to develop interventions to slow or reverse the degeneration of dopamine neurons in Parkinson’s disease after *** that preclinical and clinical studies suggest benefits of dietary n-3 polyunsaturated fatty acids,such as docosahexaenoic acid,and exercise in Parkinson’s disease,we investigated whether both could synergistically interact to induce recovery of the dopaminergic ***,mice received a unilateral stereotactic injection of 6-hydroxydopamine into the striatum to establish an animal model of nigrostriatal *** weeks after lesion,animals were fed a docosahexaenoic acid-enriched or a control diet for the next 8 *** this period,the animals had access to a running wheel,which they could use or *** acid treatment,voluntary exercise,or the combination of both had no effect on(i)distance traveled in the open field test,(ii)the percentage of contraversive rotations in the apomorphine-induction test or(iii)the number of tyrosine-hydroxylase-positive cells in the substantia nigra pars ***,the docosahexaenoic acid diet increased the number of tyrosine-hydroxylase-positive terminals and induced a rise in dopamine concentrations in the lesioned *** to docosahexaenoic acid treatment or exercise alone,the combination of docosahexaenoic acid and exercise(i)improved forelimb balance in the stepping test,(ii)decreased the striatal dOPAC/dopamine ratio and(iii)led to increased dopamine transporter levels in the lesioned *** present results suggest that the combination of exercise and docosahexaenoic acid may act synergistically in the striatum of mice with a unilateral lesion of the dopaminergic system and provide support for clinical trials combining nutrition and physical exercise in the treatment of Parkinson’s disease.

关键词： 6-hydroxydopamine dopamine dopamine transporter exercise neurorestoration Parkinson’s disease polyunsaturated fatty acids omega-3

Polyethylene glycol fusion repair of severed sciatic nerves accelerates recovery of nociceptive sensory perceptions in male and female rats of different strains

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Neural Regeneration Research 2025年第9期20卷 2667-2681页

作者： Liwen Zhou Karthik Venkudusamy Emily A.Hibbard Yessenia Montoya Alexa Olivarez Cathy Z.Yang Adelaide Leung Varun Gokhale Guhan Periyasamy Zeal Pathak dale R.Sengelaub George d.Bittner department of Neuroscience University of TexasAustinTXUSA Program in Neuroscience Indiana UniversityBloomingtonINUSA department of Molecular Biosciences University of TexasAustinTXUSA

Successful polyethylene glycol fusion(PEG-fusion)of severed axons following peripheral nerve injuries for PEG-fused axons has been reported to:(1)rapidly restore electrophysiological continuity;(2)prevent distal Wallerian degeneration and maintain their myelin sheaths;(3)promote primarily motor,voluntary behavioral recoveries as assessed by the Sciatic Functional Index;and,(4)rapidly produce correct and incorrect connections in many possible combinations that produce rapid and extensive recovery of functional peripheral nervous system/central nervous system connections and reflex(e.g.,toe twitch)or voluntary *** preceding companion paper describes sensory terminal field reo rganization following PEG-fusion repair of sciatic nerve transections or ablations;howeve r,sensory behavioral recovery has not been explicitly explored following PEG-fusion *** the current study,we confirmed the success of PEG-fusion surgeries according to criteria(1-3)above and more extensively investigated whether PEG-fusion enhanced mechanical nociceptive recovery following sciatic transection in male and female outbred Sprague-dawley and inbred Lewis *** nociceptive responses were assessed by measuring withdrawal thresholds using von Frey filaments on the dorsal and midplantar regions of the *** von Frey filament tests were a more reliable method than plantar von Frey filament tests to assess mechanical nociceptive sensitivity following sciatic nerve *** withdrawal thresholds of the sciatic-mediated lateral dorsal region differed significantly across strain but not *** thresholds did not change significantly from baseline in chronic Unoperated and Sham-operated *** sciatic transection,all rats exhibited severe hyposensitivity to stimuli at the lateral dorsal region of the hindpaw ipsilateral to the ***,PEG-fused rats exhibited significantly earlier return to baseline withdrawal thresholds than Negative

关键词： autophagia axotomy collateral sprouting neuropathic pain peripheral nerve repair polyethylene glycol fusion(PEG-fusion) saphenous nerve sensory neurons sex and strain Wallerian degeneration

Cognitive frailty in the elderly:a concept analysis

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Frontiers of Nursing 2023年第4期10卷 393-398页

作者： Yi-yin Hu Ronnell d.dela Rosa department of Nursing The Affiliated Hospital of Guizhou Medical UniversityGuiyangGuizhou 550000China School of Nursing Philippine Women’s UniversityMalateManila 1004Philippines

Frailty is a recession of age-related reserves caused by a variety of causes and is becoming the most important clinical syndrome that affects the health of the *** the elderly,frailty and cognitive dysfunction often exist,and some people have proposed cognitive *** frailty is an elderly syndrome that increases the risk of dementia,in the same time,and can independently predict the adverse health outcomes of the patient and affect the quality of the patient's *** paper,under the guidance of Walker and Avant method,provides theoretical basis for early recognition and intervention of cognitive weakness in the elderly.

关键词： antecedents cognition concept analysis consequences defining attributes empirical referents frailty

含孔洞CoCrNiFeCu高熵合金纳米压入的分子动力学模拟

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原子与分子物理学报 2025年第3期42卷 141-148页

作者：史银花施琴江苏联合职业技术学院镇江分院镇江212016

高熵合金具有优异的力学性能、耐磨耐蚀耐高温等性能,成为未来最有发展潜力的新型材料之一.因此,本文通过分子动力学模拟的方法探究了孔洞对CoCrNiFeCu高熵合金模型纳米压痕力学性能和位错演化的影响.结果表明,屈服点、载荷、杨氏模量... 详细信息

高熵合金具有优异的力学性能、耐磨耐蚀耐高温等性能,成为未来最有发展潜力的新型材料之一.因此,本文通过分子动力学模拟的方法探究了孔洞对CoCrNiFeCu高熵合金模型纳米压痕力学性能和位错演化的影响.结果表明,屈服点、载荷、杨氏模量和硬度等力学参数随着孔洞深度d的增加呈现先增加后稳定的趋势.孔洞的存在显著影响了位错形核的位置,随着孔洞深度的增加,初始位错优先在孔洞与表面之间形成,随后集中在模型表面形成,且位错环由平面圆环状转变为“翼状”.在孔洞深度较小时(d<40A),位错环沿(110)面水平扩展,随着孔洞深度的增加,位错环开始向下扩展.此外,在压痕深度为30?时,位错密度随着孔洞深度的增加逐渐增加.

关键词： CoCrNiFeCu 分子动力学纳米压入力学性能位错演变

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胆囊癌手术治疗的现状与进展

临床肝胆病杂志 2025年第12期40卷 2366-2370页

作者：殷晓煜许琼聪中山大学附属第一医院胆胰外科广州 510080

胆囊癌是一种预后极差的恶性肿瘤，根治性手术切除仍然是其唯一有治愈希望的治疗手段。对于Tis、T1a期胆囊癌，单纯胆囊切除即可达到治愈效果；对于T1b～T2期胆囊癌，胆囊癌根治术（包括胆囊及肝部分切除和区域淋巴结清扫）是首选方式... 详细信息

胆囊癌是一种预后极差的恶性肿瘤，根治性手术切除仍然是其唯一有治愈希望的治疗手段。对于Tis、T1a期胆囊癌，单纯胆囊切除即可达到治愈效果；对于T1b～T2期胆囊癌，胆囊癌根治术（包括胆囊及肝部分切除和区域淋巴结清扫）是首选方式；对于T3～T4期患者，扩大根治术有可能改善部分患者的预后，但手术风险大、并发症发生率高，需要严格把握其适应证，并建议由经验丰富的肝胆胰外科团队实施。微创手术在胆囊癌手术治疗中的应用价值目前仍存在较多的争议，但越来越多的证据表明，在微创手术经验丰富的医学治疗中心，胆囊癌微创手术是安全可行的。本文在临床实践经验的基础上结合文献报道系统地阐述胆囊癌手术治疗现状与进展。

关键词：胆囊肿瘤外科手术治疗学

Clinical Application of Bioprosthesis in China:Current Status and Future

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Current Medical Science 2019年第4期39卷 523-525页

作者： yin WANG Wei-wei JIANG Nian-guo d0NG department of Cardiovascular Surgery Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China department of Gastroenterology Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China

China is one of the countries which have a high incidence of heart valvular disease,but the use of biological valve is limited in China before because the majority of patients are young patients suffering from rheumatic heart *** biological valve has a good application prospect in *** the one hand,the new generation of biological valves have been significantly improved in the aspects of anti-calcification treatment,anti-metabolism,material quality control,valve frame mechanics design,and leaflet sewing technology,and the application effect is improved;on the other hand,surgeons should adapt to the new concept changes,and correctly understand and rationally apply biological valves,master valve repair,atrial fibrillation ablation and other techniques,combined with interventional,minimally invasive techniques,etc.,according to the specific conditions of the disease and choose the surgery type to ensure the patients5 long-term life quality.

关键词： biological valve valve surgery clinical application China

Current status and challenges in drug discovery against the globally important zoonotic cryptosporidiosis

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Animal diseases 2021年第1期1卷 48-57页

作者： Guan Zhu Jigang yin Gregory d.Cuny Key Laboratory of Zoonosis Research Ministry of Education/Institute of Zoonosis/and College of Veterinary MedicineJilin UniversityChangchunChina department of Pharmacological&Pharmaceutical Sciences College of PharmacyUniversity of HoustonHoustonTXUSA.

The zoonotic cryptosporidiosis is globally distributed,one of the major diarrheal diseases in humans and *** oocysts are also one of the major environmental concerns,making it a pathogen that fits well into the One Health *** its importance,fully effective drugs are not yet ***-cryptosporidial drug discovery has historically faced many unusual challenges attributed to unique parasite biology and technical *** significant progresses have been made recently,anti-cryptosporidial drug discovery still faces a major obstacle:identification of systemic drugs that can be absorbed by patients experiencing watery diarrhea and effectively pass through electron-dense(Ed)band at the parasite-host cell interface to act on the epicellular *** may be a need to develop an in vitro assay to effectively screen hits/leads for their capability to cross Ed *** the meantime,non-systemic drugs with strong mucoadhesive properties for extended gastrointestinal exposure may represent another direction in developing anti-cryptosporidial *** developing both systemic and non-systemic drugs,a non-ruminant animal model exhibiting diarrheal symptoms suitable for routine evaluation of drug absorption and anti-cryptosporidial efficacy may be very helpful.

关键词： Cryptosporidium Cryptosporidiosis drug discovery Watery diarrhea Electron-dense band drug delivery

Implications of Salt Tectonics on Hydrocarbon Ascent in the Eastern Persian Gulf:Insights into the Formation Mechanism of Salt diapirs,Gas Chimneys,and Their Sedimentary Interactions

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Journal of Ocean University of China 2024年第6期23卷 1515-1533页

作者： XUE Yang LUAN Xiwu RAVEENdRASINGHE Thanuja d WEI Xinyuan JIN Long yin Jian QIAO Jianghao College of Earth Science and Engineering Shandong University of Science and TechnologyQingdao 266590China department of Physical Sciences Faculty of Applied SciencesSouth Eastern University of Sri LankaSammanthurei 32200Sri Lanka College of Marine Geosciences Ocean University of ChinaQingdao 266100China

Gas chimneys,salt domes,and faults are vital to the movement of hydrocarbons within geological *** identification of these geological features is crucial to modeling hydrocarbon *** study explores the processes that have shaped the eastern Persian Gulf,focusing on salt diapir characteristics,origin,and fluid *** collisions between the Indian,Eurasian,and Arabian Plates have considerably impacted salt tectonics,developing key features such as the Hormuz salt,Qatar-South Fars Arch,and Zagros and Oman orogenic ***-related features were discerned through two-dimensional seismic data and drilling records,salt movement sequences were reconstructed,and fluid expulsion patterns were delineated using attribute *** results of this study revealed that fractured substrates influenced by regional tectonic forces contribute to the creation of salt diapirs,which serve as conduits for guided fluid ***,these results showed that gravity-driven downbuilding mainly controls salt flow,while the circular arrangement of salt structures results from regional stress and interactions between different salt *** stress-induced basement incisions compounded by the hindrance of initial salt movement by the Qatar Arch further contribute to the complex salt structure ***,the uplift of the Qatar Arch and stresses from the Oman and Zagros orogenies profoundly affect the salt structure geometry and depositional patterns across diverse regions,resulting in circular salt structures and gas *** study offers valuable perspectives for oil and gas exploration and provides a comprehensive understanding of the regional dynamics governing salt tectonics and hydrocarbon ascent in the eastern Persian Gulf.

关键词： Persian Gulf salt tectonics salt diapirs gas chimneys salt-sediment interaction fluid ascent

人工智能在煤矿安全监测中的潜在应用:理论框架与展望

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煤矿现代化 2025年第1期34卷 71-77页

作者：尹强潞安集团司马煤业有限公司山西长治046000

对人工智能在煤矿安全监测中的应用及其未来发展趋势进行了研究与探讨。对传统的煤矿安全监测方法及其局限性进行了总结,详细探究了人工智能在煤矿安全监测方面的应用,特别是在井下监测监控、人员定位和通讯等方面;探讨了人工智能技术... 详细信息

对人工智能在煤矿安全监测中的应用及其未来发展趋势进行了研究与探讨。对传统的煤矿安全监测方法及其局限性进行了总结,详细探究了人工智能在煤矿安全监测方面的应用,特别是在井下监测监控、人员定位和通讯等方面;探讨了人工智能技术在提高煤矿安全性方面的重要性和潜在价值。研究结果表明,人工智能能显著提升煤矿安全监测的效率和准确性,且随着技术的进步和数据质量的提高,人工智能将在提高煤矿安全生产水平、减少事故发生率方面发挥重要作用。

关键词：人工智能煤矿安全监测技术数据分析风险预测