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Advancing Wound Filling Extraction on 3d Faces:An Auto-Segmentation and Wound Face Regeneration Approach

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Computer Modeling in Engineering & Sciences 2024年第5期139卷 2197-2214页

作者： duong Q.Nguyen Thinh d.Le Phuong d.Nguyen Nga T.K.Le H.Nguyen-Xuan department of Mathematics and Statistics Quy Nhon UniversityQuy Nhon City55100Viet Nam Applied Research Institute for Science and Technology Quy Nhon UniversityQuy Nhon City55100Viet Nam CIRTECH Institute HUTECH UniversityHo Chi Minh City72308Viet Nam

Facial wound segmentation plays a crucial role in preoperative planning and optimizing patient outcomes in various medical *** this paper,we propose an efficient approach for automating 3d facial wound segmentation using a two-stream graph convolutional *** method leverages the Cir3d-FaIR dataset and addresses the challenge of data imbalance through extensive experimentation with different loss *** achieve accurate segmentation,we conducted thorough experiments and selected a high-performing model from the *** selectedmodel demonstrates exceptional segmentation performance for complex 3d facial ***,based on the segmentation model,we propose an improved approach for extracting 3d facial wound fillers and compare it to the results of the previous *** method achieved a remarkable accuracy of 0.9999993% on the test suite,surpassing the performance of the previous *** this result,we use 3d printing technology to illustrate the shape of the wound *** outcomes of this study have significant implications for physicians involved in preoperative planning and intervention *** automating facial wound segmentation and improving the accuracy ofwound-filling extraction,our approach can assist in carefully assessing and optimizing interventions,leading to enhanced patient ***,it contributes to advancing facial reconstruction techniques by utilizing machine learning and 3d bioprinting for printing skin tissue *** source code is available at https://***/SIMOGroup/WoundFilling3d.

关键词： 3d printing technology face reconstruction 3d segmentation 3d printed model

discovery of new MAX-phase-like layered ternary carbide V_(8)P_(6)C:Crystal structure,thermal expansion,and elastic properties

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Journal of Materials Science & Technology 2024年第7期174卷 55-62页

作者： H.X.Chen L.Sheng Z.L.Zhang X.C.Wen d.L.yang X.y.ye P.Q.dai School of Materials Science and Engineering Fujian University of TechnologyFuzhou 350118China Beijing Synchrotron Radiation Facility Institute of High Energy PhysicsChinese Academy of ScienceBeijing 100049China Fujian Provincial Key Laboratory of Advanced Materials Processing and Application Fuzhou 350118China State Key Laboratory of Structural Chemistry Fujian Institute of Research on the Structure of MatterChinese Academy of SciencesFuzhou 350002China

due to the laminated structure,MAX phases and MAX-phase-like compounds possess outstanding dam-age tolerance capability with good thermal/electrical conductivity and other charming functional prop-erties,showing a bright future for structural-functional ***,a new MAX-phase-like ternary car-bide V_(8)P_(6)C with layered characteristics was *** to the alternate stacking of hexagonal-arranged M/A/X atom layers in MAX phases,V_(8)P_(6)C has a layered structure formed by a repeated stacking of the slabs consisting of V_(6)C-octahedrons and VP 6-distorted-octahedrons in three-atomic layers *** thermal expansion anisotropy was revealed,with the thermal expansion coefficients(TECs)along a-axis,c-axis,and the average value,equal toα_(a)=8.55(5)μK^(−1),α_(c)=10.23(5)μK^(−1),andα_(L)=9.14(5)μK^(−1),*** dilation along the c-axis was mainly dominated by out-plane V-P bonds be-tween layered *** to the pressure-dependent lattice parameters,the polycrystalline bulk modulus(B_(0)=185(9)GPa)and high compressibility anisotropy factor(B_(a)/B_(c)=1.64)was ***-while,the second-order elastic constants were calculated,and the elastic moduli,E=303 GPa,B=198 GPa,G=122 GPa,andν=0.246,were *** the weak connection between layer slabs by out-plane V1-P bond was revealed by the bond stiffness model,with a bond stiffness close to the M-A bond in MAX ***,good damage tolerance capability was predicted according to Paugh’s ratio(G/B=0.616)and Cauchy pressure(P_(a)=0 GPa,P_(c)=-7.5 GPa),even better than those of typical MAX *** discovery of V_(8)P_(6)C provides a new member of MAX-phase-like damage-tolerant ceramic with relatively low density,moderate thermal expansion,and anisotropic compressibility,and the unique lay-ered structure is inspiring for exploring new layered ternary ceramics.

关键词： New ternary carbide MAX phase Thermal expansion Elastic constants Anisotropy

EBV-associated lymphoproliferative disease post-CAR-T cell therapy

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Frontiers of medicine 2024年第2期18卷 394-398页

作者： Shiyuan Zhang Xiaoxi Zhou Shangkun Zhang na Wang Tongcun Zhang donghua Zhang Qilin Ao yang Cao Liang Huang department of Hematology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430030China Immunotherapy Research Center for Hematologic diseases of Hubei Province Wuhan430030China Institute of Biology and medicine College of Life and Health SciencesWuhan University of Science and TechnologyWuhan430081China department of Pathology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430030China State Key Laboratory of Experimental Hematology National Clinical Research Center for Blood DiseasesHaihe Laboratory of Cell EcosystemInstitute of Hematology&Blood Diseases HospitalChinese Academy of Medical Sciences&Peking Union Medical CollegeTianjin300020China Tianjin Institutes of Health Science Tianjin301600China

Epstein–Barr virus(EBV)-associated lymphoproliferative diseases(EBV-LPds)are common complications that occur after solid organ transplantation or allogeneic hematopoietic stem-cell transplantation(HSCT).However,their occurrence and treatment post-chimeric antigen receptor-modified T(CAR-T)cell therapy has not been *** patients had been diagnosed with EBV-positive aggressive B-cell lymphoma and experienced relapses after multiple lines of *** receiving CAR-T cell therapy in tandem with autologous HSCT,the patients achieved complete ***,with a median time of 38.5 months after CAR-T cell therapy,B-cell-derived EBV-LPds were diagnosed,and they were relieved through the administration of immune checkpoint inhibitor or B-cell-depleting ***,our report suggests that EBV-LPds may represent a long-term adverse event after CAR-T cell therapy,especially in patients who previously had EBV-positive disorders,and they can be resolved by immune normalization strategy or B-cell depleting therapy.

关键词： EBV-associated lymphoproliferative disease chimeric antigen receptor T-cell autologous stem cell transplantation immune checkpoint inhibitor

MicroRna-630 alleviates inflammatory reactions in rats with diabetic kidney disease by targeting toll-like receptor 4

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World Journal of diabetes 2024年第3期15卷 488-501页

作者： Qi-Shun Wu dan-na Zheng Cheng Ji Hui Qian Juan Jin Qiang He Graduate School Medical College of Soochow UniversitySuzhou 215006Jiangsu ProvinceChina department of Nephrology Zhejiang Provincial People’s HospitalAffiliated People’s HospitalHangzhou 314408Zhejiang ProvinceChina department of Nephrology Affiliated Hospital of Jiangsu UniversityZhenjiang 212001Jiangsu ProvinceChina department of Nephrology Zhejiang Provincial People’s HospitalAffiliated People’s HospitalHangzhou Medical CollegeHangzhou 314408Zhejiang ProvinceChina Molecular Inspection Laboratory School of MedicineJiangsu UniversityZhenjiang 212000Jiangsu ProvinceChina department of Nephrology The First Affiliated Hospital of Zhejiang Chinese Medical UniversityZhejiang Provincial Hospital of Traditional Chinese MedicineHangzhou 310060Zhejiang ProvinceChina

BACKGROUNd diabetic kidney disease(dKd)is a major complication of diabetes *** tubular epithelial cell(TEC)damage,which is strongly associated with the inflammatory response and mesenchymal trans-differentiation,plays a significant role in dKd;However,the precise molecular mechanism is *** recently identified microRna-630(miR-630)has been hypothesized to be closely associated with cell migration,apoptosis,and ***,the association between miR-630 and dKd and the underlying mechanism remain *** To investigate how miR-630 affects TEC injury and the inflammatory response in dKd *** Streptozotocin was administered to six-week-old male rats to create a hypergly cemic diabetic *** the second week of modeling,the rats were divided into control,dKd,negative control of lentivirus,and miR-630 overexpression *** 8 wk,urine and blood samples were collected for the kidney injury assays,and renal tissues were removed for further molecular *** target gene for miR-630 was predicted using bioinformatics,and the association between miR-630 and toll-like receptor 4(TLR4)was confirmed using in vitro investigations and double luciferase reporter gene *** of miR-630 in dKd rats led to changes in body weight,renal weight index,basic blood parameters and histopathological *** The expression level of miR-630 was reduced in the kidney tissue of rats with dKd(Pd TLR4 expressions in rat renal TECs(NRK-52E)were measured using quantitative reverse transcription polymerase chain *** mRna expression level of miR-630 was significantly lower in the high-glucose(HG)and HG+mimic negative control(NC)groups than in the normal glucose(NG)group(Pna expression level of TLR4 was significantly higher in these groups(Pna expression increased and TLR4 mRna expression significantly decreased in the HG+miR-630 mimic group than in the HG

关键词： diabetic kidney disease MicroRna-630 Toll-like receptor 4 Mouse model Renal tubular epithelial cells damage Hyperglycemic model

Association between glucose-lowering drugs and circulating insulin antibodies induced by insulin therapy in patients with type 2 diabetes

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World Journal of diabetes 2024年第7期15卷 1489-1498页

作者： Peng Zhang Qing Jiang Bo ding Reng-na yan yun Hu Jian-Hua Ma department of Endocrinology Nanjing First HospitalNanjing Medical UniversityNanjing 210000Jiangsu ProvinceChina department of Endocrinology The Affiliated Wuxi People's Hospital of Nanjing Medical UniversityWuxi Medical CenterWuxi 214000Jiangsu ProvinceChina

BACKGROUNd Insulin antibodies(IAs)affect blood glucose control in patients receiving insulin *** To investigate the relationship between different hypoglycemic treatments and IAs in patients with type 2 diabetes mellitus(T2dM).METHOdS This cross-sectional,retrospective study included 1863 patients with T2dM who were receiving exogenous insulin *** patients received stable antidiabetic therapy in the last 3 months and IA levels were measured using an iodine-125 *** A total of 1863 patients were *** were 902(48.4%)patients who had positive IAs(IA level>5%),with a mean IA level of 11.06%(10.39%-11.72%).IA levels were positively correlated with high fasting blood glucose(odds ratio=1.069,Py(31.9%)and highest in patients using human insulin only(70.3%),Pylureas/glinides(8.3%),metformin(9.6%),and dipeptidyl peptidase-4 inhibitors(8.2%)were all lower than in patients without these drugs(all Py half of patients on insulin therapy have positive IA antibodies,and IA antibody levels are associated with blood glucose *** glargine and a combination of oral glucose-lowering drugs were correlated with lower IA levels.

关键词： Insulin antibodies Insulin therapy Glucose-lowering drugs Glargine Type 2 diabetes

Understanding the rapid spread of antimicrobial resistance genes mediated by IS26

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mLife 2024年第1期3卷 101-109页

作者： na Tang dawei Wei yuan Zeng Gang Zhang Chao Wang Jie Feng yuqin Song State Key Laboratory of Microbial Resources Institute of MicrobiologyChinese Academy of SciencesBejingChina College of Life Science University of Chinese Academy of SciencesBeijingChina

Insertion sequences(ISs)promote the transmission of antimicrobial resistance genes(ARGs)across bacterial ***,their contributions and dynamics during the transmission of resistance remain *** this study,we selected is26 as a representative transposable element to decipher the relationship between ISs and ARGs and to investigate their transfer features and transmission *** retrieved 2656 translocatable IS26-bounded units with ARGs(tiS26-bUs-ARGs)in complete bacterial genomes from the NCBI RefSeq *** total,124 ARGs spanning 12 classes of antibiotics were detected,and the average contribution rate of IS26 to these genes was 41.2%.We found that IS26-bounded units(IS26-bUs)mediated extensive ARG dissemination within the bacteria of the Gammaproteobacteria class,showing strong transfer po-tential between strains,species,and even *** Is26-bUs expanded in bacterial populations over time,and their temporal expansion trend was significantly correlated with antibiotic *** wide dissemination could be due to the nonspecific target site preference of ***,we experimentally confirmed that the introduction of a single copy of is26 could lead to the formation of a composite transposon mediating the transmission of“passenger”*** observations extend our knowledge of the IS26 and provide new insights into the mediating role of ISs in the dissemination of antibiotic resistance.

关键词： antibiotic consumption antibiotic resistance genes horizontal gene transfer insertion sequence IS26

PEG400-mediated nanocarriers improve the delivery and therapeutic efficiency of mRna tumor vaccines

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Chinese Chemical Letters 2024年第5期35卷 314-319页

作者： Wen Xiao Fazhan Wang yangzhuo Gu Xi He na Fan Qian Zheng Shugang Qin Zhongshan He yuquan Wei Xiangrong Song department of Critical Care medicine Frontiers Science Center for Disease-related Molecular NetworkState Key Laboratory of BiotherapyWest China HospitalSichuan UniversityChengdu 610041China medical Research Center The First Affiliated Hospital of Zhengzhou UniversityZhengzhou UniversityZhengzhou 450000China

dendritic cell(dC)-targeted delivery of mRna is a prominent method to boost the efficacy of mRna tumor *** targeting ligands are often modified on nanocarriers by polyethylene glycol(PEG)linker in mRna delivery *** the PEG linker length influences the targeting delivery efficiency of mRna nanocarrier in vivo remains ***,we designed and constructed dC-targeted mRna delivery systems modified by mannose via different PEG linker lengths(100/400/1000/2000)(MPn-LPX).The top candidate MP_(400)-LPX(the linker was PEG400)showed the optimal mRna expression and antigen presentation owing to the highly efficient uptake by ***,MP_(400)-LPX could better inhibited tumor growth and extended survival in the E.G7-OVA lymphoma and TC-1 cervical tumor mouse ***,these results demonstrated that PEG400 was the optimal linker for the PEGylated dC-targeted mRna *** findings provided a new platform for the rational design of targeted mRna nanovaccines with shorter-length PEG.

关键词： Cancer immunotherapy mRna vaccines dC-targeted delivery PEGylated liposomes Cellular uptake

Towards an ultrafast 3d imaging scanning LidAR system:a review

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Photonics Research 2024年第8期12卷 1709-1729页

作者： ZHI LI yAQI HAN LICAN WU ZIHAN ZANG MAOLIN dAI SZE yUN SET SHINJI yAMASHITA QIAN LI H.y.FU Tsinghua Shenzhen International Graduate School Tsinghua UniversityShenzhen 518055China department of Electrical Engineering and Information Systems The University of TokyoTokyo 113-8656Japan Research Center for Advanced Science and Technology The University of TokyoTokyo 153-8904Japan School of Electronic and Computer Engineering Peking UniversityShenzhen 518055China

Light detection and ranging(LidAR),as a hot imaging technology in both industry and academia,has undergone rapid innovation and *** current mainstream direction is towards system miniaturization and *** are many metrics that can be used to evaluate the performance of a LidAR system,such as lateral resolution,ranging accuracy,stability,size,and *** recently,with the continuous enrichment of LidAR application scenarios,the pursuit of imaging speed has attracted tremendous research ***,for autonomous vehicles running on motorways or industrial automation applications,the imaging speed of LidAR systems is a critical *** this review,we will focus on discussing the upper speed limit of the LidAR *** on the working mechanism,the limitation of optical parts on the maximum imaging speed is *** beam scanner has the greatest impact on imaging *** provide the working principle of current popular beam scanners used in LidAR systems and summarize the main constraints on the scanning ***,we highlight the spectral scanning LidAR as a new paradigm of ultrafast ***,to further improve the imaging speed,we then review the parallel detection methods,which include multiple-detector schemes and multiplexing ***,we summarize the LidAR systems with the fastest point acquisition rate reported *** the outlook,we address the current technical challenges for ultrafast LidAR systems from different aspects and give a brief analysis of the feasibility of different approaches.

关键词： LidAR scanner system

Pd-1^(+)and TIM-3^(+)T cells widely express commonγ-chain cytokine receptors in multiple myeloma patients,and IL-2,IL-7,IL-15 stimulation up-regulates Pd-1 and TIM-3 on T cells

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Oncology Research 2024年第10期32卷 1575-1587页

作者： EGOR V.BATOROV ALISA d.INESHIna TATIAna A.ARISTOVA VERA V.dENISOVA SVETLAna A.SIZIKOVA dARIA S.BATOROVA GALIna y.USHAKOVA EKATERIna y.SHEvela ELEna R.CHERNyKH Laboratory of Cellular Immunotherapy Research Institute of Fundamental and Clinical ImmunologyNovosibirsk630099Russia V.Zelman Institute of medicine and Psychology Novosibirsk National Research State UniversityNovosibirsk630090Russia department of Hematology and Bone Marrow Transplantation Research Institute of Fundamental and Clinical ImmunologyNovosibirsk630099Russia

Background:Immune checkpoint ligand-receptor interactions appear to be associated with multiple myeloma(MM)***,previous studies showed the possibility of Pd-1 and TIM-3 expression on T cells upon stimulation with commonγ-chain family cytokines in vitro and during homeostatic *** aim of the present work was to study the impact of homeostatic proliferation on the expansion of certain T cell subsets upregulating Pd-1 and TIM-3 checkpoint ***:The expression of Cd25,Cd122,Cd127 commonγ-chain cytokine receptors,phosphorylated signal transducer and activator of transcription-5(pSTAT5)and eomesodermin(EOMES)was comparatively assessed with flow cytometry in Pd-1-and TIM-3-negative and positive T cells before the conditioning and during the first post-transplant month in peripheral blood samples of MM ***:Substantial proportions of Pd-1-and TIM-3-positive T lymphocytes expressed commonγ-chain cytokine receptors and *** of cytokine receptor expressing cells were significantly higher within TIM-3+T cells compared to Pd-1+TIM-3−*** proportions of both Pd-1-/TIM-3-negative and positive Cd8+T cells express EOMES,while only moderate frequencies of Cd4+Pd-1+/TIM-3+T cells up-regulate this transcription ***,the surface presence of Cd25 and intranuclear expression of EOMES in Cd4+T cells were mutually exclusive regardless of Pd-1 and TIM-3 *** stimulation with commonγ-chain cytokines up-regulates Pd-1 and TIM-3 during the proliferation of initially Pd-1/TIM-3-negative T cells but fails to expand initially Pd-1+and TIM-3+T cell subsets in ***:Both Pd-1 and TIM-3 expressing T cells appear to be able to respond to homeostatic cytokine *** in commonγ-chain cytokine receptor expression between Pd-1+and TIM-3+T cells may reflect functional dissimilarity of these cell *** blockade appears to alleviate lymphopenia-induced prolif

关键词： Autologous hematopoietic stem cell transplantation(AHSCT) Cd25 Cd122 Eomesodermin(EOMES) Homeostatic proliferation