Dual role of FGF in proliferation and endoreplication of Drosophila tracheal adult progenitor cells
作者机构：Institute of Evolutionary Biology(Consejo Superior de Investigaciones Cientificas-Universitat Pompeu Fabra)Passeig Maritim de la Barceloneta 3708003 BarcelonaSpain
出 版 物：《Journal of Molecular Cell Biology》 (分子细胞生物学报（英文版）)
年 卷 期：2020年第12卷第1期
页 面：32-41页
核心收录：
学科分类：0710[理学-生物学] 1002[医学-临床医学] 07[理学] 071009[理学-细胞生物学] 09[农学] 0901[农学-作物学] 090102[农学-作物遗传育种]
基 金：provided by the Spanish Ministerio de Economia, Industria y Competitividad (MINECO) and Agencia Estatal de Investigacion (AEI) by the Catalan Government Generalitat de Catalunya from the Spanish MINECO, and C.d.M. was supported by FPI from the Spanish MINECO
主 题：FGF trachea adult progenitors cut proliferation endoreplication Pnt Fzr
摘 要：Adult progenitor cells activation is a key event in the formation of adult *** Drosophilat formation of abdominal adult trachea depends on the specific activation of tracheal adult progenitors(tracheoblasts)at the Tr4 and Tr5 spiracular *** of these tracheoblasts generates a pool of tracheal cells that migrate toward the posterior part of the trachea by the activation of the branchless/fibroblast growth factor(Bnl/FGF)signaling to form the abdominal adult ***,we show that,in addition to migration,Bnl/FGF signaling,mediated by the transcription factor Pointed,is also required for tracheoblast *** tracheoblast activation relies on the expression of the FGF ligand bnl in their nearby ***,we show that,in the absence of the transcription factor Cut(Ct),Bnl/FGF signaling induces endoreplication of tracheoblasts partially by promoting fizzy-related ***,our results suggest a dual role of Bnl/FGF signaling in tracheoblasts,inducing both proliferation and endoreplication,depending on the presence or absence of the transcription factor Ct,respectively.
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