In vitro degradation of pure magnesium-the synergetic influences of glucose and albumin

作     者：Wei Yan Yi-Jie Lian Zhi-Yuan Zhang Mei-Qi Zeng Zhao-Qi Zhang Zheng-Zheng Yin Lan-Yue Cui Rong-Chang Zeng 

作者机构：Corrosion Laboratory for Light MetalsCollege of Material Science and EngineeringShandong University of Science and TechnologyQingdao266590China School of Materials Science and EngineeringZhengzhou UniversityZhengzhou450002China 

出 版 物：《Bioactive Materials》 (生物活性材料（英文）)

年 卷 期：2020年第5卷第2期

页      面：318-333页

核心收录：

学科分类：0710[理学-生物学] 0831[工学-生物医学工程（可授工学、理学、医学学位）] 08[工学] 0805[工学-材料科学与工程（可授工学、理学学位）] 080502[工学-材料学] 0836[工学-生物工程] 

基　　金：supported by the National Natural Science Foundation of China(51571134) the Scientific Research Foundation of Shandong University of Science and Technology Research Fund(2014TDJH104) Undergraduate Innovation and Entrepreneurship Training Program of Shandong University of Science and Technology(201710424082) 

主　　题：Pure magnesium Albumin Degradation Glucose Biomaterial 

摘      要：The biocorrosion of magnesium in the external physiological environment is still difficult to accurately evaluate the degradation behavior in vivo,particularly,in the microenvironment of the patients with hyperglycemia or ***,we explored the synergistic effects of glucose and protein on the biodegradation of pure magnesium,so as to have a deeper understanding the mechanism of the degradation in *** surface morphology and corrosion product composition of pure magnesium were investigated using SEM,EDS,FTIR,XRD and *** effect of glucose and albumin on the degradation rate of pure magnesium was investigated via electrochemical and immersion *** adsorption of glucose and albumin on the sample surface was observed using fluorescence *** results showed that the presence of 2 g/L glucose changed the micromorphology of corrosion products on the magnesium surface by reacting with metal cations,thus inhibiting the corrosion of pure *** formed a barrier layer to protect the magnesium at early stage of *** chelation reaction between protein and magnesium surface might accelerate the degradation at later *** may be a critical glucose(albumin)*** of pure magnesium was inhibited at low concentrations and promoted at high *** synergistic effect of glucose and protein restrained the adsorption of aggressive chloride ions to a certain extent,and thus inhibited the degradation of pure magnesium ***,XPS results indicated that glucose promoted the adsorption of protein on the sample surface.