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Effects of plant-derived analgesic compounds sinomenine and salvinorin A in infant rats

journal of Integrative Medicine 2020年第2期18卷 174-180页

作者： conrad j.mascarenhas Renyu Liu Gordon A.Barr Department of Anesthesiology and Critical Care Children’s Hospital of PhiladelphiaPhiladelphiaPA 19104USA Department of Anesthesiology and Critical Care Perelman School of Medicine at the University of PennsylvaniaPhiladelphiaPA 19104USA Department of Psychology University of PennsylvaniaPhiladelphiaPA 19104USA

Objective: Premature and ill neonates undergo painful but medically necessary procedures while hospitalized. Although opiate drugs are administered as analgesics, problems associated with their side effects,tolerance, and potential dependence necessitate research into alternative pain-relieving *** we test two plant-derived compounds in infant rats: sinomenine, which targets the Mas-related G-protein-coupled receptor member X2 opioid receptor;and salvinorin A, which is a j opioid receptor agonist. In adult animals both sinomenine and salvinorin A are analgesic, but neither has been tested in ***: We used the formalin and thermal plantar tests in rats 7 and 21 days of age(PN7 and PN21) for behavioral signs of pain. In addition, brain sections were stained using Fos immunohistochemistry to examine patterns of brain activation in the midbrain periaqueductal gray and the paraventricular nucleus of the ***: Sinomenine was analgesic in both the formalin and thermal tests on animals 21 days of age. At PN7 only the highest dose elevated response latencies in the thermal test and there were no effects of sinomenine in the formalin test. Analysis of Fos expression in the sinomenine-treated animals showed no drug effect, in contrast to the behavioral results. Salvinorin A was analgesic in the formalin test only at the highest dose at 21 days of age but not in the thermal test at either ***: The increased modest effectiveness of sinomenine in older animals and the minimum salvinorin A drug effect suggest that the compounds act on sites that develop during the preweaning period(sinomenine) or after weaning(salvinorin A).

关键词： Thermal pain Formalin test Fos Ontogeny Sinomenine Salvinorin A

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A novel ZnO/reduced graphene oxide and Prussian blue modified carbon paste electrode for the sensitive determination of Rutin

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Science China Chemistry 2019年第2期62卷 262-270页

作者： Ozma j D'Souza Ronald j.mascarenhas Ashis K Satpati Basavanakote M Basavaraja Research and Development Centre Bharathiar University Electrochemistry Research Group Department of Chemistry St.Joseph's College Analytical Chemistry Division Bhabha Atomic Research Centre Anushakthi Nagar Trombay Department of Chemistry PES University

A carbon paste modified sensor based on a novel composite of zinc oxide nanoparticles deposited on reduced graphene oxide(ZnO-rGrO) and Prussian blue(PB) was drop-cast(ZnO-rGrO-PB/MCPE) for the sensitive estimation of Rutin(Rtn) at pH *** high surface area of ZnO-rGrO and electrocatalytic property of PB promotes the oxidation of Rtn. Field emission scanning electron microscope(FE-SEM) and energy-dispersive X-ray spectroscopy(EDX) techniques were employed to confirm the deposition of ZnO-rGrO and PB on carbon paste electrode(CPE). The ability of ZnO-rGrO-PB/MCPE in charge transfer at the interface was investigated using electrochemical impedance spectroscopy(EIS). The heterogeneous rate constant(ks) and the charge transfer coefficient(α) have been calculated as 6.08 s^(-1) and 0.74 respectively. This sensor showed a wide linear response for Rtn from 7.0×10^(-8)to 7.0×10^(-6) M and 7.0×10^(-6) to 1.0×10^(-4) M with a limit of detection(2.05±0.04)×10^(-8) M(S/N=3). The application of ZnO-rGrO-PB/MCPE was found in the analysis of Rtn in fruit juice samples using standard addition method. This sensor showed good reproducibility, stability, selectivity and sensitivity.

关键词： Rutin zinc oxide nanoparticles reduced graphene oxide Prussian blue modified carbon paste electrode ascorbic acid

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The origin of herbivory on land： Initial patterns of plant tissue consumption by arthropods

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Insect Science 2007年第4期14卷 259-275页

作者： conrad LABANDEIRA DepartmentofPaleobiology NationalMuseumofNaturalHistorySmithsonianInstitutionWashingtonDCandDepartmentofEntomologyUniversityofMarylandCollegeParkMarylandUSA

The early fossil record of terrestrial arthropod herbivory consists of two pulses. The first pulse was concentrated during the latest Silurian to Early Devonian （417 to 403 Ma）, and consists of the earliest evidence for consumption of sporangia and stems （and limited fungivore borings）. Herbivorization of most of these tissues was rapid, representing 0 to 20 million-year （m.y.） lags from the earliest occurrences of these organs in the fossil record to their initial consumption （Phase 1）. For approximately the next 75 m.y., there was a second, more histologically varied origination and expansion of roots, leaves, wood and seeds, whose earliest evidence for herbivorization occurred from the Middle-Late Mississippian boundary to the Middle Pennsylvanian （327 to 309 Ma）. The appearance of this second herbivory pulse during the later Paleozoic （Phase 2） is accompanied by major lags of 98 to 54 m.y. between times of appearance of each of the four organ and tissue types and their subsequent herbivory. Both pulses provide a context for three emerging questions. First is an explanation for the contrast between the near instantaneous consumption of plant tissues during Phase 1, versus the exceptionally long lags between the earliest occurrences of plant tissues and their subsequent herbivorization during Phase 2. Second is the identity of arthropod herbivores for both phases. Third is the cause behind the overwhelming targeting of seed-fern plant hosts during Phase 2. Regardless of the answers to these questions, the trace fossil record of plant-arthropod associations provides primary ecological data that remain unaddressed by the body-fossil record alone.

关键词： herbivory ecological lag Devonian Carboniferous arthropod plant-insectinteractions wood boring seed predation folivory fecal pellet response tissue sporangia,roots stems

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Ground control monitoring of retreat room–and–pillar mine in Central Appalachia

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International journal of Mining Science and Technology 2017年第1期27卷 65-69页

作者： Erik C.Westman Ryan j.Molka William j.conrad Mining and Minerals Engineering Department Virginia TechBlacksburgVA 24061USA

In order to study pillar and overburden response to retreat mining, a ground control program was conducted at a Central Appalachian Mine. The program consisted of several monitoring methods including a seismic monitoring system, borehole pressure cells in the pillars, and time-lapse photogrammetry of the pillar ribs. Two parallel geophone arrays were installed, one on each side of the panel with the sensors mounted 3 m into the roof. A total of fourteen geophones recorded more than 5000 events during the panel retreat. A MIDAS datalogger was used to record pressure from borehole pressure cells(BPCs)located in two adjacent pillars that were not mined during retreat. A series of photographs were taken of the pillars that had the BPCs as the face approached so that deformation of the entire rib could be monitored using photogrammetry. Results showed that pillar stability and cave development were as expected. The BPCs showed an increase in loading when the face was 115 m inby and a clear onset of the forward abutment at 30 m. The photogrammetry results displayed pillar deformation corresponding to the increased loading. The microseismic monitoring results showed the overburden caving inby the face, again as expected. The significance of these results lies in two points,(1) we can quantify the safe manner in which this mine is conducting retreating operations, and(2) we can use volumetric technologies(photogrammetry and microseismic) to monitor entire volumes of the mine in addition to the traditional point-location geotechnical measurements(BPCs).

关键词： Retreat mining Stress measurement Microseismic monitoring Pillar stability

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Synthesis and in vitro evaluation of new diphenyl ether derivatives as serotonin transporter ligands

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Science China Chemistry 2008年第5期51卷 457-463页

作者： DEUTHER-conrad Winnie BRUST Peter STEINBACH jrg VERCOUILLIE johnny Institute of Interdisciplinary Isotope Research

For the development of new ligands as potential imaging agents for the serotonin transporter (SERT),a series of diphenyl ether derivatives have been synthesized,characterized,and evaluated for their in vitro binding affinities to the SERT. Among the above compounds,2-(2-((dimethylamino)methyl)-4-fluoro-phenoxy)-5-bromobenzenamine (15) and 2-(2-((dimethylamino)methyl)-4-fluorophenoxy)-5-iodobenzene amine (16) show high binding affinities for the SERT with Ki values of 0.28 and 0.20 nmol·L-1,respectively. They can be further labeled with carbon-11,fluorine-18,iodine-123 or bromine-76,and evaluated as useful imaging agents for the SERT. Moreover,the study of the structure-activity relationship (SAR) provides some useful information for the future design of new ligands.

关键词： serotonin transporter diphenyl ether imaging agents in vitro evaluation

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Low-cost assembly of a cacao crop genome is able to resolve complex heterozygous bubbles

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Horticulture Research 2019年第1期6卷 1176-1188页

作者： joe Morrissey j.conrad Stack Rebecca Valls juan Carlos Motamayor Mars Chocolate 13601 Old Cutler RoadMiamiFL 33158USA

Cacao(Theobroma cacao)is a tropical tree that produces the essential raw material for *** yields have been stagnant,land use has expanded to provide for increasing chocolate *** genomes of key parents could modernize breeding programs in the remote and under-resourced locations where cacao is *** MinION,a long read sequencer that runs off of a laptop computer,has the potential to facilitate the assembly of the complex genomes of high-yielding F1 ***,we validate the MinION’s application to heterozygous crops by creating a de novo genome assembly of a key parent in breeding programs,the clone Pound *** MinION-only assembly was 20%larger than the latest released cacao genome,with 10-fold greater contiguity,and the resolution of complex heterozygosity and repetitive *** with Illumina short reads brought the predicted completeness of our assembly to similar levels to the previously released cacao genome *** contrast to previous cacao genome projects,our assembly required only a small scientific team and limited *** sequencing and assembly methods could easily be adopted by under-resourced breeding programs,speeding crop improvement in the developing world.

关键词： breeding crops assembly

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Incoherent excess noise spectrally encodes broadband light sources

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Light(Science & Applications) 2020年第1期9卷 358-366页

作者： Aaron M.Kho Tingwei Zhang jun Zhu conrad W.Merkle Vivek j.Srinivasan Department of Biomedical Engineering University of California DavisDavisCA 95616USA Department of Ophthalmology and Vision Science University of California Davis School of MedicineSacramentoCA 95817USA

Across optics and photonics,excess intensity noise is often considered a ***,we show that excess noise in broadband supercontinuum and superluminescent diode light sources encodes each spectral channel with unique intensity fluctuations,which actually serve a useful ***,we report that excess noise correlations can both characterize the spectral resolution of spectrometers and enable cross-calibration of their wavelengths across a broad *** to previous methods that use broadband interferometry and narrow linewidth lasers to characterize and calibrate spectrometers,our approach is simple,comprehensive,and rapid enough to be deployed during spectrometer ***,we employ this approach to aid alignment and reduce the depth-dependent degradation of the sensitivity and axial resolution in a spectrometer-based optical coherence tomography(OCT)system,revealing a new outer retinal ***,we achieve a pixel-to-pixel correspondence between two otherwise disparate spectrometers,enabling a robust comparison of their respective ***,excess intensity noise has useful applications in optics and photonics.

关键词： noise spectral optics

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Microseismic monitoring and analysis of induced seismicity source mechanisms in a retreating room and pillar coal mine in the Eastern United States

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Underground Space 2017年第2期2卷 115-124页

作者： Morgen R.Leake William j.conrad Erik C.Westman Setareh Ghaychi Afrouz Ryan j.Molka Mining and Minerals Engineering Department Virginia Polytechnic Institute and State University445 Old Turner Street100 Holden HallBlacksburgVA 24060USA

A microseismic monitoring system was installed in an underground room and pillar coal mine in the Eastern United States to analyze the occurrence and characteristics of induced seismicity during the retreat of two panels in the *** study is the first microseismic monitoring effort at an underground coal mine in nearly 30 *** the retreat of the first panel,an array of eight uniaxial geophones,installed 10 *** the roof,recorded events and their *** second panel was monitored using an array of twelve uniaxial geophones and two triaxial geophones,also installed 10 *** the *** the results of these studies,it has been found that the magnitude of seismic events is minimally affected by immediate roof geology or depth of ***,it was observed in both studies that the rate at which seismic events occurred did vary with changing roof geology and depth of *** the seismic data from the second panel retreat,focal mechanism solutions were generated for 50 hand-picked events in order to determine if the failure was in compression,tension,or *** of the focal mechanism solutions show that stress relief resulting in dilational events occurs at significant depths,150-200 m in this case,beneath the active mining face.

关键词： Deep mining Induced seismicity Coal mining Rock mechanics Source mechanisms Subsidence

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New jurassic Pseudopolycentropodids from China (Insecta: Mecoptera)

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Acta Geologica Sinica(English Edition) 2010年第1期84卷 22-30页

作者： REN Dong SHIH Chungkun conrad C. LABANDEIRA College of Life Science Capital Normal University Beijing 100048 China Department ofPaleobiology Smithsonian Institution National Museum of Natural History Washington DC 20560 USA

In this paper two new species of fossil Pseudopolycentropus Handlirsch, 1906 are described： Pseudopolycentropus janeannae sp. nov. and P. novokshonovi, sp. nov. All of them were recovered from the Middle jurassic non-marine sedimentary strata of northeastern China. The new material from China reveals that the early diversification of pseudopolycentropodids was well underway by the Middle jurassic.

关键词： Pseudopolycentropodidae Mecoptera fossil new taxa jurassic China

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Web-based supplier relationship framework using agent systems

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journal of Harbin Institute of Technology(New Series) 2004年第1期11卷 54-59页

作者： Oboulhas conrad Tsahat Onesime 徐晓飞战德臣 School of Computer Science and Technology Harbin Institute of Technology Harbin 150001 China

In order to enable both manufacturers and suppliers to be profitable on today’s highly competitive markets, manufacturers and suppliers must be quick in selecting best partners establishing strategic relationship, and collaborating with each other so that they can satisfy the changing competitive manufacturing requirements. A web-based supplier relationships (SR) framework is therfore proposed using multi-agent systems and linear programming technique to reduce supply cost, increase flexibility and shorten response time. Web-based SR approach is an ideal platform for information exchange that helps buyers and suppliers to maintain the availability of materials in the right quantity, at the right place, and at the right time, and keep the customer-supplier relationship more transparent. A multi-agent system prototype was implemented by simulation, which shows the feasibility of the proposed architecture.

关键词： web-based supplier relationship management supplier selection linear programming (LP) multi-agent system (MAS)

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