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Mimicking the physical cues of the ECM in angiogenic biomaterials

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Regenerative Biomaterials 2019年第2期6卷 61-73页

作者： cody O.Crosby Janet Zoldan Department of Biomedical Engineering The University of Texas at AustinAustinTX 78751USA

A functional microvascular system is imperative to build and maintain healthy *** microvasculature results in ischemia,thereby limiting the tissue’s intrinsic regeneration ***,the ability to regenerate microvascular networks is key to the development of effective cardiovascular *** stimulate the formation of new microvasculature,researchers have focused on fabricating materials that mimic the angiogenic properties of the native extracellular matrix(ECM).Here,we will review biomaterials that seek to imitate the physical cues that are natively provided by the ECM to encourage the formation of microvasculature in engineered constructs and ischemic tissue in the body.

关键词： angiogenesis biomaterial–cell interaction materials signal vascular

Hierarchically Clustered HMM for Protein Sequence Motif Extraction with Variable Length

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Tsinghua Science and Technology 2014年第6期19卷 635-647页

作者： cody Hudson Bernard Chen Dongsheng Che Department of Computer Science University of Central Arkansas ConwayAR 72034 USA Department of Computer Science East Stroudsburg University East Stroudsburg PA 18301 USA

Protein sequence motifs extraction is an important field of bioinformatics since its relevance to the structural analysis. Two major problems are related to this field：（1） searching the motifs within the same protein family; and（2） assuming a window size for the motifs search. This work proposes the Hierarchically Clustered Hidden Markov Model（HC-HMM） approach, which represents the behavior and structure of proteins in terms of a Hidden Markov Model chain and hierarchically clusters each chain by minimizing distance between two given chains＇ structure and behavior. It is well known that HMM can be utilized for clustering, however, methods for clustering on Hidden Markov Models themselves are rarely studied. In this paper, we developed a hierarchical clustering based algorithm for HMMs to discover protein sequence motifs that transcend family boundaries with no assumption on the length of the motif. This paper carefully examines the effectiveness of this approach for motif extraction on 2593 proteins that share no more than 25% sequence identity. Many interesting motifs are *** example motifs generated by the HC-HMM approach are analyzed and visualized with their tertiary *** believe the proposed method provides a unique protein sequence motif extraction strategy. The related data mining fields using Hidden Markova Model may also benefit from this clustering on HMM themselves approach.

关键词： Hidden Markov Model hierarchical clustering sequential motif bioinformatics

A Neuro-Muscular Elasto-Dynamic Model of the Human Arm Part 2:Musculotendon Dynamics and Related Stress Effects

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Journal of Bionic Engineering 2009年第2期6卷 108-119页

作者： cody B.Moody Alan A.Barhorst Lawrence Schovanec Texas Tech University Department of Mechanical Engineering Texas Tech University Department of Mathematics and Statistics

In this paper we develop an elasto-dynamic model of the human arm that includes effects of neuro-muscular control upon elastic deformation in the *** elasto-dynamic model of the arm is based on hybrid parameter multiple body system variational projection principles presented in the companion *** the technique is suitable for detailed bone and joint modeling,we present simulations for simplified geometry of the bones,discretized as Rayleigh beams with elongation,while allowing for large *** of the upper extremity is simulated by incorporating muscle forces derived from a Hill-type model of musculotendon *** effects of muscle force are modeled in two *** one approach,an effective joint torque is calculated by multiplying the muscle force by a joint moment ann.A second approach models the muscle as acting along a straight line between the origin and insertion sites of the *** arm motion is simulated by utilizing neural feedback and feedforward *** illustrate the combined effects of neural control strategies, models of muscle force inclusion,and elastic assumptions on joint trajectories and stress and strain development in the bone and tendon.

关键词： elasto-dynamics hybrid parameter system musculo skeletal model neuro-muscular model

Salvage locoregional therapies for recurrent hepatocellular carcinoma

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World Journal of Gastroenterology 2023年第3期29卷 413-424页

作者： cody R Criss Mina S Makary Heritage College of Osteopathic Medicine Ohio UniversityAthensOhio 45701United States Department of Radiology The Ohio State University Wexner Medical CenterColumbusOhio 43210United States

Hepatocellular carcinoma(HCC)is the second most common cause of cancerrelated death *** the advent of screening efforts and algorithms to stratify patients into appropriate treatment strategies,recurrence rates remain *** contrast to first-line treatment for HCC,which relies on several factors,including clinical staging,tumor burden,and liver function,there is no consensus or general treatment recommendations for recurrent HCC(R-HCC).Locoregional therapies include a spectrum of minimally invasive liver-directed treatments which can be used as either curative or neoadjuvant therapy for ***,we provide a comprehensive review of recent evidence using salvage loco-regional therapies for R-HCC after failed curative-intent.

关键词： Recurrent hepatocellular carcinoma Locoregional therapy Transarterial chemoembolization Transarterial embolization Transarterial radioembolization Ablation Salvage therapy

Metabolic engineering in woody plants: challenges, advances, and opportunities

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aBIOTECH 2021年第3期2卷 299-313页

作者： Shu Yu cody S.Bekkering Li Tian Department of Plant Sciences Mail Stop 3University of CaliforniaDavisCA 95616USA

Woody plant species represent an invaluable reserve of biochemical diversity to which metabolic engineering can be applied to satisfy the need for commodity and specialty chemicals,pharmaceuticals,and renewable *** plants are particularly promising for this application due to their low input needs,high biomass,and immeasurable ecosystem ***,existing challenges have hindered their widespread adoption in metabolic engi neering efforts,such as long generation times,large and highly heterozygous genomes,and difficulties in transfor mation and *** advances in omics approaches,systems biology modeling and plant transformation and regeneration methods provide effective approaches in overcoming these outstanding *** brought by developments in this space are steadily opening the door to widespread metabolic engineering of woody pl ants to meet the global need for a wide range of sustainably sourced chemicals and materials.

关键词： Woody plant Metabolic engineering Bioeconomy Sustainability

When traditional ground support techniques aren’t enough–Chemical injections can solve complex problems

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International Journal of Mining Science and Technology 2020年第1期30卷 119-122页

作者： cody Hildreth Frederick Cybulski Colton Cook Stephen C.Tadolini Minova Americas GeorgetownKY 40324USA Arch Coal Inc.SharplesWV 25183USA

Broken and jointed ground is extremely hazardous and requires unique stabilization techniques to protect workers and critical *** techniques,even the most advanced pre-load to create roof compression,can leave large gaps of unconfined and separated *** roof can also be susceptible to water inflows which only exacerbate the support *** types of conditions existed on long-term development main entry accessing several future longwall *** geotechnical assessment identified well defined jointing systems that also permitted water to flow between the roof separations,which"lubricated"the roof material and minimized any frictional *** injections of polyurethane materials,Minova Carbopur WS,was placed beyond the bolted horizon to move the water to the rib lines and reinforce the fractured and broken *** injection materials permitted the effective use of bolting patterns and helped ensure long-term stability of critical *** paper describes the evaluation techniques,design patterns,basis for chemical selection and application,and results and recommendations.

关键词： Chemical injection Polyurethane Water stoppage

TURNING RED Photographer cody Ellinghams First Impression of Chinas Global Financial Hub

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城市漫步（上海版、英文） 2018年第10期 12-15页

作者： Dominic Ngai cody Ellingham 不详

For cody Ellingham(@cbje_tokyo),a New Zealand-born,Tokyo-based photographer who's been living in Japan since 2012,his current home base screams 1980s-an era that served as the inspiration for the cyberpunk aesthetics ... 详细信息

关键词： culture TURN Ell

From plastids to the cytosol:Redefining boundaries for provitamin A biofortification in plants

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Molecular Plant 2023年第7期16卷 1109-1112页

作者： Shu Yu cody S.Bekkering Li Tian Department of Plant Sciences University of CaliforniaDavisDavisCA 95616USA

Carotenoids:Importanceand integration ofmicrobial biosyntheticpathwaysin plants Carotenoids are essential molecules found in plants that fulfill critical functions in light capture,photoprotection,and *** also act as precursors for apocarotenoid signaling compounds including phytohormones such as abscisic acid and *** plants,carotenoids play a significant role in humans;particularly,carotenoids possessing unsubstitutedβ-ionone rings can be converted into retinal,the precursor to vitamin A,making their dietary consumption important to human health(Watkins and Pogson,2020;Zheng et al.,2020).Increasing the accumulation of these carotenoid compounds,known as provitamin A carotenoids(PACs),is an important aim in the global endeavor to cultivate biofortified crops with enhanced nutritional *** availability of germplasm with variation in carotenoid accumulationis crucial for successful provitamin A biofortification initiatives that use both traditional plantbreeding methods and recently developed molecular biology techniques(Zheng et al.,2020).

关键词： substituted converted rings

Three-dimensional dynamic characterization of square-nosed slugging phenomena in a fluidized bed

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Particuology 2022年第8期20卷 35-46页

作者： Yaswanth Pottimurthy Dawei Wang cody Park Shalin Patil Andrew Tong Liang-Shih Fan Willam G.Lowrie Department of Chermical and Biomolecular Engineering.The Ohio State Univrsity ColumbusOH 43210USA

Slugging represents one of the major regimes in fluidization,which occurs in small diameter beds with large bed height-to-diameter ratio or in large diameter beds with internals that resemble multiple small diameter fluidized *** types include round-nosed slug,wall slug and square nosed *** of the slugs have been mainly focused on round-nosed or wall slugs known as half *** occurring in Geldart group A particle *** square-nosed slug typically occurring for Geldart group D particles appears to be regarded as simple in its *** Electrical Capacitance Volume Tomogra phy(ECVT)imaging of the square-nosed slugging phenomena conducted in this study reveals *** is the structure of the square nosed slug is,in fact,complex,particularly with respect to its dynamic variation in *** *** study examines experimentally the hydrodynamic character-istics of the square-nosed fluidization ***,simultaneous measurements from multiple ECVT sensors provide non-inv asive,continuous,*** imaging of the entire flow region of the slugging bed and hence enabling the dynamic characterization of the evolution of the *** analysis of the 3D images reconstructed for real time gas-solid volume fraction profile of the slugging fluidized bed indicates that there are three different *** bottom fluidization zone,the gas slug zone,and the solid slug zone,co-existing in the *** three zones present different hydrodynamic characteristics during the slug *** is found that varying the gas velocity of the slugging bed mainly varies the maximum length of the gas slug zone,while it only has a minor effect on the lengths of the bottom fluidization zone and solid slug *** also has an insignificant efect on the solid volume fraction of the three zones.

关键词： Gas-solid flow Fluidized bed Square-nosed slugging Electrical Capacitance Volume Tomography