Evolving concept of dyssynchrony and its utility

作     者：Priyanka Satish Bharat Narasimhan Andreas Hagendorff Bhupendar Tayal 

作者机构：Houston Methodist DeBakey Heart and Vascular CenterHoustonTXUSA Leipzig University HospitalDepartment of CardiologyLeipzigGermany 

出 版 物：《Journal of Geriatric Cardiology》 (老年心脏病学杂志（英文版）)

年 卷 期：2022年第19卷第1期

页      面：44-51页

核心收录：

学科分类：1002[医学-临床医学] 10[医学] 

主　　题：cardiac mortality gained 

摘      要：The role of electromechanical dyssynchrony in heart failure gained prominence in literature with the results of trials of cardiac resynchronization therapy(CRT).CRT has shown to significantly decrease heart failure hospitalization and mortality in heart failure patients with dyssynchrony.Current guidelines recommend the use of electrical dyssynchrony based on a QRS150 ms and a left bundle branch block pattern on surface electrocardiogram to identify dyssynchrony in patients who will benefit from CRT implantation.However,predicting response to CRT remains a challenge with nearly one-third of patients gaining no benefit from the device.Multiple echocardiographic measures of mechanical dyssynchrony have been studied over the past two decade.However,trials where mechanical dyssynchrony used as an additional or lone criteria for CRT failed to show any benefit in the response to CRT.This shows that a deeper understanding of cardiac mechanics should be applied in the assessment of dyssynchrony.This review discusses the evolving role of imaging techniques in assessing cardiac dyssynchrony and their application in patients considered for device therapy.