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COPPER AMINE OXIDASE1 （CuAO1） of Arabidopsis thaliana Contributes to Abscisic Acid- and Polyamine-lnduced Nitric Oxide Biosynthesis and Abscisic Acid Signal Transduction

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Molecular Plant 2011年第4期4卷 663-678页

作者： Rinukshi Wimalasekera corina Villar Tahmina Begum Giinther F. E. Scherer Leibniz Universitat Hannover Institute of Floriculture and Wood Science Section of Applied Molecular Physiology Herrenhauser Strasse 2 D-30419Hannover Germany Present address: Institute of Plant Research ETH Universitatstr. 2 8092 Zurich Switzerland Present address: ZMBP University of T~bingen Auf der Morgenstell 28 D-72076 Tubingen Germany

Polyamines （PA）, polyamine oxidases, copper amine oxidases, and nitric oxide （NO） play important roles in physiology and stress responses in plants. NO biosynthesis as a result of catabolism of PA by polyamine oxidases and copper amine oxidases may explain in part PA-mediated responses. Involvement of a copper amine oxidase gene, COPPER AMINE OXIDASEI （CuAO1）, of Arabidopsis was tested for its role in stress responses using the knockouts cuao1-1 and cuaol-2. PA-induced and ABA-induced NO production investigated bY fluorometry and fluorescence microscopy showed that the cuaol-1 and cuaol-2 are impaired in NO production, suggesting a function of CuAO1 in PA and ABA-mediated NO production. Furthermore, we found a PA-dependent increase in protein S-nitrosylation. The addition of PA and ABA also resulted in H2O2 increases, cuao1-1 and cuao1-2 showed less sensitivity to exogenous ABA supplementation during germination, seedling establishment, and root growth inhibition as compared to wild-type. In response to ABA treatment, expression levels of the stress-responsive genes RD29A and ADH1 were significantly lower in the knockouts. These observations characterize cuao1-1 and cuao1-2 as ABA-insensitive mutants. Taken together, our findings extend the ABA signal transduction network to include CuAO1 as one potential contributor to enhanced NO production by ABA.

关键词： COPPER AMINE OXIDASE1 polyamines nitric oxide abscisic acid signal transduction germination.

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Technical tailoring of pancreaticoduodenectomy in patients with hepatic artery anatomic variants

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Hepatobiliary & Pancreatic Diseases International 2011年第6期10卷 638-643页

作者： Cristian Lupascu Dan Andronic corina Ursulescu Ciprian Vasiluta Nutu Vlad First Surgical Unit "Gr.T.Popa" University of Medicine and Pharmacy Iasi "St.Spiridon" HospitalIndependentei Bld.1700111 IasiRomania Imaging Department "Gr.T.Popa" University of Medicine and Pharmacy Iasi"St.Spiridon" HospitalIndependentei Bld.1700111 IasiRomania Imaging Department "Gr.T.Popa" University of Medicine and Pharmacy Iasi "St.Spiridon" HospitalIndependentei Bld.1700111 IasiRomania

BACKGROUND:Pancreaticoduodenectomy is the treatment of choice for periampullary and pancreatic head *** case of hepatic artery abnormalities,early pancreatic transection during pancreaticoduodenectomy may prove inappropriate Early retroportal lamina dissection improves exposure of the superior mesenteric vessels and anatomic variants of the hepatic artery,where safeguarding is ***:We describe our early retroportal lamina approach in patients with anatomic variants of the hepatic artery before pancreatic ***:This approach was used during 42 pancreatico duodenectomies with a hepatic artery anatomic variant which was spared in 40 *** reconstruction was performed in 2 *** patients with a hepatic artery variant and adenocarcinoma involving the portomesenteric junction required venous resection and ***:Early retroportal lamina dissection during pancreaticoduodenectomy in patients with hepatic artery anatomic variants enables easier exposure,avoiding injuries that might compromise the liver arterial *** the portomesenteric vein is involved,this approach facilitates en bloc 'no touch' venous resection and reconstruction.

关键词： pancreaticoduodenectomy hepatic artery anatomic variants

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Music as medicine for traumatic brain injury:a perspective on future research directions

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Neural Regeneration Research 2024年第10期19卷 2105-2106页

作者： Anthony E.Kline Eleni H.Moschonas corina O.Bondi Department of Physical Medicine&Rehabilitation University of PittsburghPittsburghPAUSA Safar Center for Resuscitation Research University of PittsburghPittsburghPAUSA Center for Neuroscience University of PittsburghPittsburghPAUSA Department of Critical Care Medicine University of PittsburghPittsburghPAUSA Center for the Neural Basis of Cognition University of PittsburghPittsburghPAUSA Department of Psychology University of PittsburghPittsburghPAUSA Department of Neurobiology University of PittsburghPittsburghPAUSA

Traumatic brain injury(TBI) impacts 69 million individuals globally each year and is a leading cause of death and disability(Dewan et al.,2019).The majority of moderate-to-severe TBI survivors endure long-lasting disturbances in motor,cognitive,and affect that negatively impacts their *** a plethora of research on pharmacological interventions for TBI has been conducted,none has translated to the clinic,thus advocating for the evaluation of nonpharmacological therapeutic approaches that may increase translational success.

关键词： injury traumatic

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GIS model for identifying urban areas vulnerable to noise pollution： case study

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Frontiers of Earth Science 2017年第2期11卷 214-228页

作者： Stefan BILASCO corina GOVOR Sanda ROSCA Iuliu VESCAN Sorin FILIP loan FODOREAN "Babes-Bolyai" University Faculty of Geography 400006 Cluj-Napoca Romania Romanian Academy Cluj-Napoca Subsidiary Geography Section 9 400015 Cluj-Napoca Romania

The unprecedented expansion of the national car ownership over the last few years has been determined by economic growth and the need for the population and economic agents to reduce travel time in progressively expanding large urban centres. This has led to an increase in the level of road noise and a stronger impact on the quality of the environment. Noise pollution generated by means of transport represents one of the most important types of pollution with negative effects on a population＇s health in large urban areas. As a consequence, tolerable limits of sound intensity for the comfort of inhabitants have been determined worldwide and the generation of sound maps has been made compulsory in order to identify the vulnerable zones and to make recommendations how to decrease the negative impact on humans. In this context, the present study aims at presenting a GIS spatial analysis model-based methodology for identifying and mapping zones vulnerable to noise pollution. The developed GIS model is based on the analysis of all the components influencing sound propagation, represented as vector databases （points of sound intensity measurements, buildings, lands use, transport infrastructure）, raster databases （DEM）, and numerical databases （wind direction and speed, sound intensity）. Secondly, the hourly changes （for representative hours） were analysed to identify the hotspots characterised by major traffic flows specific to rush hours. The validated results of the model are represented by GIS databases and useful maps for the local public administration to use as a source of information and in the process of making decisions.

关键词： GIS modelling noise pollution sound intensity environmental impact vulnerability

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Control of PHERES1 Imprinting in Arabidopsis by Direct Tandem Repeats

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Molecular Plant 2009年第4期2卷 654-660页

作者： corina Belle R. Villar Aleksandra Erilova Grigory Makarevich Raphael Trosch Claudia Kohler Department of Biology and Zurich-Basel Plant Science Center Swiss Federal Institute of Technology ETH Centre CH-8092 Zurich Switzerland

Genomic imprinting is an epigenetic phenomenon that causes monoallelic expression of specific genes dependent on the parent-of-origin. Imprinting of the Arabidopsis gene PHERES1 requires the function of the FERTILIZATION INDEPENDENT SEED （FIS） Polycomb group complex as well as a distally located methylated region containing a tandem triple repeat sequence. In this study, we investigated the regulation of the close PHERES1 homolog PHERES2. We found that PHERES2 is also a direct target gene of the FIS Polycomb group complex, but, in contrast to PHERES1, PHERES2 is equally expressed from maternal and paternal alleles. Thus, PHERES2 is not regulated by genomic imprinting, correlating with the lack of tandem repeats at PHERES2. Eliminating tandem repeats from the PHERES1 locus abolishes PHERES1 imprinting, demonstrating that tandem repeats are essential forPHERES1 imprinting. Taking these results together, our study shows that the recently duplicated genes PHERES1 and PHERES2 are both target genes of the FIS Polycomb group complex but only PHERES1 is regulated by genomic imprinting, which is likely caused by the presence of repeat sequences in the proximity of the PHERES1 locus.

关键词： Chromatin structure and remodeling epigenetics gene regulation gene silencing gametogenesis and fertilization.

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Photocatalytical Inactivation of Enterococcus faecalis from Water Using Functional Materials Based on Natural Zeolite and Titanium Dioxide

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Chinese Journal of Chemical Engineering 2014年第1期22卷 38-43页

作者： Cornelia Bandas(Ratiu) corina Orha corina Misca Carmen Lazau Paula Sfirloaga Sorin Olariu National Institute for Research and Development in Microtechnologies National Institute for Research and Development in Electrochemistry and Condensed Matter Condensed Matter Department Banat’s University of Agricultural Sciences and Veterinary Medicine of Timisoara Faculty of Food Products Technology Medical and Pharmaceutical University "Victor Babes"

The functional materials based on natural zeolite （clinoptilolite）, TiO2-zeolite and Ag-TiO2-zeolite have been successfully synthesized by solid-state reaction in fast-hydrothermal conditions. The obtained functional materials were investigated by X-ray diffraction （XRD）, FT-1R （Fourier transform infrared） spectroscopy, DRUV-VIS （diffuse reflectance ultraviolet-visible） spectroscopy, BET （Brunauer-Emmett-Teller） and SEM/EDX （scanning electron microscope/energy dispersive X-ray spectrometer） analyses. The XRD results indicated that the clinoptilolite structure has a good thermal stabilization after the fast-hydrothermal treatment. Also, the high specific surface area about 92.55 m^2.g^-1 was noticed for Ag-TiO2-zeolite functional material. The presence of dopants was evidenced from EDX spectra. The enhanced bactericidal activity of Ag-TiO2-zeolite catalyst is proved through damaging of Enterococcusfaecalis colonies under visible irradiation, at different material doses and irradiation times.

关键词： titanium dioxide composite catalytic properties Enterococcusfaecalis

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Novel Design Solutions for Fishing Reel Mechanisms

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Chinese Journal of Mechanical Engineering 2015年第4期28卷 726-736页

作者： LOVASZ Erwin-Christian MODLER Karl-Heinz NEUMANN Rudolf GRUESCU corina Mihaela PERJU Dan CIUPE Valentin MANIU Inocentiu Department of Mechatronics University Politehnica Timisoara Institut für Festkrpermechanik Technische Universitt Dresden

Currently, there are various reels on the market regarding the type of mechanism, which achieves the winding and unwinding of the line. The designers have the purpose of obtaining a linear transmission function, by means of a simple and small-sized mechanism. However, the present solutions are not satisfactory because of large deviations from linearity of the transmission function and complexity of mechanical schema. A novel solution for the reel spool mechanism is proposed. Its kinematic schema and synthesis method are described. The kinematic schema of the chosen mechanism is based on a noncircular gear in series with a scotch-yoke mechanism. The yoke is driven by a stud fixed on the driving noncircular gear. The drawbacks of other models regarding the effects occurring at the ends of the spool are eliminated through achieving an appropriate transmission function of the spool. The linear function approximation with curved end-arches appropriately computed to ensure mathematical continuity is very good. The experimental results on the mechanism model validate the theoretical approach. The developed mechanism solution is recorded under a reel spool mechanism patent.

关键词： reel mechanism noncircular gears analysis synthesis transmission function

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The role of computer-assisted systems for upper-endoscopy quality monitoring and assessment of gastric lesions

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Gastroenterology Report 2021年第3期9卷 185-204,I0001页

作者： Daniela Cornelia Lazar Mihaela Flavia Avram Alexandra corina Faur Ioan Romosan Adrian Goldis Department V of Internal Medicine I Discipline of Internal Medicine IV“Victor Babes”University of Medicine and Pharmacy TimisoaraRomaniaTimisoaraRomania Department of Surgery X 1st Surgery Discipline“Victor Babes”University of Medicine and Pharmacy TimisoaraRomaniaTimisoaraRomania Department I Discipline of Anatomy and Embriology“Victor Babes”University of Medicine and Pharmacy TimisoaraRomaniaTimisoaraRomania Department VII of Internal Medicine II Discipline of Gastroenterology and Hepatology“Victor Babes”University of Medicine and Pharmacy TimisoaraRomaniaTimisoaraRomania

This article analyses the literature regarding the value of computer-assisted systems in esogastroduodenoscopy-quality monitoring and the assessment of gastric *** data show promising results in upper-endoscopy quality control and a satisfactory detection accuracy of gastric premalignant and malignant lesions,similar or even exceeding that of experienced ***,artificial systems enable the decision for the best treatment strategies in gastriccancer patient care,namely endoscopic vs surgical resection according to tumor *** so doing,unnecessary surgical interventions would be avoided whilst providing a better quality of life and prognosis for these *** these performance data have been revealed by numerous studies using different artificial intelligence(AI)algorithms in addition to white-light endoscopy or novel endoscopic techniques that are available in expert endoscopy *** is expected that ongoing clinical trials involving AI and the embedding of computer-assisted diagnosis systems into endoscopic devices will enable real-life implementation of AI endoscopic systems in the near future and at the same time will help to overcome the current limits of the computer-assisted systems leading to an improvement in *** benefits should lead to better diagnostic and treatment strategies for gastric-cancer ***,the incorporation of AI algorithms in endoscopic tools along with the development of large electronic databases containing endoscopic images might help in upper-endoscopy assistance and could be used for telemedicine purposes and second opinion for difficult cases.

关键词： artificial intelligence computer-assisted diagnosis gastric cancer premalignant gastric lesion upper-endoscopy quality control

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Pegylated-interferon alpha 2a treatment for chronic hepatitis C in patients on chronic haemodialysis

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World Journal of Gastroenterology 2006年第26期12卷 4191-4194页

作者： Ioan Sporea Alina Popescu Roxana ■irli Ovidiu Golea CameliaTotolici Mirela Dǎnilǎ corina Vernic Department of Gastroenterology and Hepatology University of Medicine and Pharmacy "Victor Babes" Timisoara Romania Department of Haemodialysis and Renal Transplantation County Hospital Timisoara Romania Department of Medical Informatics University of Medicine and Pharmacy "Victor Babes" Timisoara Romania

AIM： To evaluate the response to pegylated-interferon alpha 2a in chronic hepatitis C patients on chronic haemodialysis. METHODS： Ten patients with chronic C hepatitis were enrolled in this study. All had increased aminotransferases for more than 6 too, positive antiHCV antibodies and positive PCR HCV-RNA. We administrated Peg-Interferon alpha 2a 180 μg/wk for 48 wk. After 12 wk of treatment we evaluated the biochemical and early virological response （EVR）. At the end of the treatment we evaluated the biochemical response and 24 wk after the end of the treatment we evaluated the sustained virological response （SVR）. We monitored the sideeffects during the treatment. RESULTS： Two patients dropped out in the first 12 wk of treatment and 2 after the first 12 wk of treatment. After 12 wk of treatment, 7 out of 8 patients had biochemical response and EVR and 1 had biochemical response but persistent viremia. We had to reduce the dose of pegylated-interferon to 135 μg/wk in 2 cases. Three out of 6 （50%） patients had SVR 24 wk after the end of the treatment. Intention-to-treat analysis showed that 3 out of 10 patients （30%） had SVR. Side-effects occurred in most of the patients （flu-like syndrome, thrombocytopenia or leucopoenia）, but they did not impose the discontinuation of treatment. CONCLUSION： After 12 wk of treatment with Peg-Interferon alpha 2a （40 ku） in patients on chronic haemodialysis with chronic C hepatitis, EVR was obtained in 87.5% （7/8） of the cases. SVR was achieved in 50% of the cases （3/6 patients） that finished the 48 wk of treatment.

关键词： Chronic hepatitis C Pegylated-interferon alpha 2a Haemodialysis Biochemical response Virological response

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Petrology of ultramafic to mafic cumulate rocks from the G?ksun(Kahramanmaras) ophiolite,southeast Turkey

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Geoscience Frontiers 2020年第1期11卷 109-128页

作者： Osman Parlak Utku Bagcı Tamer Rızaoglu corina Ionescu GüzideÖnal Volker Höck Hüseyin Kozlu Çukurova Universitesi Jeoloji Mühendisligi BölümüBalcalıTR-01330 AdanaTurkey State Key Laboratory of Geological Processes and Mineral Resources Center for Global TectonicsSchool of Earth SciencesChina University of GeosciencesWuhan 430074China Mersin Universitesi Jeoloji Mühendisligi BölümüÇiftlikköyTR-33343 MersinTurkey Kahramanmaras¸SütçüImam Universitesi Jeoloji Mühendisligi BölümüAvs¸ar KampüsüTR-46100 KahramanmarasTurkey Babes-Bolyai University Geology Department1 Kogalniceanu Str.RO-400084 Cluj-NapocaRomania Kazan(Volga Region)Federal University Archeotechnologies&Archeological Material Sciences Laboratory18 Kremlevskaya Str.420000 KazanRussia University of Salzburg Division of Geography and Geology34 Hellbrunner Str.A-5020 SalzburgAustria Türkiye Petrolleri Anonim Ortaklıgı TR-06520 AnkaraTurkey

The G?ksun(Kahramanmaras)ophiolite(GKO),cropping out in a tectonic window bounded by the Malatya metamorphic unit on both the north and south,is located in the EW-trending lower nappe zone of the southeast Anatolian orogenic belt(Turkey).It exhibits a complete oceanic lithospheric section and overlies the Middle Eocene Maden Group/Complex with a tectonic contact at its *** ophiolitic rocks and the tectonically overlying Malatya metamorphic(continental)unit were intruded by I-type calc-alkaline Late Cretaceous granitoid(~81-84 Ma).The ultramafic to cumulates in the GKO are represented by wehrlite,plagioclase wehrlite,olivine gabbro and *** crystallization order for the cumulate rocks is as follows:olivine±chromian spinel→clinopyroxene→*** major and trace element geochemistry as well as the mineral chemistry of the ultramafic to mafic cumulate rocks suggest that the primary magma generating the GKO is compositionally similar to that observed in the modern island-arc tholeiitic *** mineral chemistry of the ultramafic to mafic cumulates indicates that they were derived from a mantle source that was previously depleted by earlier partial melting *** highly magnesian olivine(Fo77-83),clinopyroxene(Mg#of 82-90)and the highly Ca-plagioclase(An81-89)exhibit a close similarity to those,which formed in a supra-subduction zone(SSZ)*** field and the geochemical evidence suggest that the GKO formed as part of a much larger sheet of oceanic lithosphere,which accreted to the base of the Tauride active continental margin,including the ispendere,K?mürhan and the Guleman *** latter were contemporaneous and genetically/tectonically related within the same SSZ setting during the closure of the Neotethyan oceanic basin(Berit Ocean)between the Taurides to the north and the Bitlis-Pütürge massif to the south during the Late Cretaceous.

关键词： Göksun(Kahramanmaras)ophiolite Cumulate SSZ-Spreading Neotethys Late Cretaceous SE Anatolia

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