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Biomimetic transformation of gentiopicroside to erythrocentaurin

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Chinese Chemical Letters 2009年第2期20卷 150-152页

作者： cui ling wang Jian Li Liu Zhu Lan Liu Xin Sheng Li Xiao Yong Cao School of Life Science Northwest University Xi'an 710069 China Department of Biology Shaanxi University of Technology Hanzhong 723001 China

Biomimetic transformation of gentiopicroside was carded out by β-glucosidase at pH 7.0 for 3 days at 37 ℃. Two products, erythrocentaurin and 5,6-dihydro-5-formyl-6-methyl-1H,3H-pyrano[3,4-c]pyran-1-one were isolate... 详细信息

关键词： Gentiopicroside Biomimetic transformation β-Glucosidase Erythrocentaurin 5,6-Dihydro-5-formyl-6-methyl-1H,3H-pyrano[3,4-c]pyran-1-one

Factors driving surface deformations in plain area of eastern Zhengzhou City,China

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Journal of Groundwater Science and Engineering 2023年第4期11卷 347-364页

作者： Zi-jun Zhuo Dun-yu Lv Shu-ran Meng Jian-yu Zhang Song-bo Liu cui-ling wang Institute of Hydrogeology and Environmental Geology Chinese Academy of Geological SciencesShijiazhuang 050061China China University of Geosciences(Beijing) Beijing 100083China Key Laboratory of Quaternary Chronology and Hydro-Environmental Evolution China Geological Survey(CGS)&Hebei ProvinceShijiazhuang 050061China

With the rapid socio-economic development and urban expansion,land subsidence has emerged as a major environmental issue,impeding the high-quality development of the plain area in eastern Zhengzhou City,Henan Province,***,effective prevention and control of land subsidence in this region have been challenging due to the lack of comprehensive surface deformations monitoring and the quantitative analysis of the factors driving these *** order to accurately identify the dominant factor driving surface deformations in the study area,this study utilized the Persistent Scattered Interferometric Synthetic Aperture Radar(PS-InSAR)technique to acquire the spatio-temporal distribution of surface deformations from January 2018 to March *** acquired data was verified using leveling ***,GIS spatial analysis was employed to investigate the responses of surface deformations to the driving *** findings are as follows:Finally,the geographical detector model was utilized to quantify the contributions of the driving factors and reveal the mechanisms of their *** findings are as follows:(1)Surface deformations in the study area are dominated by land subsidence,concentrated mainly in Zhongmu County,with a deformation rate of−12.5–−37.1 mm/*** contrast,areas experiencing surface uplift are primarily located downtown,with deformation rates ranging from 0 mm to 8 mm;(2)Groundwater level,lithology,and urban construction exhibit strong spatial correlations with cumulative deformation amplitude;(3)Groundwater level of the second aquifer group is the primary driver of spatially stratified heterogeneity in surface deformations,with a contributive degree of *** contributive degrees of driving factors are significantly enhanced through *** level and the cohesive soil thickness in the second aquifer group show the strongest interactions in the study *** total contributive degree increases to 0.5722 af

关键词： PS-InSAR GIS spatial analysis Geographical detector model Degree of contribution of a driving factor Spatially stratified heterogeneity

Project of Underground Natural Gas Storage in Dagang Oilfield

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China Oil & Gas 1998年第3期5卷 147-148页

作者： cui Lihong and wang ling(Geogical Research Institute of Dagang Oilfield Group Ltd, Company)

Adsorption Behavior of Hexavalent Chromium in Vadose Zone

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Journal of Groundwater Science and Engineering 2013年第3期1卷 83-88页

作者： cui-ling wang Chang-li Liu Ya-jie Pang Li-xin Pei Yun Zhang Institute of Hydrogeology and Environmental Geology Center for Hydrogeology and environmental Geology Survey

Adsorption behavior of Cr(Ⅵ) in vadose zone, which is silty clay and clayey soil, was studied through kinetics experiments, isothermal adsorption experiments under various conditions, including different ph, temperature and organic contents. The results from kinetics experiments showed that the sorption progress of Cr(Ⅵ) has clear features in different stages, and adsorption equilibrium showed at 30 min, the adsorption rate of silty clay and clayey soil were 60%. The isothermal adsorption curve of Cr(Ⅵ) fitted closely with Freundlich equation model. When pH is 3-5 a plateau were seen, thereafter with increase in pH the adsorption rate of Cr(Ⅵ) dropped sharply and the minimum achieved at pH 10, the adsorption rate were only 35%. Adsorption rate of Cr(Ⅵ) increased gradually with the increase of temperature, the temperature of vadose zone is 14.7 ℃, according to the experimental results, the adsorption rate of Cr(Ⅵ) is about 40%. The use of organics represents an important contribution to the sorption of Cr(Ⅵ), sorption rate up to 100% when 30% of organic content. These studies will provide basis for manager to minimize the impacts, and provide basic data for pollution prevention and remediation of vadose zone.

关键词： Cr (VI) Adsorption Behavior Vadose zone

The complex effects of miR-146a in the pathogenesis of Alzheimer's disease

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Neural Regeneration Research 2025年第5期20卷 1309-1323页

作者： Yunfan Long Jiajia Liu Yu wang Haidong Guo Guohong cui Department of Neurology Shanghai No.9 People’s HospitalShanghai Jiaotong University School of MedicineShanghaiChina Academy of Integrative Medicine Shanghai University of Traditional Chinese MedicineShanghaiChina School of Integrative Medicine Shanghai University of Traditional Chinese MedicineShanghaiChina Department of Neurology Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese MedicineShanghaiChina

Alzheimer's disease is a neurodegenerative disorder characterized by cognitive dysfunction and behavioral *** plaques formed through the extracellular deposition of amyloid-βproteins,as well as neurofibrillary tangles formed by the intracellular deposition of hyperphosphorylated tau proteins,comprise two typical pathological features of Alzheimer's *** symptomatic treatment,there are no effective therapies for delaying Alzheimer's disease ***(miR)are small,non-coding RNAs that negatively regulate gene expression at the transcriptional and translational levels and play important roles in multiple physiological and pathological ***,miR-146a,a NF-κB-regulated gene,has been extensively implicated in the development of Alzheimer's disease through several *** has demonstrated substantial dysregulation of miR-146a both during the initial phases and throughout the progression of this *** R-146a is believed to reduce amyloid-βdeposition and tau protein hyperphosphorylation through the TLR/IRAK1/TRAF6 pathway;however,there is also evidence supporting that it can promote these processes through many other pathways,thus exacerbating the pathological manifestations of Alzheimer's *** has been widely reported that miR-146a mediates synaptic dysfunction,mitochondrial dysfunction,and neuronal death by targeting m RNAs encoding synapticrelated proteins,mitochondrial-related proteins,and membrane proteins,as well as other *** the impact on glial cells,miR-146a also exhibits differential *** one hand,it causes widespread and sustained inflammation through certain pathways,while on the other hand,it can reverse the polarization of astrocytes and microglia,alleviate neuroinflammation,and promote oligodendrocyte progenitor cell differentiation,thus maintaining the normal function of the myelin sheath and exerting a protective effect on *** this review,we provide a

关键词： Alzheimer's disease amyloid-β glial cells microRNAs miR-146a neuroinflammatory

Mechanism of inflammatory response and therapeutic effects of stem cells in ischemic stroke:current evidence and future perspectives

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Neural Regeneration Research 2025年第1期20卷 67-81页

作者： Yubo wang Tingli Yuan Tianjie Lyu ling Zhang Meng wang Zhiying He Yongjun wang Zixiao Li Vascular Neurology Department of NeurologyBeijing Tiantan HospitalCapital Medical UniversityBeijingChina China National Clinical Research Center for Neurological Diseases Beijing Tiantan HospitalCapital Medical UniversityBeijingChina Shanghai Engineering Research Center of Stem Cells Translational Medicine ShanghaiChina National Center for Healthcare Quality Management in Neurological Diseases Beijing Tiantan HospitalCapital Medical UniversityBeijingChina Institute for Regenerative Medicine Shanghai East HospitalSchool of Life Sciences and TechnologyTongji UniversityShanghaiChina Chinese Institute for Brain Research BeijingChina Research Unit of Artificial Intelligence in Cerebrovascular Disease Chinese Academy of Medical SciencesBeijingChina Beijing Engineering Research Center of Digital Healthcare for Neurological Diseases BeijingChina

Ischemic stroke is a leading cause of death and disability worldwide,with an increasing trend and tendency for onset at a younger ***,in particular,bears a high burden of stroke *** recent years,the inflammatory response after stroke has become a research hotspot:understanding the role of inflammatory response in tissue damage and repair following ischemic stroke is an important direction for its *** review summarizes several major cells involved in the inflammatory response following ischemic stroke,including microglia,neutrophils,monocytes,lymphocytes,and ***,we have also highlighted the recent progress in various treatments for ischemic stroke,particularly in the field of stem cell ***,understanding the complex interactions between inflammation and ischemic stroke can provide valuable insights for developing treatment strategies and improving patient *** cell therapy may potentially become an important component of ischemic stroke treatment.

关键词： cell therapy immune cell inflammatory ischemic stroke stem cell

Spatiotemporal evolution of wildfire activity during the PaleoceneEocene Thermal Maximum in China

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Science China Earth Sciences 2025年

作者： Xueting wang Zuoling CHEN Linlin cui Xu wang State Key Laboratory of Lithospheric and Environmental Coevolution Institute of Geology and Geophysics Chinese Academy of Sciences University of Chinese Academy of Sciences College of Earth and Planetary Sciences Institute of Geology and Geophysics Chinese Academy of Sciences

The Paleocene-Eocene Thermal Maximum（PETM） was the most prominent warming event in the Cenozoic and serves as a geological analog for the current global warming driven by anthropogenic CO2emissions from burning fossil *** a primary disruptor of Earth's ecosystems, wildfire activity affects the balance of ecosystems, the global carbon cycle, and climate change. Therefore, studying the evolution and driving mechanisms of wildfires during the PETM is essential for predicting wildfire activity under global warming scenarios and for understanding the carbon cycle in the context of wildfire disturbances. Current research on wildfires during the PETM has mainly focused on the Northern Hemisphere, particularly Europe and North America, whereas studies on Chinese mainland remain limited. In this study, we analyzed black carbon（BC）concentration and carbon isotope(δ13C) in the Beigou section of the Nanyang Basin and the Xilutian section of the Fushun Basin to reconstruct the spatiotemporal evolution of wildfires in arid/semi-arid and humid zones. We integrated these findings with those of previous studies on the paleoclimate of the research area to elucidate the driving mechanisms behind wildfire occurrences. Our results indicate that wildfire activity weakened at the onset of the PETM, with the negative carbon isotope period characterized by low wildfire activity, except for a brief resurgence in the Nanyang Basin. During the recovery phase of the PETM, wildfire activity gradually increased, returning to the pre-PETM levels. The prolonged low wildfire state was likely caused by extremely high temperatures and precipitation as well as the resulting vegetation succession. During the PETM recovery phase, increased wildfire activity transformed “short-term carbon sinks” of the biological-atmospheric carbon cycle into “long-term carbon sinks” through the burial of BC. This process of carbon sink conversion may have acted as a negative feedback mechanism, contributing to carbo

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A Novel Model for Describing Rail Weld Irregularities and Predicting Wheel-Rail Forces Using a Machine Learning Approach

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Computer Modeling in Engineering & Sciences 2025年第1期142卷 555-577页

作者： Linlin Sun Zihui wang Shukun cui Ziquan Yan Weiping Hu Qingchun Meng State Key Laboratory of High-Speed Railway Track System China Academy of Railway Sciences Corporation LimitedBeijing100081China Railway Engineering Research Institute China Academy of Railway Sciences Corporation LimitedBeijing100081China School of Aeronautic Science and Engineering Beihang UniversityBeijing100191China

Rail weld irregularities are one of the primary excitation sources for vehicle-track interaction dynamics in modern high-speed *** can cause significant wheel-rail dynamic interactions,leading to wheel-rail noise,component damage,and *** researchers have employed the vehicle-track interaction dynamic model to study the dynamic interactions between wheel and rail induced by rail weld geometry ***,the cosine wave model used to simulate rail weld irregularities mainly focuses on the maximum value and neglects the geometric *** this study,novel theoretical models were developed for three categories of rail weld irregularities,based on measurements of the high-speed railway from Beijing to *** vertical dynamic forces in the time and frequency domains were compared under different running *** forces generated by the rail weld irregularities that were measured and modeled,respectively,were compared to validate the accuracy of the proposed ***,based on the numerical study,the impact force due to rail weld irrregularity is modeled using an Artificial Neural Network(ANN),and the optimum combination of parameters for this model is *** results showed that the proposed model provided a more accurate wheel/rail dynamic evaluation caused by rail weld irregularities than that established in the *** ANN model used in this paper can effectively predict the impact force due to rail weld irrregularity while reducing the computation time.

关键词： Rail weld irregularity high-speed railway vehicle-track coupled dynamics wheel/rail dynamic vertical force artificial neural networks

An Improved Practical Byzantine Fault-Tolerant Algorithm Based on XGBoost Grouping for Consortium Chains

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Computers, Materials & Continua 2025年第1期82卷 1295-1311页

作者： Xiaowei wang Haiyang Zhang Jiasheng Zhang Yingkai Ge Kexin cui Zifu Peng Zhengyi Li Lihua wang College of Electronic and Information Engineering Shandong University of Science and TechnologyQingdao266590China

In response to the challenges presented by the unreliable identity of the master node,high communication overhead,and limited network support size within the Practical Byzantine Fault-Tolerant(PBFT)algorithm for consortium chains,we propose an improved PBFT algorithm based on XGBoost grouping called XG-PBFT in this ***-PBFT constructs a dataset by training important parameters that affect node performance,which are used as classification indexes for *** XGBoost algorithm then is employed to train the dataset,and nodes joining the system will be grouped according to the trained grouping *** them,the nodes with higher parameter indexes will be assigned to the consensus group to participate in the consensus,and the rest of the nodes will be assigned to the general group to receive the consensus *** order to reduce the resource waste of the system,XG-PBFT optimizes the consensus protocol for the problem of high complexity of PBFT ***,we evaluate the performance of *** experimental results show that XG-PBFT can significantly improve the performance of throughput,consensus delay and communication complexity compared to the original PBFT algorithm,and the performance enhancement is significant compared to other algorithms in the case of a larger number of *** results demonstrate that the XG-PBFT algorithm is more suitable for large-scale consortium chains.

关键词： Consortium chain PBFT grouping reputation XGBoost