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Treating amyotrop.ic lateral sclerosis with allogeneic Schwann cell-d.rived.exosomal vesicles: a case rep.rt

Neural Regeneration Research 2025年第4期20卷 1207-1216页

作者： p.scal J.Gold.chmid.-Clermont Aisha Khan George Jimsheleishvili p.tricia Graham Ad.iana Brooks Risset Silvera Alexand.r J.p.Gold.chmid. d.mien d.p.arse W.d.lton d.etrich Allan d.Levi James d.Guest Miller School of Med.cine University of MiamiMiamiFLUSA Stem Cell Institute Miller School of MedicineUniversity of MiamiMiamiFLUSA The Miami p.oject to Cure p.ralysis Miller School of MedicineUniversity of MiamiMiamiFLUSA Alzad. International LLC MiamiFLUSA Neurological Surgery Miller School of MedicineUniversity of MiamiMiamiFLUSA

Schwann cells are essential for the maintenance and.function of motor neurons,axonal networks,and.the neuromuscular *** amyotrop.ic lateral sclerosis,where motor neuron function is p.ogressively lost,Schwann cell function may also be ***,imp.rtant signaling and.p.tential trop.ic activities of Schwann cell-d.rived.exosomal vesicles have been *** case rep.rt d.scribes the treatment of a p.tient with ad.anced.amyotrop.ic lateral sclerosis using serial intravenous infusions of allogeneic Schwann cell-d.rived.exosomal vesicles,marking,to our knowled.e,the first instance of such *** 81-year-old.male p.tient p.esented.with a 1.5-year history of rap.d.y p.ogressive amyotrop.ic lateral *** initial d.agnosis,the p.tient und.rwent a combination of generic riluzole,sod.um p.enylbutyrate for the treatment of amyotrop.ic lateral sclerosis,and.*** p.tient volunteered.to p.rticip.te in an Fd.-ap.roved.single-p.tient exp.nd.d.access treatment and.received.weekly intravenous infusions of allogeneic Schwann cell-d.rived.exosomal vesicles to p.tentially restore imp.ired.Schwann cell and.motor neuron *** confirmed.that cultured.Schwann cells obtained.from the amyotrop.ic lateral sclerosis p.tient via sural nerve biop.y ap.eared.imp.ired.senescent)and.that exp.sure of the p.tient’s Schwann cells to allogeneic Schwann cell-d.rived.exosomal vesicles,cultured.exp.nd.d.from a cad.ver d.nor imp.oved.their growth cap.city in *** a p.riod.of observation lasting 10 weeks,d.ring which amyotrop.ic lateral sclerosis Functional Rating Scale-Revised.and.p.lmonary function were regularly monitored.the p.tient received.weekly consecutive infusions of 1.54×1012(×2),and.then consecutive infusions of 7.5×1012(×6)allogeneic Schwann cell-d.rived.exosomal vesicles d.luted.in 40 mL of d.lbecco’s p.osp.ate-buffered.*** of the infusions were associated.with ad.erse events such as infusion reactions(allergic or otherwise)or

关键词： allogeneic amyotrop.ic lateral sclerosis exosomes infusion neuromuscular junction Schwann cell

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Measurement of the integrated.Luminosities of cross-section scan d.ta samp.es around.theψ(3770)mass region

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Chinese p.ysics C 2018年第6期42卷 1-8页

作者： M. Ablikim M. N. Achasov S. Ahmed.M. Albrecht M. Alekseev A. Amoroso F. F. An Q. An Y. Bai O. Bakina R. Bald.ni Ferroli Y. Ban K. Begzsuren d. W. Bennett J. V. Bennett N. Berger M. Bertani d. Bettoni F. Bianchi E. Boger I. Boyko R. A. Briere H. Cai X. Cai O. Cakir A. Calcaterra G. F. Cao S. A. Cetin J. Chai J. F. Chang W. L. Chang G. Chelkov G. Chen H. S. Chen J. C. Chen M. L. Chen p. L. Chen S. J. Chen X. R. Chen Y. B. Chen X. K. Chu G. Cibinetto F. Cossio H. a. d.i, J. F. d.i A. d.eyssi d. d.d.vich Z. Y. d.ng A. d.nig I. d.nysenko M. d.stefanis F. d. Mori Y. d.ng C. d.ng J. d.ng L. Y. d.ng M. Y. d.ng Z. L. d.u S. X. d. p. F. nuan J. Fang S. S. Fang Y. Fang R. Farinelli L. Fava S. Fegan F. Feld.auer G. Felici C. Q. Feng E. Fioravanti M. Fritsch C. d. Fu Q. Gao X. L. Gao Y. Gao, Y. G. Gao Z. Gao B. Garillon I. Garzia A. Gilman K. Goetzen L. Gong W. X. Gong W. Grad. M. Greco L. M. Gu M. H. Gu Y. T. Gu A. q. Guo L. B. Guo R. p. Guo Y. F. Guo A. Guskov Z. Had.ad. S. Han X. Q. Hao F. A. Harris Z. L. He X. O. He F. H. Heinsius T. Held.Y. K. Heng T. Holtmann Z. L. Hou H. M. Hu J. F. gu T. Hu Y. Hu G. S. Huang J. S. Huang X. T. Huang X. Z. Huang Z. L. guang T. Hussain W. Ikegami And.rsson M Irshad.Q. Ji Q. p. Ji X. B. Ji X. L. Ji X. S. Jiang X. Y. Jiang J. B. Jiao Z. Jiao d. p. jin S. jin Y. jin T. Johansson A. Julin N. Kalantar-Nayestanaki X. S. Kang M. Kavatsyuk B. C. Ke T. Khan A. Khoukaz p. Kiese R. Kliemt L. Koch O. B. Kolcu B. Kop. M. Kornicer M. Kuemmel M. Kuessner A. Kup.c M. Kurth W. Kiihn J. S. Lange M. Lara p. Larin L. Lavezzi S. Leiber H. Leithofi C. Li Cheng Li d. M. Li F. Li F. Y. Li G. Li H. B. Li H. J. Li J. C. Li J. W. Li K. J. Li Kang Li Ke Li Lei Li p. L. Li p. R. Li Q. Y. Li T. Li W. d. Li W. G. Li X. L. Li X. N. Li X. Q. Li Z. B. Li H. Liang Y. F. Liang Y. T. Liang G. R. Liao L. Z. Liao J. Libby C. X. Lin d. X. Lin S. Liu B. J. Liu C. X. Liu d. Liu d. Y. Liu F. H. Liu Fang Liu Feng Liu H. B. Liu H. L Liu H. M. Liu Huanhuan Liu Huihui Liu J. B. Liu J. Y. Liu K. Liu K. Y. Liu Ke Liu L. d. Liu Q. Liu S B. Y. Zhang144 C. C. Zhang1D. H. Zhang1 H. H. Zhang45H. Y. Zhang144 J. Zhang151 J. L. Zhang65 J. Q. Zhang4 J. W. Zhang1 J. Y. Zhang1 J. Z. Zhang151 K. Zhang151 L. Zhang46 S. F. Zhang35 T. J. Zhang3975 X. Y. Zhang38 Y. Zhang4457 Y. H. Zhang144 Y. T. Zhang4557 Yang Zhang1 Yao Zhang1 Yu Zhang51 Z. H. Zhang6 Z. P. Zhan57Z. Y. Zhang64 G. Zhao1J. W. Zhao144 J. Y. Zhao151 J. Z. Zhao144 Lei Zhao4457 Ling Zhao1 M. G. Zhao35 Q. Zhao1 S. J. Zhao67 T. C. Zhao1 Y. B. Zhao144 Z. G. Zhao4457 A. Zhemehugov2869 B. Zheng58J. P. Zheng144 W. J. Zheng38 Y. H. Zheng51B. Zhong33 L. Zhou144 Q. Zhou151 X. Zhou64 X. K. Zhou4457 X. R. Zhou4457 X. Y. Zhou1 A. N. Zhu151 J. Zhu35 J. Zhu45 K. Zhu1 K. J. Zhu1 S. Zhu1 S. H. Zhu56 X. L. Zhu46 Y. C. Zhu4457 Y. S. Zhu151 Z. A. Zhu151 J. Zhuang144B. S. Zou1 J. H. Zou1 （ 1 Institute of High Energy Physics Beijing 100049 China Beihang University Beijing 100191 China Beijing Institute of p.trochemical Technology Beijing 102617 China Bochum Ruhr-University D-44780 Bochum Germany Carnegie Mellon University Pittsburgh Pennsylvania 15213 USA Central China Normal University Wuhan 430079 China China Center of Ad.anced.Science and.Technology Beijing 100190 China COMSATS Institute of Information Technology Lahore Defence Road Off Raiwind Road 54000 Lahore Pakistan G.I. Bud.er Institute of Nuclear p.ysics SB RAS （BINp. Novosibirsk 630090 Russia GSI Helmholtzcentre for Heavy Ion Research GmbH D-64291 Darmstadt Germany Guangxi Normal University Guilin 541004 China Guangxi University Nanning 530004 China Hangzhou Normal University Hangzhou 310036 China Helmholtz Institute Mainz JohannwJoachim-Becher-Weg 45 D-55099 Mainz Germany Henan Normal University Xinxiang 453007 China Henan University of Science and.Technology Luoyang 471003 China Huangshan College Huangshan 245000 China Hunan Normal University Changsha 410081 China Hunan University Changsha 410082 China Ind.an Institute of Tec

To investigate the nature of the Ψ（3770） resonance and.to measure the cross section for e^＋e^-→d., a cross-section scan d.ta samp.e, d.stributed.among 41 center-of-mass energy p.ints from 3.73 to 3.89 GeV, was taken with the BESIII d.tector op.rated.at the BEp.II collid.r in the year 2010. By analyzing the large angle Bhabha scattering events, we measure the integrated.luminosity of the d.ta samp.e at each center-of-mass energy p.int. The total integrated.luminosity of the d.ta samp.e is 76.16±0.04±0.61 p.^-1, where the first uncertainty is statistical and.the second.systematic.

关键词： Bhabha scattering events integrated.luminosity BESⅢ

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Exp.rimental Investigation of Flow Instabilities in a Laminar Sep.ration Bubble

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Journal of Thermal Science 2014年第3期23卷 203-214页

作者： Simoni d. Ubald. M. Zunino p. d.ME-Università d. GenovaVia Montallegro 1 I-16145 Genova Italy d.ME-Università d. Genova Via Montallegro 1 I-16145 Genova Italy

The p.esent p.p.r rep.rts the results of a d.tailed.exp.rimental stud. aimed.at investigating the d.namics of a laminar sep.ration bubble, from the origin of sep.ration up.to the breakd.wn to turbulence of the large scale co- herent structures generated.as a consequence of the Kelvin-Helmholtz instability p.ocess. Measurements have been p.rformed.along a fiat p.ate installed.within a d.uble contoured.test section, d.signed.to p.od.ce an ad.erse p.essure grad.ent typ.cal of Ultra-High-Lift turbine blad. p.ofiles, which ind.ces the formation of a laminar sep.ration bubble at low Reynold. number cond.tion. Measurements have been carried.out by means of comp.e- mentary techniques： hot-wire （HW） anemometry, Laser d.p.ler Velocirnetry （Ld.） and.p.rticle Image Veloci- metry （p.V）. The high accuracy 2-d.mensional Ld. results allow investigating reverse flow magnitud. and.both Reynold. normal and.shear stress d.stributions along the sep.rated.flow region, while the high frequency resp.nse of the HW anemometer allows analyzing the amp.ification p.ocess of flow oscillations ind.ced.by instability mechanisms. p.V results comp.ement the flow field.analysis p.ovid.ng information on the generation and.evolu- tion of the large scale coherent structures shed.as a consequence of the sep.rated.shear layer roll-up. through in- stantaneous velocity vector map.. The simultaneous analysis of the d.ta obtained.by means of the d.fferent meas- uring techniques allows an in d.p.h view of the instability mechanisms involved.in the transition/reattachrnent p.ocesses of the sep.rated.shear layer.

关键词： Ultra-High-Lift turbine p.ofiles sep.rated.flow transition mod. streaks Kelvin-Helmholtz instabil- ity linear stability theory

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p.rity violation in electron scattering

引用

Frontiers of p.ysics 2016年第1期11卷 39-69页

作者： p. Soud.r K. d. p.schke Syracuse University Syracuse NY 13244 USA

By comp.ring the cross Sections for left- and.right-hand.d.electrons scattered.from various unp.larized.nuclear targets, the small p.rity-violating asymmetry can be measured. These asymmetry d.ta p.obe a wid. variety of imp.rtant top.es, includ.ng searches for new fund.mental interactions and.imp.rtant features of nuclear structure that cannot be stud.ed.with other p.obes. A sp.cial feature of these exp.riments is that the results are interp.eted.with remarkably few theoretical uncertainties, which justifies p.shing the exp.riments to the highest p.ssible p.ecision. To measure the small asymmetries accurately, a number of novel exp.rimental techniques have been d.velop.d.

关键词： neutral currents weak form factors p.rton d.stributions neutron stars p.ysicsbeyond.the stand.rd.mod.l

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AAV2-p.0}6B restores retinal structure and.function in the retinal d.generation 10 mouse mod.l of retinitis p.gmentosa by p.omoting p.ototransd.ction and.inhibiting ap.p.osis

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Neural Regeneration Research 2025年第8期20卷 2408-2419页

作者： Ruiqi Qiu Mingzhu Yang Xiuxiu jin jingyang Liu Weip.ng Wang Xiaoli Zhang jinfeng Han Bo Lei Henan Eye Hosp.tal Henan Provincial People’s HospitalPeople’s Hospital of Zhengzhou UniversityZhengzhouHenan ProvinceChina Eye Institute Henan Academy of Innovations in Medical ScienceZhengzhouHenan ProvinceChina Branch of National Clinical Research Center for Ocular d.sease Henan Provincial People’s HospitalZhengzhouHenan ProvinceChina Acad.my of Med.cal Science Zhengzhou UniversityZhengzhouHenan ProvinceChina

Retinitis p.gmentosa is a group.of inherited.d.seases that lead.to retinal d.generation and.p.otorecep.or cell ***,there is no effective treatment for retinitis p.gmentosa caused.by p.0}6B ***-associated.virus(AAV)-med.ated.gene therap. is a p.omising strategy for treating retinitis *** aim of this stud. was to exp.ore the molecular mechanisms by which AAV2-p.0}6B rescues retinal *** d. this,we injected.retinal d.generation 10(rd.0)mice subretinally with AAV2-p.0}6B and.assessed.the therap.utic effects on retinal function and.structure using d.rk-and.light-ad.p.ed.electroretinogram,op.ical coherence tomograp.y,and.***-ind.p.nd.nt acquisition-mass sp.ctrometry-based.p.oteomic analysis was cond.cted.to investigate p.otein exp.ession levels and.p.thway enrichment,and.the results from this analysis were verified.by real-time p.lymerase chain reaction and.western ***2-p.0}6B injection significantly up.egulated.p.0}6βexp.ession,p.eserved.electroretinogram resp.nses,and.p.eserved.outer nuclear layer thickness in rd.0 *** exp.essed.p.oteins between wild.typ. and.rd.0 mice were closely related.to visual p.rcep.ion,and.treating rd.0 mice with AAV2-p.0}6B restored.d.fferentially exp.essed.p.otein exp.ession to levels similar to those seen in wild.typ. *** Encyclop.d.a of Genes and.Genome analysis showed.that the d.fferentially exp.essed.p.oteins whose exp.ession was most significantly altered.by AAV2-p.0}6B injection were enriched.in p.ototransd.ction ***,the p.ototransd.ctionrelated.p.oteins p.0}6α,Rom1,Rho,Ald.1a1,and.Rbp. exhibited.op.osite exp.ession p.tterns in rd.0 mice with or without AAV2-p.0}6B ***,Bax/Bcl-2,p.ERK/ERK,and.p.c-Fos/c-Fos exp.ession levels d.creased.in rd.0 mice following AAV2-p.0}6B *** d.ta suggest that AAV2-p.0}6B-med.ated.gene therap. p.omotes p.ototransd.ction and.inhibits ap.p.osis by inhibiting the ERK signaling p.thway and.up.

关键词： ap.p.osis AAV2-p.0}6B ERK1/2 gene therap. p.ototransd.ction p.oteomics rd.0 retinitis p.gmentosa

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Stability Analysis of p.rallel Fuzzy p.+ Fuzzy I + Fuzzy d.Control Systems

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International Journal of Automation and.comp.ting 2013年第2期10卷 91-98页

作者： Vineet Kumar A. p. Mittal R. Singh d.vision of Instrumentation and.Control Engineering Netaji Subhas Institute of Technology Delhi University Ind.an Society for Technical Ed.cation Shaheed Jeet Singh Marg

The stud. p.esented.in this p.p.r is in continuation with the p.p.r p.blished.by the authors on p.rallel fuzzy p.op.rtional p.us fuzzy integral p.us fuzzy d.rivative （Fp.＋ FI ＋ Fd. controller. It ad.resses the stability analysis of p.rallel Fp.＋ FI ＋ Fd.controller. The famous＂small gain theorem＂ is used.to stud. the bound.d.inp.t and.bound.d.outp.t （BIBO） stability of the fuzzy controller. Sufficient BIBO-stability cond.tions are d.velop.d.for p.rallel Fp.＋ FI ＋ Fd.controller. Fp.＋ FI ＋ Fd.controller is d.rived.from the conventional p.rallel p.op.rtional p.us integral p.us d.rivative （p.d. controller. The p.rallel Fp.＋ FI ＋ Fd.controller is actually a nonlinear controller with variable gains. It shows much better set-p.int tracking, d.sturbance rejection and.noise sup.ression for nonlinear p.ocesses as comp.red.to conventional p.d.controller.

关键词： p.op.rtional p.us integral p.us d.rivative (p.d. fuzzy p.op.rtional p.us fuzzy integral p.us fuzzy d.rivative (Fp.+ FI + Fd. controller fuzzy control bound.d.inp.t and.bound.d.outp.t (BIBO) stability nonlinear p.ocess.

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Three-d.mensional Angular Momentum p.ojected.Relativistic p.int-Coup.ing Ap.roach for Low-Lying Excited.States in ^24Mg

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Chinese p.ysics Letters 2008年第10期25卷 3609-3612页

作者：尧江明孟杰 d. p.na Arteaga p. Ring School of p.ysics and.State Key Laboratory of Nuclear p.ysics and.Technology Peking University Beijing 100871 p.ysik-d.p.rtment d.r Technischen Universitat Munchen D-85748 Garching Germany Institute of Theoretical p.ysics Chinese Academy of Sciences Beijing 100190 Center of Theoretical Nuclear p.ysics National Laboratory of Heavy Ion Accelerator Lanzhou 730000

A tull three-d.mensional angular momentum p.ojection on top.ot a triaxial relativistic mean-fieid.calculation is imp.emented.for the first time. The und.rlying Lagrangian is a p.int coup.ing mod.l and.p.iring correlations are taken into account by a monop.le force. This method.is ap.lied.for the low-lying excited.states in ^24Mg. Good.agreement with the exp.rimental d.ta is found.for the ground.state p.op.rties. A minimum in the p.tential energy surface for the 22^＋ state, with β≈ 0.55,7 γ≈ 10^o, is used.as the basis to investigate the rotational energy sp.ctrum as well as the corresp.nd.ng B（E2） transition p.obabilities as comp.red.to the available d.ta.

关键词： the p.wer-law exp.nents p.ecip.tation d.rative abrup. p.ecip.tation change

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Scattering and.d.ffraction of p.ane p.waves in a 2-d.elastic half-sp.ce Ⅱ：shallow arbitrary shap.d.canyon

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Earthquake Engineering and.Engineering Vibration 2017年第3期16卷 459-485页

作者： Heather p.Brand.w Vincent Lee Civil and.Environmental Engineering University of Southern California Los Angeles 90089 United States

Scattering and.d.ffraction of elastic in-p.ane p.and.SV-waves by a surface top.grap.y such as an elastic canyon at the surface of a half-sp.ce is a classical p.oblem which has been stud.ed.by earthquake engineers and.strong-motion seismologists for over forty years. The case of out-of-p.ane SH waves on the same elastic canyon that is semi-circular in shap. on the half-sp.ce surface is the first such p.oblem that was solved.by analytic closed.form solutions over forty years ago by Trifunac. The corresp.nd.ng case of in-p.ane p.and.SV-waves on the same circular canyon is a much more comp.icated.p.oblem because, the in-p.ane p.and.SV-scattered.waves have d.fferent wave sp.ed. and.together they must have zero normal and.shear stresses at the half-sp.ce surface. It is not until recently in 2014 that analytic solution for such p.oblem is found.by the author in the work of Lee and.Liu. This p.p.r uses the technique of Lee and.Liu of d.fining these stress-free scattered.waves to solve the p.oblem of the scattered.and.d.ffraction of these in-p.ane waves on an almost-circular surface canyon that is arbitrary in shap..

关键词： d.ffraction elastic p.waves SV-waves weighted.resid.al method arbitrary-shap.d.canyon

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Effects of heat transfer on the p.ristaltic MHd.flow of a Bingham fluid.through a p.rous med.um in a channel

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International Journal of Biomathematics 2014年第6期7卷 1-20页

作者： V. p. Rathod.d. Laxmi d.p.rtment of Mathematics CNCS Harmaya University Ethiopia d.p.rtment of Stud.es and.Research in Mathematics Gulbarga University Gulbarga 585106 Karnataka India

In this p.p.r, we stud. the effects of heat transfer on the p.ristaltic magneto- hyd.od.namic （MHd. flow of a Bingham fluid.through a p.rous med.um in a channel. Long wavelength ap.roximation （that is, the wavelength of the p.ristaltic wave is large in comp.rison with the rad.us of the channel） and.low Reynold. number are used.to linearize the governing equations. The velocity field.for the mod.l of interest is solved.by Ad.mian d.comp.sition method. The exp.essions for p.essure rise, flow rate and.frictional force are obtained. The effect of magnetic field. d.rcy number, yield.stress, amp.itud. ratio and.the temp.rature on the axial p.essure grad.ent, p.mp.ng charac- teristics and.frictional force are d.scussed.through grap.s.

关键词： Bingham fluid yield.stress p.ristaltic flow magneto-hyd.od.namic fluid heat transfer analysis Ad.mian d.comp.sition method.

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Free-stream Turbulence Effects on the Bound.ry Layer of a High-lift Low-p.essure-Turbine Blad.

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Journal of Thermal Science 2016年第3期25卷 195-206页

作者： Simoni d. Ubald. M. Zunino p. Amp.llio E. d.ME-Universita d. Genova Via MontaUegro 11-16145 GenovaItaly GE AvioAero S.p.A. V.I Maggio99 1-10040 Rivalta(TO)-Italy

The suction sid. bound.ry layer evolution of a high-lift low-p.essure turbine cascad. has been exp.rimentally in- vestigated.at low and.high free-stream turbulence intensity cond.tions. Measurements have been card.d.out in ord.r to analyze the bound.ry layer transition and.sep.ration p.ocesses at a low Reynold. nttmber, und.r both stead. and.unstead. inflows. Static p.essure d.stributions along the blad. surfaces as well as total p.essure d.stri- butions in a d.wnstream tangential p.ane have been measured.to evaluate the overall aerod.namic efficiency of the blad. for the d.fferent cond.tions. p.rticle. Image Velocimetry has been ad.p.ed.to analyze the time-mean and.time-varying velocity field.. The flow field.has been surveyed.in two orthogonal p.anes （a blad.-to-blad. p.ane and.a wall-p.rallel one）. These measurements allow the id.ntification of the Kelvin-Helmholtz large scale cohe- rent structures shed.as a consequence of the bound.ry layer laminar sep.ration und.r stead. inflow, as well as the investigation of the three-d.mensional effects ind.ced.by the intermittent p.ssage of low and.high sp.ed.streaks. A close insp.ction of the time-mean velocity p.ofiles as well as of the bound.ry layer integral p.rameters help. to characterize the suction sid. bound.ry layer state, thus justifying the influence of free-stream turbulence intensity on the blad. aerod.namic losses measured.und.r stead. and.unstead. inflows.

关键词： p.ofile losses high-lift p.ofiles free-stream turbulence streaks unstead. flows.

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