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Analysis of monitored ground support and rock mass response in a longwall tailgate entry

International Journal of Mining Science and Technology 2018年第1期28卷 43-51页

作者： G.S.Esterhuizen d.f.gearhart I.B.Tulu NIOSH Pittsburgh Mining Research division PittsburghPA 15236USA West Virginia University MorgantownWV 26506USA

A comprehensive monitoring program was conducted to measure the rock mass displacements, support response, and stress changes at a longwall tailgate entry in West *** was initiated a few days after development of the gateroad entries and continued during passage of the longwall panels on both sides of the *** included overcore stress measurements of the initial stress within the rock mass, changes in cable bolt loading, standing support pressure, roof deformation, rib deformation,stress changes in the coal pillar, and changes in the full three-dimensional stress tensor within the rock mass at six locations around the monitoring *** the passage of the first longwall, stress measurements in the rock and coal detected minor changes in loading while minor changes were detected in roof *** a result of the relatively favorable stress and geological conditions, the support systems did not experience severe loading or rock deformation until the second panel approached within 10–15 m of the instrumented *** reaching the peak loading at about 50–75 mm of roof sag, the cable bolts started to unload, and load was transferred to the standing *** standing support system was able to maintain an adequate opening inby the shields to provide ventilation to the first crosscut inby the face, as *** results were used to calibrate modeled cable bolt response to field data, and to validate numerical modeling procedures that have been developed to evaluate entry support *** is concluded that the support system was more than adequate to control the roof of the tailgate up to the longwall face *** monitoring results have provided valuable data for the development and validation of support design strategies for longwall tailgate entries.

关键词： Longwall mining Support Tailgate Monitoring Coal mining

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Vertical load capacities of roof truss cross members

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International Journal of Mining Science and Technology 2016年第3期26卷 517-520页

作者： gearhart david f. Mohamed Khaled Morsy Office of Mine Safety & Health Research National Institute for Occupational Safety & Health

Trusses used for roof support in coal mines are constructed of two grouted bolts installed at opposing forty-five degree angles into the roof and a cross member that ties the angled bolts together. The load on the cross member is vertical, which is transverse to the longitudinal axis, and therefore the cross member is loaded in the weakest direction. Laboratory tests were conducted to determine the vertical load capacity and deflection of three different types of cross members. Single-point load tests, with the load applied in the center of the specimen and double-point load tests, with a span of 2.4 m, were conducted. for the single-point load configuration, the yield of the 25 mm solid bar cross member was nominally 98 kN of vertical load, achieved at 42 cm of deflection. for cable cross members, yield was not achieved even after 45 cm of deflection. Peak vertical loads were about 89 kN for 17 mm cables and67 kN for the 15 mm cables. for the double-point load configurations, the 25 mm solid bar cross members yielded at 150 kN of vertical load and 25 cm of deflection. At 25 cm of deflection individual cable strands started breaking at 133 and 111 kN of vertical load for the 17 and 15 mm cable cross members respectively.

关键词： Roof truss Coal mining Ground control Load capacity Roof support

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Anti-amyloid antibodies in Alzheimer’s disease: what did clinical trials teach us?

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Neural Regeneration Research 2025年第4期20卷 1092-1093页

作者： danko Jeremic Lydia Jiménez-díaz Juan d.Navarro-López NeuroPhysiology&Behavior Lab University of Castilla-La ManchaBiomedical Research Center(CRIB)School of Medicine of Ciudad RealCiudad RealSpain

Although many causes of Alzheimer’s disease(Ad)may exist,both the original amyloid cascade and tau hypotheses posit that abnormal misfolding and accumulation of amyloid-β(Aβ)and tau protein is the central event causing the ***,that conclusion could be only partly true,and there is conflicting evidence about the role of both proteins in Ad,being able to precede and influence one *** researchers argue that these proteins are mere executors rather than primary causes of ***,there have been continuing refinements of both hypotheses,with alternative explanations proposed.Aβand tau proteins may be independently involved in specific neurotoxic pathways;yet there may be other crucial processes going on in early ***,accumulating evidence suggests that Aβand tau act synergistically,rather than additively in disease onset(Jeremic et al.,2021,2023a).

关键词： amyloid Alzheimer additive

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Remaking a connection:molecular players involved in post-injury synapse formation

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Neural Regeneration Research 2025年第6期20卷 1719-1720页

作者： diogo Tomé Ramiro d.Almeida iBiMEd-Institute of Biomedicine Department of Medical SciencesUniversity of AveiroAveiroPortugal CNC-Center for Neuroscience and Cell Biology University of CoimbraCoimbraPortugal

functional recovery from central nervous system(CNS)trauma depends not only on axon regeneration or compensatory sprouting of uninjured fibers but also on the ability of newly grown axons to establish functional synapses with appropriate *** several studies have successfully promoted long-distance axonal regeneration in distinct CNS injury models,none of them have resulted in a viable therapeutic approach for patient recovery.A possible reason may be the lack of new synaptogenesis for reestablishing the circuitry lost after ***,we discuss how our understanding of the mechanisms that instruct synapse formation in the injured nervous system may contribute to the design of new strategies to promote functional restoration in traumatic CNS disorders.

关键词： viable injury instru

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Analysis of gateroad stability at two longwall mines based on field monitoring results and numerical model analysis

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International Journal of Mining Science and Technology 2019年第1期29卷 35-43页

作者： Gabriel S.Esterhuizen david.f.gearhart Ted Klemetti Heather dougherty Mark van dyke National Institute for Occupational Safety and Health

Coal mine longwall gateroads are subject to changing loading conditions induced by the advancing longwall face. The ground response and support requirements are closely related to the magnitude and orientation of the stress changes, as well as the local geology. This paper presents the monitoring results of gateroad response and support performance at two longwall mines at a 180-m and 600-m depth of *** the first mine, a three-entry gateroad layout was used. The second mine used a four-entry, yieldabutment-yield gateroad pillar system. Local ground deformation and support response were monitored at both sites. The monitoring period started during the development stage and continued during first panel retreat and up to second panel retreat. The two data sets were used to compare the response of the entries in two very different geotechnical settings and different gateroad layouts. The monitoring results were used to validate numerical models that simulate the loading conditions and entry response for these widely differing conditions. The validated models were used to compare the load path and ground response at the two mines. This paper demonstrates the potential for numerical models to assist mine engineers in optimizing longwall layouts and gateroad support systems.

关键词： Coal mining Longwall Gateroad Support Numerical models

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Assessing support alternatives for longwall gateroads subject to changing stress

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International Journal of Mining Science and Technology 2021年第1期31卷 103-110页

作者： Gabriel S.Esterhuizen I.Berk Tulu dave f.gearhart Heather dougherty Mark Van dyke National Institute for Occupational Safety and Health Pittsburgh Mining Research DivisionPittsburghPA 15236USA West Virginia University MorgantownWV 26506USA

Longwall gateroad entries are subject to changing horizontal and vertical stress induced by redistribution of loads around the extracted *** stress changes can result in significant deformation of the entries that may include roof sag,rib dilation,and floor *** operators install different types of supports to control the ground response and maintain safe access and ventilation of the longwall *** paper describes recent research aimed at quantifying the effect of longwall-induced stress changes on ground stability and using the information to assess support *** research included monitoring of ground and support interaction at several operating longwall mines in the U.S.,analysis and calibration of numerical models that adequately represent the bedded rock mass,and observation of the support systems and their response to changes in *** models were then used to investigate the impact of geology and stress conditions on ground deformation and support response for various depths of cover and geologic *** research results were summarized in two regression equations that can be used to estimate the likely roof deformation and height of roof yield due to longwall-induced stress *** information is then used to assess the ability of support systems to maintain the stability of the *** application of the method is demonstrated with a retrospective analysis of the support performance at an operating longwall mine that experienced a headgate roof *** method is shown to produce realistic estimates of gateroad entry stability and support performance,allowing alternative support systems to be assessed during the design and planning stage of longwall operations.

关键词： Longwall Gateroad Support design Coal Standing support

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Treating amyotrophic lateral sclerosis with allogeneic Schwann cell-derived exosomal vesicles: a case report

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Neural Regeneration Research 2025年第4期20卷 1207-1216页

作者： Pascal J.Goldschmidt-Clermont Aisha Khan George Jimsheleishvili Patricia Graham Adriana Brooks Risset Silvera Alexander J.P.Goldschmidt damien d.Pearse W.dalton dietrich Allan d.Levi James d.Guest Miller School of Medicine University of MiamiMiamiFLUSA Stem Cell Institute Miller School of MedicineUniversity of MiamiMiamiFLUSA The Miami Project to Cure Paralysis Miller School of MedicineUniversity of MiamiMiamiFLUSA Alzady International LLC MiamiFLUSA Neurological Surgery Miller School of MedicineUniversity of MiamiMiamiFLUSA

Schwann cells are essential for the maintenance and function of motor neurons,axonal networks,and the neuromuscular *** amyotrophic lateral sclerosis,where motor neuron function is progressively lost,Schwann cell function may also be ***,important signaling and potential trophic activities of Schwann cell-derived exosomal vesicles have been *** case report describes the treatment of a patient with advanced amyotrophic lateral sclerosis using serial intravenous infusions of allogeneic Schwann cell-derived exosomal vesicles,marking,to our knowledge,the first instance of such *** 81-year-old male patient presented with a 1.5-year history of rapidly progressive amyotrophic lateral *** initial diagnosis,the patient underwent a combination of generic riluzole,sodium phenylbutyrate for the treatment of amyotrophic lateral sclerosis,and *** patient volunteered to participate in an fdA-approved single-patient expanded access treatment and received weekly intravenous infusions of allogeneic Schwann cell-derived exosomal vesicles to potentially restore impaired Schwann cell and motor neuron *** confirmed that cultured Schwann cells obtained from the amyotrophic lateral sclerosis patient via sural nerve biopsy appeared impaired(senescent)and that exposure of the patient’s Schwann cells to allogeneic Schwann cell-derived exosomal vesicles,cultured expanded from a cadaver donor improved their growth capacity in *** a period of observation lasting 10 weeks,during which amyotrophic lateral sclerosis functional Rating Scale-Revised and pulmonary function were regularly monitored,the patient received weekly consecutive infusions of 1.54×1012(×2),and then consecutive infusions of 7.5×1012(×6)allogeneic Schwann cell-derived exosomal vesicles diluted in 40 mL of dulbecco’s phosphate-buffered *** of the infusions were associated with adverse events such as infusion reactions(allergic or otherwise)or

关键词： allogeneic amyotrophic lateral sclerosis exosomes infusion neuromuscular junction Schwann cell

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IMAGING REdOX STATE HETEROGENEITY WITHIN INdIVIdUAL EMBRYONIC STEM CELL COLONIES

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Journal of Innovative Optical Health Sciences 2011年第3期4卷 279-288页

作者： HE N.XU RUSSELL C.AddIS dAVIdA f.GOINGS SHOKO NIOKA BRITTON CHANCE JOHN d.gearhart LIN Z.LI Molecular Imaging Laboratory Department of Radiology University of PennsylvaniaSchool of Medicine PhiladelphiaPA 19104USA Institute for Regenerative Medicine and department of Cell and developmental Biology University of Pennsylvania School of Medicine PhiladelphiaPA 19104USA Britton Chance Laboratory of Redox Imaging Johnson Research foundation department of Biochemistry and Biophysics University of Pennsylvania School of Medicine PhiladelphiaPA 19104USA Institute of Translational Medicine and Therapeutics University of Pennsylvania PhiladelphiaPA 19104USA

Redox state mediates embryonic stem cell(ESC)differentiation and thus offers an important complementary approach to understanding the pluripotency of stem *** redox ratio(NAdH/(fp t NAdH)),where NAdH is the reduced form of nicotinamide adenine dinucleotide and fp is the oxidizedflavoproteins,has been established as a sensitive indicator of mitochondrial redox *** this paper,we report our redox imaging data on the mitochondrial redox state of mouse ESC(mESC)colonies and the implications *** low-temperature NAdH/fp redox scanner was employed to image mESC colonies grown on a feeder layer of gamma-irradiated mouse embryonicfibroblasts(MEfs)on glass cover *** result showed significant heterogeneity in the mitochondrial redox state within individual mESC colonies(size:~200-440μm),exhibiting a core with a more reduced state than the *** more reduced state positively correlates with the expression pattern of Oct4,a well-established marker of *** observation is thefirst to show the heterogeneity in the mitochondrial redox state within a mESC colony,suggesting that mitochondrial redox state should be further investigated as a potential new biomarker for the stemness of embryonic stem cells.

关键词： Redox imaging pluripotency NAdH flavoproteins redox ratio

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Biochemical dissection of STAT3 signaling in amyotrophic lateral sclerosis

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Neural Regeneration Research 2025年第11期20卷 3229-3230页

作者： Savina Apolloni Nadia d’Ambrosi department of Biology University of Rome Tor VergataRomeItaly

Amyotrophic lateral sclerosis(ALS)is a progressive neurodegenerative disease characterized by the loss of upper and lower motor neurons,clinically marked by muscle atrophy and *** the clinical course is highly variable,the average time from the onset of symptoms to the need for respiratory support or death is 3-5 *** is the most prevalent motor neuron disease in adults,occurring at a rate of 2 per 100,000 individuals and affecting 5.4 per 100,000 individuals overall.

关键词： STAT3 dissection sclerosis

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Analysis of global and local stress changes in a longwall gateroad

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International Journal of Mining Science and Technology 2018年第1期28卷 127-135页

作者： I.B.Tulu G.S.Esterhuizen d.gearhart T.M.Klemetti K.M.Mohamed d.W.H.Su department of Mining Engineering West Virginia University NIOSH Pittsburgh Mining Research Division

A numerical-model-based approach was recently developed for estimating the changes in both the horizontal and vertical loading conditions induced by an approaching longwall *** this approach, a systematic procedure is used to estimate the model's *** along the bedding planes is modeled with ubiquitous joint elements and interface *** is modeled with a newly developed coal mass *** response of the gob is calibrated with back analysis of subsidence data and the results of previously published laboratory tests on rock *** model results were verified with the subsidence and stress data recently collected from a longwall mine in the eastern United States.

关键词： Longwall mining Gateroad design flac3d Horizontal angle Gob loading Hollow inclusion cells

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