检索结果-南通市图书馆

Novel data-driven subtypes and stages of brain atrophy in the ALS-FTD spectrum

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Translational Neurodegeneration 2023年第1期12卷 50-69页

作者： Ting Shen Jacob W.Vogel Jeffrey Duda Jeffrey S.Phillips Philip ACook James Gee Lauren Elman colin Quinn Defne A.Amado michael Baer Lauren Massimo Murray Grossman David J.Irwin Corey T.McMillan Penn Frontotemporal Degeneration Center Department of NeurologyPerelman School of MedicineUniversity of PennsylvaniaPhiladelphiaPA 19104USA Department of Clinical Sciences SciLifeLabLund University22242 LundSweden Penn Image Computing and Science Lab(PICSL) Department of RadiologyPerelman School of MedicineUniversity of Penn-sylvaniaPhiladelphiaPA 19104USA Department of Neurology Perelman School of MedicineUniversity of PennsylvaniaPhiladelphiaPA 19104USA Digital Neuropathology Laboratory Department of NeurologyPerelman School of MedicineUniversity of PennsylvaniaPhiladelphiaPA 19104USA.

Background TDP-43 proteinopathies represent a spectrum of neurological disorders,anchored clinically on either end by amyotrophic lateral sclerosis(ALS)and frontotemporal degeneration(FTD).The ALS-FTD spectrum exhibits a diverse range of clinical presentations with overlapping phenotypes,highlighting its *** study was aimed to use disease progression modeling to identify novel data-driven spatial and temporal subtypes of brain atrophy and its progression in the ALS-FTD *** We used a data-driven procedure to identify 13 anatomic clusters of brain volume for 57 behavioral variant FTD(bvFTD;with either autopsy-confirmed TDP-43 or TDP-43 proteinopathy-associated genetic variants),103 ALS,and 47 ALS-FTD patients with likely TDP-43.A Subtype and Stage Inference(SuStaIn)model was trained to identify subtypes of individuals along the ALS-FTD spectrum with distinct brain atrophy patterns,and we related subtypes and stages to clinical,genetic,and neuropathological features of *** SuStaIn identified three novel subtypes:two disease subtypes with predominant brain atrophy in either prefrontal/somatomotor regions or limbic-related regions,and a normal-appearing group without obvious brain *** limbic-predominant subtype tended to present with more impaired cognition,higher frequencies of pathogenic variants in TBK1 and TARDBP genes,and a higher proportion of TDP-43 types B,E and *** contrast,the prefrontal/somatomotor-predominant subtype had higher frequencies of pathogenic variants in C9orf72 and GRN genes and higher proportion of TDP-43 type *** normal-appearing brain group showed higher frequency of ALS relative to ALS-FTD and bvFTD patients,higher cognitive capacity,higher proportion of lower motor neuron onset,milder motor symptoms,and lower frequencies of genetic pathogenic *** overall SuStaIn stages also correlated with evidence for clinical progression including longer disease duration,higher King’s stage,and cog

关键词： Amyotrophic lateral sclerosis Frontotemporal degeneration Disease heterogeneity SuStaIn model

外用非甾体类消炎药治疗骨关节炎疗效的Meta分析

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

中国循证医学杂志 2005年第9期5卷 667-674页

作者：林金盈张维亚 Adrian jones michael Doherty 广西壮族自治区人民医院风湿科南宁530021 英国诺丁汉大学城市医院风湿病研究所英国诺丁汉大学城市医院风湿科

目的评价外用非甾体类消炎药治疗骨关节炎的疗效。方法计算机检索MEDLINE,EM-BASE,SCI,CINAHL,Cochrane图书馆和中国生物医学文献数据库等。手工检索已发表和未发表的所有外用非甾体类消炎药随机对照试验,对其逐个进行质量评价,并合并... 详细信息

目的评价外用非甾体类消炎药治疗骨关节炎的疗效。方法计算机检索MEDLINE,EM-BASE,SCI,CINAHL,Cochrane图书馆和中国生物医学文献数据库等。手工检索已发表和未发表的所有外用非甾体类消炎药随机对照试验,对其逐个进行质量评价,并合并数据进行Meta分析。检索时间截至2005年3月30日。结果共纳入13篇随机对照试验,包括1983例患者,均为高质量研究。对治疗有效率的Meta分析结果显示,外用非甾体类消炎药治疗骨关节炎引起的疼痛仅在第1、2周疗效优于安慰剂,疼痛减轻的效应量分别是0·41[95%CI(0·16,0·660)]和0·40[95%CI(0·15,0·65)],而第3、4周疗效与安慰剂比较差异无统计学意义。结论现仅有短期(<4周)的随机对照试验评价外用非甾体类消炎药治疗骨关节炎的疗效。外用非甾体类消炎药用于治疗骨关节炎的疗效仅在第1、2周优于安慰剂,2周后其疗效与安慰剂的差异无统计学意义。目前还没有足够的临床试验证明,使用非甾体类消炎药治疗骨关节炎超过2周仍然有效。

关键词：骨关节炎治疗外用非甾体类消炎药 Meta分析随机对照试验

Information Needs and Self-Care Practices of Diabetic Patients in Mbala, Northern Province, Zambia

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Journal of Biosciences and Medicines 2023年第3期11卷 136-146页

作者： Chisha jones Simuyemba Patricia Katowa-Mukwato Patricia Kabwe Chitundu michael Mumba Kanyanta Facalty of General Nursing Mbala College of Nursing and Midwifery Mbala Zambia Department of Basic and Clinical Nursing Sciences University of Zambia Lusaka Zambia Department of Mental Health and Psychiatric Nursing University of Zambia Lusaka Zambia

Introduction: Diabetes mellitus (DM) is a chronic disease that occurs either when the pancreas does not produce enough insulin or when the body cannot effectively use the insulin it produces. It is “a group of metabolic diseases characterized by hyperglycemia resulting from defects in insulin secretion, insulin action or both” manifested by carbohydrates, fat and protein metabolism abnormality. If untreated high blood sugar can damage the nerves, eyes, kidneys, and other organs. The purpose of this study was to assess the information needs and self-care practice of Diabetic Patients in Mbala, Northern Province Zambia. Methods: This was an analytical cross-sectional study where 105 respondents aged 18 years and above participated in the study. Participants were randomly selected. A structured interview schedule and a check list were used to collect data. Statistics Package for Social Sciences computer software package version 23.0 was used to analyze data. Chi square and fisher’s exact tests were used to test the significance of the association between Knowledge of Diabetes Mellitus, attitude towards self-care practices, self-care practices among Diabetic patients and the need for information among Diabetic patients. A 95% confidence interval and P value of 0.05 were used to ascertain the degree of significance. Multi-variate binary logistic regression model to determine predictors of self-care practices and need for information was also used. Result: On analyzing the dependent variables, more than half (61.9%), had high need for information and three quarters (85.7%) of respondents had poor self-care practices. Slightly more than half (58.1%) had high knowledge levels majority (78.1%), had a negative attitude. Significant associations were found P Conclusion: Negative attitudes and lack of information among Diabetic patients were the main reasons associated with poor self-care practices. Particular attention should therefore be given to ensuring that Diabetic patien

关键词： Information Needs Self-Care Practices Knowledge Attitude Diabetes Mellitus

Comparison of adipose particle size on autologous fat graft retention in a rodent model

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Plastic and Aesthetic Research 2020年第2期7卷 51-63页

作者： Xiaonan Yang Francesco M.Egro Taraneh jones W.Vincent Nerone michael Yousefpour Jeffrey A.Gusenoff J.Peter Rubin Lauren E.Kokai Department of Plastic Surgery University of Pittsburgh School of MedicinePittsburghPA 15213USA No.16 Department of Plastic Surgery Plastic Surgery HospitalChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100730China Department of Chemical Engineering University of PittsburghPittsburghPA 15213USA McGowan Institute for Regenerative Medicine PittsburghPA 15219USA

Aim:Unpredictable retention outcomes remain a significant issue in autologous fat grafting *** cannula variation leads to variability in fat particle *** data suggest that the size of fat particles is closely related to graft healing outcomes;however,this remains a point of contention due to potential confounding variables such as tissue trauma with *** aim of this study was to compare autologous fat grafting outcomes with variable fat particle sizes in an animal model which isolated fat particle size as the primary experimental *** overall goal of this work was to determine if reducing fat particle size is an effective method for enhancing graft retention in autologous fat ***:The range of fat particle diameter harvested by four common liposuction cannulas was quantified to define relevant small and large particle target *** determine if particle size impacted nutrient and oxygen permeability,small and large particles were incubated in vitro in a spinner flask with an abundance of culture media and vascular endothelial growth factor secretion was measured with enzyme-linked immunosorbent ***,small and large fat grafts were prepared from subcutaneous mouse fat pads and grafted in syngeneic Balb/CJ *** and volume retention were evaluated at 1,4,8,and 12 *** analysis with Masson's trichrome and perilipin immunofluorescent staining was ***-time quantitative polymerase chain reaction was performed foradipogenic,inflammatory and apoptotic ***:The range of fat particle diameters harvested with four commonly used cannulas was 2-7 *** vitro studies showed that 5-7-mm particles had significantly increased VEGF secretion normalized to weight,indicating increased tissue hypoxia in these particles compared to 2-4-mm ***,in vivo comparison in two unique studies showed 2-4-mm and 5-7-mm fat particles had comparable graft retention(P=0.5329).

关键词： Fat grafting particle size lipofilling lipoharvesting adipocyte viability clinical translation

Caregiver burden is increased in Parkinson’s disease with mild cognitive impairment (PD-MCI)

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Translational Neurodegeneration 2017年第1期6卷 165-173页

作者： Ann J.jones Roeline G.Kuijer Leslie Livingston Daniel Myall Kyla Horne michael MacAskill Toni Pitcher Paul T.Barrett Tim J.Anderson John C.Dalrymple-Alford New Zealand Brain Research Institute 66 Stewart StreetChristchurch 8011New Zealand Department of Psychology University of CanterburyChristchurchNew Zealand Department of Medicine University of OtagoChristchurchNew Zealand Cognadev UK Ltd.SandtonSouth Africa Department of Neurology Christchurch HospitalChristchurchNew Zealand Brain Research New Zealand Centre of Research Excellence ChristchurchNew Zealand

Background:There is limited evidence on caregiver outcomes associated with mild cognitive impairment in patients with Parkinson’s disease(PD-MCI)and the coping strategies used by these ***:To investigate this relationship,we examined levels of burden,depression,anxiety,coping strategies and positive aspects of caregiving in the informal caregivers of 96 PD *** PD patients were classified using MDS-Task Force Level II criteria as showing either normal cognition(PD-N;n=51),PD-MCI(n=30)or with dementia(PDD;n=15).Results:Mean Zarit Burden Interview(ZBI)score increased significantly between carers of PD-N(M=13.39,SD=12.22)compared to those of PD-MCI patients(M=22.00,SD=10.8),and between carers of PD-MCI and PDD patients(M=29.33,SD=9.59).Moreover,the proportion of carers showing clinically significant levels of burden(ZBI score≥21)also increased as the patients’cognitive status declined(18% for PD-N;60% for PD-MCI;and 80%for PDD)and was mirrored by an increasing amount of time spent providing care by the *** ZBI score was independent of patient neuropsychiatric symptoms,motor function,disease duration and time that caregivers spent *** use of different coping strategies increased with worsening ***,we found only equivocal evidence that the use of problem-focused,emotion-focused and dysfunctional coping mediated the association between patient cognitive status and caregiver burden,because the inverse models that used caregiver burden as the mediator were also ***:The study highlights the impact of Parkinson’s disease on those providing care when the patient’s cognition is poor,including those with *** well-being has important implications for caregiver support,nursing home placement and disease course.

关键词： Parkinson’s disease Mild cognitive impairment Zarit caregiver burden interview Coping Depression Anxiety Positive aspects of caregiving

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

龙卷预报参数——螺旋度的试验结果

气象科技 1993年第1期21卷 40-45页

作者： Robert Davies-jones Donald Burgess michael Foster 李术华美国国家强风暴实验室美国国家气象局预报台

1 引言垂直风切变是预报龙卷的一个重要参数,在某些情况下与风暴运动同等重要。然而直到最近才认识到有利于中尺度气旋及相伴龙卷发展的高空风分布特征。大多数中尺度气旋（中尺度反气旋）生成于相对于风暴（s-r）的低空环境风很强(≥10... 详细信息

1 引言垂直风切变是预报龙卷的一个重要参数,在某些情况下与风暴运动同等重要。然而直到最近才认识到有利于中尺度气旋及相伴龙卷发展的高空风分布特征。大多数中尺度气旋（中尺度反气旋）生成于相对于风暴（s-r）的低空环境风很强(≥10ms-1)

关键词：龙卷预报参数螺旋度试验

Predicting Levels of Crude Protein, Digestibility, Lignin and Cellulose in Temperate Pastures Using Hyperspectral Image Data

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

American Journal of Plant Sciences 2014年第7期5卷 997-1019页

作者： Susanne Thulin michael J. Hill Alex Held Simon jones Peter Woodgate AusCover CSIRO Marine and Atmospheric Research Canberra Australia Cooperative Research Centre for Spatial Information Carlton Australia Department of Earth System Science and Policy University of North Dakota Grand Forks USA Department of Geospatial Sciences RMIT Univer-sity Melbourne Australia Department of Geospatial Sciences RMIT University Melbourne Australia Brockmann-Geomatics Sweden AB Kista Sweden

Hyperspectral sensors provide the potential for direct estimation of pasture feed quality attributes. However, remote sensing retrieval of digestibility and fibre (lignin and cellulose) content of vegetation has proven to be challenging since tissue optical properties may not be propagated to the canopy level in mixed cover types. In this study, partial least squares regression on spectra from HyMap and Hyperion imagery were used to construct predictive models for estimation of crude protein, digestibility, lignin and cellulose concentration in temperate pastures. HyMap and Hyperion imagery and field spectra were collected over four pasture sites in southern Victoria, Australia. Co-incident field samples were analyzed with wet chemistry methods for crude protein, lignin and cellulose concentration, and digestibility was calculated from fiber determinations. Spectral data were subset based on sites and time of year of collection. Reflectance spectra were extracted from the hyperspectral imagery and collated for analysis. Six different transformations including derivatives and continuum removal were applied to the spectra to enhance absorption features sensitive to the quality attributes. The transformed reflectance spectra were then subjected to partial least squares regression, with full cross-validation “leave-one-out” technique, against the quality attributes to assess effects of the spectral transformations and post-atmospheric smoothing techniques to construct predictive models. Model performance between spectrometers, subsets and attributes were assessed using a coefficient of variation (CV), —the interquantile (IQ) range of the attribute values divided by the root mean square error of prediction (RMSEP) from the models. The predictive models with the highest CVs were obtained for digestibility for all spectra types, with HyMap the highest. However, models with slightly lower CVs were obtained for crude protein, lignin and cellulose. The spectral regions for di

关键词： Pasture Quality Crude Protein Digestibility Lignin Cellulose Hyperspectral Remote Sensing Partial-Least Squares Regression

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

AutoCAD 2000建筑设计

丛书名： Autodesk 设计技术丛书

2000年

作者：（美）（A.杰弗里斯）Alan Jefferis （美）（M.琼斯）michael jones 张雷等译

经汤姆森公司授权出版:附光盘 ISBN 7-980007-34-4:本书着重讲解运用AutoCAD 2000绘图命令进行建筑绘图的方法和技巧，内容包含AutoCAD的最新工具，对每条命令都同它在建筑上的应用联系起来加以介绍。

ISBN: (数字)7111081161

ISBN: (纸本)7111081161

关键词：建筑制图制图程序

来源：畅想之星图书光盘版（南... 评论

在线全文

畅想之星图书光盘版（南通市图书馆镜像）

学校读者我要写书评

暂无评论

消化不良的处理原则

临床消化病杂志 1990年第3期2卷 135-136页

作者： Duncan G colin-jones 许军英 MD.FRCP

非溃疡性消化不良是一种最常见的症状群,其发病机理尚未完全明瞭,治疗用药多而杂乱,疗效较难评价,然而,每年耗资甚大,严重影响社会劳动力.因此,本征的严重性,已开始引起我国消化系病临床工作者的重视。中美合资天津史克制药有限公司提... 详细信息

非溃疡性消化不良是一种最常见的症状群,其发病机理尚未完全明瞭,治疗用药多而杂乱,疗效较难评价,然而,每年耗资甚大,严重影响社会劳动力.因此,本征的严重性,已开始引起我国消化系病临床工作者的重视。中美合资天津史克制药有限公司提供本刊一书(Practical Approaches to the Management of Dyspepsia),汇集了国际上知名学者对本症的诊治经验,对提高我们对本病的认识甚有助益.本刊特组织人员参加翻译,后经编辑部审校删节,以专辑形式刊出,供读者参考,并向史克公司表示谢忱.

关键词：天津史克症状群史克公司上消化道疾病社会劳动力处理原则中美合资抗酸剂吞气症器质性病