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Potential Mechanisms Underlying the Therapeutic Effects of Electroconvulsive Therapy

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Neuroscience Bulletin 2017年第3期33卷 339-347页

作者： Jiangling Jiang Jijun Wang chunbo li Shanghai Key Laboratory of Psychotic Disorders Shanghai Mental Health CenterShanghai Jiao Tong University School of MedicineShanghai Jiao Tong UniversityShanghai 200030China Bio-X Institutes Key Laboratory for the Genetics of Developmental and Neuropsychiatric DisordersMinistry of EducationShanghai Jiao Tong UniversityShanghai 200030China Brain Science and Technology Research Center Shanghai Jiao Tong UniversityShanghai 200030China

In spite of the extensive application of electroconvulsive therapy（ECT）, how it works remains *** far, researchers have made great efforts in figuring out the mechanisms underlying the effect of ECT treatment via determining the levels of neurotransmitters and cytokines and using genetic and epigenetic tools, as well as structural and functional neuroimaging. To help address this question and provide implications for future research, relevant clinical trials and animal experiments are reviewed.

关键词： Electroconvulsive therapy Neurotransmitters Neurotrophins Inflammatory factors Epigenetics Neuroimaging

Single-cell transcriptomics provides insights into the origin and immune microenvironment of cervical precancerous lesions

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Cancer Communications 2023年第9期43卷 1055-1058页

作者： chunbo li Keqin Hua Department of Obstetrics and Gynecology Obstetrics and Gynecology Hospital of Fudan UniversityShanghaiP. R. China

Dear editors,Despite efforts to implement vaccination and screening programs,cervical cancer(CC)remains a public health problem[1].Over 90%of cases are associated with persistent human papillomavirus(HPV)*** integrates its DNA into the basal cells of the transformation zone,the region where the epithelium transitions from the columnar epithelial cells of the endocervix to the stratified squamous epithelium cells of the ectocervix,leading to the production of proteins(E6 and E7)that eventually cause dysplasia[2,3].Squamous cell carcinoma(SCC)and cervical adenocarcinoma(AD)are the two most common types of HPV-related CC[4].SCC and AD have a longterm stage of preinvasive(PRE)lesion,which are named high-grade squamous intraepithelial lesion(HSIL)or adenocarcinoma in situ(AIS),respectively[5].However,no studies were conducted to determine why some individuals with HPV infections develop HSIL while others develop AIS.

关键词： cervical epithelium adenocarcinoma

Transient fault identification method for bipolar short-circuit fault on MMC‐HVDC overhead lines based on hybrid HVDC breaker

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High Voltage 2021年第5期6卷 881-893页

作者： Botong li chunbo li Bin li Weijie Wen Hanqing Cui Jiang Su School of Electrical and Information Engineering Tianjin UniversityTianjinChina

A bipolar short‐circuit transient fault identification method for overhead transmission lines in modular multi‐level converter‐based high voltage direct current(MMC‐HVDC)grid based on the hybrid HVDC breaker is *** circuit breakers on both sides of the positive and negative overhead transmission lines will trip after a bipolar short‐circuit fault in the MMC‐HVDC *** order to identify whether the fault is a transient fault,the isolating switch of the DC breaker on one line side is reclosed first,and the voltage change on this line side in the case of transient and permanent faults is *** comparing the electrical characteristics of the voltage on the line side under transient and permanent faults,a transient fault identification method is proposed,and the calculation method of the setting value of the criterion is ***,by building the MMC‐HVDC system model for simulation in power systems computer aided design,the accuracy and effectiveness of the proposed method for transient fault identification are verified.

关键词： fault transient bipolar

Speech databases for mental disorders: A systematic review

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General Psychiatry 2019年第3期32卷 119-129页

作者： Yiling li Yi lin Hongwei Ding chunbo li School of Foreign Languages Shanghai Jiao Tong University Shanghai China Shanghai Key Laboratory of Psychotic Disorders Shanghai Mental Health Center School of Medicine Shanghai Jiao Tong University Shanghai China Center for Excellence in Brain Science and Intelligence Technology (CEBSIT) Chinese Academy of Sciences Shanghai China

Background The employment of clinical databases in the study of mental disorders is essential to the diagnosis and treatment of patients with mental illness. While text corpora obtain merely limited information of content, speech corpora capture tones, emotions, rhythms and many other signals beyond content. Hence, the design and development of speech corpora for patients with mental disorders is increasingly important. Aim This review aims to extract the existing speech corpora for mental disorders from online databases and peer-reviewed journals in order to demonstrate both achievements and challenges in this area. Methods The review first covers publications or resources worldwide, and then leads to the reports from China, followed by a comparison between Chinese and nonChinese regions. Results Most of the speech databases were recorded in Europe or the United States by audio or video. Some were even supplemented by brain images and Event- Related Potential (ERP) statistics. The corpora were mostly developed for patients with neurocognitive disorders like stutter and aphasia, and mental illness like dementia, while other types of mental illness such as bipolar disorder, anxiety, d即ression and autism were scarce in number in database development. Strengths and limitations The results demonstrated that database development of neurocognitive disorders in China is much scarcer than that in some European countries, but the existing databases pave an instructive road for psychiatric problems. Also, the methods and applications of databases from the leading countries are inspiring for Chinese scholars, who are searchi ng methods for developing a comprehensive resource for clinical studies.

关键词： Speech databases mental disorders A systematic review

Massachusetts General Hospital and the Shanghai Mental Health Center:the past,present and future of a psychiatric research partnership

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General Psychiatry 2019年第6期32卷 346-348页

作者： Tristan Barako chunbo li Albert Yeung Development Massachusetts General HospitalBostonMassachusettsUSA Shanghai Key Laboratory of Psychotic Disorders Shanghai Mental Health CenterShanghai Jiao Tong University School of MedicineShanghaiChina Psychiatry Massachusetts General HospitalBostonMassachusettsUSA Psychiatry Harvard Medical SchoolBostonMassachusettsUSA

INTRODUCTION There are many obstacles to developing,maintaining and strengthening international research collaborations,whether they are posed by geography,culture or,most recently,global economics and *** is critically important to overcome these obstacles,especially when it comes to fostering the types of breakthrough biomedical science that benefit from diverse perspectives,methodologies and data ***,the research underlying these breakthroughs unfolds over the course of years,and even *** these reasons,and more,the Department of Psychiatry at Massachusetts General Hospital(Mass General)and the Shanghai Mental Health Center(SMHC)are taking the long view:exploring and implementing numerous collaborative research and training projects that are leading to better care and treatments for patients,both in the USA and China,who suffer from a range of psychiatric disorders.

关键词： breakthrough overcome Massachusetts

Segregation between the parietal memory network and the default mode network： effects of spatial smoothing and model order in ICA

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Science Bulletin 2016年第24期61卷 1844-1854页

作者： Yang Hu Jijun Wang chunbo li Yin-Shan Wang Zhi Yang Xi-Nian Zuo Key Laboratory of Behavioral Science Laboratory for HumanConnectome and Development Magnetic Resonance ResearchCenter Institute of Psychology Chinese Academy of SciencesBeijing 100101 China University of Chinese Academy of Sciences Beijing 100049China Shanghai Key Laboratory of Psychotic Disorders Shanghai Mental Health Center Shanghai Jiao Tong University School of Medicine Shanghai 200030 China

Abstract A brain network consisting of two key parietal nodes, the precuneus and the posterior cingulate cortex, has emerged from recent fMRI studies. Though it is anatomically adjacent to and spatially overlaps with the default mode network （DMN）, its function has been associated with memory processing, and it has been referred to as the parietal memory network （PMN）. Independent component analysis （ICA） is the most common data-driven method used to extract PMN and DMN simultaneously. However, the effects of data preprocessing and parameter determi- nation in ICA on PMN-DMN segregation are completely unknown. Here, we employ three typical algorithms of group ICA to assess how spatial smoothing and model order influence the degree of PMN-DMN segregation. Our findings indicate that PMN and DMN can only be stably separated using a combination of low-level spatial smoothing and high model order across the three ICA algorithms. We thus argue for more considerations on parametric settings for interpreting DMN data.

关键词： Default mode network Parietal memory network Independent component analysis Model order Resting-state fMRI Spatial smoothing

Effect of Heat Treatment on Microstructure and Mechanical Behavior of Cu-Bearing 316L Stainless Steel Produced by Selective Laser Melting

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Acta Metallurgica Sinica(English Letters) 2024年第1期37卷 169-180页

作者： Huan Yang Ying liu Jianbo Jin Kunmao li Junjie Yang lingjian Meng chunbo li Wencai Zhang Shengfeng Zhou Sino-German College of Intelligent Manufacturing Shenzhen Technology UniversityShenzhen518118China Institute of Advanced Wear and Corrosion Resistance and Functional Materials Jinan UniversityGuangzhou510632China Department of Orthopedics First Affiliated Hospital of Jinan UniversityGuangzhou510632China

Cu-bearing stainless steels(SSs)with high strength,excellent plasticity,and effective antimicrobial properties hold significant potential for applications in the marine *** this study,Cu-bearing SSs with copper ranging from 0 to 6.0 wt%were successfully prepared using selective laser melting(SLM)*** the Cu-bearing SSs with different copper contents,the effect of heat treatment on the microstructural and mechanical behaviors was studied *** observations revealed that the subgrain size of Cu-bearing SSs increased with heat treatment at 500℃ and 700℃ for 6 ***,the tensile strength and elongation increased after the heat treatment temperature due to the combined effect of dislocations,twins,andε-Cu precipitated ***,after heat treatment at 700℃,the SLM4.5Cu sample exhibited an abnormal rise in tensile strength and *** finding suggests that the diffusion strengthening caused byε-Cu precipitates exceeded the stacking fault ***,the tensile strength and elongation reached 693.32 MPa and 56.94%,*** work provides an efficient approach for preparing Cu-bearing SSs with exceptional strength and plasticity.

关键词： Selective laser melting Cu-bearing stainless steel(SS) Heat treatment Mechanical properties

Interface Modification of TiO_(2)Electron Transport Layer with PbCl_(2)for Perovskiote Solar Cells with Carbon Electrode

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Tsinghua Science and Technology 2022年第4期27卷 741-750页

作者： Abolfazl Amraeinia Yuhua Zuo Jun Zheng Zhi liu Guangze Zhang liping Luo Buwen Cheng Xiaoping Zou chunbo li Key Laboratory on Integrated Optoelectronics Institute of SemiconductorChinese Academy of SciencesBeijing 100083China Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of SciencesBeijing 100049China Beijing Advanced Innovation Center for Materials Genome Engineering Beijing Key Laboratory for SensorMOE Key Laboratory for Modern Measurement and Control TechnologyBeijing Information Science and Technology UniversityBeijing 100101China School of Science Minzu University of ChinaBeijing 100081China

Perovskite Solar Cells(PSCs)have attracted considerable attention because of their unique features and high ***,the stability of perovskite solar cells remains to be *** this study,we modified the TiO_(2)Electron Transport Layer(ETL)interface with PbCl_(2).The efficiency of the perovskite solar cells with carbon electrodes increased from 11.28%to 13.34%,and their stability obviously *** addition of PbCl_(2)had no effect on the morphology,crystal structure,and absorption property of the perovskite absorber ***,it affected the band energy level alignment of the solar cells and accelerated the electron extraction and transfer at the interface between the perovskite layer and the ETL,thus enhancing the overall photovoltaic *** interfacial modification of ETL with PbCl_(2)is a promising way for the potential commercialization of low-cost carbon electrode-based perovskite solar cells.

关键词： Perovskite Solar Cell(PSC) Electron Transport Layer(ETL) electron and hole recombination modification stability

Efficacy and safety of repetitive transcranial magnetic stimulation for generalised anxiety disorder: A metaanalysis

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General Psychiatry 2019年第5期32卷 237-248页

作者： Huiru Cui lijuan Jiang Yanyan Wei Wei li Hui li Junjuan Zhu Jiaoyan Pang Jijun Wang chunbo li Shanghai Key Laboratory of Psychotic Disorders Shanghai Mental Health CenterShanghai Jiao Tong University School of MedicineShanghaiChina School of government Shanghai University of Political Science and LawShanghaiChina Institute of Psychology and Behavioral Science Shanghai Jiao Tong UniversityShanghaiChina Center for Excellence in Brain Science and Intelligence Technology(CEBSIT) Chinese Academy of ScienceShanghaiChina Brain Science and Technology Research Center Shanghai Jiao Tong UniversityShanghaiChina

Background Pharmacological and conventional nonpharmacological treatments are only moderately effective in treatingeneralised anxiety disorder(GAD).Recently,repetitive transcranial magnetic stimulation(rTMS)has attracted interest because of its potential therapeutic *** To investigate the efficacy and safety of rTMS treatment for *** literature studies published in English or Chinese were screened in 10 electronic databases up to 5 December *** included studies'bias risk was assessed using Cochrane risk of bias assessment ***-analysis was performed to compute the standardised mean difference(SMD)and risk ratio(RR)along with its 95%Cis through using RevMan *** was inspected by I2 and the χ2 *** performed subgroup analysis and meta-regression to investigate *** used funnel plot to assess publication *** used the GRADE approach to assess the whole quality of *** Twenty-one studies,with a total sample size of 1481,were *** risk of bias in most studies included is moderate,the majority of which are lacking of blinding methods of treatment *** treatment had beneficial effects in the rTMS group compared with the control group in mean anxiety score(SMD=-0.68;95%Cl-0.89 to-0.46).None of the 21 studies included here reported severe adverse *** for dropout rates,there are no statistically significant differences between the two groups(RR 1.14,95%Cl 0.72 to 1.82)or adverse events(RR 0.95,95%Cl 0.77 to 1.18).No particular influence on the heterogeneity of any variable was *** risk of publication bias was *** to the GRADE approach,the evidence levels of primary outcome(treatment effects)and secondary outcomes(acceptability and safety)were rated as‘medium’.Conclusion The use of rTMS combined with medication treatment may have a significant positive anti-anxiety effect on patients with ***,we should interpret the results cautiously due to the relatively hi

关键词： stimulation treatment magnetic