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A study on monoterpenoid-based natural deep eutectic solvents

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Green Chemical Engineering 2023年第1期4卷 99-114页

作者： Sara Rozas Lorena Zamora cristina Benito Mert Atilhan Santiago Aparicio Department of Chemistry University of BurgosBurgos09001Spain Department of Chemical and Paper Engineering Western Michigan UniversityKalamazooMI49008-5462USA

Herein,the synthesis and characterization methods of natural deep eutectic solvents based on monoterpenoids have been *** viscous fluids with suitable physicochemical properties are *** materials are non-toxic,biodegradable,and ***,they can be used to develop sustainable solvents for various processes and can find their applications in various fields.A theoretical study based on quantum chemistry and classical molecular dynamics is used for the nanoscopic characterization of structure,dynamics,and hydrogen *** reported results help analyze the properties of this new family of *** required information for developing structure–property relationships for proper solvent design to form a sustainable chemistry framework is obtained.

关键词： Natural deep eutectic solvents Terpenes DFT MD COSMO-RS CO_(2)solubility

Beyond the Expected-Residual Risk and Cases of Overload in the Context of Managing Alpine Natural Hazards

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International Journal of Disaster Risk Science 2021年第2期12卷 205-219页

作者： Sönke Hartmann Lydia Pedoth cristina Dalla Torre Stefan Schneiderbauer Eurac Research Institute for Earth Observation39100BolzanoSouth TyrolItaly Eurac Research Institute for Regional Development39100BolzanoSouth TyrolItaly Institute for Environment and Human Security United Nations University53113BonnGermany

Structural protection measures are designed to protect the population and infrastructure against natural hazards up to a specific predefined protection *** events with intensities that exceed the capacity of these protection structures are called“cases of overload”and are associated with“residual risks”that remain after the implementation of protection *** order to address residual risks and to reduce the damages from overload events,a combination of structural protection measures with additional,nonstructural measures is *** on data collected through a literature review,a questionnaire survey,expert interviews,and an expert workshop we highlight the status quo as well as key challenges of dealing with residual risks and cases of overload in Alpine countries in the context of geohydrological hazards and gravitational mass *** present a holistic conceptual framework that describes the relationships of residual risks,cases of overload,and protection goals in the context of both risk governance and integrated risk *** framework is valuable for decision makers aiming at an improved management of natural hazards that takes adequate account of residual risk and cases of overload in Alpine countries and mountain areas worldwide.

关键词： Alpine countries Cases of overload Integrated risk management Natural hazards Residual risk Risk governance

Novel synthesis method combining a foaming agent with freeze-drying to obtain hybrid highly macroporous bone scaffolds

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Journal of Materials Science & Technology 2020年第8期36卷 52-63页

作者： Paulina Kazimierczak Aleksandra Benko Krzysztof Palka cristina Canal Dorota Kolodynska Agata Przekora Department of Biochemistry and Biotechnology Medical University of LublinChodzki 120-093LublinPoland AGH University of Science and Technology Faculty of Materials Science and CeramicsA.Mickiewicza 30 Ave.30-059KrakowPoland Department of Materials Engineering Lublin University of TechnologyNadbystrzycka 3620-618LublinPoland Biomaterials Biomechanics and Tissue Engineering GroupDepartment of Materials Science and MetallurgyUniversitat Politècnica de CatalunyaBarcelona08019Spain Research Centre in Multiscale Science and Engineering Universitat Politècnica de CatalunyaBarcelona08019Spain Department of Inorganic Chemistry Maria Curie-Sklodowska UniversityMaria Curie Sklodowska Sq.220-031LublinPoland

Three-dimensional macroporous scaffolds are commonly used in bone tissue engineering applications since they provide sufficient space for cell migration and proliferation, facilitating bone ingrowth and implant vascularisation. The aim of this work was to combine two simple methods, freeze-drying and gas-foaming, in order to fabricate highly macroporous bone scaffolds made of chitosan/agarose matrix reinforced with nanohydroxyapatite. The secondary goal of this research was to comprehensively assess biomedical potential of developed biomaterials. In this work, it was demonstrated that simultaneous application of freeze-drying and gas-foaming technique allows to obtain hybrid(as proven by ATR-FTIR)macroporous bone scaffolds(pore diameter > 50 um) characterized by high open(70%) and interconnected porosity. Novel scaffolds were non-toxic, favoured osteoblasts adhesion and growth and induced apatite formation on their surfaces, indicating their high bioactivity that is essential for good implant osseointegration. Biomaterials were also prone to enzymatic degradation, degradation in acidified microenvironment(e.g. osteoclast-mediated), and slow degradation under physiological p H of ***, the scaffolds revealed microstructure(70% open porosity, SSA approx. 30 m2/g, high share of macropores with diameter in the range 100-410 um) and compressive strength(1–1.4 MPa) comparable to cancellous bone, indicating that they are promising implants for cancellous bone regeneration.

关键词： Agarose Chitosan Nanohydroxyapatite Biomaterial porosity Biodegradation Cryogel

Occurrence of human pathogenic viruses in drinking water and in its sources:A review

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Journal of Environmental Sciences 2023年第10期132卷 145-161页

作者： Marco Panizzolo Marta Gea Elisabetta Carraro Giorgio Gilli Silvia Bonetta cristina Pignata Department of Public Health and Pediatrics University of TorinoPiazza Polonia 9410126TorinoItaly Department of Life Sciences and Systems Biology University of Torinovia Accademia Albertina 1310123TorinoItaly

Since many waterborne diseases are caused by human pathogenic viruses,virus monitoring of drinking water(DW)and DW sources is crucial for public ***,the aim of this review was to describe the occurrence of human pathogenic viruses in DW and DW sources;the occurrence of two viruses proposed as novel indicators of human faecal contamination(Peppermild mottle virus and Tobacco mosaic virus)was also *** research was focused on articles that assessed viral occurrence using molecular methods in the surface water used for DW production(SW-D),groundwater used for DW production(GW-D),DW and bottled-DW(BW).A total of 1544 studies published in the last 10 years were analysed,and 79 were ultimately *** considering the detection methods,filtration is the most common concentration technique,while quantitative polymerase chain reaction is the most common quantification *** virus occurrence in SW-D,GW-D,and DW,high percentages of positive samples were reported for adenovirus,polyomavirus and Pepper mild mottle *** genomes were frequently detected in SW-D and rarely in GW-D,suggesting that GW-D may be a safe DW *** genomes were also detected in DW,posing a possible threat to human *** lowest percentages of positive samples were found in Europe,while the highest were found in Asia and South *** three articles assessed viral occurrence in *** review highlights the lack of method standardization and the need for legislation updates.

关键词： Drinking water Enteric virus Human health Microbial water quality Molecular methods Surface water

The relationship between fire severity and burning efficiency for estimating wildfire emissions in Mediterranean forests

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Journal of Forestry Research 2023年第5期34卷 1195-1206页

作者： Bountouraby Balde cristina Vega-Garcia Pere Joan Gelabert Aitor Ameztegui Marcos Rodrigues Department of Agriculture and Forest Engineering University of LleidaAv.Alcalde Rovira Roure19125198 LleidaSpain Department of Geography and Land Management University of ZaragozaPedro Cerbuna 1250009 SaragossaSpain

Forests are exposed to changing climatic conditions reflected by increasing drought and heat waves that increase the risk of wildfire ignition and *** variables such as rain and wind as well as vegetation structure,land configuration and forest management practices are all factors that determine the burning potential of *** assessment of emissions released by vegetation combustion is essential for determining greenhouse gases and air *** estimation of wildfire-related emissions depends on factors such as the type and fraction of fuel(i.e.,live biomass,ground litter,dead wood)consumed by the fire in a given area,termed the burning *** approaches estimate live burning efficiency from optical remote sensing *** study used a data-driven method to estimate live burning efficiency in a Mediterranean *** severity estimations from Lands at imagery(dNBR),which relate to fuel consumption,and quantitative field data from three national forest inventory data were combined to establish the relationship between burning severity and live burning *** proxies explored these relationships based on dNBR interval classes,as well as regres sion *** correlation results between live burning efficiency and dNBR for conifers(R=0.63)and broad-leaved vegetation(R=0.95)indicated ways for improving emissions *** estimations by severity class(low,moderate-low,moderate-high,and high)are provided for conifers(0.44-0.81)and broad-leaves(0.64-0.86),and regression models for the live fraction of the tree canopy susceptible to burning(7 branches,and leaves).The live burning efficiency values by severity class were higher than previous studies.

关键词： Forest wildfires Emissions Greenhouse gases Satellite images

Molecular regulations of circadian rhythm and implications for physiology and diseases

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Signal Transduction and Targeted Therapy 2022年第3期7卷 666-685页

作者： Francesca Fagiani Daniele Di Marino Alice Romagnoli cristina Travelli Davide Voltan Lorenzo Di Cesare Mannelli Marco Racchi Stefano Govoni cristina Lanni Department of Drug Sciences(Pharmacology Section) University of PaviaV.le Taramelli 1427100 PaviaItaly Department of Life and Environmental Sciences Polytechnic University of Marchevia Brecce Blanche60131 AnconaItaly New York-Marche Structural Biology Center(NY-MaSBiC) Polytechnic University of Marchevia Brecce Bianche60131 AnconaItaly NEUROFARBA Department University of FlorenceFlorenceItaly

The term"circadian rhythms"describes endogenous oscillations with ca.24-h period associated with the earth’s daily rotation and light/dark *** rhythms reflect the existence of an intrinsic circadian clock that tempor... 详细信息

关键词： rotation earth Molecular

Competitive role of nitrogen functionalities of N doped GO and sensitizing effect of Bi_(2)O_(3)QDs on TiO_(2)for water remediation

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Journal of Environmental Sciences 2021年第10期33卷 107-119页

作者： Saima Noor Shamaila Sajjad Sajjad Ahmed Khan Leghari cristina Flox Saeed Ahmad International Islamic University Islamabad 44000Pakistan Department of Chemistry and Materials Science Aalto UniversityEspoo 16100Fl-00076Finland Pakistan Institute of Engineering and Applied Sciences Islamabad 44000Pakistan Department of Applied Physics Aalto UniversityEspoo 15100Fl-00076Finland

The promising solar irradiated photocatalyst by pairing of bismuth oxide quantum dots(BQDs)doped TiO_(2)with nitrogen doped graphene oxide(NGO)nanocomposite(NGO/BQDs-TiO_(2))was *** was used for degradation of organic pollutants like 2,4-dichlorophenol(2,4-DCP)and stable dyes,*** B and Congo Red.X-ray diffraction(XRD)profile of NGO showed reduction in oxygenic functional groups and restoring of graphitic crystal *** characteristic diffraction peaks of TiO_(2)and its composites showed crystalline anatase TiO_(2).Morphological images represent spherical shaped TiO_(2)evenly covered with BQDs spread on NGO *** surface linkages of NO-O-Ti,C-O-Ti,Bi-O-Ti and vibrational modes are observed by Fourier transform infrared spectroscopy(FTIR)and Raman *** and NGO modified TiO_(2)results into red shifting in visible region as studied in diffused reflectance spectroscopy(DRS).NGO and BQDs in TiO_(2)are linked with defect centers which reduced the recombination of free charge carriers by quenching of photoluminescence(PL)intensities.X-ray photoelectron spectroscopy(XPS)shows that no peak related to C-O in NGO/BQDs-TiO_(2)is *** indicated that doping of nitrogen into GO has reduced some oxygen functional *** functionalities in NGO and photosensitizing effect of BQDs in ternary composite have improved photocatalytic activity against organic *** byproducts during photo degradation process of 2,4-DCP were studied through high performance liquid chromatography(HPLC).Study of radical scavengers indicated that O_(2)^(·-) has significant role for degradation of 2,*** investigations propose that fabricated nanohybrid architecture has potential for degradation of environmental pollutions.

关键词： Bi_(2)O_(3)quantum dots Nitrogen doped graphene oxide Nitrogen defects TiO_(2) 2,4-Dichlorophenol Water treatment

The challenge of drug resistance in pancreatic ductal adenocarcinoma:a current overview

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Cancer Biology & Medicine 2019年第4期16卷 688-699页

作者： Francisco Quinonero cristina Mesas Kevin Doello Laura Cabeza Gloria Perazzoli cristina Jimenez-Luna Ana Rosa Rama Consolación Melguizo Jose Prados Institute of Biopathology and Regenerative Medicine(IBIMER) Center of Biomedical Research(CIBM)University of Gran adaz Gran ada 18100Spain Department of An atomy and Embryology Faculty of Medici neUn iversity of Gran adaGranada 18071Spain Instituto Biosanitario de Granada(ibs.GRANADA) Granada 18014Spain Medical Oncology Service Virgen de las Nieves HospitalGranada 1812Spain Department of Oncology Ludwig Institute for Cancer ResearchUniversity of LausanneEpalinges 1066Switzerland Department of Health Scienee University of JaenJa6n 23071Spain

Pancreatic ductal adenocarcinoma(PDAC)has one of the highest mortality rates among all cancer *** delayed diagnosis precludes curative resection,thus most of the current therapies against PDAC are based on chemo-and ***,these strategies are insufficient to improve its poor *** the advances made in chemotherapy(***-paclitaxel and gemcitabine),many patients with PDAC are unable to benefit from them due to the rapid development of drug ***,more than 165 genes have been found to be implicated in drug resistance of pancreatic tumors,including different integrins,mucins,NF-κB,RAS and ***,drug resistance in PDAC is thought to be mediated by the modulation of miRNAs(***-21,miRNA-145 and miRNA-155),which regulate genes that participate in cell proliferation,invasion and ***,cancer stem cells are intimately related to drug resistance in PDAC due to their ability to overexpress ABC genes-involved in drug transport-,and enzymes such as aldehyde dehydrogenases-implicated in cellular drug metabolism-and poly(ADP-ribose)polymerases-involved in drug-induced DNA damage *** the mechanisms involved in drug resistance will contribute to the development of efficient therapeutic strategies and to improve the prognosis of patients with PDAC.

关键词： Pancreatic ductal adenocarcinoma chemotherapy drug resistance cancer stem cells therapeutic strategies

Dual role of FGF in proliferation and endoreplication of Drosophila tracheal adult progenitor cells

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Journal of Molecular Cell Biology 2020年第1期12卷 32-41页

作者： cristina de Miguel Josefa Cruz David Martin Xavier Franch-Marro Institute of Evolutionary Biology(Consejo Superior de Investigaciones Cientificas-Universitat Pompeu Fabra) Passeig Maritim de la Barceloneta 3708003 BarcelonaSpain

Adult progenitor cells activation is a key event in the formation of adult *** Drosophilat formation of abdominal adult trachea depends on the specific activation of tracheal adult progenitors(tracheoblasts)at the Tr4 and Tr5 spiracular *** of these tracheoblasts generates a pool of tracheal cells that migrate toward the posterior part of the trachea by the activation of the branchless/fibroblast growth factor(Bnl/FGF)signaling to form the abdominal adult ***,we show that,in addition to migration,Bnl/FGF signaling,mediated by the transcription factor Pointed,is also required for tracheoblast *** tracheoblast activation relies on the expression of the FGF ligand bnl in their nearby ***,we show that,in the absence of the transcription factor Cut(Ct),Bnl/FGF signaling induces endoreplication of tracheoblasts partially by promoting fizzy-related ***,our results suggest a dual role of Bnl/FGF signaling in tracheoblasts,inducing both proliferation and endoreplication,depending on the presence or absence of the transcription factor Ct,respectively.

关键词： FGF trachea adult progenitors cut proliferation endoreplication Pnt Fzr