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101例肾肿瘤病人经皮射频消融术后肾晕轮征的发生率及其临床重要性

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国际医学放射学杂志 2009年第6期 590-591页

作者： T.C.Schirmang W.W.Mayo-Smith d.e.dupuy M.d.Beland d.J.Grand 范文哲 department of diagnostic Imaging Rhode Island Hospital and arren Alpert Medical School of Brown University593 Eddy StProvidenceRI 02903USA

目的报道肾肿瘤病人经皮射频消融(radiofrequen-cy ablation,RFA)术后肾晕轮征的发生率及其临床重要性。材料与方法本回顾性研究遵照HIPAA规定,获得伦理委员会批准。101例病人共106个实性肾肿瘤行经皮RFA。3名经委员会认证的放射专家回... 详细信息

目的报道肾肿瘤病人经皮射频消融(radiofrequen-cy ablation,RFA)术后肾晕轮征的发生率及其临床重要性。材料与方法本回顾性研究遵照HIPAA规定,获得伦理委员会批准。101例病人共106个实性肾肿瘤行经皮RFA。3名经委员会认证的放射专家回顾性分

关键词：肾肿瘤 RFA 泌尿系肿瘤发生率晕轮病人

热催化凝胶对肺微波消融区体积的影响:猪的实验研究

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国际医学放射学杂志 2019年第4期 484-484页

作者：吴酥 A.W.P.Maxwell W.K.C.Park G.L.Baird d.W.Martin K.A.Lombardo d.e.dupuy department of diagnostic Imaging The Warren Alpert Medical School of Brown University

摘要肿瘤热消融可能与局部肿瘤进展率高有关。为了扩大热消融区,研制了一种热催化凝胶,以提高生物组织中微波能量的透射率。目的确定热催化凝胶对猪肺微波消融

关键词：微波消融热催化

用肿瘤介电常数反馈控制肺恶性肿瘤术中微波消融:连续10例病人消融和切除研究

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国际医学放射学杂志 2012年第2期 176-176页

作者： F.J.Wolf B.Aswad T.Ng d.e.dupuy 梁斌 department of diagnostic Imaging Office of Research AdministrationAlpert Medical School of Brown UniversityRhode Island Hospital593 Eddy StProvidenceRI 02903USA

目的确定肿瘤介电常数反馈控制微波消融(MWA)系统(可实现能源功率和频率实时调控)治疗肺恶性肿瘤引起的组织学变化。材料与方法本前瞻性消融-切除研究符合HIPAA要求,并得到机构审查委员会批准,获取病人知情同

关键词：恶性肿瘤消融带微波消融介电常数电容率介电性质病人反馈控制闭环控制术中

原发性非小细胞肺癌:射频消融治疗后肿瘤复发的频率、部位和时间

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国际医学放射学杂志 2010年第2期 177-177页

作者： M.d.Beland e.J.Wasser W.W.Mayo-Smith d.e.dupuy 蒋涛 department of diagnostic Imaging Rhode Island HospitalWarren Alpert Medical School of Brown University593 Eddy StProvidenceRI 02903USA

目的探讨CT引导下经皮穿刺射频消融治疗非小细胞肺癌(NSCLC)病人的复发模式。材料与方法本研究经医院学术委员会授权,符合HIPAA要求,无需填写知情同意书。回

关键词：肿瘤复发肺癌治疗后肺肿瘤射频消融治疗局部复发

肺肿瘤经皮射频和微波消融治疗后肋骨骨折:发生率及相关性

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国际医学放射学杂志 2013年第3期 272-272页

作者： e.S.Alexander C.A.Hankins J.T.Machan T.T.Healey d.e.dupuy 钟垚莹 Warren Alpert Medical School of Brown University Rhode Island HospitalDepartment of Diagnostic Imaging

目的回顾性地确认肺肿瘤病人经皮射频消融(RFA)和微波消融(MWA)后肋骨骨折的发生率及可能的危险因素,并确认与肋骨骨折有关的并发症。材料与方法机构审查委员会批准获得了HIPAA依从性的回顾性研究。以2004年2月—2010年4月期间接受RFA和... 详细信息

目的回顾性地确认肺肿瘤病人经皮射频消融(RFA)和微波消融(MWA)后肋骨骨折的发生率及可能的危险因素,并确认与肋骨骨折有关的并发症。材料与方法机构审查委员会批准获得了HIPAA依从性的回顾性研究。以2004年2月—2010年4月期间接受RFA和(或)MWA治疗的195个肺肿瘤的163例病人为研究对象。由取得委员会认证资格的放射医师用至少3个月一次的随访CT影像做回顾性分析,来确定是否存在肋骨骨折。用广义上的估计方程来评估病人的人口统计资料、肿瘤特点、治疗参数、消融区特点等对肋骨骨折发展的影响。用Kaplan-Meier曲线评估病人消融后肋骨骨折概率的时间函数。对确定骨折的病人评估其临床参数(即肋骨或胸部的疼痛,肋骨骨折引起的脏器损害)。结果 13.5%(22/163例)的病人发现消融区邻近肋骨骨折。肋骨骨折的估计概率1年为9%、3年为22%。消融治疗后女性病人比男性病人更容易发生骨折(P=0.041)。肿瘤靠近胸壁的病人(P=0.0009)、消融区累及脏层胸膜的病人(P=0.039)更容易发生骨折。由于RFA和MWA引起肋骨骨折的病人中,未见报道发生骨折相关的脏器损害,但有9.1%(2/22例)的病人有轻度疼痛。结论肺肿瘤病人在经皮RFA和MWA治疗后13.5%出现肋骨骨折。对那些消融区靠近胸壁的病人需监测肋骨骨折情况。

关键词：肺肿瘤病人概率肋骨骨折发生率经皮

development of a multiple level underground limestone mine from geology through mine planning

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International Journal of Mining Science and Technology 2020年第1期30卷 63-67页

作者： Christopher Newman david Newman Robert dupuy Appalachian Mining&engineering Inc.LexingtonKYUSA Rogers Group Inc.NashvilleTNUSA

The development of a multiple level underground mine is a complex task in which geology,engineering,ground control,and unit operations are integrated into a single mine *** components are interdependent and must function cohesively to ensure a profitable underground mining *** optimize reserve recovery,mine planning should begin from the lowest level and progress *** limits any misjudgments or oversights of a given level affecting the underlying levels and ensures the ability to maximize recovery from each *** planning should start with the exploration and characterization of the geologic *** the reserve geology and quality is well understood,then mine planning can begin with respect to the following:(1)orientation of mine works with respect to horizontal stress;(2)access to the reserve;(3)determination of opening widths;(4)selection of back,floor horizons and pillar centers;(5)selection of development and secondary mining heights;(6)appropriate inter-burden thicknesses;and(7)examining the stability of the multiple level mine through numerical *** multiple level mine design process and decisions are presented through a case history *** theme is that there is one opportunity to"get it right"and many chances to overlook a small aspect within the design that will plague the mine throughout all levels and through the entirety of its operating life.

关键词： Limestone Mine planning Geology Multiple level Rock mechanics

Biochemical dissection of STAT3 signaling in amyotrophic lateral sclerosis

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Neural Regeneration Research 2025年第11期20卷 3229-3230页

作者： Savina Apolloni Nadia d’Ambrosi department of Biology University of Rome Tor VergataRomeItaly

Amyotrophic lateral sclerosis(ALS)is a progressive neurodegenerative disease characterized by the loss of upper and lower motor neurons,clinically marked by muscle atrophy and *** the clinical course is highly variable,the average time from the onset of symptoms to the need for respiratory support or death is 3-5 *** is the most prevalent motor neuron disease in adults,occurring at a rate of 2 per 100,000 individuals and affecting 5.4 per 100,000 individuals overall.

关键词： STAT3 dissection sclerosis

Anti-amyloid antibodies in Alzheimer’s disease: what did clinical trials teach us?

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Neural Regeneration Research 2025年第4期20卷 1092-1093页

作者： danko Jeremic Lydia Jiménez-díaz Juan d.Navarro-López NeuroPhysiology&Behavior Lab University of Castilla-La ManchaBiomedical Research Center(CRIB)School of Medicine of Ciudad RealCiudad RealSpain

Although many causes of Alzheimer’s disease(Ad)may exist,both the original amyloid cascade and tau hypotheses posit that abnormal misfolding and accumulation of amyloid-β(Aβ)and tau protein is the central event causing the ***,that conclusion could be only partly true,and there is conflicting evidence about the role of both proteins in Ad,being able to precede and influence one *** researchers argue that these proteins are mere executors rather than primary causes of ***,there have been continuing refinements of both hypotheses,with alternative explanations proposed.Aβand tau proteins may be independently involved in specific neurotoxic pathways;yet there may be other crucial processes going on in early ***,accumulating evidence suggests that Aβand tau act synergistically,rather than additively in disease onset(Jeremic et al.,2021,2023a).

关键词： amyloid Alzheimer additive

Remaking a connection:molecular players involved in post-injury synapse formation

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Neural Regeneration Research 2025年第6期20卷 1719-1720页

作者： diogo Tomé Ramiro d.Almeida iBiMed-Institute of Biomedicine Department of Medical SciencesUniversity of AveiroAveiroPortugal CNC-Center for Neuroscience and Cell Biology University of CoimbraCoimbraPortugal

Functional recovery from central nervous system(CNS)trauma depends not only on axon regeneration or compensatory sprouting of uninjured fibers but also on the ability of newly grown axons to establish functional synapses with appropriate *** several studies have successfully promoted long-distance axonal regeneration in distinct CNS injury models,none of them have resulted in a viable therapeutic approach for patient recovery.A possible reason may be the lack of new synaptogenesis for reestablishing the circuitry lost after ***,we discuss how our understanding of the mechanisms that instruct synapse formation in the injured nervous system may contribute to the design of new strategies to promote functional restoration in traumatic CNS disorders.

关键词： viable injury instru