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Ink-structing the future of vascular tissue engineering:a review of the physiological bioink design

Bio-Design and Manufacturing 2024年第2期7卷 181-205页

作者： Judith Synofzik Sebastian Heene Rebecca Jonczyk cornelia Blume Institute for Technical Chemistry Leibniz University Hannover30167 HannoverGermany

Three-dimensional(3D)printing and bioprinting have come into view for a plannable and standardizable generation of implantable tissue-engineered constructs that can substitute native tissues and *** tissue-engineered structures are intended to integrate with the patient’s *** tissue engineering(TE)is relevant in TE because it supports the sustained oxygenization and nutrition of all tissue-engineered *** have a specific role,representingthenecessarymedium for printability and vascular cell *** review aims to understand the requirements for the design of vascular ***,an in-depth analysis of vascular cell interaction with their native environment must be gained.A physiological bioink suitable for a tissue-engineered vascular graft(TEVG)must not only ensure good printability but also induce cells to behave like in a native vascular vessel,including self-regenerative and growth *** review describes the general structure of vascular walls with wall-speciﬁc cell and extracellular matrix(ECM)components and biomechanical properties and ***,the physiological role of vascular ECM components for their interaction with vascular cells and the mode of interaction is *** currently available or imaginable bioinks are described from physiological matrix proteins to nonphysiologically occurring but natural chemical compounds useful for vascular *** physiological performance of these bioinks is evaluated with regard to biomechanical properties postprinting,with a view to current animal studies of 3D printed vascular ***,the main challenges for further bioink development,suitable bioink components to create a self-assembly bioink concept,and future bioprinting strategies are *** concepts are discussed in terms of their suitability to be part of a TEVG with a high potential for later clinical use.

关键词： Vascular wall histology Vascular cells Microenvironment Extracellular matrix Cell–matrix interaction Bioink Printability

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A novel homozygous missense variant in ARSk causes MPS X,a new subtype of mucopolysaccharidosis

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Genes & Diseases 2024年第3期11卷 87-90页

作者： Miao Sun cornelia k.kam.nsky Philip Deppe Mai-Brittllse Frederic M.Vaz Barbara Plecko Torben Lubke Linda M.Randolph Division of Genomic Medicine Department of Pathology and Laboratory MedicineChildren's Hospital Los Angeles/Keck School of Medicine of USCLos AngelesCA 90027USA Department of Radiology Children's Hospital Los Angeles/Keck School of Medicine of USCLos AngelesCA 90027USA Department of Chemistry BiochemistryBielefeld UniversityBielefeld 33615Germany Amsterdam UMC Location University of Amsterdam Department of Clinical Chemistry and PediatricsLaboratory Genetic Metabolic DiseasesEmma Children's HospitalMeibergdreef 9Amsterdam 1100 DEthe Netherlands Amsterdam Gastroenterology Endocrinology Metabolism Inborn Errors of MetabolismAmsterdam 1105 BKthe Netherlands Core Facility Metabolomics Amsterdam UMC Location University of AmsterdamAmsterdam 1100DDthe Netherlands Department of Pediatrics Division of General PediatricsMedical Universityof GrazGraz8036Austria Division of Medical Genetics Department of PediatricsChildren's Hospital Los Angeles/Keck School of Medicine of USCLos AngelesCA 90027USA

Mucopolysaccharidoses(MPS)are a group of rare inborn errors of metabolism caused by defective lysosomal enzymes which prevent cells from degrading and recycling certain carbohydrates and fats,resulting in the storage of glycosaminoglycans in cells throughout the *** leads to multisystem abnormalities involving bone,connective tissues,brain,blood,spinal cord,skin,and other tissues.

关键词： metabolism doses polys

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Prospective cohort study on facial profile changes in infants with Robin sequence and healthy controls

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World Journal of Pediatrics 2024年第6期20卷 581-589页

作者： cornelia Wiechers Julian Sowula karen kreutzer Christoph E.Schwarz Christina Weismann Michael krimmel Christian F.Poets Bernd koos Department of Neonatology Tuebingen University HospitalCalwerstrasse 772076 TuebingenGermany Center for Cleft Lip Palate and Craniofacial MalformationsTuebingen University HospitalTuebingenGermany Department of Orthodontics Tuebingen University HospitalTuebingenGermany Department of Oral and Maxillofacial Surgery Tuebingen University HospitalTuebingenGermany

Background Various conservative and surgical approaches exist to treat Robin sequence(RS),but their effects on facial profile and mandibular catch-up growth are unclear.A functional treatment concept,used in our centre for 25 years,includes an individualized palatal plate with a velo-pharyngeal extension and intensive feeding *** We performed a prospective study to objectively describe facial profiles in infants with RS treated with the above *** with isolated RS were admitted to our tertiary perinatal and national referral centre for craniofacial malformations between May 2018 and Nov *** with RS received 3D-photographs during clinically indicated *** controls were recruited from Dec 2018 to Sep 2019 and received 3D-photographs every 3 *** digitally measured jaw index(JI),defined as alveolar overjet(O)x maxillary arch(U)/mandibular arch(L),and the soft tissue reference points A’-point,Nasion’,B’-point angle(ANB’),describing the relative position of maxilla to mandible,were *** mixed models were used to examine time trajectories in JI and ANB’.Results A total of 2073D images,obtained in 19 infants with RS and 32 controls,were *** and ANB’decreased over time in both groups[for JI−0.18(95%CI−0.25 to−0.10);for ANB’:−0.40°per month[(95%CI−0.48 to−0.32)]]but remained lower in controls[for JI−2.5(95%CI−3.2 to−1.8);for ANB’-1.7°(95%CI−2.4 to−1.0)].Also,the ANB’model showed a significant effect of the interaction term diagnosis x *** Based on longitudinal 3D images,we describe changes in objective parameters of facial profile in infants with and without RS during the first year of *** findings indicate catch-up growth in infants treated for RS.

关键词： Infant Mandibular catch-up growth Pre-epiglottic Baton Plate Robin sequence Three-dimensional photography

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Eight of ten patients return to daily activities, work, and sports after total knee arthroplasty

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World Journal of Orthopedics 2024年第7期15卷 608-617页

作者： Maud cornelia Wilhelmina Maria Peters Yvette Pronk Justus-Martijn Brinkman Department of Research Kliniek ViaSanaMill 5451 AANetherlands Department of Orthopedic Surgery Kliniek ViaSanaMill 5451 AANetherlands

BACkGROUND Besides return to work(RTW)and return to sports(RTS),patients also prefer to return to daily activities(RTA)such as walking,sleeping,grocery shopping,and domestic work following total knee arthroplasty(TkA).However,evidence on the timelines and probability of patients’RTA is *** To assess the percentage of patients able to RTA,RTW,and RTS after TkA,as well as the timeframe and influencing factors of this *** A retrospective cohort study with prospectively collected data was conducted at a medium-sized Dutch orthopedic *** of RTA,RTW,and RTS were performed at 3 mo and/or 6 mo following *** factors en-compassed patient characteristics,surgical characteristics,and preoperative patient-reported *** TkA patients[n=2063;66 years old(interquartile range[IQR]:7 years);47%male;28 kg/m2(IQR:4 kg/m2)]showed RTA ranging from 28%for kneeling to 94%for grocery shopping,with 20 d(IQR:27 d)spent for putting on shoes to 74 d(IQR:57 d)for *** rates varied from 62%for medium-impact work to 87%for low-impact work,taking 33 d(IQR:29 d)to 78 d(IQR:55 d).RTS ranged from 48%for medium-impact sports to 90%for low-impact sports,occurring within 43 d(IQR:24 d)to 90 d(IQR:60 d).One or more of the investigated factors influenced the return to each of the 14 activities examined,with R²values ranging from 0.013 to *** Approximately 80%of patients can RTA,RTW,and RTS within 6 mo after *** is not consistently in-fluenced by predictive *** help set realistic pre-and postoperative expectations.

关键词： knee Arthroplasty Replacement Return to work Return to daily activities Return to sports

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Pseudospin-2 in photonic chiral borophene

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Photonics Research 2023年第5期11卷 869-877页

作者： PHILIP MENZ HAISSAM HANAFI DANIEL LEYkam JÖRG IMBROCk cornelia DENZ Institute of Applied Physics University of MuensterMuenster 48149Germany Centre for Quantum Technologies National University of SingaporeSingapore 117543Singapore Physikalisch-Technische Bundesanstalt(PTB) 38116 BraunschweigGermany

Pseudospin is an angular momentum degree of freedom introduced in analogy to the real electron spin in the effective massless Dirac-like equation used to describe wave evolution at conical intersections such as the Dirac cones of ***,we study a photonic implementation of a chiral borophene allotrope hosting a pseudospin-2 conical intersection in its energy-momentum *** presence of this fivefold spectral degeneracy gives rise to quasiparticles with pseudospin up to±*** report on conical diffraction and pseudospin-orbit interaction of light in photonic chiral borophene,which,as a result of topological charge conversion,leads to the generation of highly charged optical phase vortices.

关键词： spectrum chiral momentum

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Artificial intelligence as a noninvasive tool for pancreatic cancer prediction and diagnosis

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World Journal of Gastroenterology 2023年第12期29卷 1811-1823页

作者： Alexandra Corina Faur Daniela cornelia Lazar Laura Andreea Ghenciu Department of Anatomy and Embriology “Victor Babeș”University of Medicine and Pharmacy TimișoaraTimișoara 300041TimișRomania Department V of Internal Medicine I Discipline of Internal Medicine IVUniversity of Medicine and Pharmacy“Victor Babes”TimișoaraTimișoara 300041TimișRomania DepartmentⅢ Discipline of Pathophysiology“Victor Babeș”University of Medicine and PharmacyTimișoara 300041TimișRomania

Pancreatic cancer(PC)has a low incidence rate but a high mortality,with patients often in the advanced stage of the disease at the time of the first *** detected,early neoplastic lesions are ideal for surgery,offering the best *** lesions of the pancreas include pancreatic intraepithelial neoplasia and mucinous cystic neoplasms,with intraductal papillary mucinous neoplasms being the most commonly *** study focused on predicting PC by identifying early signs using noninvasive techniques and artificial intelligence(AI).A systematic English literature search was conducted on the PubMed electronic database and other *** obtained a total of 97 studies on the subject of pancreatic *** final number of articles included in our study was 44,34 of which focused on the use of AI algorithms in the early diagnosis and prediction of pancreatic *** algorithms can facilitate diagnosis by analyzing massive amounts of data in a short period of *** can be made through AI algorithms by expanding image and electronic medical records databases,which can later be used as part of a screening program for the general ***-based screening models should involve a combination of biomarkers and medical and imaging data from different *** requires large numbers of resources,collaboration between medical practitioners,and investment in medical infrastructures.

关键词： Pancreatic cancer Early pancreatic lesions Pancreatic neoplasia Artificial intelligence Deep learning Machine learning Radiomics Diagnosis Pancreas

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Wheat yield prediction by zero sink and equilibrium-type soil phosphorus tests

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Pedosphere 2022年第4期32卷 543-554页

作者： Walter W.WENZEL cornelia MESMER Eric J.FLORIDA Markus PUSCHENREITER Holger kIRCHMANN Institute of Soil Research Department of Forest and Soil SciencesUniversity of Natural Resources and Life Sciences ViennaKonrad-Lorenz-Straße 24Tulln A-3430Austria College of Agriculture and Forestry Mindanao State University at NaawanNaawan 9023Philippines Department of Soil and Environment Swedish University of Agricultural SciencesBox 701475007 UppsalaLennart Hjelms väg 9Uppsala 75651Sweden

Diffusive gradients in thin films(DGT)measurements have been shown to outperform other phosphorus(P)tests in soils with strong P sorption,but this has not been confirmed for moderately weathered European *** compared the performance of DGT in predicting wheat grain yield in Swedish long-term fertility experiments with those of standard intensity(water-extractable P(P-H2O))and quantity(ammonium lactate-extractable P(P-AL))tests.A Mitscherlich-type model was used to fit wheat yield response to P application rates(0,15,30 or 35,and 45 kg P ha-1 year-1)in each individual trial replicate to estimate the maximum *** trials with clear plateau-type yield responses and the goodness of fit(R2)>0.75,relative yields(RYs)were calculated for each P treatment and plotted against the soil P test results(n=143).The goodness of the Mitscherlich-type fits decreased in the following order:DGT-measured P(P-DGT)(R2=0.35)>P-H2O(R2=0.18)>P-AL(R2=0.13).When excluding soils with P-AL:P-DGT≥0.1 L g-1,R2 was considerably improved to 0.55 for P-AL,0.46 for P-H2O,and 0.65 for P-DGT(n=61).At 95%of maximum yield,the upper limit of P deficiency for P-DGT was 44.8(the soils with P-AL:P-DGT<0.1 L g-1)and 61.9μg L-1(all soils),falling within the range reported for other European and Australian soils(6.0–142μg L-1).We show that in the investigated Swedish soils,DGT performed better than the quantity and intensity tests,which is attributed to its ability to capture P diffusion and resupply from the soil solid phase,similar to plant roots in the rhizosphere.

关键词： ammonium lactate-extractable phosphorus diffusive gradients in thin films(DGT) distribution coefficient long-term field experiment Mitscherlich-type model

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Growth efficiency,intestinal biology,and nutrient utilization and requirements of black soldier fly(Hermetia illucens)larvae compared to monogastric livestock species:a review

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Journal of Animal Science and Biotechnology 2022年第5期13卷 1262-1281页

作者： Mohammad M.Seyedalmoosavi Manfred Mielenz Teun Veldkamp Gurbuz Das cornelia C.Metges Research Institute for Farm Animal Biology(FBN) Institute of Nutritional Physiology18196 DummerstorfGermany Wageningen UR Livestock ResearchP.O.Box 3386700AH WageningenNetherlands

In recent years,interest in the larvae of black soldier fly(BSF)(Hermetia illucens)as a sustainable protein resource for livestock feed has increased ***,knowledge on the nutritional and physiological aspects of this insect,especially compared to other conventional farmed animals is *** review presents a critical comparison of data on the growth potential and efficiency of the BSF larvae(BSFL)compared to conventional monogastric livestock *** of BSFL over other monogastric livestock species includes their high growth rate and their ability to convert low-grade organic waste into high-quality protein and fat-rich biomass suitable for use in animal *** using literature data suggest that BSFL are more efficient than broilers,pigs and fish in terms of conversion of substrate protein into body mass,but less efficient than broilers and fish in utilization of substrate gross energy to gain body *** growth efficiency varies greatly depending on the nutrient quality of their dietary *** might be associated with the function of their gastrointestinal tract,including the activity of digestive enzymes,the substrate particle characteristics,and their intestinal microbial *** conceived advantage of BSFL having an environmental footprint better than conventional livestock is only true if BSFL is produced on low-grade organic waste and its protein would directly be used for human ***,their potential role as a new species to better close nutrient cycles in agro-ecological systems needs to be reconsidered,and we conclude that BSFL is a complementary livestock species efficiently utilizing organic waste that cannot be utilized by other *** addition,we provide comparative insight into morpho-functional aspects of the gut,characterization of digestive enzymes,gut microbiota and fiber ***,current knowledge on the nutritional utilization and requirements of BSFL in te

关键词： Black soldier fly Comparative growth performance Farm animals Insects as feed Intestinal function Nutrient cycles Nutrition and physiology

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Ginkgo biloba Extract EGb 761^® Improves Central Vestibular Vertigo in Patients Undergoing Vestibular Exercises: A Randomised Placebo-Controlled Trial

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Neuroscience & Medicine 2022年第3期13卷 91-102页

作者： Wolfgang Heide Birgit Adlung cornelia körtke Robert Hoerr Department of Neurology General Hospital Celle Celle Germany Private Practice for Radiology Bad Zwischenahn Germany Private Practice for Neurology Lübeck-St. Lorenz Süd Germany Research & Development Dr. Willmar Schwabe GmbH & Co. KG Karlsruhe Germany

Background: Ginkgo biloba extract EGb 761® is widely used to treat various types of vertigo. Aims: An exploratory trial was conducted to evaluate the efficacy of EGb 761® in addition to vestibular exercises in central vestibular vertigo caused by vertebro-basilar ischaemia. Subjects and Methods: In this randomised, placebo-controlled, double-blind trial, 40 patients were enrolled in the vertigo clinic of a neurological university hospital and treated with daily doses of 240 mg EGb 761® or placebo for a period of 180 days. All patients regularly performed vestibular exercises in addition. Efficacy was assessed using: a visual analogue scale for the patients to rate the overall intensity of vertigo;a numeric scale for physician-rated change;a vertigo score based on intensity, duration, and frequency of vertigo;and electronystagmography. Results: Until day 180, the mean patient-rated intensity of vertigo decreased by 46% during EGb 761® treatment and by 19% with placebo (p ® group compared to the placebo group. Nystagmus or other eye movement disorders were present only in small subgroups of patients without sufficient statistical power to detect differences between treatment groups. Conclusions: EGb 761® alleviated vertigo caused by ischaemic lesions in the brainstem or cerebellum in patients undergoing vestibular exercises.

关键词： Ginkgo biloba Extract EGb 761® Randomised Controlled Trial (RCT) Vertigo Dizziness Vestibular Exercises

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Economic implications of the sixth plenary session of the 19th CPC Central Committee for China’s Hong kong

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Economic and Political Studies 2022年第1期10卷 9-18页

作者： Terence Tai Leung Chong cornelia Yip Patrick Ming Yu Ngai Lau Chor Tak Institute of Global Economics and Finance and Department of Economics The Chinese University of Hong KongHong Kong SARChina Laboratory of Artificial Intelligence and Digital Finance Guizhou University of Finance and EconomicsGuiyangChina CUHk Business School The Chinese University of Hong KongHong Kong SARChina HkU Business School The University of Hong KongHong Kong SARChina

The sixth plenary session of the 19th Central Committee of the Communist Party of China(CPC),also known as‘the Sixth Plenum’,was successfully held in Beijing from 8 to 11 November *** passed a historic resolution on the major achievements and historical experience of the CPC over the past 100 years and set forth the direction of China’s development in the next few *** paper aims to analyse the conclusions reached in the sixth plenary session of the 19th Central Committee of the CPC and discuss its economic implications for the Hong kong SAR.

关键词： The sixth plenary session historic resolution 14th Five-year Plan China’s Hong kong

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