Universal soldier： Pseudomonas aeruginosa -- an opportunistic generalist

作     者：Jeremy GROSS Ian J. PASSMORE Jade C. S. CHUNG Olena RZHEPISHEVSKA Madeleine RAMSTEDT Martin WELCH 

作者机构：Department of Biochemistry University of Cambridge Cambridge CB2 1QW UK Department of Chemistry Umed University Umed 901 87 Sweden 

出 版 物：《Frontiers in Biology》 (生物学前沿（英文版）)

年 卷 期：2013年第8卷第4期

页      面：387-394页

核心收录：

学科分类：0710[理学-生物学] 0831[工学-生物医学工程（可授工学、理学、医学学位）] 090603[农学-临床兽医学] 0830[工学-环境科学与工程（可授工学、理学、农学学位）] 1001[医学-基础医学(可授医学、理学学位)] 09[农学] 0906[农学-兽医学] 0836[工学-生物工程] 0713[理学-生态学] 

基　　金：Biotechnology and Biological Sciences Research Council, BBSRC Isaac Newton Trust 

主　　题：Pseudomonas aeruginosa cystic fibrosis evolution adaptive radiation antibiotic resistance quorum sensing 

摘      要：The opportunistic pathogen Pseudomonas aeruginosa commonly causes chronic and ultimately deadly lung infections in individuals with the genetic disease cystic fibrosis （CF）. P. aeruginosa is metabolically diverse; it displays a remarkable ability to adapt to and successfully occupy almost any niche, including the ecologically complex CF lung. These P. aeruginosa lung infections are a fascinating example of microbial evolution within a ＂natural＂ ecosystem. Initially, P. aeruginosa shares the lung niche with a plethora of other microorganisms and is vulnerable to antibiotic challenges. Over time, adaptive evolution leads to certain commonly-observed phenotypic changes within the P. aeruginosa population, some of which render it resistant to antibiotics and apparently help it to out-compete the other species that co-habit the airways. Improving genomics techniques continue to elucidate the evolutionary mechanisms of P. aeruginosa within the CF lung and will hopefully identify new vulnerabilities in this robust and versatile pathogen.