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Anti-amyloid antibodies in Alzheimer’s disease: what did clinical trials teach us?

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Neural Regeneration Research 2025年第4期20卷 1092-1093页

作者： danko Jeremic Lydia Jiménez-díaz Juan d.Navarro-López NeuroPhysiology&Behavior Lab University of Castilla-La ManchaBiomedical Research Center(CRIB)School of Medicine of Ciudad RealCiudad RealSpain

Although many causes of Alzheimer’s disease(Ad)may exist,both the original amyloid cascade and tau hypotheses posit that abnormal misfolding and accumulation of amyloid-β(Aβ)and tau protein is the central event causing the ***,that conclusion could be only partly true,and there is conflicting evidence about the role of both proteins in Ad,being able to precede and influence one *** researchers argue that these proteins are mere executors rather than primary causes of ***,there have been continuing refinements of both hypotheses,with alternative explanations proposed.Aβand tau proteins may be independently involved in specific neurotoxic pathways;yet there may be other crucial processes going on in early ***,accumulating evidence suggests that Aβand tau act synergistically,rather than additively in disease onset(Jeremic et al.,2021,2023a).

关键词： amyloid Alzheimer additive

Remaking a connection:molecular players involved in post-injury synapse formation

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Neural Regeneration Research 2025年第6期20卷 1719-1720页

作者： diogo Tomé Ramiro d.Almeida iBiMEd-Institute of Biomedicine Department of Medical SciencesUniversity of AveiroAveiroPortugal CNC-Center for Neuroscience and Cell Biology University of CoimbraCoimbraPortugal

Functional recovery from central nervous system(CNS)trauma depends not only on axon regeneration or compensatory sprouting of uninjured fibers but also on the ability of newly grown axons to establish functional synapses with appropriate *** several studies have successfully promoted long-distance axonal regeneration in distinct CNS injury models,none of them have resulted in a viable therapeutic approach for patient recovery.A possible reason may be the lack of new synaptogenesis for reestablishing the circuitry lost after ***,we discuss how our understanding of the mechanisms that instruct synapse formation in the injured nervous system may contribute to the design of new strategies to promote functional restoration in traumatic CNS disorders.

关键词： viable injury instru

Hermitian-Einstein Metrics on Parabolic Stable Bundles

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Acta Mathematica Sinica,English Series 1999年第1期15卷 93-114页

作者： M.S.narasimhan Mathematics Section International Centre for Theoretic PhysicsP.O.Box 58634100 TriesteItaly

Let $$\overline M $$ be a compact complex manifold of complex dimension two with a smooth Kähler metric and d a smooth divisor ... 详细信息

Let $$\overline M $$ be a compact complex manifold of complex dimension two with a smooth Kähler metric and d a smooth divisor on $$\overline M $$ . If E is a rank 2 holomorphic vector bundle on $$\overline M $$ with a stable parabolic structure along d, we prove the existence of a metric on $$E'{\text{ = }}E|_{\overline M \backslash d} $$ (compatible with the parabolic structure) which is Hermitian-Einstein with respect to the restriction of the Kähler metric to $$\overline M $$ Ěd. A converse is also proved.

关键词： Hermitian-Einstein Metrics on Parabolic Stable Bundles Math

Treating amyotrophic lateral sclerosis with allogeneic Schwann cell-derived exosomal vesicles: a case report

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Neural Regeneration Research 2025年第4期20卷 1207-1216页

作者： Pascal J.Goldschmidt-Clermont Aisha Khan George Jimsheleishvili Patricia Graham Adriana Brooks Risset Silvera Alexander J.P.Goldschmidt damien d.Pearse W.dalton dietrich Allan d.Levi James d.Guest Miller School of Medicine University of MiamiMiamiFLUSA Stem Cell Institute Miller School of MedicineUniversity of MiamiMiamiFLUSA The Miami Project to Cure Paralysis Miller School of MedicineUniversity of MiamiMiamiFLUSA Alzady International LLC MiamiFLUSA Neurological Surgery Miller School of MedicineUniversity of MiamiMiamiFLUSA

Schwann cells are essential for the maintenance and function of motor neurons,axonal networks,and the neuromuscular *** amyotrophic lateral sclerosis,where motor neuron function is progressively lost,Schwann cell function may also be ***,important signaling and potential trophic activities of Schwann cell-derived exosomal vesicles have been *** case report describes the treatment of a patient with advanced amyotrophic lateral sclerosis using serial intravenous infusions of allogeneic Schwann cell-derived exosomal vesicles,marking,to our knowledge,the first instance of such *** 81-year-old male patient presented with a 1.5-year history of rapidly progressive amyotrophic lateral *** initial diagnosis,the patient underwent a combination of generic riluzole,sodium phenylbutyrate for the treatment of amyotrophic lateral sclerosis,and *** patient volunteered to participate in an FdA-approved single-patient expanded access treatment and received weekly intravenous infusions of allogeneic Schwann cell-derived exosomal vesicles to potentially restore impaired Schwann cell and motor neuron *** confirmed that cultured Schwann cells obtained from the amyotrophic lateral sclerosis patient via sural nerve biopsy appeared impaired(senescent)and that exposure of the patient’s Schwann cells to allogeneic Schwann cell-derived exosomal vesicles,cultured expanded from a cadaver donor improved their growth capacity in *** a period of observation lasting 10 weeks,during which amyotrophic lateral sclerosis Functional Rating Scale-Revised and pulmonary function were regularly monitored,the patient received weekly consecutive infusions of 1.54×1012(×2),and then consecutive infusions of 7.5×1012(×6)allogeneic Schwann cell-derived exosomal vesicles diluted in 40 mL of dulbecco’s phosphate-buffered *** of the infusions were associated with adverse events such as infusion reactions(allergic or otherwise)or

关键词： allogeneic amyotrophic lateral sclerosis exosomes infusion neuromuscular junction Schwann cell

Graph-based structural joint pose estimation in non-line-of-sight conditions

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Earthquake Engineering and Engineering Vibration 2023年第2期22卷 371-386页

作者： Alexander Thoms Zaid Al-Sabbag Sriram narasimhan department of Mechanical and Aerospace Engineering University of California-Los AngelesUSA department of Civil and Environmental Engineering University of WaterlooCanada department of Civil and Environmental Engineering University of California-Los AngelesUSA

In post-earthquake surveys,it is difficult(and often infeasible)to observe and quantify displacements beyond line-of-sight(LOS),given seismic force-resisting and gravity systems exist completely or partially within a building′s *** overcome this limitation,we develop a novel framework that generalizes graph-based state estimation towards structural joint localization via engineered *** landmarks provide an indirect means to estimate residual displacements where direct LOS is *** our framework,engineered landmarks define topologies of uniquely identifiable landmarks that are either visible or non-visible to a robot performing simultaneous localization and mapping(SLAM).Within the SLAM approach,factors encoding robot odometry and robot-to-visible landmark measurements are formulated for the cases of wireless sensing and fiducial object detection and *** landmarks are rigidly attached to non-visible landmark subsets for each engineered landmark,where the complete set of non-visible landmarks form globally rigid and localizable connectivity graphs via range-based *** subsets of non-visible landmarks are embedded within the base structure and uniquely define joint pose via geometric *** factors are unified within a common graph to solve for the maximum a posteriori estimate of robot,landmark,and joint states via nonlinear least squares *** demonstrate the applicability of our approach,we apply the Monte Carlo method over a parameterization of system noise to calculate residual joint pose error distributions,maximum average inter-story drift ratios,and related summary statistics for a 19-story nonlinear structural *** performing nonlinear time history analyses over sets of service-level and maximum considered earthquakes,our parametric study gives insight into our method′s application towards post-earthquake building evaluation in non-LOS conditions.

关键词： state estimation engineered landmarks post-earthquake residual displacement

Biochemical dissection of STAT3 signaling in amyotrophic lateral sclerosis

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Neural Regeneration Research 2025年第11期20卷 3229-3230页

作者： Savina Apolloni Nadia d’Ambrosi department of Biology University of Rome Tor VergataRomeItaly

Amyotrophic lateral sclerosis(ALS)is a progressive neurodegenerative disease characterized by the loss of upper and lower motor neurons,clinically marked by muscle atrophy and *** the clinical course is highly variable,the average time from the onset of symptoms to the need for respiratory support or death is 3-5 *** is the most prevalent motor neuron disease in adults,occurring at a rate of 2 per 100,000 individuals and affecting 5.4 per 100,000 individuals overall.

关键词： STAT3 dissection sclerosis

Oligodendroglial heterogeneity in health,disease,and recovery:deeper insights into myelin dynamics

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Neural Regeneration Research 2025年第11期20卷 3179-3192页

作者： Pieter-Jan Serneels Julie d.de Schutter Lies de Groef Lieve Moons Steven Bergmans KU Leuven Leuven Brain InstituteDepartment of BiologyAnimal Physiology and Neurobiology DivisionNeural Circuit Development&Regeneration Research GroupLeuvenBelgium KU Leuven Leuven Brain InstituteDepartment of BiologyAnimal Physiology and Neurobiology DivisionCellular Communication&Neurodegeneration Research GroupLeuvenBelgium

decades of research asserted that the oligodendroglial lineage comprises two cell types:oligodendrocyte precursor cells and ***,recent studies employing single-cell RNA sequencing techniques have uncovered novel cell states,prompting a revision of the existing *** forward,the oligodendroglial lineage should be delineated into five distinct cell states:oligodendrocyte precursor cells,committed oligodendrocyte precursor cells,newly formed oligodendrocytes,myelin-forming oligodendrocytes,and mature *** new classification system enables a deeper understanding of the oligodendroglia in both physiological and pathological *** this uniform terminology will facilitate comparison and integration of data across ***,including the consolidation of findings from various demyelinating models,is essential to better understand the pathogenesis of demyelinating ***,comparing injury models across species with varying regenerative capacities can provide insights that may lead to new therapeutic strategies to overcome remyelination ***,by standardizing terminology and synthesizing data from diverse studies across different animal models,we can enhance our understanding of myelin pathology in central nervous system disorders such as multiple sclerosis,Alzheimer's disease,and amyotrophic lateral sclerosis,all of which involve oligodendroglial and myelin dysfunction.

关键词： animal models demyelination fish mammals multiple sclerosis myelin neurodegeneration oligodendrocytes oligodendroglial lineage remyelination

'nAb'the self-reactive activity in the COVId-19 combat

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Signal Transduction and Targeted Therapy 2021年第4期6卷 1077-1078页

作者： Madhusudhanan narasimhan Lenin Mahimainathan Alagarraju Muthukumar department of Pathology University of Texas Southwestern Medical CenterDallasTXUSA

The recent article in Cell by Kreye et al.1 discovered that non-self-reactive-neutralizing antibody(ns-nAb)could be an effective way to combat SARS-CoV-2 *** observations provide new perspectives for therapeutic antib... 详细信息

关键词： al. reactive neutral

Evolving concept of dyssynchrony and its utility

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Journal of Geriatric Cardiology 2022年第1期19卷 44-51页

作者： Priyanka Satish Bharat narasimhan Andreas Hagendorff Bhupendar Tayal Houston Methodist deBakey Heart and Vascular Center HoustonTXUSA Leipzig University Hospital Department of CardiologyLeipzigGermany

The role of electromechanical dyssynchrony in heart failure gained prominence in literature with the results of trials of cardiac resynchronization therapy(CRT).CRT has shown to significantly decrease heart failure hospitalization and mortality in heart failure patients with *** guidelines recommend the use of electrical dyssynchrony based on a QRS>150 ms and a left bundle branch block pattern on surface electrocardiogram to identify dyssynchrony in patients who will benefit from CRT ***,predicting response to CRT remains a challenge with nearly one-third of patients gaining no benefit from the *** echocardiographic measures of mechanical dyssynchrony have been studied over the past two ***,trials where mechanical dyssynchrony used as an additional or lone criteria for CRT failed to show any benefit in the response to *** shows that a deeper understanding of cardiac mechanics should be applied in the assessment of *** review discusses the evolving role of imaging techniques in assessing cardiac dyssynchrony and their application in patients considered for device therapy.

关键词： cardiac mortality gained