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Chinese Neurosurgical Journal 2021年第2期7卷 131-136页

作者： Hui Ma Lian Xu Cui Ping Kuen Lam cindy s.w.tong Kin K.Y.Lo George K.C.wong wai sang Poon Division of Neurosurgery Chow Tai Fook-Cheng Yu Tung Surgical Stem Cell Research CenterDepartment of SurgeryThe Chinese University of Hong KongShatinHong KongSARChina Division of Neurosurgery Department of SurgeryFo Shan First People’s HospitalFoshanGuangdongChina

Background:Our previous studies showed that topical application of mesenchymal stem cells(MsCs)improved functional recovery in rat traumatic brain injury(TBI)model,and hypoxic precondition further enhanced the therapeutic effects of *** was no previous study on the attenuation of cerebral edema by *** investigated whether topical application of normoxic and hypoxic MsCs could reduce cerebral edema in an experimental TBI ***:Two million normoxic(N=24)and hypoxic(N=24)MsCs were applied topically to exposed the cerebral cortex in a controlled cortical impact(CCI)*** MsCs were fixed in position with fibrin *** treatment was given to control animals(TBI only:n=24).After surgery,four animals in each group were sacrificed daily(day 1 to day 6)for edema *** animals without TBI were used as reference(n=4).The expressions of GFAP,AQP4,and MMP9 were also investigated by immunofluorescence staining and RT-PCR at day ***:The edema peaked within 3 days after *** with the control,hypoxic MsCs reduced brain water content significantly(psCs downregulated the expression of MMP9 and normalized AQP4 distribution to astrocyte end ***:Our preliminary study showed that topical application of hypoxic MsCs suppressed both vasogenic and cytotoxic edema formation.

关键词： Topical MsCs Cerebral edema TBI

Use of tree species by three species of Magicicada(Hemiptera:Cicadidae)in an Appalachian forest

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Journal of Forestry Research 2023年第6期34卷 2051-2063页

作者： cindy Perkovich David ward Department of Biology and Toxicology Ashland UniversityAshlandOH 44805USA Department of Biological sciences Kent State UniversityKentOH 44242USA

Periodical cicadas(Magicicada spp.)are endemic to deciduous forests in the eastern United *** successional forests,they must partition resources such as host trees to *** measured tree size,emergence holes,oviposition scar bundles,and chorusing center abundances of Magicicada species on 12 common tree species in a deciduous forest to understand host-tree *** predicted that the abundance of periodical cicadas and use of specific host-tree species would change depending on the Magicicada species and tree life *** considered the size of the tree(diameter at breast height)as a covariate to control for tree size and collected eggs for a greenhouse experiment to assess whether nymphs prefer to feed on Quercus rubra or Acer *** emergence holes were found below Quercus species than any other tree *** abundance of periodical cicadas on host trees used for chorusing centers varied depending on the Magicicada species,but were most abundant on Quercus *** scar bundles were also more frequent on *** nymphs were found on Quercus than Acer in the nymph preference *** periodical cicadas used Quercus hosts more than other tree species,their abundances on different host tree sizes and species differed *** cicada species may use specific host species and life stages as a way to partition resources and minimize competition among the Magicicada species during emergence years.

关键词： Ecological succession Habitat partitioning Periodical cicadas successional forests

Using induced pluripotent stem cells derived neurons to model brain diseases

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Neural Regeneration Research 2017年第7期12卷 1062-1067页

作者： cindy E.McKinney iPsC Lab/Edward Via College of Osteopathic Medicine and The Gibbs Research Institute Spartanburg SC USA

The ability to use induced pluripotent stem cells（i PsC）to model brain diseases is a powerful tool for unraveling mechanistic alterations in these *** models of brain diseases have spurred understanding of pathology but the concern arises that they may not recapitulate the full spectrum of neuron disruptions associated with human *** derived neurons,or other neural cell types,provide the ability to access pathology in cells derived directly from a patient＇s blood sample or skin biopsy where availability of brain tissue is ***,utilization of iPsC to study brain diseases provides an unlimited resource for disease modelling but may also be used for drug screening for effective therapies and may potentially be used to regenerate aged or damaged cells in the *** brain diseases across the spectrum of neurodevelopment,neurodegenerative and neuropsychiatric are being approached by iPsC *** goal of an iPsC based disease model is to identify a cellular phenotype that discriminates the disease-bearing cells from the control *** this mini-review,the importance of iPsC cell models validated for pluripotency,germline competency and function assessments is *** examples for the variety of brain diseases that are being approached by iPsC technology to discover or establish the molecular basis of the neuropathology are discussed.

关键词： induced pluripotent stem cells neuron cell models brain diseases molecular mechanisms therapeutics translational medicine

Chitosan-praseodymium complex for adsorption of fluoride ions from water

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Journal of Rare Earths 2015年第10期33卷 1104-1113页

作者： Eny Kusrini Nofrijon sofyan Nyoman suwartha Gefin Yesya cindy Rianti Priadi Department of Chemical Engineering Faculty of Engineering Universitas Indonesia Department of Metallurgical and Materials Engineering Faculty of Engineering Universitas Indonesia Department of Civil Engineering Faculty of Engineering Universitas Indonesia

Engineering of chitosan by praseodymium has been investigated to improve the adsorption properties as well as physical characteristics of chitosan. Modification of chitosan changes the original properties of chitosan so that it can be more suitable for adsorption of fluoride ions. In this study, chitosan-praseodymium （Chi-Pr） was synthesized by impregnation method. The Chi-Pr complex was characterized by scanning electron microscopic-energy dispersive X-ray spectroscopy （sEM-EDX）, Fourier transform infrared （FTIR） and employed as an adsorbent for removal of fluorides ions from water in the batch system. The variables such as contact time, concentration of Pr, adsorbent dose, initial concentration of fluoride ions, and competitor anions were studied. The adsorption efficiency of fluoride ions （n） with increasing Pr loading into chitosan （5 wt.%, 10 wt.%, 15 wt.%, 20 wt.% and 25 wt.%） were 35.5%, 56.1%, 72.0%, 68.5% and 62.5%, respectively. The Chi-Pr （15 wt.%） complex had the highest fluoride removal efficiency （72.0%）. The experimental data fitted well to the Langmuir isotherm with maximum adsorption capacity （qmax） of 15.87 mg/g and an equilibrium constant （kL） of 0.15 mg. Kinetic study revealed that the adsorption of fluoride ions from water followed pseudo-second-order model with a maximum adsorption capacity （q2） of 8.20 mg/g and a rate constant （k2） of 0.01 g/***. Adsorption efficiency of fluoride ions in the simulated drinking water was diminished with the changes in pH levels. The presence of Pr3＋ in chitosan increased chitosan＇s performance as an adsorbent for adsorption of fluoride ions.

关键词： adsorption of fluoride chitosan isotherms studies kinetics study praseodymium rare earths

TRP Channels in stroke

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Neuroscience Bulletin 2024年第8期40卷 1141-1159页

作者： Pengyu Zong cindy XLi Jianlin Feng Mara Cicchetti Lixia Yue Department of Cell Biology Calhoun Cardiology CenterSchool of Medicine(UConn Health)University of ConnecticutFarmingtonCT 06030USA Institute for the Brain and Cognitive sciences University of Connecticut337 Mansfield RoadUnit 1272StorrsCT 06269USA Present Address:Department of Neuroscience University of Pittsburgh4200 Fifth AvePittsburghPA 15260USA

Ischemic stroke is a devastating disease that affects millions of patients ***,there are no effective medications for mitigating brain injury after ischemic *** channels are evolutionally ancient biosensors that detect external stimuli as well as tissue or cellular *** date,many members of the TRP superfamily have been reported to contribute to ischemic brain injury,including the TRPC subfamily(1,3,4,5,6,7),TRPV subfamily(1,2,3,4)and TRPM subfamily(2,4,7).These TRP channels share structural similarities but have distinct channel functions and *** activation during ischemic stroke can be beneficial,detrimental,or even *** this review,we focus on discussing the interesting features of stroke-related TRP channels and summarizing the underlying cellular and molecular mechanisms responsible for their involvement in ischemic brain injury.

关键词： stroke TRP channels-Neuronal death Immune cell infiltration Blood-brain barrier Glial activation

In vitro Response of Human Mesenchymal stromal Cells to Titanium Coated Peek Films and Their suitability for Magnetic Resonance Imaging

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Journal of Materials science & Technology 2015年第5期31卷 427-436页

作者： cindy Elschner Carolin Noack Carolin PreilBler Andreas Krause Ulrich scheler Ute Hempel Leibniz-Institut fr Polymerforschung Dresden e.V. Hohe Str.601069 DresdenGermany CRTD/DFG-Center for Regenerative Therapies Dresden Fetscherstr.10501307 DresdenGermany Institut fr Physiologische Chemie Technische Universitt DresdenFiedlerstr.4201307 DresdenGermany NaMlab gGmbH Nthnitzer Str.6401187 DresdenGermany

Medical imaging is an important tool for the post-operative checkup of an accurate position of an implant as well as for monitoring the integration in the adjacent tissue that may influence the success of a medical ***,the possibility to use imaging methods is associated with the implant material and all the established metallic materials for surgery do not show a proper 'imaging compatibility'.The present study is a combined investigation of the in vitro response to human mesenchymal stromal cells（hMsC） and magnetic resonance imaging（MRI） compatibility of the potential material combination polyetheretherketone/titanium（PEEK/Ti） for medical *** of the advantageous imaging properties and the mechanical and chemical stability,PEEK becomes more and more an alternative to common metallic implant materials like titanium or ***,PEEK is a bioinert material having a limited ability for direct bone *** to its excellent biocompatibility,Ti was chosen as coating material to enhance the cellular *** result is a combination with advantageous properties:the magnetic susceptibility and elastic modulus close to bone,corrosion resistance and mechanical flexibility of PEEK and the excellent biocompatibility of *** appearance of metal-related artifact was discussed in electrical resistivity and magnetic ***,two titanium coatings have been investigated:a complete coating and a structured surface avoiding surface *** determine the in vitro biocompatibility,the cell responses were assessed in terms of the overall morphology of the hMsC and their cell area distribution,proliferation,osteogenic differentiation and mineral *** cellular stress was evaluated by the prostaglandin *** bonded materials both produced no disturbing artifacts in magnetic resonance *** to the pure PEEK material,the titanium coated specimens showed an enhanced biocompatibilit

关键词： Polyetheretherketone Titanium coating Biocompatibi

Tool Failure Analysis in High speed Milling of Titanium Alloys

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武汉理工大学学报 2006年第S1期28卷 137-142页

作者： MEYER Kevin YU cindy s M wu Manufacturing Research Center University of MichiganAnn ArborMIUSA48109

In high speed milling of titanium alloys the high rate of tool failure is the main reason for its high manufacturing cost. In this study,fractured tools which were used in a titanium alloys 5-axis milling process have been observed both in the macro scale using a PG-1000 light microscope and in the micro scale using a scanning Electron Microscope (sEM) respectively. These observations indicate that most of these tool fractures are the result of tool chipping. Further analysis of each chipping event has shown that beachmarks emanate from points on the cutting edge. This visual evidence indicates that the cutting edge is failing in fatigue due to cyclical mechanical and/or thermal stresses. Initial analyses explaining some of the outlying conditions for this phenomenon are discussed. Future analysis regarding determining the underlying causes of the fatigue phenomenon is then outlined.

关键词： titanium alloys high speed milling cutting edge chipping tool failure analysis

Hyperparameter optimization for cardiovascular disease data-driven prognostic system

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Visual Computing for Industry,Biomedicine,and Art 2023年第1期6卷 218-244页

作者： Jayson saputra cindy Lawrencya Jecky Mitra saini suharjito suharjito Industrial Engineering Department BINUS Graduate Program-Master of Industrial EngineeringBina Nusantara UniversityJakarta 11480Indonesia

Prediction and diagnosis of cardiovascular diseases(CVDs)based,among other things,on medical examinations and patient symptoms are the biggest challenges in *** 17.9 million people die from CVDs annually,accounting for 31%of all deaths *** a timely prognosis and thorough consideration of the patient’s medical history and lifestyle,it is possible to predict CVDs and take preventive measures to eliminate or control this life-threatening *** this study,we used various patient datasets from a major hospital in the United states as prognostic factors for *** data was obtained by monitoring a total of 918 patients whose criteria for adults were 28-77 years *** this study,we present a data mining modeling approach to analyze the performance,classification accuracy and number of clusters on Cardiovascular Disease Prognostic datasets in unsupervised machine learning(ML)using the Orange data mining *** techniques are then used to classify the model parameters,such as k-nearest neighbors,support vector machine,random forest,artificial neural network(ANN),naïve bayes,logistic regression,stochastic gradient descent(sGD),and *** determine the number of clusters,various unsupervised ML clustering methods were used,such as k-means,hierarchical,and density-based spatial clustering of applications with noise *** results showed that the best model performance analysis and classification accuracy were sGD and ANN,both of which had a high score of 0.900 on Cardiovascular Disease Prognostic *** on the results of most clustering methods,such as k-means and hierarchical clustering,Cardiovascular Disease Prognostic datasets can be divided into two *** prognostic accuracy of CVD depends on the accuracy of the proposed model in determining the diagnostic *** more accurate the model,the better it can predict which patients are at risk for CVD.

关键词： Cardiovascular disease Data-driven analytics Data mining Hyperparameter optimization Orange data mining software Prognostic system Unsupervised machine learning

Implantation of trabecular micro-bypass stent using a novel “landing strip” technique

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International Journal of Ophthalmology(English edition) 2017年第5期10卷 738-741页

作者： cindy X.Zheng Marlene R.Moster Priyanka Gogte Yang Dai Remy s.Manzi Michael waisbourd Glaucoma Research Center Wills Eye Hospital PhiladelphiaPA 19107 USA

AIM：To describe a novel technique of creating a landing strip within the trabecular meshwork to guide trabecular micro-bypass stent（istent） implantation in patients who underwent ***：Thirty-four eyes from 30 patients who underwent i stent implantation after phacoemulsification from May 2014 to February 2015 were included in our retrospective study. All istents were implanted via the ＂landing strip＂ technique. A 25-gauge microvitreoretinal blade was used to bisect the trabecular meshwork to less than 1 clock-hour, effectively creating a landing strip. The istent applicator was pressed along the landing strip and then the stent was released into the trabecular meshwork. REsULTs：Of the 34 eyes with istent implantation, 27（79.4%） eyes had primary open-angle glaucoma, 6（17.6%） eyes had pseudoexfoliation glaucoma, and 1（2.9%） eye had ocular hypertension. At 6-month follow-up（n=17）, the mean number of hypotensive medications decreased from 2.2±1.2 at baseline to 0.8±1.3（P=0.05） and mean intraocular pressure decreased from 19.7±4.1 mm Hg at baseline to 16.7±2.1 mm Hg（P=0.58）. Two eyes（5.9%） required subsequent trabeculectomy. CONCLUsION：The ＂landing strip＂ technique appears to be an effective way to assist with is tent implantation.

关键词： istent trabecular micro-bypass stent microinvasive glaucoma surgery glaucoma trabecular meshwork

贵州中三叠世混形黔鳄(爬行纲:主龙类)海生适应性的再研究

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北京大学学报（自然科学版） 2023年第6期59卷 961-969页

作者： cindy X.s.U 周敏顾书纶 Ryosuke Motani 江大勇北京大学地球与空间科学学院北京100871 北京大学地质博物馆北京100871 Department of Earth and Planetary sciences University of California DavisDavisCA 95616-8605

基于对混形黔鳄(Qianosuchus mixtus)新标本的观察和测量,对其海生适应性进行再研究。按照非鸟类四足动物的海生适应性的5个阶段(M1~M5),将混形黔鳄的测量数据与其他类群进行对比,判断混形黔鳄处于对海洋生活适应的M2-3阶段,尚不能将其... 详细信息

基于对混形黔鳄(Qianosuchus mixtus)新标本的观察和测量,对其海生适应性进行再研究。按照非鸟类四足动物的海生适应性的5个阶段(M1~M5),将混形黔鳄的测量数据与其他类群进行对比,判断混形黔鳄处于对海洋生活适应的M2-3阶段,尚不能将其归为真正的海生动物。对新标本形态的观察表明,虽然混形黔鳄的四肢未显示适应海生的形态特征变化,但在身体的总体形态结构和尾部特征上表现出明显适应波动式或半波动式游泳的变化,说明其可能具有与现生鳄类和海鬣蜥相似的适应海生生活的演化趋势。与现生鳄类等类群相比较显示,即使混形黔鳄发育特化的尾部,也无法进行快速或长距离的游泳。综合上述信息,结合盘县动物群四足动物的习性,推测混形黔鳄可能生活于存在岛屿的台内盆地,混形黔鳄等较高营养层级捕食者具有复杂的生态。

关键词：混形黔鳄中三叠世海生适应性生态

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