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Metastatic pancreatic and l.ng cancer patient in compl.te remission fol.owing immunotherapy: A case report and review of l.terature

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Worl. Journal.of Gastrointestinal.Oncol.gy 2024年第5期16卷 2233-2240页

作者： Joaquina Martínez-Gal.n cristina Jiménez-l.na Isabel.Rodriguez El.sabeth Maza Carl.s García-Col.ado Antonio Rodríguez-Fernández Javier l.is l.pez-Hidal.o Octavio Caba Department of Medical.Oncol.gy Virgen de las Nieves University HospitalGranada 18014Spain Instituto de Investigación Biosanitaria Ibs.GranadaGranada 18012Spain Institute of Biopathol.gy and Regenerative Medicine(IBIMER) University of GranadaGranada 18016Spain Pharmacogenetics Unit Virgen de las Nieves University HospitalGranada 18014Spain Department of Medicina Nucl.ar Virgen de las Nieves University HospitalGranada 18014Spain Department of Anatomía Patol.gica Virgen de las Nieves University HospitalGranada 18014Spain

BACKGROUND Metastatic pancreatic ductal.adenocarcinoma(PDAC)is a l.thal.mal.gnancy with dispiriting survival.*** is a promising approach to many cancer types,but achieves poor outcomes in advanced PDAC due to its immunosuppressive tumor *** describe a case of metastatic PDAC effectivel. treated with *** SUMMARY We report the case of a 67-year-ol. woman with unresectabl. l.cal.y advanced PDAC,treated with gemcitabine pl.s nab-pacl.taxel.fol.owed by radiotherapy pl.s *** nine months,pancreatic tumor progression was observed at the l.vel.of the hepatic hil.m with the appearance of a new pul.onary nodul. suggestive of a second primary,confirmed by l.ft l.ng *** immunotherapy was then initiated with pembrol.zumab,an immune checkpoint inhibitor targeting programmed cel. death protein-1 that covers the two tumor *** patient showed a compl.te metabol.c response that was maintained throughout the *** patient continues to be disease-free at 5.6 years since the start of *** These resul.s suggest that the administration of pembrol.zumab after chemoradiotherapy has a beneficial.effect in patients with metastatic *** our knowl.dge,this is the first reported case of a patient with metastatic PDAC and metastatic l.ng cancer showing such a l.ng-l.sting compl.te response after pembrol.zumab treatment without curative *** studies are required to determine biomarkers that identify PDAC patients most l.kel. to benefit from this immunotherapy.

关键词： Pancreatic ductal.adenocarcinoma l.ng cancer Immunotherapy Pembrol.zumab Programmed cel. death protein-1 Case report

Effects of chl.rpyrifos on enzymatic systems of Cydia pomonel.a （l.pidoptera： Tortricidae） adul.s

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Insect Science 2017年第3期24卷 455-466页

作者： l.ura Beatriz Parra Moral.s Raul.Adol.o Al.ogaray l.l.ana Cichon Sil.ina Garrido Jimena Sol.no cristina Monica Montagna l.boratorio de Investigaciones Bioquimicas Quimicas y de Medio Ambiente Facultad de Ingenieria Universidad Nacional del ComahueBuenos Aires 1400 (Q83001BX) Neuquen Facul.ad de Ciencias del.Ambiente y l. Sal.d Universidad Nacional del Comahue Buenos Aires 1400 Neuquen Centro de Investigaciones de Pl.gas e Insecticidas (CIPEIN-UNIDEFICONICET) Villa Martelli Buenos Aires Instituto de Investigacion e Ingenieria Ambiental.(3iA-UNSAM) San Martin Provincia de Buenos Aires Instituto Nacional.de Tecnol.gia Agropecuaria Estacion Experimental Alto Valle General Roca Argentina

The control.program of codl.ng moth （Cydia pomonel.a l.） in the Rio Negro and Neuqu6n Val.ey is intended to neonate l.rvae. However, adul.s may be subjected to subl.thal.pesticide concentrations generating stress which might enhance both mutation rates and activity of the detoxification system. This study assessed the exposure effects of chl.rpyrifos on target enzyme and, both detoxifying and antioxidant systems of surviving adul.s from both a l.boratory susceptibl. strain （l.S） and a fiel. popul.tion （FP）. The resul.s showed that the FP was as susceptibl. to chl.rpyrifos as the l.S and, both exhibited a simil.r chl.rpyrifos-inhibitory concentration 50 （IC50） of acetyl.hol.nesterase （ACHE）. The FP displ.yed higher carboxyl.sterase （CarE） and 7-ethoxycoumarine O-deethyl.se （ECOD） activities than l.S. Both l.S and FP showed an increase on CarE activity after the exposure to l.w-chl.rpyrifos concentrations, fol.owed by enzyme inhibition at higher concentrations. There were no significant differences neither in the activities of gl.tathione S-transferases （GST）, catal.se （CAT） and superoxide dismutase （SOD） nor in the reduced gl.tathione （GSH） content between l.S and FP. Moreover, these enzymes were unaffected by chl.rpyrifos. In concl.sion, control.adul.s from the FP exhibited higher CarE and ECOD activities than control.adul.s from the l.S. AChE and CarE activities were the most affected by chl.rpyrifos. Control.strategies used for C. pomonel.a, such as rotations of insecticides with different modes of action, wil. probabl. del.y the evol.tion of insecticide resistance in FPs from the study area.

关键词： acetyl.hol.nesterase antioxidant system chl.rpyrifos codl.ng moth detoxification enzymes

Fol.ar Nutrient Bal.nce Standards for Maize (&l.;i>Zea mays&l.;/i>l.) at High-Yiel. l.vel

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American Journal.of Pl.nt Sciences 2014年第4期5卷 497-507页

作者： Viviane cristina Modesto Serge-étienne Parent Wil.iam Natal. l.on Etienne Parent Departamento de Sol.s e Adubos Unesp Universidade Estadual Paulista Jabotocabal Brazil ERSAM Department of Soils and Agrifood Engi-neering Université Laval Québec Canada

Maize is one of the most nutrient demanding stapl. crops. Tissue nutrient diagnosis of maize is currentl. conducted using critical.nutrient concentration or dual.ratio ranges, but such diagnoses are pathol.gical.as biased by data redundancy, sub-compositional.incoherence and non-normal.distribution. The use of orthogonal.bal.nces, a compositional.data anal.sis technique, avoids such biases. Our objective was to devel.p fol.ar nutrient bal.nce standards for maize. We col.ected 758 grain yiel.s (15.5% moisture content) and fol.ar sampl.s at sil. stage in maize fiel.s of southern Quebec, Canada, and anal.zed ten nutrients in tissues (N, P, K, Ca, Mg, B, Cu, Zn, Mn, Fe). Nutrients were arranged into ad hoc bal.nces and computed as isometric l.g ratios (il.). An optimized binary cl.ssification performed by a customized receiver operating characteristic procedure showed that a critical.Mahal.nobis distance of 4.21 separated bal.nced from imbal.nced specimens about yiel. cut-off of 11.83 Mg grain·ha-1 with test performance of 86%. Quebec maize bal.nce standards differed from publ.shed standards computed from DRIS norms col.ected in other agroecosystems. The Redfiel. N/P ratio in maize l.aves was found to be the l.ast variabl. bal.nce across regions of the worl.. The DRIS dual.ratios and raw concentration val.es were found to be geometrical.y inadequate for conducting diagnosis. The unbiased nutrient bal.nce diagnosis combined the critical.Mahal.nobis distance and a mobil. representation of nutrient bal.nces with il. means of true negative (TN) specimens centered at ful.rums and back-transformed il. val.es of TN specimens into raw concentrations l.ading the buckets bel.w. Nutrients can be appreciated as rel.tive shortage, adequacy or excess in the concentration domain fol.owing statistical.anal.sis and diagnosis in the unbiased bal.nce domain.

关键词： Compositional Data Anal.sis Critical Range Diagnosis and Recommendation Integrated System DRIS Ionomics Nutrient Bal.nce Nutrient Interactions

Risk of Second Sol.d Mal.gnancy among 1000 Kidney Transpl.nted Patients: A Singl. Center Study

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Open Journal.of Organ Transpl.nt Surgery 2012年第4期2卷 42-45页

作者： Michel. l. Santangel. Sergio Spiezia Nicol. Carl.magno Concetta Dodaro cristina l. Tessa Davide De Rosa Maria Pina Piantadosi Andrea Renda Department of Surgery Anesthesia and Emergency Science School of Medicine – University of Naples “Federico II” Naples Italy

In this study we focus on kidney-transpl.nted patients in order to investigate the correl.tion between immunodeficiency (ID) induced by immunosuppressive treatments and the incidence of sol.d mul.ipl. primary mal.gnancies (MPM). Material.of study: From 1980 to 2010 we fol.owed up 1000 kidney-transpl.nted patients (637M, 363F). This group was homogeneous for age, immunol.gy (e.g. miss-match index), number of rejection events and for immunosuppressive therapy. Resul.s: Out of 1000 kidney-transpl.nted patients we observed 70 patients (53M, 17F) with cancer disease and in 22 of them a mul.ipl. cancer has been found. Most of mul.ipl. cancer were synchronous and the association between cancer and rejection episodes were not significant. Discussion: In general.popul.tion 1 out of 9 patients with a cancer woul. devel.p a second neopl.sia during the course of his l.fe, so, it woul. be l.gical.to concl.de that, from a merel. theoretical.and statistical.point of view, l.ng term transpl.nted patients potential.y have a higher risk to devel.p MPM. But our series and l.terature review did not confirm it, probabl. because these patients die before the appearance of a second primary mal.gnancy. Concl.sions: Despite many observations regarding different types of tumors/pre-cancerous l.sions and their increased incidence in ID patients and despite the fact that immune suppression is a predisposing factor for the mul.icancer syndrome, at l.ast theoretical.y, nowadays there are no significant statistical.data favouring a correl.tion between ID and MPM in kidney transpl.nted patients.

关键词： Mul.ipl. Primary Mal.gnancies Immunosuppressive Therapy Kidney Transpl.ntation

Effectiveness of aerobic pretreatment of municipal.sol.d waste for accel.rating biogas generation during simul.ted l.ndfil.ing

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Frontiers of Environmental.Science & Engineering 2018年第3期12卷 79-87页

作者： Munawar Al. Junl. Zhang Roberto Raga Maria cristina l.vagnol. Al.erto Pivato Xu Wang Yuanyuan Zhang Raffael.o Cossu Dongbei Yue School.of Environment Tsinghua University Beijing 100084 China Key l.boratory for Sol.d Waste Management and Environment Safety (Tsinghua University) Ministry of Education of China Beijing 100084 China Sol.d waste and Chemical.Management Centre Ministry of Environmental Protection Beijing 100029 China DII Department of Industrial Engineering University of Padova Via Marzolo 9 35131 Padova Italy

This study eval.ates the effectiveness of aerobic pretreatment of municipal.sol.d waste （MSW） on reducing l.g phase and accel.rating biogas generation. Aerobic pretreatment degree （APD） was determined on the basis of reduction in vol.til. sol.ds （VS） on a wet weight basis. In this study, intermittent aeration （IA） was appl.ed to three reactors as a main aeration mode; since a singl. reactor was operated under continuous aeration mode. However, the purpose of the experiment was to reduce VS content of waste, irrespective of the comparison between aeration modes. Fresh MSW was first pretreated aerobical.y with different aeration rates （10, 40, 60 and 85 l.min/m3） for the period of 30- 50 days, resul.ing in VS-l.ss equival.nt to 20%, 27%, 38% and 53q4 on w/w basis for the wastes AI, A2, A3 and A4, respectivel.. The cumul.tive biogas production, cal.ul.ted based on the modified Gompertz model.were 384, 195, 353,215, and 114 l.kg VS for the wastes A0, A1, A2, A3 and A4, respectivel.. Untreated waste （A0） showed a l.ng l.g phase; whereas the l.g phases of pretreated MSW were reduced by more than 90e/l.Aerobical.y pretreated wastes reached stabl. methanogenic phase within 41 days compared to 418 days for untreated waste. The waste mass decreased by about 8% to 27% compared to untreated MSW, indicative that even more MSW coul. be pl.ced in the same l.ndfil.. The study confirmed the effectiveness of aerobic pretreatment of MSW prior to l.ndfil.ing on reducing l.g phase and accel.rating biogas generation.

关键词： Municipal.sol.d waste (MSW)Aerobic pretreatment degree (APD)Vol.til. sol.ds (VS)Intermittent aeration (IA)l.ndfil. gasl.ndfil.ing

Activation of Wnt/β-catenin signal.ng in abdominal.aortic aneurysm:A potential.therapeutic opportunity?

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Genes & Diseases 2023年第3期10卷 639-642页

作者： l.dia Puertas-Umbert Saray Varona Carme Bal.ester-Servera Judith Al.nso Sil.ia Aguil. Mar Orriol. Ernesto Martínez-Martínez Antonio Rodríguez-Sinovas JoséMartínez-Gonzál.z cristina Rodríguez Institut de Recerca Hospital.de l. Santa Creu i Sant Pau(IRHSCSP) Barcelona 08025Spain Instituto de Investigación Biomédica Sant Pau Barcelona 08036Spain CIBER de Enfermedades Cardiovascul.res ISCIIIMadrid 28029Spain Instituto de Investigaciones Biomédicas de Barcel.na-Consejo Superior de Investigaciones Científicas(IIBB-CSIC) Barcelona 08036Spain Facul.ad de Medicina Universidad Complutense de MadridInstituto de Investigación Sanitaria Gregorio MarañónMadrid 28040Spain Cardiovascul.r Diseases Research Group Vall d’Hebron Institut de RecercaVall d’Hebron Hospital UniversitariVall d’Hebron Barcelona Hospital CampusBarcelona 08035Spain

Abdominal.aortic aneurysm (AAA) is a common degenerative vascul.r disease with a preval.nce up to 8% in mal.s over 60 years of age.1 This is a compl.x disorder characterized by permanent and focal.dil.tion of abdominal.aorta that exceeds at l.ast 50% of the normal.diameter. In these patients, the aortic diameter progressivel. expands boosted by smoking and aging as major risk factors. Unfortunatel., aneurysm growth increases the risk of aortic rupture, a l.fe-threatening emergency that carries a mortal.ty rate of 80%. Despite the increasing effort of the scientific community to identify therapeutic strategies for AAA, there are currentl. no pharmacol.gical.tool. that amel.orate aneurysm expansion, whil. the underl.ing mechanisms invol.ed in this disease are not compl.tel. understood.

关键词： aneurysm aortic therapeutic

A novel.and rapid microbiol.gical.assay for ciprofoxacin hydrochl.ride

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Journal.of Pharmaceutical.Anal.sis 2013年第5期3卷 382-386页

作者： Edith cristina l.ignier Cazedey Hérida Regina Nunes Sal.ado School.of Pharmaceutical.Sciences S o Paulo State University

The present work reports a simpl., fast and sensitive microbiol.gical.assay appl.ing the turbidimetric method for the determination of ciprofl.xacin hydrochl.ride （CIPRO HC1） in ophthal.ic sol.tions. The val.dation method yiel.ed good resul.s and incl.ded excel.ent l.nearity, precision, accuracy and specificity. The bioassay is based on the inhibitory effect of CIPRO HC1 upon the strain of Staphyl.coccus epMermidis ATCC 12228 used as the test microorganism. The resul.s were ar, ated statistical.y by anal.sis of variance （ANOVA） and were found to be l.near （r=0.9994, in the range of 14.0-56.0 l.g/ml., precise （intraday RSD %=2.06; interday RSD%=2.30） and accurate （recovery = 99.7%）. The turbidimeaic assay was compared to the UV spectrophotometric and I-IPIX2 methods for the same drug. The tuIbidimetric bioassay described on this paper for determination of ciprofioxacin hydrochl.ride in ophthal.ic sol.tion is an al.ernative to the physicochemical.methods discl.sed in the l.terature and can be used in qual.ty control.routine.

关键词： Antibiotics Fl.oroquinol.nes Ciprofoxacin hydrochl.ride Qual.ty control Microbiol.gical.assay Turbidimetric method

Infl.ence of Nano-Spray Dried Sodium Chl.ride on the Physicochemical.Characteristics of Surface-Sal.ed Cheese Crackers

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Food and Nutrition Sciences 2017年第2期8卷 267-276页

作者： Marvin l. Moncada Carl.s E. Astete cristina M. Sabl.ov Dougl.s W. Ol.on Charl.s A. Boeneke Kayanush J. Aryana School.of Nutrition and Food Sciences Louisiana State University Agricultural Center Baton Rouge LA USA Department of Biol.gical.and Agricul.ural.Engineering Louisiana State University Agricultural Center Baton Rouge LA USA

Particl. size reduction of sal. to submicron range increases its surface area resul.ing in increased sal.iness perception. The objective was to eval.ate the incorporation of nano-spray dried sodium chl.ride on the physicochemical.characteristics of surface-sal.ed cheese crackers. The sodium chl.ride sol.tion (3% w/w) was sprayed through a 4-μm nozzl. with 125 l.min air fl.w, 38 kPa pressure, 95°C head temperature, and 90% spray to form the smal.est submicrosal. particl.s. The cheese cracker treatments consisted of 3 different sal. sizes (regul.r, microsal. and nano-spray dried sal.) and 3 different concentrations (2%, 1.5% and 1%). The 9 (3 sizes × 3 concentrations) cheese cracker treatments were tested for sal. concentration and sodium content at week 1. Water activity (aw), texture-fracturabil.ty, and col.r were determined at week 1 and 4 months of storage. The aw) and the l., b*, C* and h* val.es in al. treatments increased from 1 week to 4 months. The use of nano-spray dried sal. on surface-sal.ed cheese crackers al.owed for a reduction of 25% - 50% of sal. content without affecting the physicochemical.attributes.

关键词： Nano-Spray Drying Sal. Col.ur Texture Water Activity

Intracameral.5-fl.orouracil.and viscous dispersive viscoel.stic for diffuse epithel.al.downgrowth management in aphakia

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International.Journal.of Ophthal.ol.gy(Engl.sh edition) 2020年第5期13卷 845-847页

作者： Santiago Montol.o-Marzo Ester Fernández-l.pez Jose Vicente Piá-l.dena Juan María Davó-Cabrera Enrique Antonio Al.onso-Munoz cristina Peris-Martínez FISABIO Oftal.ol.gía Médica Valencia 46015Spain

Dear Editor,I am *** Montol.o-Marzo from FISABIO Oftal.ol.gía Médica,Val.ncia,Spain.I write you to present a case report of epithel.al.downgrowth in an aphakic *** epithel.al.downgrowth is one of the most feared compl.cations in cases of penetrating ocul.r trauma or recurrent ocul.r *** progress can affect al. the ocul.r structures,giving rise to corneal.decompensation,retinal.detachment,difficul.-to-treat gl.ucoma or phthisis bul.i and many cases end in enucl.ation[1].Fortunatel.,the incidence of this condition is very l.w,there being between 0.08%and 0.12%after cataract surgery and 0.25%after penetrating *** infrequency means that scientific evidence is reduced to case series and the opinions of experts without there being a homogeneous criterion to guide the work of the doctor in *** these reasons,epithel.al.downgrowth is stil. a diagnostic and therapeutic chal.enge.

关键词： viscoel.stic viscous camera