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Interaction of major facilitator superfamily domain containing 2A with the blood-brain barrier

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Neural Regeneration Research 2025年第8期20卷 2133-2152页

作者： Yilun Ma Taiwei dong Fei luan Juanjuan Yang Feng Miao Peifeng Wei college of Pharmacy and First clinical Medical college Shaanxi University of Chinese MedicineXianyangShaanxi ProvinceChina National drug clinical Trial Agency The Second Affiliated Hospital of Shaanxi University of Chinese Medicine/Xixian New District Central HospitalXi′anShaanxi ProvinceChina

The functional and structural integrity of the blood-brain barrier is crucial in maintaining homeostasis in the brain microenvironment;however,the molecular mechanisms underlying the formation and function of the blood-brain barrier remain poorly *** major facilitator superfamily domain containing 2A has been identified as a key regulator of blood-brain barrier *** plays a critical role in promoting and maintaining the formation and functional stability of the blood-brain barrier,in addition to the transport of lipids,such as docosahexaenoic acid,across the blood-brain ***,an increasing number of studies have suggested that major facilitator superfamily domain containing 2A is involved in the molecular mechanisms of blood-brain barrier dysfunction in a variety of neurological diseases;however,little is known regarding the mechanisms by which major facilitator superfamily domain containing 2A affects the blood-brain *** paper provides a comprehensive and systematic review of the close relationship between major facilitator superfamily domain containing 2A proteins and the blood-brain barrier,including their basic structures and functions,cross-linking between major facilitator superfamily domain containing 2A and the blood-brain barrier,and the in-depth studies on lipid transport and the regulation of blood-brain barrier *** comprehensive systematic review contributes to an in-depth understanding of the important role of major facilitator superfamily domain containing 2A proteins in maintaining the structure and function of the blood-brain barrier and the research progress to *** will not only help to elucidate the pathogenesis of neurological diseases,improve the accuracy of laboratory diagnosis,and optimize clinical treatment strategies,but it may also play an important role in prognostic *** addition,the effects of major facilitator superfamily domain containing 2A on blood-brain barrier lea

关键词： blood-brain barrier(BBB) caveolin-1 central nervous system docosahexaenoic acid endothelial cells lysophosphatidylcholine major facilitator superfamily domain containing 2A(MFSd2A) transcytosis

Postnatal development of rat retina:a continuous observation and comparison between the organotypic retinal explant model and in vivo development

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Neural Regeneration Research 2025年第3期20卷 900-912页

作者： Baoqi Hu Rui Wang Hanyue Zhang Xiou Wang Sijia Zhou Bo Ma Yan luan Xin Wang Xinlin chen Zhichao Zhang Qianyan Kang department of Ophthalmology The First Affiliated Hospital of Xi’an Jiaotong UniversityXi’anShaanxi ProvinceChina department of Ophthalmology The First Affiliated Hospital of Northwest UniversityXi’anShaanxi ProvinceChina Institute of Neurobiology Xi’an Jiaotong University Health Science CenterXi’anShaanxi ProvinceChina

The organotypic retinal explant culture has been established for more than a decade and offers a range of unique advantages compared with in vivo experiments and cell ***,the lack of systematic and continuous comparison between in vivo retinal development and the organotypic retinal explant culture makes this model controversial in postnatal retinal development ***,we aimed to verify the feasibility of using this model for postnatal retinal development studies by comparing it with the in vivo *** this study,we showed that postnatal retinal explants undergo normal development,and exhibit a consistent structure and timeline with retinas in ***,we used SOX2 and PAX6 immunostaining to identify retinal progenitor *** then examined cell proliferation and migration by immunostaining with Ki-67 and doublecortin,***-67-and doublecortin-positive cells decreased in both in vivo and explants during postnatal retinogenesis,and exhibited a high degree of similarity in abundance and distribution between ***,we used ceh-10 homeodomain-containing homolog,glutamate-ammonia ligase(glutamine synthetase),neuronal nuclei,and ionized calcium-binding adapter molecule 1 immunostaining to examine the emergence of bipolar cells,Müller glia,mature neurons,and microglia,*** timing and spatial patterns of the emergence of these cell types were remarkably consistent between in vivo and explant *** study showed that the organotypic retinal explant culture model had a high degree of consistency with the progression of in vivo early postnatal retina *** findings confirm the accuracy and credibility of this model and support its use for long-term,systematic,and continuous observation.

关键词： bipolar cells differentiation in vivo microglia Müller glia organotypic retinal explant culture postnatal retina development proliferation retinal progenitor cells

Ultra‑Transparent and Multifunctional IZVO Mesh Electrodes for Next‑Generation Flexible Optoelectronics

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Nano-Micro Letters 2025年第1期17卷 293-309页

作者： Kiran A.Nirmal Tukaram d.dongale Atul c.Khot chenjie Yao Nahyun Kim Tae Geun Kim School of Electrical Engineering Korea UniversityAnam‑ro 145Seongbuk‑guSeoulRepublic of Korea computational Electronics and Nanoscience Research Laboratory School of Nanoscience and BiotechnologyShivaji UniversityKolhapur 416004India

Mechanically durable transparent electrodes are essential for achieving long-term stability in flexible optoelectronic ***,they are crucial for applications in the fields of energy,display,healthcare,and soft *** meshes represent a promising alternative to traditional,brittle,metal oxide conductors due to their high electrical conductivity,optical transparency,and enhanced mechanical *** this paper,we present a simple method for fabricating an ultra-transparent conducting metal oxide mesh electrode using selfcracking-assisted *** this method,we produced an electrode with ultra-transparency(97.39%),high conductance(Rs=21.24Ωsq^(−1)),elevated work function(5.16 eV),and good mechanical *** also evaluated the effectiveness of the fabricated electrodes by integrating them into organic photovoltaics,organic light-emitting diodes,and flexible transparent memristor devices for neuromorphic computing,resulting in exceptional device *** addition,the unique porous structure of the vanadium-doped indium zinc oxide mesh electrodes provided excellent flexibility,rendering them a promising option for application in flexible optoelectronics.

关键词： Self-cracking template Vanadium-doped indium zinc oxide mesh Organic solar cells Organic light-emitting diodes Flexible transparent memory

Status and prospects for symmetric organic redox flow batteries

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Journal of Energy chemistry 2025年第1期100卷 125-143页

作者： Md Al Raihan c.Adam dyker department of chemistry University of New Brunswick

As environmental concerns from fossil fuel consumption intensify, large-scale energy storage becomes imperative for the integration of renewable sources like wind, hydro, and solar with the electrical *** flow batteries, particularly those employing organic molecules, are positioned as a key technology for this purpose. This review explores the growing field of symmetric organic redox flow batteries(ORFBs) within this context. Unlike traditional asymmetric designs based on unique active materials for each electrode, symmetric ORFBs involve a single bipolar species for both electrodes. This review highlights the benefits of a symmetric design, and categorizes five distinct classes of organic bipolar molecules used in both aqueous and non-aqueous solvents. By providing a comprehensive overview of their cell cycling and performance characteristics, the strengths and weaknesses of the diverse categories of bipolar molecules are highlighted for both solvent systems, as are opportunities for future development. This should guide new research directions and advance the development of practical symmetric ORFBs.

关键词： Redox flow battery Symmetric battery Organic battery Aqueous electrolyte Non-aqueous electrolyte

基于PLUS模型的典型农牧交错带土地利用驱动力分析与多情景模拟

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水土保持研究 2025年第1期32卷 368-378页

作者：张启扬刘仁志栾朝旭北京师范大学环境学院水环境模拟国家重点实验室

[目的]实现农牧交错带地区破碎化土地利用变化的精准预测，为农牧交错带土地利用预测与结构调整提供重要工具。[方法]研究针对性构建了农牧交错带土地利用模拟方法(APE-PLUS),引入土地扩张分析策略(LEAS)、基于多类型随机斑块种子的cA模... 详细信息

[目的]实现农牧交错带地区破碎化土地利用变化的精准预测，为农牧交错带土地利用预测与结构调整提供重要工具。[方法]研究针对性构建了农牧交错带土地利用模拟方法(APE-PLUS),引入土地扩张分析策略(LEAS)、基于多类型随机斑块种子的cA模型(cARS)、Markov模型和土地利用情景设计，解决农牧交错带土地利用模拟中斑块零散、景观破碎、变化机制复杂的问题。采用二调、三调土地利用数据，分析了2014—2020年土地利用变化及其驱动力，模拟了2032年科左后旗自然增长、生态优先、耕地保护和可持续发展情景下的土地利用格局。[结果](1)农牧交错带土地利用模拟方法(APE-PLUS)精度较高，Kappa系数为0.87,总体精度达到0.92;(2)科左后旗2014—2020年土地利用变化显著，全旗47.85%的土地类型发生改变，14.65%的土地由耕地转变为草地，dEM和水资源是这一时期土地利用变化的主要驱动力；(3) 2032年多情景预测中，可持续发展情景耕地面积增长1.31%,林地和草地分别减少了0.77%和1.72%,其他用地面积减小28.4%,相比于其他3种情景，土地利用数量结构与空间格局更合理。此情景有助于减缓耕地扩张趋势和草地缩减趋势，有效控制水土流失、土壤沙化问题，提高生态保护与经济发展的协调程度。[结论]农牧交错带土地利用模拟方法(APE-PLUS)对科左后旗的土地利用具有较高的模拟精度，可以对农牧交错带斑块级的土地利用变化进行高精度的预测。

关键词：土地利用变化农牧交错带 PLUS模型科尔沁左翼后旗驱动因子

Identification of Orientia tsutsugamushi,spotted fever group and typhus group Rickettsia by duplex and nested PcR methods

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Asian Pacific Journal of Tropical Medicine 2008年第4期1卷 1-8页

作者： M-c luan d-Z Yu L Tang L-J Zhang department of Rickettsiology National Institute of Communicable Disease Control and PreventionChina CDC department of Microorganism Dalian Center for Disease Control and Prevention department of Microecology Dalian medical university department of Rickettsiology National Institute of Communicable Disease Control and PreventionChina.CDC

Objective:To identify members of genera of rickettsia and *** ***:Rapid and duplex and nested PcR methods have been established by designing primers based on the conserved regions of heat shock protein GroEL gene.345 mouse viscera samples including liver,spleen and kidney,96 Xenopsylla cheopis and 32 chiggers collected from Hongta areas of Yuxi city,Yunnan province were tested by the new PcR ***:The result of the study showed that the new PcR methods could identify most members of genera -Rickettsia and Orientia simultaneously with 100%specificity and its sensitivity could test one copy per *** results of detection prevalence of rickettsioses in mouse,flea and mites dNA samples showed that the total rickettsia infection rate in mouse was 34.78%(120/345).The total infection rates in ***,O.t Karp and *** of mouse samples were 28.12%(97/345),19.71%(68/345) and O. 29%(1/345) ***-infection rates in *** and 0.t Karp of mouse samples were 13.33%(46/ 345).O.t Karp type has been the main epidemic strain in these ***:We concluded that this PcR method could be used to detect multi-genera rickettsia *** evidences provided in this and previous studies strongly support that Hongta areas of Yuxi city are a natural focus for typhus and scrub typhus with the common occurrence of their confection.

关键词： Rickettsia,GroEL gene duplex and nested PcR

Synergetic organocatalysis for stereoregular ring-opening polymerization of O-carboxyanhydrides to isotactic functionalized polyesters

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材料导报 2020年第12期34卷 12001-12002页

作者： luan Shifang State Key Laboratory of Polymer Physics and chemistry Changchun Institute of Applied ChemistryChinese Academy of SciencesChangchun 130022China

Polyesters,such as polylactide(PLA),are a class of biodegra-dable and biocompatible polymers that have received increasing attention in biomedicine,agriculture,and commodity thermoplastics[1-2].However,the lack of pendant functionality of conventional polyesters makes it difficult to modify and modulate the physicochemical properties in subsequent applications[3-4].Since 2006[5],the ring-opening polymerization(ROP)of O-carbox-yanhydrides(OcAs),which can be readily synthesized from amino acid or hydroxyl acid precursors,has been recognized as a promising route to functionalized polyesters[3-4].However,due to the increased methine c-H acidity,significant racemization of the stereogenic center and decreased stereoregularity have been identified for most OcAs,for instance,ManOcA[6](OcA from mandelic acid)and SerOcA[7](OcA from serine),when using typical 4-(dimethylamino)pyridine(dMAP)as *** minimize epimerization,some classical metal-based catalysts of coordination polymerization have been introduced to mediate ROP of OcAs,furnishing isotactic polyesters[8].

关键词： polyester polymerization stereo

Plasmon-enhanced Performance of dye-sensitized Solar cells Based on Electrodeposited Ag Nanoparticles

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Journal of Materials Science & Technology 2014年第1期30卷 1-7页

作者： Xinning luan Ying Wang department of Mechanical & Industrial Engineering Louisiana State University

In the present work, pulse current deposition is used to deposit evenly distributed and uniformly sized Ag nanoparticles onto a TiO2 nanotube array as photoelectrode in dye-sensitized solar cells （dSScs）, and the size and amount of loading Ag nanoparticles are controlled by the pulse deposition time. due to the enhanced light absorption and electron-hole separation caused by plasmon effect, dSScs based on Ag-modified TiO2 nanotube arrays show higher energy conversion efficiencies than those based on bare nanotubes with the same tube length. Particularly, dSSc based on nanotubes modified using pulse deposition time 1 s/3 s delivers the highest energy conversion efficiency of 1.68% and the largest short-circuit current of 4.37 mA/ cm2, while dSSc consisting of bare nanotubes exhibits efficiency of 1.20% and short-circuit current of 2.27 mA/cm2, which represents a 40% enhancement of cell efficiency in dSSc based on Ag-modified Ti02 nanotubes. It is also noted that overly long pulse deposition time will not further increase dSSc efficiency due to agglomeration of Ag particles. For example, when the pulse deposition time is increased to 2 s/6 s, dSSc based on Ag-modified nanotubes exhibits a lower efficiency of 1.42%. Moreover, high-concentration TicI4 treatment on TiO2 nanotube arrays can further increase the energy conversion efficiencies to 3.82% and 2.61% for dSSc based on Ag-modified TiO2 nanotubes and dSSc based on bare TiO2 nanotubes, respectively, by significantly creating more surface area for dye loading.

关键词： TiO2 nanotube dye-sensitized solar cell Pulse current deposition Ag nanoparticle TicI4 treatment

design of performance robustness for uncertain nonlinear time-delay systems via neural network

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Journal of Systems Engineering and Electronics 2007年第4期18卷 852-857,884页

作者： luan Xiaoli Liu Fei Inst. of Automations Southern Yangtze Univ. Wuxi 214122 P. R. China

Performance robustness problems via the state feedback controller are investigated for a class of uncertain nonlinear systems with time-delay in both state and control, in which the neural networks are used to model the nonlinearities. By using an appropriate uncertainty description and the linear difference inclusion technique, sufficient conditions for existence of such controller are derived based on the linear matrix inequalities （LMIs）. Using solutions of LMIs, a state feedback control law is proposed to stabilize the perturbed system and guarantee an upper bound of system performance, which is applicable to arbitrary time-delays.

关键词： nonlinear system time-delay uncertainties neural network linear matrix inequality