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Secular trends in the etiology and comorbidity of hospitalized patients with congestive heart failure: A single-center retrospective study

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Journal of Geriatric Cardiology 2012年第4期9卷 361-365页

作者： Zhi-Yong Pei Yu-Sheng Zhao Jia-Yue Li qiao Xue Lei Gao Shi-Wen Wang Institute of Geriatric Cardiology Chinese PLA General Hospital Beijing 100853 China Department of Geriatric Cardiology Beijing Military General Hospital Beijing 100700 China Institute of Geriatric Cardiology Chinese PLA General Hospital Beijing 100853 China

Objective To assess the secular trends in the etiology and comorbidity ofpatients hospitalized with congestive heart failure (CHF).Methods Data of 7,319 patients (mean age 59.6 years, 62.1% male) with a primary discharge diagnosis of CHF, hospitalized from January 1, 1993 to December 31, 2007 at the Chinese People’s Liberation Army (PLA) General Hospital were extracted and analyzed. These patients were divided into three groups according to hospitalization period: 1993–1997 (n = 1623), 1998–2002 (n = 2444), and 2003–2007 (n = 3252). The etiological characteristics and comorbidities were assessed. Results Over the study period, the proportion of patients with ischemic heart disease (IHD) increased from 37.2% during the period 1993–1997 to 46.8% during the period 2003–2007, while that with valvular heart disease (VHD) decreased from 35.2%during the period 1993–1997 to 16.6% during the period 2003–2007 (both P < 0.05). Atrial fibrillation (AF) was the most common comorbidity of heart failure (23.2%, 23.0% and 20.6%, respectively, in the three periods). Compared to that of the period of 1993–1997 with that of, the proportion of patients with myocardial infarction, pneumonia, renal function impairment and hepatic cirrhosis of the period of 2003–2007 increased significantly (P < 0.05) and the proportion of patients with chronic obstructive pulmonary disease and atrial fibrillation decreased significantly (P < 0.05). Conclusions This study implies that IHD has became a more common etiology of CHF, while VHD has deceased as an etiology of CHF in Chinese patients during the last two decades.

关键词： Atrial fibrillation Comorbidity congestive heart failure Etiology Hospitalization

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Preventive Oncology International:A brief history of HPV self-collected vaginal specimens for cervical cancer screening

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Gynecology and Obstetrics Clinical Medicine 2023年第3期3卷 144-148页

作者： Jerome L.Belinson Robert G.Pretorius Ruifang Wu Youlin qiao Preventive Oncology International Inc.Women's Health InstituteCleveland ClinicUSA Department of Ob/Gyn Southern California Permanente GroupFontanaCAUSA Department of Ob/Gyn Peking University Shenzhen HospitalShenzhenChina School of Population Medicine and Public Health Chinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing100005PR China

Since 1998,Preventive Oncology International,Inc.(POI)has been at the forefront of studying human papillomavirus(HPV)self-collection for cervical cancer screening,with a significant focus in *** multiple clinical trials over the past 25 years,POI has explored various aspects related to self-collection *** 2004–2006,POI established that self-collection could be equivalent to direct endocervical ***,a large randomized trial involving 10,000 patients in 2010 further confirmed that self-collected vaginal specimens,tested for high-risk HPV(hrHPV)using a PCR-based assay with high analytic sensitivity,could effectively replace endocervical specimens with minimal loss of sensitivity and a slight decrease in *** the years,POI's research has encompassed several crucial topics,including patient acceptance,the development of new cost-effective,simpler,and faster assays,exploring different collection devices,devising efficient methods of specimen transport,and implementing population-based screening *** findings strongly support the integration of self-collection methodologies into cervical cancer control programs worldwide,particularly in medically underserved *** HPV self-collection continues to evolve,ongoing research and innovations are expected to play a pivotal role in achieving the global mission of combating cervical cancer.

关键词： Human papillomavirus(HPV) Self-collection Self-sampling Cervical cancer screening

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In situ Study on the Growth Behavior of Primary Al_3Ni Phase in Solidifying Al–Ni Alloy by Synchrotron Radiography

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Acta Metallurgica Sinica(English Letters) 2018年第6期31卷 668-672页

作者： Si-Yu Sun qiao-Dan Hu Wen-Quan Lu Zong-Ye Ding Ming-Qin Xu Ming-Xu Xia Jian-Guo Li Shanghai Key Laboratory of Materials Laser Processing and Modification School of Materials Science and EngineeringShanghai Jiao Tong University

The growth behavior of Al_3Ni intermetallic compounds（IMCs）during the directional solidification of Al-10 wt%Ni alloy was investigated by synchrotron *** main growth patterns of primary Al_3Ni phase,I-like and V-like,appeared during solidification,and I-like Al_3Ni phase grew faster than V-like phase,which can be explained by the minimum energy *** growth of I-like phase can be divided into two stages and was mainly affected by undercooling and Ni *** also found that V-like Al_3Ni phase can evolve into M-like phase during solidification.

关键词： Synchrotron radiography Directional solidification Intermetallic compounds Al–Ni alloy

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Impact of social isolation and resident intruder stress on aggressive behavior in the male rat

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Neural Regeneration Research 2010年第15期5卷 1175-1179页

作者： Sheng Wei Huiyun Zhang Jie Gao Ling Xue Peng Sun Yubin Chao Gang Xue Mingqi qiao Key Laboratory of Classic Theories on Traditional Chinese Medicine Shandong University of Traditional Chinese Medicine Ministry of Education Jinan 250355 Shandong Province China

Stress studies frequently utilize physical stressors to establish animal models of stress. In the majority of cases, these models are not consistent with human circumstances. The present study simulated a social isolation plus resident intruder stress model in the rat. The rats were subjected to daily social isolation and resident intruder stress for 2 weeks. Behaviors were then tested. Rats subjected to social stress exhibited different aggressive behavior styles; some rats had greater scores on composite aggression behaviors, as well as locomotor and exploratory activity, but lower scores on latency than others. The high-aggressive group exhibited predominantly anger-out, while the low-aggressive group exhibited anger-in. Results suggest that social isolation plus resident intruder may serve as an appropriate model for anger-in and anger-out emotion modeling in the rat.

关键词： aggressive behavior test social isolation resident intruder stress rat model anger-out/anger-in

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Antioxidant and biotechnological potential of Pediococcus pentosaceus RZ01 and Lacticaseibacillus paracasei RZ02 in a millet‑based fermented substrate

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Systems Microbiology and Biomanufacturing 2023年第4期3卷 571-584页

作者： Sunday Bulus Peter Zhina qiao Hero Nmeri Godspower Jacob Ojobi Omedi Xian Zhang Meijuan Xu Zhiming Rao The Key Laboratory of Industrial Biotechnology Ministry of EducationSchool of BiotechnologyJiangnan University1800 Lihu AvenueWuxi 214122JiangsuPeople’s Republic of China The State Key Laboratory of Food Science and Technology Laboratory of Baking and Fermentation ScienceCereals/Sourdough and Ingredient Functionality ResearchSchool of Food Science and TechnologyJiangnan University1800 Lihu AvenueWuxi 214122JiangsuPeople’s Republic of China

Lactobacillus and Bifidobacterium are the most known genera of the therapeutic niche of organisms that have developed various defense mechanisms through their antioxidative activity which help mitigate the abnormality caused by reactive oxygen species to cell ***,for these probiotic organisms to exert their beneficial effects,the need to enhance functionality and protect bacterial cells in the gastrointestinal tract requires an efficient method for a better selection of favorable fermentation conditions with a sufficient yield of desired property or *** we reported the potential and antioxidant activities of isolated probiotic strains,with a considerable viable cell count between 10^(8) and 10^(9) CFU/mL,as the pH of both fermented millet substrate decreased from 6.13 to 3.62 at 35℃ within 14 h using a statistical optimization *** identified strains Pediococcus pentosaceus RZ01 and Lacticaseibacillus paracasei RZ02 alongside the refer-ence strain had an overall gastrointestinal tolerance of 60%under simulated conditions,with Pediococcus pentosaceus RZ01 showing the highest bile salt survival rate(123.07%).Lactobacillus paracasei RZ02 indicates a high hydrophobicity potential(86.48%),suggesting a better adhesion ability to the gastrointestinal ***,Pediococcus pentosaceus RZ01 and Lactobacillus paracasei RZ02 fermented substrate had 39.69 and 44.51%of 2,2-Diphenyl-1-picrylhydrazyl(DPPH)radical scavenging activity,with the release of bioactive compounds of health *** provide important references for formulating novel probiotic fermented cereal product,understanding of probiotic-prebiotic relationship,as well as pave way for biotechnological application of identified and related probiotics.

关键词： potential oxidative desired

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Geochemical Characteristics of Eolian Deposits in the Chengdu Plain of Sichuan Province and the Implications for Provenance

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Acta Geologica Sinica(English Edition) 2013年第6期87卷 1712-1723页

作者： TAN Yuanlong qiao Yansong ZHAO Zhizhong WANG Yan QI Lin FU Jianli LIU Zongxiu YAO Haitao WANG Shubing JIANG Fuchu Institute of Geomechanics Chinese Academy of Geological Sciences Key Laboratory of Neotectonic Movement and Geohazard

In this study Chengdu Red Earth （CRE） from the Chengdu Plain （CP）,Sichuan province,was analyzed for its elemental （major and trace elements） and isotopic （Sm-Nd） geochemistry and compared with Pleistocene loess and paleosol samples from the Chinese Loess Plateau （CLP） in Northern *** geochemical composition of CRE is similar to north China loess,and also resembles the average *** indicates that CRE,as loess deposits in Northern China,was derived from well-mixed sedimentary protoliths that have undergone numerous upper crustal recycling ***,obvious differences in the geochemical characteristics of CRE and the north China loess are also revealed in our *** chemically stable elements,CRE has higher Ti,Zr,Hf and lower ΣREE,Ba contents in comparison with loess samples from the *** analysis shows that CRE has higher TiO2/Al2O3,SiO2/Al2O3,Ba/Rb and lower Ce/Yb,Eu/Yb,LaN/YbN and ΣLREE/ ΣHREE *** Sm-Nd isotopic geochemistry,Sm and Nd content and the εNd（0） value in CRE are significantly higher than those in north China *** higher TiO2 content in CRE coincided with a high background concentration of Ti in the Sichuan Basin and the surrounding *** lower ΣREE and higher Sm,Nd,εNd（0） values are related to the wide distribution of basalt in the southwest Sichuan *** elemental and isotopic geochemistry of CRE indicates that eolian materials in the CP predominantly come from the Sichuan Basin and the surrounding regions,which differs from loess deposits in the CLP.

关键词： The Chengdu Plain Chengdu red earth eolian deposits geochemical characteristics provenance

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Relationship between expression of NADPH oxidase 2 and invasion and prognosis of human gastric cancer

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World Journal of Gastroenterology 2015年第20期21卷 6271-6279页

作者： Peng Wang qiao Shi Wen-Hong Deng Jia Yu Teng Zuo Fang-Chao Mei Wei-Xing Wang Department of Hepatobiliary Surgery Renmin Hospital of Wuhan University Department of Gastrointestinal Surgery Renmin Hospital of Wuhan University

AIM: To assess the expression and prognostic value of nicotinamide adenine dinucleotide phosphate oxidase 2(NOX2) in gastric cancer, and its correlation with vascular endothelial growth factor(VEGF) and epidermal growth factor receptor(EGFR).METHODS: Tumor and adjacent tissues were obtained from 123 patients who underwent radical surgery for gastric cancer at Renmin Hospital of Wuhan University from 2008-2009. The expression of NOX2, VEGF, EGFR and CD68 in tumor tissues was detected by immunohistochemistry. The expression of NOX2 in gastric cancer and adjacent tissues was detected by Western blot analysis. Spearman's correlation was performed to elucidate the relationship of NOX2 with VEGF and EGFR. The Kaplan-Meier method was used to calculate survival time, and the log-rank test was used to evaluate differences in survival. Cox‘s proportional hazards regression model was applied in a stepwise manner to analyze the independent prognostic ***: NOX2 exhibited positive expression in 47.2%(58/123) of the gastric cancer tissues. Western blot analysis revealed that NOX2 was up-regulated in tumor tissues compared to the adjacent tissue [39.0%(48/123)]. Immunohistochemistry staining revealed that CD68, which is a specific marker of macrophages, and NOX expression presented a similar localization and staining intensity. The expression of NOX2 was positively correlated with that of VEGF and EGFR. Comparison of the 5-year survival rates of the NOX2 positive and NOX2 negative groups showed that the NOX2 positive group presented a poor ***: NOX2 positively correlates with the levels of VEGF and EGFR. NOX2 may be used as a new biomarker and a potential therapeutic target for gastric cancer.

关键词： NADPH oxidase 2 Macrophages Vascularendothelial growth factor Epidermal growth factorreceptor Prognosis Survival time

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An investigation of corrosion-induced stress during SCC

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Journal of University of Science and Technology Beijing 2003年第1期10卷 1-7页

作者： Wuyang Chu, Kewei Gao, Lijie qiao, and Yue ZhangDepartment of Materials Physics, University of Science and Technology Beijing, Beijing 100083, China Univ Sci & Technol Dept Mat Phys Beijing 100083 Peoples R China

TEM (Transmission Electron Microscope) observations show that corrosion process during stress corrosion cracking (SCC) enhances dislocation emission and motion; and microcrack of SCC initiates when the corrosion-enhanced dislocation emission and motion reaches a certain condition. The passive film or dealloyed layer formed during corrosion or SCC can induce a large tensile stress, which can assist the applied stress to enhance dislocation emission and motion, and then SCC occurs. Experiments show that the variation of SCC susceptibility of brass,α-Ti and stainless steel with the applied potential and pH value of the solution is consistent with that of the corrosion-induced additive stress. Molecular dynamics simulations show that a dealloyed layer can generate a tensile stress; and the corrosion (dealloyed layer)-induced tensile stress can assist the applied stress to enhance dislocation emission and crack propagation.

关键词： stress corrosion cracking dislocation emission and motion corrosion-induced stress molecular dynamic simulation

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Large Disparity between Prevalence and Treatment Rates for Hepatitis C in Western China

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Journal of Clinical and Translational Hepatology 2018年第4期6卷 385-390页

作者： Zhi-Wei Chen Zhao Li qiao-He Wang Xiao-Ling Wu Hu Li Hong Ren Peng Hu Department of Infectious Diseases Institute for Viral HepatitisThe Key Laboratory of Molecular Biology for Infectious DiseasesChinese Ministry of EducationThe Second Affiliated Hospital of Chongqing Medical UniversityChongqingChina

Background and Aims:Recently,the World Health Organization adopted the first-ever global hepatitis strategy with the dream of eliminating viral hepatitis as a public health threat by ***,the epidemiology and treatment rates of hepatitis C virus(HCV)infection in Western China are still ***:A total of 111,916 adult individuals(15-96 years)who underwent the HCV-antibody(HCV-Ab)test in the Second Affiliated Hospital of Chongqing Medical University between 2013 and 2015 were included in this *** retrospectively analyzed the electronic medical records'data for each,and the positivity of HCV-Ab and the treatment of HCV RNA-positive patients were ***:During 2013-2015,the crude prevalence of HCVAb was 1.4%(95%CI:1.4-1.5;1,611/111,916)and the adjusted prevalence of HCV-Ab was 1.7%(95%CI:1.6-1.8),which was higher than in the 2006 national study(0.43%).The prevalence was 2-times higher in males than females(2.0%vs.1.1%,p<0.01).Notably,only 46%(434/951)of the HCV RNA-positive patients received standard peginterferon plus ribavirin treatment,with 370(82%)that completed treatment,of whom 272(74%)achieved sustained virologic response(SVR).Particularly,11%(32/292)of HCV RNA-positive patients were HBsAg-positive,and the SVR rate for them was lower than for the HBsAg-negative patients,but no significant difference was ***:HCV infection may have increased since 2006 in Western *** SVR rate of peg-interferon plus ribavirin treatment was high,but the proportion of untreated HCV patients was ***,more efforts need to be made by the government to create a scientific-based policy for HCV treatment and prevention.

关键词： Epidemiology Hepatitis C virus Hospital-based population study Treatment

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Quantum Teleportation of One-to-Many Using （n ＋ 1）-Particle Entanglement

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Communications in Theoretical Physics 2007年第4X期48卷 623-625页

作者： SHA Jin-qiao FANG Jian-Xing JIANG Wei-Xing School of Physical Science and Technology Suzhou University Suzhou 215006 China

In this paper, quantum teleportatlon of one-to-many using （n ＋1）-particle entanglement is presented. If the sender （Alice） wants to transmit an unknown quantum state to a distant receiver （Bob）, similar to the previous schemes, Alice performs Bell-state measurement on particles belonging to herself and informs the receiver the results through the classical channel. After that, it needs to perform the Hadamard operation on the other （n - 1） particles and measure them as well. With the aid of the measurement results, Bob can operate a corresponding unitary transformation on his particle to reconstruct the original state. Of course, the reconstruction may realize at either location of n, but it cannot realize at all locations at the same time.

关键词： quantum teleportation quantum entangled state unitary transformation

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