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Optimized nerve block techniques while performing percutaneous hepatic ablation: Literature review and practical use

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Journal of Interventional Medicine 2020年第4期3卷 161-166页

作者： DM Liu A Hadjivassiliou D Valenti SG Ho D Klass JB chung PT Kim LM Boucher Faculty of Medicine University of British ColumbiaCanada Miller School of Medicine University of MiamiUSA Department of Radiology-Division of Interventional Radiology Vancouver General HospitalCanada Department of Radiology Vancouver General HospitalCanada Department of Surgery Division of Hepatopancraticobiliary Surgery/Liver Transplantation Vancouver General HospitalVancouverCanada Faculty of Medicine McGill UniversityDepartment of RadiologyDivision of Interventional RadiologyMcGill University Health CentreMontrealCanada Faculty of Applied Science University of British ColumbiaCanada

Percutaneous image guided thermal ablation has become a cornerstone of therapy for patients with oligometastatic disease and primary liver *** from percutaneous ethanol injection(PEI),thermal ablation utilizing radiofrequency ablation(RFA)and microwave ablation(MWA)have become the standard approach in the treatment of isolated lesions that fit within the size criteria for curative intent therapy(typically 3-4 cm).With the evolution of more intense thermal ablation,such as MWA,the dramatic increase in both the size of ablation zone and intensity of heat generation have extended the limits of this *** a result of these innovations,intra-procedural and post-procedural pain have also significantly increased,requiring either higher levels of intravenous sedation or,in some institutions,general *** addition to the increase in therapeutic intensity,the use of intravenous sedation during aggressive ablation procedures carries the risk of over-sedation when the noxious insult(*** ablation)is removed,adding further difficulty to post-procedural recovery and ***,high subdiaphragmatic lesions become challenging in this setting due to issues relating to sedation and compliance with breath hold/breathing *** general anesthesia may mitigate these complications,the added resources associated with providing general anesthesia during ablation is not cost effective and may result in substantial delays in *** reduction of Aerosol Generating Medical Procedures(AGMP),such as intubation due to the COVID-19 Pandemic,must also be taken into *** to the potential increased risk of infection transmission,alternatives to general anesthesia should be considered when safe and *** abdominal regional nerve block techniques have been used to manage pain related to trauma,surgery,and cancer;however,blocks of this nature are not well described in the interventional radiology ***

关键词： anesthesia ablation corners

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Apalutamide for metastatic castration-sensitive prostate cancer:final analysis of the Asian subpopulation in the TITAN trial

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Asian Journal of Andrology 2023年第6期25卷 653-661页

作者： Byung Ha chung Jian Huang Hiroji Uemura Young Deuk Choi Zhang-Qun Ye Hiroyoshi Suzuki Taek Won Kang Da-Lin He Jae Young Joung Sabine D Brookman-May Sharon McCarthy Amitabha Bhaumik Anildeep Singh Suneel Mundle Simon Chowdhury Neeraj Agarwal Ding-Wei Ye Kim N Chi Hirotsugu Uemura Gangnam Severance Hospital Yonsei University College of MedicineSeoul 06273South Korea Sun Yat-Sen Memorial Hospital Sun Yat-Sen UniversityGuangzhou 510123China Yokohama City University Medical Center Minami-kuYokohamaKanagwa 232-0024Japan Severance Hospital Yonsei University College of MedicineSeoul 03722South Korea Tongji Hospital Tongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Toho University Sakura Medical Center Chiba 285-0841Japan Chonnam National University Hospital and Medical School Gwangju 61469South Korea Department of Urology The First Affiliated Hospital of Xi’an Jiaotong UniversityXi’an 710061China Prostate Cancer Center National Cancer CenterGoyang 10408South Korea Janssen Research and Development Spring HousePA 19002USA Ludwig Maximilians University Munich 80539Germany Janssen Research and Development RaritanNJ 08869USA Janssen Medical Affairs Asia PacificSingapore 118222Singapore Guy’s and St Thomas’NHS Foundation Trust London SE14YBUK University of Utah Huntsman Cancer Institute Salt Lake CityUT 84112USA Fudan University Shanghai Cancer Center Shanghai 200032China Vancouver Prostate Centre University of British ColumbiaVancouverBritish Columbia V6H 3Z6Canada Kindai University Faculty of MedicineOsaka-Sayama 589-8511Japan

The final analysis of the phase 3 Targeted Investigational Treatment Analysis of Novel Anti-androgen(TITAN)trial showed improvement in overall survival(OS)and other efficacy endpoints with apalutamide plus androgen deprivation therapy(ADT)versus ADT alone in patients with metastatic castration-sensitive prostate cancer(mCSPC).As ethnicity and regional differences may affect treatment outcomes in advanced prostate cancer,a post hoc final analysis was conducted to assess the efficacy and safety of apalutamide in the Asian ***-driven endpoints were OS,and time from randomization to initiation of castration resistance,prostate-specific antigen(PSA)progression,and second progression-free survival(PFS2)on first subsequent therapy or *** endpoints were assessed using the Kaplan–Meier method and Cox proportional-hazards models without formal statistical testing and adjustment for *** Asian patients received once-daily apalutamide 240 mg(n=111)or placebo(n=110)plus *** a median follow-up of 42.5 months and despite crossover of 47 placebo recipients to open-label apalutamide,apalutamide reduced the risk of death by 32%(hazard ratio[HR]:0.68;95%confidence interval[CI]:0.42–1.13),risk of castration resistance by 69%(HR:0.31;95%CI:0.21–0.46),PSA progression by 79%(HR:0.21;95%CI:0.13–0.35)and PFS2 by 24%(HR:0.76;95%CI:0.44–1.29)relative to *** outcomes were comparable between subgroups with low-and high-volume disease at *** new safety issues were *** provides valuable clinical benefits to Asian patients with mCSPC,with an efficacy and safety profile consistent with that in the overall patient population.

关键词： apalutamide Asia event-driven analysis metastatic castration-sensitive prostate cancer overall survival

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The integration of artificial intelligence models to augment imaging modalities in pancreatic cancer

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Journal of Pancreatology 2020年第4期3卷 173-180页

作者： Xianze Wang Wen Yuan chung Elon Correa Yi Zhu Eyad Issa Ashley R.Dennison Department of Surgery Peking Union Medical College HospitalChinese Academy of Medical Science&Peking Union Medical CollegeBeijingChina Department of Hepatobiliary and Pancreatic Surgery Leicester General HospitalLeicester School of Computing Science and EngineeringUniversity of SalfordManchester Language Technology Lab University of CambridgeCambridgeUK

Pancreatic ductal adenocarcinoma(PDAC)is an aggressive malignancy with a limited number of effective *** emerging technologies such as artificial intelligence(AI)to facilitate the earlier diagnosis and decision-making process represents one of the most promising areas for *** integration of AI models to augment imaging modalities in PDAC has made great progression in the past 5 years,especially in organ segmentation,AI-aided diagnosis,and radiomics based individualized *** this article,we review the developments of AI in the field of PDAC and the present clinical *** also examine the barriers to future development and more widespread application which will require increased familiarity of the underlying technology among clinicians to promote the necessary enthusiasm and collaboration with computer professionals.

关键词： Artificial intelligence Deep learning Imaging modality Machine learning Pancreatic ductal adenocarcinoma

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Universal soldier： Pseudomonas aeruginosa -- an opportunistic generalist

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Frontiers in Biology 2013年第4期8卷 387-394页

作者： Jeremy GROSS Ian J. PASSMORE Jade C. S. chung Olena RZHEPISHEVSKA Madeleine RAMSTEDT Martin WELCH Department of Biochemistry University of Cambridge Cambridge CB2 1QW UK Department of Chemistry Umed University Umed 901 87 Sweden

The opportunistic pathogen Pseudomonas aeruginosa commonly causes chronic and ultimately deadly lung infections in individuals with the genetic disease cystic fibrosis （CF）. P. aeruginosa is metabolically diverse; it displays a remarkable ability to adapt to and successfully occupy almost any niche, including the ecologically complex CF lung. These P. aeruginosa lung infections are a fascinating example of microbial evolution within a ＂natural＂ ecosystem. Initially, P. aeruginosa shares the lung niche with a plethora of other microorganisms and is vulnerable to antibiotic challenges. Over time, adaptive evolution leads to certain commonly-observed phenotypic changes within the P. aeruginosa population, some of which render it resistant to antibiotics and apparently help it to out-compete the other species that co-habit the airways. Improving genomics techniques continue to elucidate the evolutionary mechanisms of P. aeruginosa within the CF lung and will hopefully identify new vulnerabilities in this robust and versatile pathogen.

关键词： Pseudomonas aeruginosa cystic fibrosis evolution adaptive radiation antibiotic resistance quorum sensing

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Safety of acupotomy in a real-world setting:A prospective pilot and feasibility study

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Journal of Integrative Medicine 2022年第6期20卷 514-523页

作者： Sang-Hoon Yoon Chan-Young Kwon Hee-Geun Jo Jae-uk Sul Hyangsook Lee Jiyoon Won Su Jin Jeong Jun-Hwan Lee Jungtae Leem chung-Yeon Korean Medicine Clinic Gangnam-guSeoul 06224Republic of Korea Department of Oriental Neuropsychiatry Dong-eui University College of Korean MedicineBusanjin-guBusan 47340Republic of Korea Department of Herbal Pharmacology College of Korean MedicineGachon University1342 Seongnamdae-roSujeong-guSeongnam 13120Republic of Korea Department of Korean Rehabilitation Medicine Dongshin University Korean Medicine HospitalGwangju 61619Republic of Korea Acupuncture and Meridian Science Research Center Kyung Hee UniversityDongdaemun-guSeoul 02447Republic of Korea Department of Science in Korean Medicine Graduate SchoolKyung Hee UniversityDongdaemun-guSeoul 02447Republic of Korea KM Science Research Division Korea Institute of Oriental MedicineDaejeon 34054Republic of Korea Department of Statistics Support Medical Science Research InstituteKyung Hee University Medical CenterDongdaemun-guSeoul 02447Republic of Korea Clinical Medicine Division Korea Institute of Oriental MedicineYuseong-guDaejeon 34054Republic of Korea Korean Medicine Life Science University of Science&Technology(UST)Campus of Korea Institute of Oriental MedicineYuseong-guDaejeon 34054Republic of Korea College of Korean Medicine Wonkwang UniversityIksanJeollabuk-do54538Republic of Korea

Objective:Acupotomy is a modern acupuncture method that includes modern surgical *** acupotomy is relatively more invasive than filiform acupuncture treatment,it is important to establish the safety profile of this *** justify further large-scale prospective observational studies,this preliminary study was performed to assess the feasibility of the approach and investigate the safety profile and factors potentially associated with adverse events(AEs).Methods:This was a prospective pilot study that assessed the feasibility of a large-scale forthcoming safety study on acupotomy treatment in a real-world *** feasibility(call response rate,dropout rate,response rate for each variable and recruitment per month)and safety profile(incidence,type,severity and causality of AEs,and factors potentially associated with AEs)were ***:A total of 28 participants joined the study from January to May 2018.A follow-up assessment was achieved in 258(1185 treatment points)out of 261 sessions(1214 treatment points).The response rate via telephone on the day after treatment was 87.3%.There were 8 systemic AEs in all the sessions(8/258;3.11%)and 27 local AEs on the total points treated(27/1185;2.28%).Severe AEs did not *** AE and local AE occurrence were associated with blade width and the number of needle stimulations per treatment ***:The findings suggest that it could be feasible to analyze the safety of acupotomy in a realworld ***,the primary data on some relevant AEs could be *** are planning large-scale prospective studies based on these *** registration:Clinical Research Information Service(CRIS)KCT0002849(https://***/cris/search/***/11487).

关键词： Acupotomy Acupuncture Safety Adverse effects Observational study Traditional Chinese medicine

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Magnesium: The Neglected Electrolyte? A Clinical Review

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Pharmacology & Pharmacy 2014年第7期5卷 762-772页

作者： Pranev Sharma Christine chung Marcela Vizcaychipi Imaging & Anaesthetics Chelsea & Westminster Hospital London UK Magill Department of Anaesthesia Chelsea & Westminster Hospital London UK

Magnesium, Mg2+, is the second most abundant intracellular cation after potassium and the fourth most abundant in the body. It was first isolated in 1808 by the English chemist, Sir Humphrey Davy. Magnesium is essential to numerous biochemical reactions. It modulates key physiological processes such as metabolic biochemistry, nucleic acid synthesis, receptor-binding and ion flux. The western diet falls short of the recommended daily allowance of 4.5 mg/Kg/day and important dietary sources are seeds, grains, nuts and green vegetables. It is used as a therapeutic agent in a broad range of pathologies: neurological, cardiovascular, respiratory, gastrointestinal and obstetric. The pharmacokinetics and pharmacodynamics of magnesium, as a drug, are not well understood. Despite its fundamental importance to human physiology, it remains an electrolyte that is not routinely measured as part of the “urea & electrolytes” test and is the most overlooked electrolyte deficiency in hospital inpatients. This review will summarise the importance of magnesium homeostasis, its pharmacological effects and clinical applications.

关键词： Magnesium Pharmacology Pharmacodynamics Pharmacokinetics Physiology Arrhythmias Eclampsia Pre-Eclampsia Phaeochromocytoma

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Stearoyl-CoA desaturase 1 inhibitor supplemented with gemcitabine treatment reduces the viability and fatty acid content of pancreatic cancer cells in vitro

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Journal of Pancreatology 2021年第4期4卷 170-177页

作者： Amon B.Hackney Wen Y.chung John Isherwood Ashley R.Dennison Naomi Martin Faculty of Health and Life Sciences De Montfort University Department of Hepatobiliary and Pancreatic Surgery Leicester General Hospital Department of Respiratory Sciences University of LeicesterLeicesterUK

Objective:Pancreatic cancer(PC)is an aggressive cancer with ineffective *** of stearoyl-CoA desaturase 1(SCD1)suppresses cancer proliferation and might act as a novel chemotherapy supplement,but this has not been investigated in ***,the effects of SCD1 inhibitor CAY10566 supplemented with gemcitabine treatment(gemcitabine+CAY10566)on PC cell viability,apoptosis,phenotype,fatty acid content,platelet-derived growth factor release,and cell size were ***:Human PC cell line(PANC-1)was treated with SCD1 inhibitor CAY10566 with or without *** viability was assayed using 3-[4,5-dimethylthiazol-2-yl]-2,5 diphenyl tetrazolium bromide and apoptosis and phenotype were determined using flow *** acid content and platelet-derived growth factor release were measured by enzyme-linked immunosorbent *** size was determined using scanning electron ***:Half-maximal inhibitory concentration of gemcitabine or CAY10566 significantly reduced PANC-1 viability compared to gemcitabine alone(P0.05).Apoptosis was significantly increased following incubation with CAY10566(P<0.05).Fatty acid content of cells was significantly higher following gemcitabine treatment compared to CAY10566 alone or gemcitabine+CAY10566(P<0.05).Platelet-derived growth factor released by gemcitabine-treated cells was significantly increased compared to 142 nM CAY10566 alone or gemcitabine+CAY10566(P<0.01).CAY10566 did not affect the size of isolated tumor cells but gemcitabine+CAY10566 significantly increased the size compared to the control(P<0.05).Cell viability decreased significantly after the treatment with gemcitabine+CAY10566 compared with CAY10566 alone(P<0.05)and gemcitabine alone(P<0.01).However,when cycles of chemotherapy were mimicked and treatment was removed,the number of cell v

关键词： Gemcitabine Metabolomics Pancreatic cancer SCD1 inhibitor Viability

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Observational constraints on running vacuum model

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Chinese Physics C 2019年第2期43卷 132-137页

作者：张进军 chung-Chi Lee 耿朝强 School of Physics and Information Engineering Shanxi Normal University DAMTP Centre for Mathematical Sciences University of Cambridge Department of Physics National Tsing Hua University National Center for Theoretical Sciences

We investigate the power spectra of the CMB temperature and matter density in the running vacuum model(RVM) with the time-dependent cosmological constant of A=3 vH^2+ Λ_0, where H is the Hubble parameter. In this model, dark energy decreases in time and decays to both matter and radiation. By using the Markov chain Monte Carlo method, we constrain the model parameter v as well as the cosmological observables. Explicitly, we obtain v ≤1.54× 10^(-4)(68% confidence level) in the RVM with the best-fit χ_(RVM)~2 =13968.8, which is slightly smaller thanχ_(ΛCDM)~2= 13969.8 in the ΛCDM model of v = 0.

关键词： matter power spectrum running vacuum model CMB temperature spectrum cosmological constant

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Three-Dimensional Thermo-Elastic-Plastic Finite Element Method Modeling for Predicting Weld-Induced Residual Stresses and Distortions in Steel Stiffened-Plate Structures

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World Journal of Engineering and Technology 2018年第1期6卷 176-200页

作者： Myung Su Yi chung Min Hyun Jeom Kee Paik Department of Naval Architecture and Ocean Engineering Pusan National University Busan Korea Central Research Institute Samsung Heavy Industries Co. Ltd. Geoje Korea The Korea Ship and Offshore Research Institute (The Lloyd’s Register Foundation Research Centre of Excellence) Pusan National University Busan Korea Department of Mechanical Engineering University College London London UK

The objective of the present paper is to develop nonlinear finite element method models for predicting the weld-induced initial deflection and residual stress of plating in steel stiffened-plate structures. For this purpose, three-dimensional thermo-elastic-plastic finite element method computations are performed with varying plate thickness and weld bead length (leg length) in welded plate panels, the latter being associated with weld heat input. The finite element models are verified by a comparison with experimental database which was obtained by the authors in separate studies with full scale measurements. It is concluded that the nonlinear finite element method models developed in the present paper are very accurate in terms of predicting the weld-induced initial imperfections of steel stiffened plate structures. Details of the numerical computations together with test database are documented.

关键词： Steel Stiffened-Plate Structures Weld-Induced Initial Distortion Weld-Induced Residual Stress Nonlinear Finite Element Method Three-Dimensional Ther-mo-Elastic-Plastic Finite Element Analysis Full Scale Measurements

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Development and validation of an artificial intelligence model for predicting post-transplant hepatocellular cancer recurrence

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Cancer Communications 2023年第12期43卷 1381-1385页

作者： Quirino Lai Carmine De Stefano Jean Emond Prashant Bhangui Toru Ikegami Benedikt Schaefer Maria Hoppe-Lotichius Anna Mrzljak Takashi Ito Marco Vivarelli Giuseppe Tisone Salvatore Agnes Giuseppe Maria Ettorre Massimo Rossi Emmanuel Tsochatzis chung Mau Lo Chao-Long Chen Umberto Cillo Matteo Ravaioli Jan Paul Lerut the EurHeCaLT and the West-East LT Study Group General Surgery and Organ Transplantation Unit AOU Policlinico Umberto I Sapienza University of Rome Rome Italy Data Science and Engineering Polytechnic of Turin Turin Italy Division of Liver Transplantation and Hepatobiliary Surgery Department of Surgery Weill Cornell Medicine-Columbia University New York US Medanta Institute of Liver Transplantation and Regenerative Medicine Medanta-The Medicity Gurgaon India Department of Surgery and Science Kyushu University Fukuoka Japan Department of Medicine I Gastroenterology Hepatology and Endocrinology Medical University of Innsbruck Innsbruck Austria Klinik für Allgemein- Viszeral- und Transplantationschirurgie Universitätsmedizin Mainz Mainz Germany Liver Transplant Centre Merkur University of Zagreb Zagreb Croatia Division of Hepato-Biliary-Pancreatic and Transplant Surgery Department of Surgery Graduate School of Medicine Kyoto Japan Unit of Hepatobiliary Surgery and Transplantation AOU Ospedali Riuniti Polytechnic University of Marche Ancona Italy Department of Surgical Sciences and Medical Sciences University of Rome-Tor Vergata Rome Italy Liver Unit Department of Surgery Catholic University-Fondazione Policlinico Universitario Agostino Gemelli IRCCS Rome Italy Department of Transplantation and General Surgery San Camillo Hospital Rome Italy UCL Institute for Liver and Digestive Health and Royal Free Sheila Sherlock Liver Centre Royal Free Hospital London UK Hong Kong University–Department of Surgery Queen Mary Hospital University of Hong Kong Hong Kong P. R. China Department of Surgery Kaohsiung Chang Gung Memorial Hospital Chang Gung University College of Medicine Kaohsiung Taiwan P. R. China Department of Surgery Oncology and Gastroenterology University of Padua Padua Italy Department of General Surgery and Transplantation IRCCS Azienda Ospedaliero-Universitaria di Bologna Bologna University Bologna Italy Institut de Recherche Clinique Université catholique de Louvain Brussels Belgium 不详

Dear Editor,In recent years,criteria based on the combinationof morphology and biology have been proposed forimproving the selection of hepatocellular cancer(HCC)patients waiting for liver transplantation(LT)[1,2].Since all the proposed models showed suboptimalresults in predicting the risk of postLT recurrence,aprediction model constructed using artificial intelligence(Al)could be an attractive way to surpass this limit[3,4].Therefore,the Time_Radiological-response_Alpha-fetoproteIN_Artificial-Intelligence(TRAIN-AI)modelwas developed,combining morphology and biology tumorvariables.

关键词： hepatocellular cancer artificial

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