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Effects of 7-methylxanthine on form-deprivation myopia in pigmented rabbits

International Journal of Ophthalmology(English edition) 2012年第2期5卷 133-137页

作者： Hao-Hui Nie, Dong-mei cui State Key Laboratory of Ophthalmology Zhongshan Ophthalmic Center SunYat-sen University Guangzhou 510060 Guangdong Province China Trier Research Laboratories Tingskiftevej 6 DK-2900 Hellerup Denmark

AIM: To determine the effect of 7-methylxanthine (7-MX) on the posterior sclera of form-deprivation myopia (FDM) in pigmented rabbits. METHODS: Sixteen pigmented rabbits were monocularly deprived (MD) by suturing the right eyelids after natural eye opening (ten-day old) for a period of 30 days. Two groups of pigmented rabbits were fed either 7-MX (30 mg per kg body weight; n=8) or vehicle control (saline equal volume with 7-MX; n=8). Ocular refractions, axial lengths and body weights were measured at the start and the end of the experiment 30 days later. Electron microscopy was used to measure and determine the collagen fibril diameters in the posterior pole of sclera. RESULTS: In vehicle control MD pigmented rabbits, 30 days of MD produced -1.10D+/- 0.78D of myopia and the axial length increased 0.51mm+/- 0.09mm. In MD pigmented rabbits fed with 7-MX, 30 days of MD induced only -0.21D+/- 0.11D of myopia and the axial length increased 0.07mm+/- 0.10mm. There was significant change in axial length of vehicle control MD pigmented rabbits (13.11mm +/- 0.19mm versus 12.60mm+/- 0.06mm; P =0.03). The changes in refraction and axial length of two MD groups' contalateral eyes during the 30 days were not significantly different (2.75D+/- 0.27D versus 2.75D 0.35D, P>0.05; 12.60mm+/- 0.06mm versus 12.45mm +/- 0.14mm, P >0.05). The weights of the two groups pigmented rabbits had no significant changes (187g+/- 22.1g versus 189g+/- 19.3g, P>0.05). The diameter cif scleral collagen fibers increased in both eyes of 7-MX treated pigmented rabbits. There was significant difference in collagen fibril diameters of inner layer (111.34nm+/- 28.30nm versus 94.80nm +/- 27.52nm, P =0.002) and outer layer (167.92nm +/- 55.82nm versus 144.04nm +/- 47.02nm P =0.016) in the posterior sclera between the myopic eyes of vehicle control MD group and contralateral eyes of 7-MX treated MD group. CONCLUSION: 7-MX appears to prevent FDM in pigmented rabbits by remodeling the posterior sclera.

关键词： 7-methylxanthine pigmented rabbits myopia

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In vitro degradation of pure magnesium-the synergetic influences of glucose and albumin

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Bioactive Materials 2020年第2期5卷 318-333页

作者： Wei Yan Yi-Jie Lian Zhi-Yuan Zhang mei-qi Zeng Zhao-qi Zhang Zheng-Zheng Yin Lan-Yue cui Rong-Chang Zeng Corrosion Laboratory for Light Metals College of Material Science and EngineeringShandong University of Science and TechnologyQingdao266590China School of Materials Science and Engineering Zhengzhou UniversityZhengzhou450002China

The biocorrosion of magnesium in the external physiological environment is still difficult to accurately evaluate the degradation behavior in vivo,particularly,in the microenvironment of the patients with hyperglycemia or ***,we explored the synergistic effects of glucose and protein on the biodegradation of pure magnesium,so as to have a deeper understanding the mechanism of the degradation in *** surface morphology and corrosion product composition of pure magnesium were investigated using SEM,EDS,FTIR,XRD and *** effect of glucose and albumin on the degradation rate of pure magnesium was investigated via electrochemical and immersion *** adsorption of glucose and albumin on the sample surface was observed using fluorescence *** results showed that the presence of 2 g/L glucose changed the micromorphology of corrosion products on the magnesium surface by reacting with metal cations,thus inhibiting the corrosion of pure *** formed a barrier layer to protect the magnesium at early stage of *** chelation reaction between protein and magnesium surface might accelerate the degradation at later *** may be a critical glucose(albumin)*** of pure magnesium was inhibited at low concentrations and promoted at high *** synergistic effect of glucose and protein restrained the adsorption of aggressive chloride ions to a certain extent,and thus inhibited the degradation of pure magnesium ***,XPS results indicated that glucose promoted the adsorption of protein on the sample surface.

关键词： Pure magnesium Albumin Degradation Glucose Biomaterial

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Stabilizing perovskite precursors with the reductive natural amino acid for printable mesoscopic perovskite solar cells

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Journal of Energy Chemistry 2024年第3期90卷 32-39,I0003页

作者： Wenjing Hu Jian Yang Chuang Yang Xufeng Xiao Chaoyang Wang Zhaozhen cui qiaojiao Gao Jianhang qi Minghao Xia Yaqiong Su Anyi mei Hongwei Han Michael Gratzel Center for Mesoscopic Solar Cells Wuhan National Laboratory for OptoelectronicsKey Laboratory of Materials Chemistry for Energy Conversion and Storage of Ministry of Education Huazhong University of Science and TechnologyWuhan 430074HubeiChina School of Chemistry Xi'an Key Laboratory of Sustainable Energy Materials ChemistryState Key Laboratory of Electrical Insulation and Power EquipmentXi'an Jiaotong UniversityXi'an 710049ShaanxiChina

Solution processability significantly advances the development of highly-efficient perovskite solar ***,the precursor solution tends to undergo irreversible degradation reactions,impairing the device performance and ***,we utilize a reductive natural amino acid,Nacetylcysteine(NALC),to stabilize the precursor solution for printable carbon-based hole-conductorfree mesoscopic perovskite solar *** find that I_(2) can be generated in the aged solution containing methylammonium iodide(MI) in an inert atmosphere and speed up the MA-FA^(+)(formamidinium) reaction which produces large-size cations and hinders the formation of perovskite *** effectively stabilizes the precursor via its sulfhydryl group which reduces I_(2) back to I^(-)and provides H^(+).The NALC-stabilized precursor which is aged for 1440 h leads to devices with a power conversion efficiency equivalent to 98% of that for devices prepared with the fresh ***,NALC improves the device power conversion efficiency from 16.16% to 18.41% along with enhanced stability under atmospheric conditions by modifying grain boundaries in perovskite films and reducing associated defects.

关键词： Perovskite solar cells Perovskite precursor Degradation Stabilization Reductive natural amino acid

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Anti-inflammatory activity of curcumin-loaded tetrahedral framework nucleic acids on acute gouty arthritis

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Bioactive Materials 2022年第2期7卷 368-380页

作者： mei Zhang Xiaolin Zhang Taoran Tian qi Zhang Yuting Wen Junyao Zhu Dexuan Xiao Weitong cui Yunfeng Lin State Key Laboratory of Oral Diseases National Clinical Research Center for Oral DiseasesWest China Hospital of StomatologySichuan UniversityChengdu610041PR China College of Biomedical Engineering Sichuan UniversityChengdu610041PR China

Gouty arthritis is a very familiar inflammatory *** inflammation is the key to preventing gouty ***,colchicine,the most highly represented drug used in clinical practice,has strict contraindications owing to some severe side ***(Cur),a natural anti-inflammatory drug,has demonstrated good safety and ***,the rapid degradation,poor aqueous solubility,and low bioavailability of Cur limit its therapeutic *** strengthen the effectiveness and bioavailability of *** loaded tetrahedral framework nucleic acids(Cur-TFNAs)were synthesized to deliver *** with free Cur,Cur-TFNAs exhibit a preferable drug stability,good biocompatibility(CCK-8 assay),ease of uptake(immunofluorescence),and higher tissue utilization(in vivo biodistribution).Most importantly,Cur-TFNAs present better anti-inflammatory effect than free Cur both in vivo and in vitro experiments through the determination of inflammation-related cytokines ***,we believe that Cur-TFNAs have great prospects for the prevention of gout and similar inflammatory diseases.

关键词： Tetrahedral framework DNA nanoparticle Oxidative stress NF-κB signaling pathway Macrophage Gouty arthritis

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Role of 7-methylxanthine in myopia prevention and control: a mini-review

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International Journal of Ophthalmology(English edition) 2023年第6期16卷 969-976页

作者： Lu Lai Klaus Trier Dong-mei cui Shenzhen Eye Hospital Jinan UniversityShenzhen Eye InstituteFutian DistrictShenzhen 518040Guangdong ProvinceChina Trier Research Laboratories Ojenlage Klaus Trier ApSHellerup DK-2900Denmark

·Myopia is becoming increasingly common. By 2050 around 10% of the world’s population is expected to be highly myopic(<-5 diopters) and therefore particularly at risk of suffering from sight-threatening complications. Currently used myopia control treatments, such as multifocal soft contact lenses or spectacle lenses, orthokeratology, and atropine eyedrops, either do not completely arrest myopia progression or are associated with significant ocular and possibly systemic side effects. A new candidate for pharmaceutical control of myopia progression and excessive eye elongation, the non-selective adenosine antagonist 7-methylxanthine(7-MX), appears to be nontoxic and effective in reducing myopia progression and axial eye growth in experimental and clinical studies. The latest findings regarding 7-MX for myopia control and evaluate its potential as a supplement to existing treatment options were reviewed.

关键词： 7-methylxanthine myopia pharmaceutical therapy

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Dealloying corrosion of anodic and nanometric Mg41Nd5 in solid solution-treated Mg-3Nd-1Li-0.2Zn alloy

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Journal of Materials Science & Technology 2021年第24期83卷 161-178页

作者： Gui-Jia Gao mei-qi Zeng En-Liang Zhang Rong-Chang Zeng Lan-Yue cui Dao-kui Xu Feng-qin Wang M.Bobby Kannan Corrosion Laboratory for Light Metals College of Materials Science and EngineeringShandong University of Science and TechnologyQingdao266590China School of Materials Science and Engineering Zhengzhou UniversityZhengzhou450002China Key Laboratory of Nuclear Materials and Safety Assessment Institute of Metal ResearchChinese Academy of SciencesShenyang110016China School of Engineering University of NewcastleCallaghanNew South Wales 2308Australia

The microstructure and chemical compositions of the solid solution-treated Mg-3 Nd-1 Li-0.2 Zn alloy were characterized using optical microscope,scanning electron microscope(SEM),transmission electron microscope(TEM),electron probe micro-analyzer(EPMA)and X-ray photoelectron spectroscopy(XPS).The corrosion behaviour of the alloy was investigated via electrochemical polarization,electrochemical impedance spectroscopy(EIS),hydrogen evolution test and scanning Kelvin probe(SKP).The results showed that the microstructure of the as-extruded Mg-3 Nd-1 Li-0.2 Zn alloy containedα-Mg matrix and nanometric second phase Mg_(41)Nd_(5).The grain size of the alloy increased significantly with the increase in the heat-treatment duration,whereas the volume fraction of the second phase decreased after the solid solution *** surface film was composed of oxides(Nd_(2)O_(3),Mg O,Li_(2)O and Zn O)and carbonates(Mg CO3 and Li_(2)CO3),in addition to *** as-extruded alloy exhibited the best corrosion resistance after an initial soaking of 10 min,whereas the alloy with 4 h-solution-treatment possessed the lowest corrosion rate after a longer immersion(1 h).This can be attributed to the formation of Nd-containing oxide film on the alloys and a dense corrosion product *** dealloying corrosion of the second phase was related to the anodic Mg_(41)Nd_(5)with a more negative Volta potential relative toα-Mg *** preferential corrosion of Mg_(41)Nd_(5)is proven by in-situ observation and *** solid solution treatment of Mg-3 Nd-1 Li-0.2 Zn alloy led to a shift in corrosion type from pitting corrosion to uniform corrosion under long-term exposure.

关键词： Magnesium alloy Corrosion Second phase Rare metal Dealloying

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Synthesis and Crystal Structure of an Indenylnickel(II) NHC Complex (Ind)NiBr(1,3-bisbenzylimidazol-2-ylidene)

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Chinese Journal of Structural Chemistry 2006年第10期25卷 1255-1259页

作者： HU Dong-mei SUN Hong-mei WANG Yong-Sheng SHEN qi XUE Feng The Key Lab of Organic Synthesis of Jiangsu Province College of Chemistry and Chemical Engineering Suzhou University Suzhou 215123 China Department of Chemistry The National University of Singapore Singapore 117543 Republic of Sinapore

The complex （Ind）NiBr（1,3-bisbenzylimidazol-2-ylidene）（Ind = indenyl） 1 has been prepared in ca. 65% yield via the reaction of （Ind）2Ni with an equivalent of 1,3-bis-benzylimidazolium bromide in THF/CH2Cl2 at 45℃, supported by elemental analysis, NMR spectroscopy and X-ray crystal determination. The crystal belongs to the triclinic system, space group Pi with a = 7.072（1）, b = 11.264（2）, c = 14.541（3）°A, α = 102.21（3）,β = 93.44（3）,γ = 90.81（3）°, V = 1129.7（4）°A^3, Z = 2, Mr = 502.08, Dc = 1.476 g/cm^3, F（000） = 512, μ= 2.642 mm^-1, R = 0.0490 and wR = 0.1137 for 3913 observed reflections （I〉 2σ（I））. The center nickel atom is coordinated by a bromide ligand, a carbene carbon and three carbon atoms of the five-membered indenyl group to form either a highly distorted square pyramid or a highly distorted square plane.

关键词： nickel complex indenyl ligand N-heterocyclic carbene

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The role of amyloid beta clearance in cerebral amyloid angiopathy:more potential therapeutic targets

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Translational Neurodegeneration 2017年第1期6卷 205-216页

作者： Xue-mei qi Jian-fang Ma Department of Neurology&Institute of Neurology Ruijin Hospital Affiliated to Shanghai Jiaotong University School of MedicineShanghai 200025China

Cerebral amyloid angiopathy(CAA)is characterized by the deposition of amyloid β-protein(Aβ)in the leptomeningeal and cortical blood vessels,which is an age-dependent risk factor for intracerebral hemorrhage(ICH),ischemic stroke and contributes to cerebrovascular dysfunction leading to cognitive *** clinical prevention and treatment of the disease is very difficult because of its occult onset and severity of the *** recent years,many anti-amyloid β immunotherapies have not demonstrated clinical efficacy in subjects with Alzheimer’s disease(AD),and the failure may be due to the deposition of Aβ in the cerebrovascular export pathway resulting in further damage to blood vessels and aggravating *** decreased clearance of Aβ in blood vessels plays a crucial role in the development of CAA and AD,and identification of the molecular pathways involved will provide new targets for *** this review,we mainly describe the mechanisms of Aβ clearance through vessels,especially in terms of some proteins and receptors involved in this process.

关键词： Cerebral amyloid angiopathy Alzheimer’s disease Amyloidβ-protein Clearance

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Interfacial engineering of perfluoroalkyl functionalized covalent organic framework achieved ultra-long cycled and dendrite-free lithium anodes

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Nano Research 2023年第7期16卷 9289-9298页

作者： Yongxin Yang Conghui Zhang Zhiyuan mei Yongjiang Sun qi An qi Jing Genfu Zhao Hong Guo International Joint Research Center for Advanced Energy Materials of Yunnan Province Yunnan Key Laboratory of Carbon Neutrality and Green Low-carbon TechnologiesSchool of Materials and EnergyYunnan UniversityKunming 650091China

The finite lithium-ion utilization,short cycling life,and lower capacity retention caused by irreversible dendrite growth become the maximum dilemma in lithium metal batteries’(LMBs’)***,a perfluoroalkyl-functionalized covalent organic framework(COF-F6)equipped with high stability and supernal proton conduction is introduced as an artificial solid electrolyte interface to stable the lithium metal *** from the strong electron-withdrawing effect of perfluoroalkyl,Li^(+)will be freed more by the competition of electronegative fluorine(F)and bis(trifluoromethanesulphonyl)imide anion(TFSI^(-)).The dissociation of LiTFSI and process of Li^(+)desolvation are easier to *** addition,high electronegative fluorine can also regulate local electron-cloud density to induce the fast immigration of Li^(+).All the above roles contribute to improving the Li^(+)transfer number(0.7)and achieving the goal of inhibiting Li *** a result,the perfluoroalkyl COF-F6 modified LMB presents outstanding cycling *** symmetric batteries accomplish an overlong life-span of more than 5000 h with a lower hysteresis voltage(11 mV)at 5 mA·cm^(-2).Also,no dendrites are observed when using an in-situ optical microscope to learn the process of Li ***,this dendrite-free protection tactic holds broad prospects for the practical application of Li metal anodes.

关键词： perfluoroalkyl-functionalized covalent organic framework(COF-F6) artificial solid electrolyte interface strong electronwithdrawing effect dendrite-free lithium metal anode

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Edge Intelligence with Distributed Processing of DNNs:A Survey

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Computer Modeling in Engineering & Sciences 2023年第7期136卷 5-42页

作者： Sizhe Tang Mengmeng cui Lianyong qi Xiaolong Xu School of Computer and Software Nanjing University of Information Science and TechnologyNanjing210000China School of Computer Science Qufu Normal UniversityQufu273100China

Withthe rapiddevelopment of deep learning,the size of data sets anddeepneuralnetworks(DNNs)models are also *** a result,the intolerable long time for models’training or inference with conventional strategies can not meet the satisfaction of modern tasks ***,devices stay idle in the scenario of edge computing(EC),which presents a waste of resources since they can share the pressure of the busy devices but they do *** address the problem,the strategy leveraging distributed processing has been applied to load computation tasks from a single processor to a group of devices,which results in the acceleration of training or inference of DNN models and promotes the high utilization of devices in edge *** with existing papers,this paper presents an enlightening and novel review of applying distributed processing with data and model parallelism to improve deep learning tasks in edge *** the practicalities,commonly used lightweight models in a distributed system are introduced as *** the key technique,the parallel strategy will be described in *** some typical applications of distributed processing will be ***,the challenges of distributed processing with edge computing will be described.

关键词： Distributed processing edge computing parallel strategies acceleration of DNN processing

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