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Opioid receptors:single molecule studies shed light on mechanisms of efficacy

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Signal Transduction and Targeted Therapy 2024年第9期9卷 3555-3556页

作者： cornelius Krasel Moritz bünemann Institute for Pharmacology and Clinical Pharmacy Philipps-University MarburgMarburgGermany

In a study recently published in Nature,Zhao et al.1 investigate the conformational dynamics of theμ-opioid receptor(μOR).They found evidence for previously unknown conformations of this receptor which could eventually improve the therapy of severe ***μOR is the primary target of opioids,the most potent painkillers ***,their use is often complicated by undesirable side effects such as respiratory depression and addiction.

关键词： eventually conformational conformation

Wave packet dynamics of nonlinear Gazeau–Klauder coherent states of a position-dependent mass system in a Coulomb-like potential

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Chinese Physics b 2021年第6期30卷 154-163页

作者： Faustin blaise Migueu Mercel Vubangsi Martin Tchoffo Lukong cornelius Fai Unitéde Recherche de Matière Condensée d'Électronique et de Traitement du SignalDépartement de PhysiqueFacultédes SciencesUniversitéde DschangB.P:67DschangCameroon Computational Material Science Laboratory Higher Technical Teachers'Training College BambiliUniversity of BamendaPO Box 39BamendaCameroon Centre d'Études et de Recherches en Agronomie et en biodiversité Universitéde DschangDschangCameroon

AD = 1 position-dependent mass approach to constructing nonlinear quantum states for a modified Coulomb potential is used to generate Gazeau–Klauder coherent states. It appears that their energy eigenvalues are scaled down by the quantum number and the nonlinearity coefficient. We study the basic properties of these states, which are found to be undefined on the whole complex plane, and some details of their revival structure are discussed.

关键词： deformed Coulomb potential energy spectrum coherent states photon number distribution quantum revivals

Diabetic heart disease:A clinical update

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World Journal of Diabetes 2021年第4期12卷 383-406页

作者： Jake Rajbhandari cornelius James Fernandez Mayuri Agarwal beverly Xin Yi Yeap Joseph M Pappachan College of Medical and Dental Sciences University of Birmingham Medical SchoolBirmingham B152THUnited Kingdom Department of Endocrinology and Metabolism Pilgrim HospitalBoston PE219QSUnited Kingdom Department of Medicine The University of Manchester Medical SchoolManchester M139PLUnited Kingdom Department of Endocrinology and Metabolism Lancashire Teaching Hospitals NHS TrustPreston PR29HTUnited Kingdom Faculty of Science Manchester Metropolitan UniversityManchester M156BHUnited Kingdom Faculty of biology Medicine and HealthThe University of ManchesterManchester M139PLUnited Kingdom

Diabetes mellitus(DM) significantly increases the risk of heart disease,and DMrelated healthcare expenditure is predominantly for the management of cardiovascular *** heart disease is a conglomeration of coronary artery disease(CAD),cardiac autonomic neuropathy(CAN),and diabetic cardiomyopathy(DCM).The Framingham study clearly showed a 2 to 4-fold excess risk of CAD in patients with *** mechanisms,clinical presentation,and management options for DM-associated CAD are somewhat different from CAD among *** prevalence at a lower age and more aggressive disease in DM-associated CAD make diabetic individuals more vulnerable to premature *** common among diabetic individuals,CAN and DCM are often under-recognised and undiagnosed cardiac *** and functional alterations in the myocardial innervation related to uncontrolled diabetes result in damage to cardiac autonomic nerves,causing ***,damage to the cardiomyocytes from complex pathophysiological processes of uncontrolled DM results in DCM,a form of cardiomyopathy diagnosed in the absence of other causes for structural heart *** optimal management of DM from early stages of the disease can reduce the risk of diabetic heart disease,it is often impractical in the real world due to many ***,it is imperative for every clinician involved in diabetes care to have a good understanding of the pathophysiology,clinical picture,diagnostic methods,and management of diabetes-related cardiac illness,to reduce morbidity and mortality among *** clinical review is to empower the global scientific fraternity with up-to-date knowledge on diabetic heart disease.

关键词： Diabetic heart disease Type 2 diabetes mellitus Type 1 diabetes mellitus Coronary artery disease Cardiovascular disease Cardiac autonomic neuropathy Diabetic cardiomyopathy

Time course of plant diversity effects on Centaurea jacea establishment and the role of competition and herbivory

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Journal of Plant Ecology 2010年第2期3卷 109-121页

作者： Norma Nitschke Anne Ebeling Tanja Rottstock Christoph Scherber cornelius Middelhoff Sylvia Creutzburg Alexandra Weigelt Teja Tscharntke Markus Fischer Wolfgang WWeisser Institute of Ecology Friedrich-Schiller-University JenaDornburger Strasse 15907743 JenaGermany Agroecology Georg-August-University GottingenWaldweg 2637073 GottingenGermany Institute of biochemistry and biology University of PotsdamMaulbeerallee 114469 PotsdamGermany Max-Planck-Institute for biogeochemistry Hans-Knoll-Strasse 1007745 JenaGermany Institute of biology I University of LeipzigJohannisallee 21-2304103LeipzigGermany Institute of Plant Sciences University of BernAltenbergrain 213013 BernSwitzerland

Aims Invasion resistance in experimental plant communities is known to increase with increasing diversity and further to depend on the presence of particular functional *** test whether these effects also hold true for the invader establishment phase beyond the seedling stage,we studied survival and performance of Centaurea jacea L.(brown knapweed)planted into experimental grassland communities of varying plant biodiversity over three consecutive ***,we analysed the role of insect herbivory and biomass of the recipient community for mediating diversity *** In 2005,seedlings of Centaurea were transplanted into experimental grassland communities(the Jena Experiment)covering a species richness(1–60)and functional group richness(1–4)*** of these transplants and the community surrounding them in each plot were sprayed with insecticide while the other half served as *** 2006 and 2007(during the second and third year after transplantation),we recorded survival,growth-related(*** biomass,height)and reproduction-related traits(*** of flower heads).Annual data on community aboveground biomass served as covariate to investigate mediating effects of aboveground competition with the recipient *** Findings Species richness was the most important factor responsible for Centaurea *** levels of diversity decreased survival and all performance traits in both *** diversity effects were partly driven by community biomass,but not fully explained by that covariate,suggesting the importance also of further *** influence of functional group richnesswas strong in the second year after transplantation and weaker in the third *** the particular functional groups,only the presence of legumes showed strong negative effects on Centaurea survival and weak negative effects on growth and reproduction,the latter two being mediated by *** herbivore reduction considerably b

关键词： invasion resistance aboveground competition biomass Jena Experiment experimental grassland Centaurea jacea

Studying the Impact of Anions Pre-generated Iron Corrosion Products on the Efficiency of Contaminant Removal in Fe0/H2O Systems

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Journal of Environmental Science and Engineering(b) 2018年第1期7卷 1-10页

作者： cornelius Tsamo Djibrine Sali Meali Hippolyte Todou Assaouka Department of Chemistry Maroua UniversityMaroua 55Cameroon Department of Agricultural and Environmental Engineering Bamenda UniversityBambili 39Cameroon

The effects of Fe0 pre-corrosion by water,bicarbonate,chloride,phosphate and sulfate on the efficiency of Fe0 systems for water treatment were *** experiments were conducted for a total duration of 72 days with Mb(Methylene blue)and MO(Methyl Orange).The efficiency of used Fe0 was assessed by characterizing the extent of Mb and MO discoloration,pH variation and amount of iron released as a function of anion *** dye addition,used Fe0 in Fe0/sand and 100%Fe0 systems was allowed to equilibrate with H2O or the anionic solution for 0 to 44 ***-corrosion has low impact on Mb discoloration but has negative impact on MO *** to the reference system(anion free system,H2O),all the tested anions enhanced Mb discoloration but decreased that of ***4 2-and HCO3-severely affects MO *** pH of the medium governs the discoloration with Mb performing better at higher pH and MO doing same at lower *** Mb,Fe0/sand system shows higher efficiency than 100%Fe0 *** the two systems show similar efficiency for *** will help in the design and functioning of Fe0 based filtration systems and other water treatment designs using Fe0.

关键词： Corrosion products dye discoloration major anions pre-corrosion zero-valent iron

Influence of CRT Glass Quantity on the Properties of Red Mud-CRT Glass Ceramics Fired at Different Temperatures

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材料科学与工程（中英文b版） 2019年第4期9卷 133-143页

作者： Paul Nestor Djomou Djonga cornelius Tsamo Harouna Massai Department of Chemistry Faculty of ScienceUniversity of MarouaMarouaP.O.Box 46Cameroon Department of Chemistry Higher Teachers’Training CollegeUniversity of MarouaMarouaP.O.Box 55Cameroon

This paper reports the production of ceramics using CRT(cathode ray tube)glass and red mud by varying the amount of waste glass and firing from 700-950℃.The raw materials were characterized using chemical composition,IR(infra-red spectroscopy),XRD(X-ray diffraction),DSC-TGA(differential scanning calorimetry-thermo gravimetric analyses)and SEM(scanning electron microscopy)*** ceramic specimen was produced by mixing a constant quantity of red mud and 0%-40%of waste glass,then firing from 700-950℃.The linear shrinkage,water absorption,apparent porosity,bulk density,weight loss on ignition,flexural strength and chemical resistance test were used to evaluate the produced *** materials had good fluxing properties which were improved with *** the specimens produced had water absorption values below the maximum value of 20% specified by the norm for roofing tiles while specimens with 30%-40% CRT glass and fired at 850°C,and specimens with 20%-40% CRT glass and fired at 950℃ had water absorption values below 10%,which is the norm for ceramic *** specimens 0%-40% CRT glass fired at 950℃,specimens 5%-40% CRT glass fired at 850℃,specimens 10%-40% CRT glass fired at 750℃ and specimen with 20%CRT glass fired at 700℃,water absorption values were all lower than 17% which is ASTM C62 specifications for *** norm of flexural strength for floor tiles>25 MPa but all values were less than 25 *** ceramic shows a maximum loss of 0.10%in HNO3 against 0.06%for *** two waste materials can effectively be used to produce ceramic materials with good properties.

关键词： CRT glass red mud ceramics firing roofing tiles floor tiles

Regression Equations for Predicting the Effect of Tine Width on Draught and Soil Translocation in Moderately Fine Textured Soil

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Journal of Environmental Science and Engineering(b) 2012年第6期1卷 820-825页

作者： Seth Idowu Manuwa Olugboyega cornelius Ademosun Adebola Adesina Department of Agricultural Engineering School of Engineering and Engineering Technology The Federal University of TechnologyAkure 704 Nigeria

Experiments were conducted in an indoor soil bin filled with sandy clay loam soil. Tests were carried out with tillage tines to study the effect tool width on soil disturbance and draught. Depth of operation was held constant at 35 mm and then at 70 mm while speed was varied at three levels of 1.0, 3.6 and 9.0 km/h. The widths of the tines tested were 10, 20, 31, 40, 51, 88, 126, 163 and 200 mm. The cone penetration resistance of the soil varied from 400 to 600 kPa. Draught was measured with a load cell while soil disturbance was measured with a profile meter and meter rule. Draught increased at a decreasing rate with tine width. Quadratic models best fitted the data points with high R2 values. The increase in draught was affected by the forward speed since higher draught values were obtained at higher speed. Results show that the parameters of soil disturbance increased with increase in tine width, except height of ridge （hr）, which did not show any specific trend. The specific draught was highest （10.63 N/cm） with tine T20 while Tine T1 had the least specific draught of 5.2 N/cm.

关键词： Soil bin tillage tines draught soil disturbance parameters rake angle forward speed regression analysis

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美国梦:正慢慢变成现实还是一个萎缩的幻影

浙江传媒学院学报 2015年第5期22卷 49-55页

作者： cornelius b.Pratt 黄晓琴美国天普大学战略传播系浙江传媒学院国际文化传播学院

本研究比较了中国梦和美国梦的异同,提出为什么美国人仍然追逐着美国梦等问题。美国联邦政府为稳定和刺激经济的货币政策以及高就业率是保证美国梦的关键。当下美国处于2008年9月以来的最低失业率,表明就业市场有所改善,自2013年以来增... 详细信息

本研究比较了中国梦和美国梦的异同,提出为什么美国人仍然追逐着美国梦等问题。美国联邦政府为稳定和刺激经济的货币政策以及高就业率是保证美国梦的关键。当下美国处于2008年9月以来的最低失业率,表明就业市场有所改善,自2013年以来增长了1.9%。本研究发现当人们对实现美国梦抱有乐观态度时,也许往往高估向上的动力,而经济指标指向一个不温不火的信心:美国梦仍然强劲,70%的美国人仍抱有信心。

关键词：美国梦中国梦教育保罗和黛西索罗斯新移民奖学金

Thermodynamic Properties and Decoherence of a Central Electron Spin of Atom Coupled to an Anti-Ferromagnetic Spin bath

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Journal of Quantum Information Science 2013年第1期3卷 10-15页

作者： Martin Tchoffo Georges Collince Fouokeng Lukong cornelius Fai Mathurin Esouague Ateuafack Mesoscopic and Multilayer Structures Laboratory Department of Physics Faculty of Science University of Dschang Dschang Cameroon

The decoherence of a central electron spin of an atom coupled to an anti-ferromagnetic spin bath in the presence of a time varying b-Field (VbF) is investigated applying the Holstein-Primak off and bloch transformations approaches. The boltzmann entropy and the specific heat capacity at a given temperature are obtained and show the correlation of the coupling of the spin bath and the electron spin of the central atom. At low frequencies the coherence of the coupled system is dominated by the magnetic field intensity. At low VbF intensity, there is decrease in entropy and heat capacity at increase external magnetic field that show the decoherence suppression of the central electron spin atom. The crossing observed in the specific heat capacity corresponds to the critical field point bc of the system which represents the point of transition from the anti-ferromagnetic system to the ferromagnetic one.

关键词： Entropy Specific Heat Capacity Varying b-Field Decoherence