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BioPerine Encapsulated Nanoformulation for Overcoming drug-Resistant Breast Cancers

Asian Journal of Pharmaceutical Sciences 2020年第6期15卷 701-712页

作者： Sindhu C Pillai Ankita Borah Amandeep Jindal Eden Mariam Jacob Yohei Yamamoto d.sakthi kumar Bio-Nano Electronics Research Centre Graduate School of Interdisciplinary New ScienceToyo UniversitySaitama 350-8585Japan department of Materials Science Faculty of Pure and Applied SciencesUniversity of TsukubaTsukubaIbaraki 305-8573Japan

The evolving dynamics of drug resistance due to tumor heterogeneity often creates impediments to traditional therapies making it a challenging issue for cancer *** cancer often faces challenges of current therapeutic interventions owing to its multiple complexities and high drug resistivity,for example against drugs like trastuzumab and *** resistance in the majority of breast cancer is often aided by the overtly expressed P-glycoprotein(P-gp)that guides in the rapid drug efflux of chemotherapy *** continuous endeavors and ground-breaking achievements in the pursuit of finding better cancer therapeutic avenues,drug resistance is still a menace to hold *** newer therapeutic approaches,the application of phytonutrients such as alkaloids to suppress P-gp activity in drug-resistant cancers has found an exciting niche in the arena of alternative cancer *** this work,we would like to present a black pepper alkaloid derivative known as Bio Perine-loaded chitosan(CS)-polyethylene glycol(PEG)coated polylactic acid(PLA)hybrid polymeric nanoparticle to improve the bioavailability of Bio Perine and its therapeutic efficacy in suppressing P-gp expression in MdA-MB 453 breast cancer cell *** findings revealed that the CS-PEG-Bio PerinePLA nanoparticles demonstrated a smooth spherical morphology with an average size of316 nm,with improved aqueous solubility,and provided sustained Bio Perine *** nanoparticles also enhanced in vitro cytotoxicity and downregulation of P-gp expression in MdA-MB 453 cells compared to the commercial inhibitor verapamil hydrochloride,thus promising a piece of exciting evidence for the development of Bio Perine based nano-drug delivery system in combination with traditional therapies as a crucial approach to tackling multi-drug resistance in cancers.

关键词： drug Resistant cancer P-glycoprotein BioPerine Chitosan PLA nanoparticle

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Translocator protein and neurodegeneration: insights from Alzheimer’s disease

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Neural Regeneration Research 2025年第4期20卷 1090-1091页

作者： Arpit kumar Pradhan Rainer Rupprecht Gerhard Rammes Klinik für Anaesthesiologie und Intensivmedizin der Technischen Universität München Klinikum rechts der IsarMunichGermany Graduate School of Systemic Neurosciences Ludwig-Maximilians-Universität MünchenMartinsriedGermany department of Psychiatry and Psychotherapy University RegensburgRegensburgGermany

The 18 kda translocator protein(TSPO)located on the outer mitochondrial membrane regulates several key cellular processes including mitochondrial homeostasis,cholesterol transport,apoptosis,cell proliferation,and maintenance of mitochondrial health(Rupprecht et al.,2022,2023).TSPO is expressed in both peripheral organs and the central nervous system,with a more pronounced expression in tissues that produce *** main reason why TSPO has garnered so much attention is because it plays a key role in neurosteroidogenesis by transferring cholesterol from the outer to the inner mitochondrial membrane,which is the rate-limiting step in neurosteroid synthesis.A cholesterol-recognizing amino acid consensus domain has been identified in the cytosolic C terminus of the TSPO protein by both in vitro and site-directed mutagenesis experiments(Li et al.,2001).However,the role of TSPO in the process of neurosteroid synthesis has been challenged by several studies,particularly TSPO knockout models,which suggest that TSPO removal does not affect the phenotype or the system’s viability(Tu et al.,2014).However,ligands targeting TSPO have been shown to enhance levels of neurosteroids which suggests that neurosteroidogenesis is one of the major functional roles mediated by the TSPO protein.

关键词： cholesterol organs

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Ultra-fast microwave aided synthesis of gold nanocages and structural maneuver studies

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Nano Research 2017年第3期10卷 1078-1091页

作者： Sreejith Raveendran Anindito Sen Toru Maekawa d. sakthi kumar Bio-Nano Electronics Research Centre Graduate School of Interdisciplinary New Science Toyo University 2100 Kujirai Kawagoe Saitama 350-8585 Japan JEOL Ltd. 13F Ohtemachi Nomura Building 2-1-10htemachi Chiyoda-Ku. Tokyo 100-0004 Japan

Gold nanocages （AuNcgs） are well-studied, hollow, metallic nanostructures that have fascinated researchers in the fields of nanotechnology, materials science, photoelectronics, biotechnology, and medical science for the last decade. However, the time-consuming synthesis of AuNcgs has limited their widespread use in materials science and nano-biotechnology. A novel, ultra-fast, simple, and highly convenient method for the production of AuNcgs using microwave heating is demonstrated herein. This quick method of AuNcg synthesis requires mild laboratory conditions for large-scale production of AuNcgs. The microwave heating technique offers the advantage of precise mechanical control over the temperature and heating power, even for the shortest reaction period （i.e., seconds）. Microwave-synthesized AuNcgs were compared with conventionally synthesized AuNcgs. Structural maneuver studies employing the conventionally produced AuNcgs revealed the formation of screw dislocations and a shift in the lattice plane. detailed characterization of the microwave-generated AuNcgs was performed using high resolution transmission electron microscopy （HRTEM）, scanning electron microscopy （SEM）, X-ray powder diffraction （XRd）, and spectroscopic techniques.

关键词： gold nanocages nanocages nanoboxes microwave technology ultra-fast screw dislocation

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Advancing engineered approaches for sustainable wound regeneration and repair:Harnessing the potential of green synthesized silver nanoparticles

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Engineered Regeneration 2024年第3期5卷 306-325页

作者： J.Nandhini E.Karthikeyan E.Elizabeth Rani V.S.Karthikha d.sakthi Sanjana H.Jeevitha S.Rajeshkumar Vijayan Venugopal A.Priyadharshan department of Pharmaceutics Saveetha College of PharmacySaveetha Institute of Medical and Technical SciencesChennai 602105India department of Pharmaceutical Chemistry Saveetha College of PharmacySaveetha Institute of Medical and Technical SciencesChennai 602105India department of Pharmacology Saveetha Dental College and HospitalSaveetha Institute of Medical and Technical SciencesChennaiIndia department of Pharmaceutics School of PharmacySri Balaji Vidyapeeth(Deemed to be university)PuducherryIndia department of conservative dentistry and Endodontics Saveetha Dental College and HospitalSaveetha Institute of Medical and Technical SciencesSaveetha UniversityChennaiIndia

Wound healing is a crucial biological process for tissue repair and regeneration,preventing infections and ***’s been a growing interest in exploring sustainable wound healing strategies in recent *** review examines the use of green-synthesized silver nanoparticles(AgNPs)in sustainable wound healing *** highlights the need for innovative approaches and the challenges posed by *** current wound therapies and treatments,highlighting gaps in existing methodologies,are *** review provides a com-prehensive overview of the current state-of-the-art in green synthesis techniques for the synthesis of *** properties and characterization of AgNPs are elucidated,providing insights into their *** biocompati-bility of AgNPs in wound healing is also explored,emphasizing safety in medical *** synthesized AgNPs incorporated wound dressings are detailed,showcasing their potential in clinical *** and future perspectives are discussed,addressing hurdles to widespread *** conclusion consolidates key findings,offering a synthesized perspective on the potential of green-synthesized AgNPs in revolutionizing current knowledge on innovative approaches for sustainable wound healing practices.

关键词： Green synthesis Wound healing AgNPs Wound healing mechanism Eco-friendly synthesis

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Anti-amyloid antibodies in Alzheimer’s disease: what did clinical trials teach us?

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Neural Regeneration Research 2025年第4期20卷 1092-1093页

作者： danko Jeremic Lydia Jiménez-díaz Juan d.Navarro-López NeuroPhysiology&Behavior Lab University of Castilla-La ManchaBiomedical Research Center(CRIB)School of Medicine of Ciudad RealCiudad RealSpain

Although many causes of Alzheimer’s disease(Ad)may exist,both the original amyloid cascade and tau hypotheses posit that abnormal misfolding and accumulation of amyloid-β(Aβ)and tau protein is the central event causing the ***,that conclusion could be only partly true,and there is conflicting evidence about the role of both proteins in Ad,being able to precede and influence one *** researchers argue that these proteins are mere executors rather than primary causes of ***,there have been continuing refinements of both hypotheses,with alternative explanations proposed.Aβand tau proteins may be independently involved in specific neurotoxic pathways;yet there may be other crucial processes going on in early ***,accumulating evidence suggests that Aβand tau act synergistically,rather than additively in disease onset(Jeremic et al.,2021,2023a).

关键词： amyloid Alzheimer additive

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Remaking a connection:molecular players involved in post-injury synapse formation

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Neural Regeneration Research 2025年第6期20卷 1719-1720页

作者： diogo Tomé Ramiro d.Almeida iBiMEd-Institute of Biomedicine Department of Medical SciencesUniversity of AveiroAveiroPortugal CNC-Center for Neuroscience and Cell Biology University of CoimbraCoimbraPortugal

Functional recovery from central nervous system(CNS)trauma depends not only on axon regeneration or compensatory sprouting of uninjured fibers but also on the ability of newly grown axons to establish functional synapses with appropriate *** several studies have successfully promoted long-distance axonal regeneration in distinct CNS injury models,none of them have resulted in a viable therapeutic approach for patient recovery.A possible reason may be the lack of new synaptogenesis for reestablishing the circuitry lost after ***,we discuss how our understanding of the mechanisms that instruct synapse formation in the injured nervous system may contribute to the design of new strategies to promote functional restoration in traumatic CNS disorders.

关键词： viable injury instru

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Size tuning and oxygen plasma induced pore formation on silica nanoparticles

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Progress in Natural Science:Materials International 2012年第3期22卷 193-200页

作者： Remya Nair Y. Yoshida T. Maekawa d. sakthi kumarn BioNano Electronics Research Center Graduate School of Interdisciplinary New Science Toyo University

Silica nanoparticles have been prepared from tetraethylorthosilicate dissolved in ethanol followed by base-catalyzed condensation. Earlier works reported that at least four parameters, namely concentration of tetraethylorthosilicate, ethanol, water and ammonia solution are needed to be optimized for the size tuning of silica nanoparticles. In this work size tuning of 5 nm-250 nm has been achieved by varying a single synthesis parameter i.e., the concentration of ammonia solution. Oxygen plasma was found to be successful for generating pores on silica nanoparticles without using any structure directing agents. The properties and morphology of nanoparticles were investigated by transmission electron microscopy, scanning electron microscopy, energy dispersive X-ray spectroscopy and Fourier transformed infrared spectroscopy.

关键词： Silica nanoparticles Size tuning Plasma treatment Pore induction

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A Local Contrast Fusion Based 3d Otsu Algorithm for Multilevel Image Segmentation

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IEEE/CAA Journal of Automatica Sinica 2020年第1期7卷 200-213页

作者： Ashish kumar Bhandari Arunangshu Ghosh Immadisetty Vinod kumar department of Electronics and Communication Engineering National Institute of Technology Patna

To overcome the shortcomings of 1 d and 2 d Otsu’s thresholding techniques, the 3 d Otsu method has been *** all Otsu’s methods, 3 d Otsu technique provides the best threshold values for the multi-level thresholding processes. In this paper, to improve the quality of segmented images, a simple and effective multilevel thresholding method is introduced. The proposed approach focuses on preserving edge detail by computing the 3 d Otsu along the fusion phenomena. The advantages of the presented scheme include higher quality outcomes, better preservation of tiny details and boundaries and reduced execution time with rising threshold levels. The fusion approach depends upon the differences between pixel intensity values within a small local space of an image;it aims to improve localized information after the thresholding process. The fusion of images based on local contrast can improve image segmentation performance by minimizing the loss of local contrast, loss of details and gray-level distributions. Results show that the proposed method yields more promising segmentation results when compared to conventional1 d Otsu, 2 d Otsu and 3 d Otsu methods, as evident from the objective and subjective evaluations.

关键词： 1d Otsu 2d Otsu 3d Otsu image fusion local contrast multi-level image segmentation

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Room-Temperature Gas Sensors Under Photoactivation:From Metal Oxides to 2d Materials

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Nano-Micro Letters 2020年第11期12卷 292-328页

作者： Rahul kumar Xianghong Liu Jun Zhang Mahesh kumar department of Electrical Engineering Indian Institute of Technology JodhpurJodhpur 342037India College of Physics Center for Marine Observation and CommunicationsQingdao UniversityQingdao 266071People’s Republic of China Key Laboratory of Advanced Energy Materials Chemistry(Ministry of Education) Nankai UniversityTianjin 300071People’s Republic of China

Room-temperature gas sensors have aroused great attention in current gas sensor technology because of deemed demand of cheap,low power consumption and portable sensors for rapidly growing Internet of things *** an important approach,light illumination has been exploited for room-temperature operation with improving gas sensor's attributes including sensitivity,speed and *** review provides an overview of the utilization of photoactivated nanomaterials in gas sensing ***,recent advances in gas sensing of some exciting different nanostructures and hybrids of metal oxide semiconductors under light illumination are ***,excellent gas sensing performance of emerging two-dimensional materialsbased sensors under light illumination is discussed in details with proposed gas sensing *** impressive features from the interaction of photons with sensing materials are elucidated in the context of modulating sensing ***,the review concludes with key and constructive insights into current and future perspectives in the light-activated nanomaterials for optoelectronic gas sensor applications.

关键词： Gas sensor Room temperature Photoactivation Metal oxide 2d materials

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Treating amyotrophic lateral sclerosis with allogeneic Schwann cell-derived exosomal vesicles: a case report

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Neural Regeneration Research 2025年第4期20卷 1207-1216页

作者： Pascal J.Goldschmidt-Clermont Aisha Khan George Jimsheleishvili Patricia Graham Adriana Brooks Risset Silvera Alexander J.P.Goldschmidt damien d.Pearse W.dalton dietrich Allan d.Levi James d.Guest Miller School of Medicine University of MiamiMiamiFLUSA Stem Cell Institute Miller School of MedicineUniversity of MiamiMiamiFLUSA The Miami Project to Cure Paralysis Miller School of MedicineUniversity of MiamiMiamiFLUSA Alzady International LLC MiamiFLUSA Neurological Surgery Miller School of MedicineUniversity of MiamiMiamiFLUSA

Schwann cells are essential for the maintenance and function of motor neurons,axonal networks,and the neuromuscular *** amyotrophic lateral sclerosis,where motor neuron function is progressively lost,Schwann cell function may also be ***,important signaling and potential trophic activities of Schwann cell-derived exosomal vesicles have been *** case report describes the treatment of a patient with advanced amyotrophic lateral sclerosis using serial intravenous infusions of allogeneic Schwann cell-derived exosomal vesicles,marking,to our knowledge,the first instance of such *** 81-year-old male patient presented with a 1.5-year history of rapidly progressive amyotrophic lateral *** initial diagnosis,the patient underwent a combination of generic riluzole,sodium phenylbutyrate for the treatment of amyotrophic lateral sclerosis,and *** patient volunteered to participate in an FdA-approved single-patient expanded access treatment and received weekly intravenous infusions of allogeneic Schwann cell-derived exosomal vesicles to potentially restore impaired Schwann cell and motor neuron *** confirmed that cultured Schwann cells obtained from the amyotrophic lateral sclerosis patient via sural nerve biopsy appeared impaired(senescent)and that exposure of the patient’s Schwann cells to allogeneic Schwann cell-derived exosomal vesicles,cultured expanded from a cadaver donor improved their growth capacity in *** a period of observation lasting 10 weeks,during which amyotrophic lateral sclerosis Functional Rating Scale-Revised and pulmonary function were regularly monitored,the patient received weekly consecutive infusions of 1.54×1012(×2),and then consecutive infusions of 7.5×1012(×6)allogeneic Schwann cell-derived exosomal vesicles diluted in 40 mL of dulbecco’s phosphate-buffered *** of the infusions were associated with adverse events such as infusion reactions(allergic or otherwise)or

关键词： allogeneic amyotrophic lateral sclerosis exosomes infusion neuromuscular junction Schwann cell

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