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内蒙古地区气候生产潜力变化及其敏感性分析

中国农业气象 2018年第8期39卷 531-537页

作者：刘新刘林春尤莉张宇内蒙古自治区气候中心呼和浩特010051 内蒙古自治区气象台呼和浩特010051

利用内蒙古地区110个气象站1961-2016年年平均气温、降水量数据,基于Miami模型和Thornthwaite Memorial模型计算气候生产潜力,分析内蒙古地区年平均气温、年降水量及气候生产潜力的时空变化特征,并通过敏感性试验,分析不同气象要素变化... 详细信息

利用内蒙古地区110个气象站1961-2016年年平均气温、降水量数据,基于Miami模型和Thornthwaite Memorial模型计算气候生产潜力,分析内蒙古地区年平均气温、年降水量及气候生产潜力的时空变化特征,并通过敏感性试验,分析不同气象要素变化情景下的气候生产潜力敏感性。结果表明:(1)内蒙古气温和降水量地区间差异显著,56a来平均气温显著上升,97%的站点平均气温上升趋势极显著(P<0.01),降水量呈波动变化,其线性变化趋势不显著;(2)气候生产潜力呈东南-西北向的带状分布,地区间差异较大,年变化趋势不显著,呼伦贝尔地区气候生产潜力显著增加(P<0.05);(3)气候生产潜力对降水量更敏感,未来在内蒙古地区显著变暖的背景下,降水量的多寡决定气候生产潜力的变化;(4)粮食单产及气候资源利用率逐步提高,未来仍存在作物增产空间,但应考虑可持续发展问题,合理利用气候资源。

关键词： “镰刀弯”地区气候生产潜力气候变化敏感性气候资源利用率

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生命线工程系统减灾研究趋势与展望

大连理工大学学报 2005年第6期45卷 931-936页

作者：李宏男柳春光大连理工大学土木水利学院大连理工大学土木水利学院辽宁大连116024

全面系统地总结了国内外生命线工程系统减灾研究的内容、特点和现状,指出了目前研究方面的缺陷,如缺少实用的分析方法、研究内容不全面或不深入等问题.从科研和实际工程系统两方面出发,归纳出生命线工程系统防灾减灾研究的发展趋势.即... 详细信息

全面系统地总结了国内外生命线工程系统减灾研究的内容、特点和现状,指出了目前研究方面的缺陷,如缺少实用的分析方法、研究内容不全面或不深入等问题.从科研和实际工程系统两方面出发,归纳出生命线工程系统防灾减灾研究的发展趋势.即生命线工程系统未来的发展方向应是多学科的相互靠近和融合,建立生命线工程系统的场地危险性评估方法、重大生命线工程破坏机理的分析方法、工程系统的设防标准、性态设计与优化分析方法、地震预警与应急和恢复策略、地震功能失效分析方法、地震灾害损失估计与控制方法,研制防震减灾智能决策信息系统,开发符合实际城市生命线工程系统特征、可以在线运行或实时监测的城市生命线工程系统模拟软件等,从而为直接指导城市生命线工程系统规划、建设,防灾减灾,控制与管理工作提供理论依据.

关键词：生命线工程防灾减灾发展趋势

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无证书两方密钥协商方案

软件学报 2011年第11期22卷 2843-2852页

作者：刘文浩许春香杭州师范大学信息科学与工程学院浙江杭州310012 电子科技大学计算机科学与工程学院四川成都611731

给出了一个无双线性对的无证书两方密钥协商方案,并演示了这些不安全无证书方案存在的攻击.只要每方至少有1个未泄露的秘密值,该方案在最强的安全模型下就是安全的.即使密钥生成中心知道双方的临时私钥或显示双方的秘密值/替换公钥(但... 详细信息

给出了一个无双线性对的无证书两方密钥协商方案,并演示了这些不安全无证书方案存在的攻击.只要每方至少有1个未泄露的秘密值,该方案在最强的安全模型下就是安全的.即使密钥生成中心知道双方的临时私钥或显示双方的秘密值/替换公钥(但不能同时),但只要计算Diffie-Hellman假设成立,该方案在随机预言机模型下也被证明是安全的.该方案消除了对运算,与其他无证书密钥协商方案相比,该方案是己知无证书安全协商方案中计算复杂度最低的.该方案尤其适合于带宽受限的通信环境中使用,如Ad hoc网络、无线传感器网络等.

关键词：密钥协商两方协议无证书无双线性对

A Single-institution Experience with Open Irreversible Electroporation for Locally Advanced Pancreatic Carcinoma

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Chinese Medical Journal 2016年第24期129卷 2920-2925页

作者： Li Yan Yong-Liang Chen Ming Su Tian liu Kai Xu Feng Liang Wan-Qing Gu Shi-chun Lu Department of Hepatobiliary Surgery Chinese PLA General Hospital Beijing 100853 China Department of General Surgery People's Hospital of Rizhao Rizhao Shandong 276800 China

Background： Locally advanced pancreatic carcinoma （LAPC） is characterized by poor prognosis despite recommended concurrent chemoradiotherapy. Irreversible electroporation （IRE） has emerged as a potential option for the management of unresectable pancreatic cancer. This study was conducted to evaluate the safety and short-term efficacy of open IRE for the treatment of LAPC. Methods： Retrospective data of 25 consecutive patients receiving IRE for T3 lesions from July 2015 to June 2016 at a single center were analyzed. The perioperative and long-term IRE-related complications were reviewed to evaluate the safety of the procedure. The tumor reduction and biological response were analyzed through computed tomography/magnetic resonance imaging; the serum level of CA19-9 was measured as a secondary endpoint to evaluate the short-term efficacy of IRE. Results： All patients were successfully treated; the median tumor size was 4.2 cm and the median IRE time was 36 min. Four intraoperative procedure-related complications were observed （16%）： two transient hypertensive episodes, one hypotension case, and one transient supraventricular tachycardia case. Nine postoperative complications were described, including three Grade A pancreatic fistulas, three delayed gastric emptying, one acute pancreatitis, one upper gastrointestinal hemorrhage, and one portal vein thrombosis. The overall rate of stable disease was 28%, 36% achieved partial response, and lower serum CA19-9 levels were recorded in all patients at discharge. Conclusions： IRE is feasible for the treatment of LAPC and is a reasonable intervention strategy owing to its combined attributes of safety and efficacy.

关键词： CA 19-9 Irreversible Electroporation Locally Advanced Pancreatic Carcinoma

Magnetism and piezoelectricity of hexagonal boron nitride with triangular vacancy

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Chinese Physics B 2018年第1期27卷 450-455页

作者：赵路丝陈春平刘林林于洪侠陈怡王晓春 Institute of Atomic and Molecular Physics Jilin University Jilin Provincial Key Laboratory of Applied Atomic and Molecular Spectroscopy (Jilin University)

First-principle calculations reveal that the configuration system of hexagonal boron nitride （h-BN） monolayer with triangular vacancy can induce obvious magnetism, contrary to that of the nonmagnetic pristine boron nitride monolayer. Interestingly, the h-BN with boron atom vacancy （VB-BN） displays metallic behavior with a total magetic moment being 0.46μB per cell, while the h-BN with nitrogen atom vacancy （VN-BN） presents a half-metallic characteristic with a total magnetic moment being 1.0μB per cell. Remarkably, piezoelectric stress coefficient ell of the VN-BN is about 1.5 times larger than that of pristine h-BN. Furthermore, piezoelectric strain coefficient dll （12.42 μm/V） of the VN-BN is 20 times larger than that of pristine h-BN and also one order of magnitude larger than the value for the h-MoS2 monolayer, which is mainly due to the spin-down electronic state in the VN-BN system. Our study demonstrates that the nitrogen atom vacancies can be an efficient route to tailoring the magnetic and piezoelectric properties of h-BN monolayer, which have promising performances for potential applications in nano-electromechanical systems （NEMS） and nanoscale electronics devices.

关键词： first-principle magnetism piezoelectric nano-electromechanical systems

home-based Early Intervention on Auditory and Speech Development in Mandarin-speaking Deaf Infants and Toddlers with Chronological Aged 7-24 Months

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Chinese Medical Journal 2015年第16期128卷 2202-2207页

作者： Ying Yang Yue-Hui liu Ming-Fu Fu chun-Lin Li Li-Yan Wang Qi Wang Xi-Bin Su Department of Otolaryngology Head and Neck Surgery The Second Affiliated Hospital of Nanchang University Nanchang Jiangxi 330006 China Key Laboratory of Speech and Hearing Sciences Ministry of Education Department of Speech and Hearing Rehabilitation Sciences East China Norma University Shanghai 200062 China Department of Orthopaedics The Second Affiliated Hospital of Nanchang University Nanchang Jiangxi 330006 China Department of Otolaryngology Head and Neck Surgery Ningbo First Hospital Ningbo Zhejiang 315700 China Department of Audiology Center China Rehabilitation Research Center for Deaf Children Beijing 100029 China

Background：Early auditory and speech development in home-based early intervention of infants and toddlers with hearing loss younger than 2 years are still spare in *** study aimed to observe the development of auditory and speech in deaf infants and toddlers who were fitted with hearing aids and/or received cochlear implantation between the chronological ages of 7-24 months,and analyze the effect of chronological age and recovery time on auditory and speech development in the course of home-based early ***：This longitudinal study included 55 hearing impaired children with severe and profound binaural deafness,who were divided into Group A （7-12 months）,Group B （13-18 months） and Group C （19-24 months） based on the chronological *** auditory performance （CAP） and speech intelligibility rating scale （SIR） were used to evaluate auditory and speech development at baseline and 3,6,9,12,18,and 24 months of *** statistics were used to describe demographic features and were analyzed by repeated measures analysis of ***：With 24 months of hearing intervention,78% of the patients were able to understand common phrases and conversation without lip-reading,96% of the patients were intelligible to a *** three groups,children showed the rapid growth of trend features in each period of *** and SIR scores have developed rapidly within 24 months after fitted auxiliary device in Group A,which performed much better auditory and speech abilities than Group B （P 〈 0.05） and Group C （P 〈 0.05）.Group B achieved better results than Group C,whereas no significant differences were observed between Group B and Group C （P 〉 0.05）.Conclusions：The data suggested the early hearing intervention and home-based habilitation benefit auditory and speech *** age and recovery time may be major factors for aural verbal outcomes in hearing impaired *** development of auditory and speech

关键词： Auditory Performance Hearing Impaired home-based Early Intervention Speech Intelligible

金属矿尾废胶结充填体破裂演化过程原位CT扫描试验研究

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岩土力学 2020年第10期41卷 3365-3373页

作者：易雪枫刘春康王宇北京科技大学土木与资源工程学院北京100083

为了揭示金属矿尾废胶结充填体(CWRB)破裂过程中的细观力学特性及尾废胶结协同作用机制,采用单轴压缩实时CT扫描力学试验对废石含量(WBP)为0%(全尾砂胶结充填体)、30%、50%和70%的充填体损伤破裂演化过程进行了可视化和数字化表征,揭示... 详细信息

为了揭示金属矿尾废胶结充填体(CWRB)破裂过程中的细观力学特性及尾废胶结协同作用机制,采用单轴压缩实时CT扫描力学试验对废石含量(WBP)为0%(全尾砂胶结充填体)、30%、50%和70%的充填体损伤破裂演化过程进行了可视化和数字化表征,揭示了充填体细观损伤和破裂演化的内在力学机制。结果表明,尾废胶结充填体中的废石含量会影响应力-应变响应,随着废石含量的增加,充填体的强度也会增加。强度增加的主要原因是试样中挠曲破裂面扩展的地质力学效应。充填体开裂后裂纹的形状受废石块形状、大小和分布的影响。基质-块体交接界面为充填体中最薄弱的部分。裂纹的形成和扩展最终导致了尾废胶结充填体的应力剪胀行为。界面损伤开裂控制了试样中裂纹扩展路径及强度特性。尾废胶结充填体的强度效应取决于块石的含量,废石-废砂胶结充填体的相互作用控制着试样强度的增加,块石间的互锁作用对于提高试样的整体刚度具有重要影响。该研究成果对于金属矿固废绿色处置及矿产资源的可持续开发具有理论指导意义。

关键词：尾废胶结充填体(CWRB) 实时CT扫描单轴压缩试验细观力学性质破裂演化

In vitro pancreas duodenal homeobox-1 enhances the differentiation of pancreatic ductal epithelial cells into insulin-producing cells

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World Journal of Gastroenterology 2007年第39期13卷 5232-5237页

作者： Tao liu chun-You Wang Feng Yu Shan-Miao Gou He-Shui Wu Jiong-Xin Xiong Feng Zhou Department of Pancreatic Surgery Union Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan 430022 Hubei Province China

AIM: To observe whether pancreatic and duodenal homeobox factor-1 enhances the differentiation of pancreatic ductal epithelial cells into insulin-producing cells in vitro. METhoDS: Rat pancreatic tissue was submitted to digestion by collegenase, ductal epithelial cells were separated by density gradient centrifugation and then cultured in RPMI1640 medium with 10% fetal bovine serum. After 3-5 passages, the cells were incubated in a six-well plate for 24 h before transfection of recombination plasmid XlHbox8VP16. Lightcycler quantitative real-time RT-PCR was used to detect the expression of PDX-1 and insulin mRNA in pancreatic epithelial cells. The expression of PDX-1 and insulin protein was analyzed by Western blotting. Insulin secretion was detected by radioimmunoassay. Insulin- producing cells were detected by dithizone-staining. RESULTS: XlHbox8 mRNA was expressed in pancreatic ductal epithelial cells. PDX-1 and insulin mRNA as well as PDX-1 and insulin protein were signifi cantly increased in the transfected group. The production and insulin secretion of insulin-producing cells differentiated from pancreatic ductal epithelial cells were higher than those of the untransfected cells in vitro with a significant difference (1.32 ± 0.43 vs 3.48 ± 0.81, P < 0.01 at 5.6 mmol/L; 4.86 ± 1.15 vs 10.25 ± 1.32, P < 0.01 at 16.7 mmol/L). CONCLUSION: PDX-1 can differentiate rat pancreaticductal epithelial cells into insulin-producing cells in vitro. In vitro PDX-1 transfection is a valuable strategy for increasing the source of insulin-producing cells.

关键词： Pancreatic ductal epithelial cells Islet Differentiation Pancreas duodenal homeobox-i

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药品专利链接制度研究

中草药 2010年第9期41卷 1558-1563页

作者：汪虹刘立春华中师范大学教育信息技术工程研究中心湖北武汉430079 华中师范大学政法学院湖北武汉430079

药品专利链接原为美国在仿制药注册过程中对其是否侵犯专利药的权利的一种审查程序。国内外学界对药品专利链接的研究主要是参考美式制度,且对药品专利链接的本质定义还未有明确界定,专利链接还局限在形式上。通过考察药品注册和专利审... 详细信息

药品专利链接原为美国在仿制药注册过程中对其是否侵犯专利药的权利的一种审查程序。国内外学界对药品专利链接的研究主要是参考美式制度,且对药品专利链接的本质定义还未有明确界定,专利链接还局限在形式上。通过考察药品注册和专利审查的特点,结合中国国情,从部门职能协同的角度对药品专利链接进行界定,通过构建普通药品和可专利药品的各自的专利链接模式对药品专利链接制度的完善提出建议。

关键词：药品专利链接药品注册可专利药品