Large Disparity between Prevalence and Treatment Rates for Hepatitis C in Western China
作者机构：Department of Infectious DiseasesInstitute for Viral HepatitisThe Key Laboratory of Molecular Biology for Infectious DiseasesChinese Ministry of EducationThe Second Affiliated Hospital of Chongqing Medical UniversityChongqingChina
出 版 物：《Journal of Clinical and Translational Hepatology》 (临床与转化肝病杂志（英文版）)
年 卷 期：2018年第6卷第4期
页 面：385-390页
核心收录：
学科分类：1004[医学-公共卫生与预防医学(可授医学、理学学位)] 100401[医学-流行病与卫生统计学] 10[医学]
基 金：supported in part by the National Natural Science Foundation of China(30930082,81171561 and 30972584) the National Science and Technology Major Project of China(2008ZX10002-006,2012ZX10002007001,2017ZX10202203-007 and 2017ZX10202203-008)
主 题：Epidemiology Hepatitis C virus Hospital-based population study Treatment
摘 要：Background and Aims:Recently,the World Health Organization adopted the first-ever global hepatitis strategy with the dream of eliminating viral hepatitis as a public health threat by ***,the epidemiology and treatment rates of hepatitis C virus(HCV)infection in Western China are still ***:A total of 111,916 adult individuals(15-96 years)who underwent the HCV-antibody(HCV-Ab)test in the Second Affiliated Hospital of Chongqing Medical University between 2013 and 2015 were included in this *** retrospectively analyzed the electronic medical records data for each,and the positivity of HCV-Ab and the treatment of HCV RNA-positive patients were ***:During 2013-2015,the crude prevalence of HCVAb was 1.4%(95%CI:1.4-1.5;1,611/111,916)and the adjusted prevalence of HCV-Ab was 1.7%(95%CI:1.6-1.8),which was higher than in the 2006 national study(0.43%).The prevalence was 2-times higher in males than females(2.0%vs.1.1%,p0.01).Notably,only 46%(434/951)of the HCV RNA-positive patients received standard peginterferon plus ribavirin treatment,with 370(82%)that completed treatment,of whom 272(74%)achieved sustained virologic response(SVR).Particularly,11%(32/292)of HCV RNA-positive patients were HBsAg-positive,and the SVR rate for them was lower than for the HBsAg-negative patients,but no significant difference was ***:HCV infection may have increased since 2006 in Western *** SVR rate of peg-interferon plus ribavirin treatment was high,but the proportion of untreated HCV patients was ***,more efforts need to be made by the government to create a scientific-based policy for HCV treatment and prevention.
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