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Polymorphisms in base excision repair genes: Breast cancer risk and individual radiosensitivity

World Journal of Clinical Oncology 2014年第5期5卷 874-882页

作者： clarice patrono Silvia Sterpone Antonella Testa Renata Cozzi Technical Unit of Radiation Biology and Human Health Italian National Agency for New Technologies Energy and Sustainable Economic Development(ENEA) Department of Science University "Roma TRE"

Breast cancer(BC) is the most common cancer among women worldwide. The aetiology and carcinogenesis of BC are not clearly defined, although genetic, hormonal, lifestyle and environmental risk factors have been established. The most common treatment for BC includes breast-conserving surgery followed by a standard radiotherapy(RT) regimen. However, radiation hypersensitivity and the occurrence of RT-induced toxicity in normal tissue may affect patients' treatment. The role of DNA repair in cancer has been extensively investigated, and an impaired DNA damage response may increase the risk of BC and individual radiosensitivity. Single nucleotide polymorphisms(SNPs) in DNA repair genes may alter protein function and modulate DNA repair efficiency, influencing the development of various cancers, including BC. SNPs in DNA repair genes have also been studied as potential predictive factors for the risk of RT-induced side effects. Here, we review the literature on the association between SNPs in base excision repair(BER) genes and BC risk. We focusedon X-ray repair cross complementing group 1(XRCC1), which plays a key role in BER, and on 8-oxoguanine DNA glycosylase 1, apurinic/apyrimidinic endonuclease 1 and poly(ADP-ribose) polymerase-1, which encode three important BER enzymes that interact with XRCC1. Although no association between SNPs and radiation toxicity has been validated thus far, we also report published studies on XRCC1 SNPs and variants in other BER genes and RT-induced side effects in BC patients, emphasising that large well-designed studies are needed to determine the genetic components of individual radiosensitivity.

关键词： Breast cancer Polymorphisms Base excision repair Susceptibility Radiosensitivity

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Overcoming fixation:Shaping BPS to fit into design practice

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Building Simulation 2024年第7期17卷 1037-1041页

作者： Pieter de Wilde clarice Bleil de Souza Division of Energy and Building Design Lund UniversitySweden Welsh School of Architecture Cardiff UniversityUK

Problem definition The use of Building Performance Simulation(BPS)to support building design has long been the‘holy grail’of building science *** can also be used during construction and operation of buildings,for instance supporting rating and certification,optimal control,or fault emulation,but design support is particularly interesting as this is where the foundations for future building performance are *** underlying premise is that good predictions of future building performance can inform and improve design decision-making,and thus help to create buildings that are more energy efficient,more comfortable,and overall perform better than buildings that are designed without such *** on BPS for design support has been carried out since the emergence of building science as a separate area of research in the 1960s(Markus et al.1972;Clarke 2001;Maver 2002;Augenbroe et al.2004).

关键词： supporting design instance

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Common dental diseases in children and malocclusion

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International Journal of Oral Science 2018年第2期10卷 65-71页

作者： Jing Zou Mingmei Meng clarice S Law Yale Rao Xuedong Zhou State Key Laboratory of Oral Diseases&National Clinical Research Center for Oral Diseases&Department of Pediatric Dentistry West China School of StomatologySichuan UniversityChengdu 610041China Sections of Pediatric Dentistry and Orthodontics Division of Growth and DevelopmentUCLA School of DentistryUniversity of CaliforniaLos AngelesCAUSA Victoria General Hospital VictoriaBCCanada

Malocclusion is a worldwide dental problem that influences the affected individuals to varying degrees. Many factors contribute to the anomaly in dentition, including hereditary and environmental aspects. Dental caries, pulpal and periapical lesions, dental trauma, abnormality of development, and oral habits are most common dental diseases in children that strongly relate to malocclusion. Management of oral health in the early childhood stage is carried out in clinic work of pediatric dentistry to minimize the unwanted effect of these diseases on dentition. This article highlights these diseases and their impacts on malocclusion in sequence. Prevention, treatment, and management of these conditions are also illustrated in order to achieve successful oral health for children and adolescents, even for their adult stage.

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Cytoprotective role of heme oxygenase-1 and heme degradation derived end products in liver injury

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World Journal of Hepatology 2013年第10期5卷 541-549页

作者： clarice Silvia Taemi Origassa Niels Olsen Saraiva Cmara Laboratory of Experimental and Clinical Immunology Nephrology Division Medicine DepartmentFederal University of So Paulo Laboratory of Transplantation Immunobiology Department of Immunology Institute of Biomedical Science ⅣUniversity of So Paulo

The activation of heme oxygenase-1(HO-1) appears to be an endogenous defensive mechanism used by cells to reduce inflammation and tissue damage in a number of injury models. HO-1, a stress-responsive enzyme that catabolizes heme into carbon monoxide(CO), biliverdin and iron, has previously been shown to protect grafts from ischemia/reperfusion and *** addition, the products of the HO-catalyzed reaction, particularly CO and biliverdin/bilirubin, have been shown to exert protective effects in the liver against a number of stimuli, as in chronic hepatitis C and in transplanted liver grafts. Furthermore, the induction of HO-1 expression can protect the liver against damage caused by a number of chemical compounds. More specifically, the CO derived from HO-1-mediated heme catabolism has been shown to be involved in the regulation of inflammation; furthermore, administration of low concentrations of exogenous CO has a protective effect against inflammation. Both murine and human HO-1 deficiencies have systemic manifestations associated with iron metabolism, such as hepatic overload(with signs of a chronic hepatitis) and iron deficiency anemia(with paradoxical increased levels of ferritin).Hypoxia induces HO-1 expression in multiple rodent,bovine and monkey cell lines, but interestingly, hypoxia represses expression of the human HO-1 gene in a variety of human cell types(endothelial cells, epithelial cells, T cells). These data suggest that HO-1 and CO are promising novel therapeutic molecules for patients with inflammatory diseases. In this review, we present what is currently known regarding the role of HO-1 in liver injuries and in particular, we focus on the implications of targeted induction of HO-1 as a potential therapeutic strategy to protect the liver against chemically induced injury.

关键词： Heme oxygenases Bilirubin Hepatitis C Kupffer cells Polymorphisms Immunoregulatory Hypoxia Liver ischemia

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Clay mineralogy affects the efficiency of sewage sludge in reducing lead retention of soils

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Journal of Environmental Sciences 2019年第6期31卷 45-57页

作者： Giovana clarice Poggere Vander Freitas Melo Beatriz Monte Serrat Ant?nio Salvio Mangrich Amanda Araújo Fran?a Rodrigo Stuart Corrêa Julierme Zimmer Barbosa Soil Science and Agricultural Engineering Department Federal University of Paraná State Chemistry Department Federal University of Paraná StateCentro Politécnico Institute of Criminalistic Civil Police

Recent studies have shown the feasibility of using of sewage sludge for the remediation of heavy metal-contaminated soils. However, there are no researches to check the influence of clay mineralogy on the efficiency of the sewage sludge to remediation of contaminated soils with heavy metals. For this purpose, we use two contrasting soils:Oxisol rich in hematite and gibbsite and Inceptisol rich in kaolinite. Thermal-treated sludge was applied to Pb-contaminated soil samples and incubated for 40 days. The soil samples were submitted to seven sequential extractions: soluble-Pb, exchangeable-Pb,precipitated-Pb, organic matter-Pb, Fe and Mn oxide-Pb, gibbsite and kaolinite-Pb, and residual-Pb. The reduction of soluble Pb forms by thermal sludge application was more pronounced in the Oxisol than in the Inceptisol because of the conversion of soluble-Pb into more stable forms, such as precipitated-Pb and oxides-Pb. For Inceptisol was necessary to apply high rates of thermal sludge to reach a significant reduction in soluble-Pb contents. The addition of humic fractions in the form of thermal sludge increased the concentration of organic matter-Pb. In confined area, the use of sewage sludge to reduce the heavy metals levels in soils must be better considered, mainly in more weathered soils.

关键词： Sequential extraction Humic fraction Fe oxides Gibbsite Kaolinite

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Cannabinoid CB_(2) receptors and spinal microglia are implicated in tingenone-mediated antinociception in mice

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Asian Pacific Journal of Tropical Biomedicine 2021年第4期11卷 141-147页

作者： clarice C.V.Moura Rafaela S.dos Santos Lucienir P.Duarte Giovane Galdino Pharmaceutical Sciences Faculty Federal University of AmazonasManausAmazonasBrazil Institute of Motricity Science Federal University of AlfenasAlfenasMinas GeraisBrazil Department of Chemistry Institute of Exact SciencesUFMGBelo HorizonteMinas GeraisBrazil

Objective:To investigate the antinociceptive effect of tingenone on inflammatory pain,as well as and the involvement of the cannabinoid receptors type 2(CB2)and spinal microglia in this ***:Male Swiss mice were subjected to inflammatory pain induced by intraplantar injection of *** nociceptive threshold was measured by von Frey filaments *** was administered orally 60 min before carrageenan *** evaluate the involvement of CB2 receptor,endocannabinoids,and microglia,AM630(a CB2 receptor antagonist),MAFP(an inhibitor of an enzyme that hydrolyses endocannabinoids),and minocycline(a microglial inhibitor)were given intrathecally 20 min before tingenone *** addition,an immunofluorescence assay was used to evaluate CB2 receptor and CD11 B(a microglial marker)expression in the spinal cord dorsal ***:Tingenone significantly reduced carrageenan-induced hyperalgesia,which was reversed by pretreatment with *** and minocycline potentiated and prolonged the tingenoneinduced ***11 B expression was increased in the spinal cord dorsal horn of mice with inflammatory pain pretreated with tingenone,which was reduced by AM630,MAFP,and ***:CB2 receptors and endocannabinoids participate in the tingenone-induced antinociception which may involve the inhibition of microglia at spinal level.

关键词： Tingenone Antinociception CB2 Cannabinoid receptor Endocannabinoids Microglia

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The Construction of Learning Object： Tools for the Teaching

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Sino-US English Teaching 2016年第8期13卷 627-643页

作者： Me. clarice Ghisi State of Secreataria Rondonia Education Brazil

The main objective of this work was the construction of a Multidisciplinary Learning Object as a tool for teaching, enabling the use of information and communication technologies for use by teachers acting in elementary school, based on Discourse Analysis, Theory Cybernetic-systemic, the Multiple Intelligences and Collaborative Learning. All of them are informed by Foucault, Pecheux, Bakhtin, Gardner, Levy, and others. The theoretical contribution is justified to the extent that the student is above all a being inserted into a user company tool created by it over time, to act on the world. Theoretical principles underlying the construction of learning objects as tools for teaching are related to teaching and learning. The developed learning object establishes the link between the fields of pedagogy and usability, the step by step construction of each of them and their purposes, characteristics, and all detailed in the development of research. The construction of the learning object follows the steps of a methodological construction for the development of a computerized product, followed by a systematic planning and the design and construction.

关键词： learning theories learning object construction

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Designing zeolites for the removal of aqueous PFAS:a perspective

Industrial Chemistry & Materials

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Industrial Chemistry & Materials 2024年第2期2卷 270-275页

作者： Charles A.Ponge David R.Corbin clarice M.Sabolay Mark B.Shiflett Institute for Sustainable Engineering University of KansasUSA Chemical and Petroleum Engineering University of KansasUSA

Zeolites possess unique sieving properties that offer a high selectivity for removing pollutants,such as perand polyfluoroalkyl substances(PFAS).However,there are limited studies examining the efficacy of zeolites as PFAS *** literature explores the effects of certain frameworks and the silica alumina ratio(SAR),and only one study has shown the effect of silanol defects on the hydrophobicity of the *** most zeolites are synthesized in hydroxide media,this leads to formation of silanol defects,which increase hydrophilicity with a greater effect than the inclusion of non-Si T *** is critical that specific characterizations be performed to demonstrate the specific effects of different properties of the *** particular,synthesis,modification,and/or repair in fluoride media can be used to increase the hydrophobicity of zeolites by reducing silanol defects,and increasing Lewis acidity.

关键词： Zeolites Aqueous adsorption PFAS Hydrophobic interaction Silica–alumina ratio

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Hepatitis C virus: Promising discoveries and new treatments

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World Journal of Gastroenterology 2016年第28期22卷 6393-6401页

作者： Juliana Cristina Santiago Bastos Marina Aiello Padilla Leonardo Cardia Caserta Noelle Miotto Aline Gonzalez Vigani clarice Weis Arns Laboratory of Virology Institute of Biology State University of Campinas - UNICAMP Internal Medicine Department Infectious Diseases division FCM-UNICAMP

Despite advances in therapy, hepatitis C virus(HCV) infection remains an important global health issue. It is estimated that a significant part of the world population is chronically infected with the virus, and many of those affected may develop cirrhosis or liver cancer. The virus shows considerable variability, a characteristic that directly interferes with disease treatment. The response to treatment varies according to HCV genotype and subtype. The continuous generation of variants(quasispecies) allows the virus to escape control by antivirals. Historically, the combination of ribavirin and interferon therapy has represented the only treatment option for the disease. Currently, several new treatment options are emerging and are available to a large part of the affected population. In addition, the search for new substances with antiviral activity against HCV continues, promising future improvements in treatment. Researchers should consider the mutation capacity of the virus and the other variables that affect treatment success.

关键词： Hepatitis C infection Hepatitis C virus Treatments Antiviral research

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Development of a panel of unigene-derived polymorphic EST–SSR markers in lentil using public database information

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The Crop Journal 2016年第5期4卷 425-433页

作者： Debjyoti Sen Gupta Peng Cheng Gaurav Sablok Dil Thavarajah Pushparajah Thavarajah clarice J.Coyne Shiv Kumar Michael Baum Rebecca J.McGee Department of Plant Sciences North Dakota State University ICAR-ARS Indian Institute of Pulses Research Division of Plant Sciences University of Missouri Department of Biodiversity and Molecular Ecology Research and Innovation Centre Fondazione Edmund Mach Agricultural and Environmental Sciences Clemson University International College Beijing China Agricultural University USDA-ARS Western Regional Plant Introduction Station Washington State University BIGM Program International Center for Agricultural Research in the Dry Areas (ICARDA) USDA-ARS Grain Legume Genetics and Physiology Research Unit Washington State University

Lentil(Lens culinaris Medik.), a diploid(2n = 14) with a genome size greater than 4000 Mbp, is an important cool season food legume grown worldwide. The availability of genomic resources is limited in this crop species. The objective of this study was to develop polymorphic markers in lentil using publicly available curated expressed sequence tag information(ESTs). In this study, 9513 ESTs were downloaded from the National Center for Biotechnology Information(NCBI) database to develop unigene-based simple sequence repeat(SSR) markers. The ESTs were assembled into 4053 unigenes and then analyzed to identify 374 SSRs using the MISA microsatellite identification tool. Among the 374 SSRs, 26 compound SSRs were *** pairs for these SSRs were designed using Primer3 version 1.14. To classify the functional annotation of ESTs and EST–SSRs, BLASTx searches(using E-value 1 × 10-5) against the public UniP rot(http://***/) and NCBI(http://***/) databases were performed. Further functional annotation was performed using PLAZA(version3.0) comparative genomics and GO annotation was summarized using the Plant GO slim category. Among the synthesized 312 primers, 219 successfully amplified Lens DNA. A diverse panel of 24 Lens genotypes was used to identify polymorphic markers. A polymorphic set of 57 markers successfully discriminated the test genotypes. This set of polymorphic markers with functional annotation data could be used as molecular tools in lentil breeding.

关键词： Lens culinaris EST-SSRs Functional annotation Unigene sequences EST database Genetic resources

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