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Relationship Between Short-chain Fatty Acids and Parkinson’s Disease:A Review from Pathology to Clinic

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Neuroscience Bulletin 2024年第4期40卷 500-516页

作者： Wen-Xiang Duan Fen Wang Jun-Yi liu chun-feng liu Department of Neurology and Clinical Research Center of Neurological Disease The Second Affiliated Hospital of Soochow UniversitySuzhou215004China Department of Neurology Dushu Lake Hospital affiliated to Soochow UniversitySuzhou215125China Jiangsu Key Laboratory of Neuropsychiatric Diseases and Institute of Neuroscience Soochow UniversitySuzhou215123China

Parkinson’s disease(PD)is a complicated neurodegenerative disease,characterized by the accumulation ofα-synuclein(α-syn)in Lewy bodies and neurites,and massive loss of midbrain dopamine *** evidence suggests that gut microbiota and microbial metabolites are involved in the development of *** these,short-chain fatty acids(SCFAs),the most abundant microbial metabolites,have been proven to play a key role in brain-gut *** this review,we analyze the role of SCFAs in the pathology of PD from multiple dimensions and summarize the alterations of SCFAs in PD patients as well as their correlation with motor and non-motor *** research should focus on further elucidating the role of SCFAs in neuroinflammation,as well as developing novel strategies employing SCFAs and their derivatives to treat PD.

关键词： Parkinson’s disease Short-chain fatty acids Microbial metabolites Brain-gut-microbiota axis

Microstructure and mechanical properties of liquid phase sintered silicon carbide composites

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2010年第10期11卷 766-770页

作者： Jing-mei MA feng YE Yan-ge CAO chun-feng liu Hai-jiao ZHANG School of Materials Science and Engineering Harbin Institute of Technology Harbin 150001 China Air China Corporation Limited Engineering and Technology Branch Beijing 101312 China

Silicon carbide (SiC) composites were prepared by hot-press sintering from α-SiC starting powders with BaAl2Si2O8 (BAS). The effects of additives on densification, microstructure, flexural strength, and fracture behavior of the liquid phase sintered (LPS) SiC composites were investigated. The results show that the served BAS effectively promotes the densification of SiC composites. The flexural strength and fracture toughness of the SiC composites can reach a maximum value of 454 MPa and 5.1 MPa·m1/2, respectively, for 40% (w/w) BAS/SiC composites. SiC grain pullout, crack deflection, and crack bridging were main toughening mechanisms for the sintered composites.

关键词： Silicon carbide (SiC) BaAl2Si2O8 (BAS) Liquid phase sintered (LPS) Mechanical properties

Acid-sensing ion channels: potential therapeutic targets for neurologic diseases

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Translational Neurodegeneration 2015年第1期4卷 68-75页

作者： Sha liu Xiao-Yu Cheng Fen Wang chun-feng liu Department of Neurology the Second Affiliated Hospital of Soochow UniversitySoochow University1055 Sanxiang RoadSuzhou 215004China Institute of Neuroscience Soochow UniversitySuzhou 215123China Beijing Key Laboratory for Parkinson’s Disease Beijing 100053China

Maintaining the physiological pH of interstitial fluid is crucial for normal cellular *** disease states,tissue acidosis is a common pathologic change causing abnormal activation of acid-sensing ion channels(ASICs),which according to cumulative evidence,significantly contributes to inflammation,mitochondrial dysfunction,and other pathologic mechanisms(i.e.,pain,stroke,and psychiatric conditions).Thus,it has become increasingly clear that ASICs are critical in the progression of neurologic *** review is focused on the importance of ASICs as potential therapeutic targets in combating neurologic diseases.

关键词： Acid sensing ionic channels Neurologic diseases Pathophysiology Neurodegeneration

Clinical Significance of REM Sleep Behavior Disorders and Other Non-motor Symptoms of Parkinsonism

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Neuroscience Bulletin 2017年第5期33卷 576-584页

作者： Hong Jin Jin-Ru Zhang Yun Shen chun-feng liu Department of Neurology and Sleep Center The Second Affiliated Hospital of Soochow University Institute of Neuroscience Soochow University

Rapid eye movement sleep behavior disorder （RBD） is one of the most common non-motor symptoms of parkinsonism, and it may serve as a prodromal marker of neurodegenerative disease. The mechanism underlying RBD is unclear. Several prospective studies have reported that specific non-motor symptoms predict a conversion risk of developing a neurodegenerative disease, including olfactory dysfunction, abnormal color vision, autonomic dysfunction, excessive daytime sleepiness, depression, and cognitive impairment. Parkinson＇s disease （PD） with RBD exhibits clinical heterogeneity with respect to motor and non-motor symptoms compared with PD without RBD. In this review, we describe the main clinical and pathogenic features of RBD, focusing on its association with other non-motor symptoms of parkinsonism.

关键词： Parkinson's disease · Rapid eye movement sleep behavior disorder · Risk factors ·Parkinsonism

The wave and vibratory power transmission in a finite L-shaped Mindlin plate with two simply supported opposite edges

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Acta Mechanica Sinica 2011年第5期27卷 785-795页

作者： chun-Chuan liu feng-Ming Li Ting-Wei Liang Wen-Hu Huang P. O. Box 137 School of AstronauticsHarbin Institute of Technology150001 Harbin China

In this paper,wave and vibratory power transmission in a finite L-shaped Mindlin plate with two simply supported opposite edges are investigated using the wave *** dynamic responses,active and reactive power flow in the finite plate are calculated by the Mindlin plate theory （MPT） and classic plate theory （CPT）.To satisfy the boundary conditions and continuous conditions at the coupled junction of the finite L-shaped plate,the near-field and far-field waves are entirely contained in the wave *** in-plane longitudinal and shear waves are also *** results indicate that the vibratory power flow based on the MPT is different from that based on the CPT not only at high frequencies but also at low and medium *** influence of the plate thickness on the vibrational power flow is *** the results it is seen that the shear and rotary inertia correction of the MPT can influence the active and reactive power at the junction of the L-shaped plate not only at high frequencies but also at low and medium ***,the effects of structural damping on the active and reactive power flow at the junction are also analyzed.

关键词： Finite L-shaped Mindlin plate Active power flow Reactive power flow Wave approach

Sympathetic transmitters control thermogenic efficacy of brown adipocytes by modulating mitochondrial complex V

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Signal Transduction and Targeted Therapy 2017年第1期2卷 43-50页

作者： Tao-Rong Xie chun-feng liu Jian-Sheng Kang CAS Key Laboratory of Nutrition and Metabolism Institute for Nutritional SciencesShanghai Institutes for Biological SciencesChinese Academy of SciencesShanghaiChina Technical Center for Animal Plant and Food Inspection and QuarantineShanghai Entry-Exit Inspection and Quarantine BureauShanghaiChina.

Obesity is a worldwide epidemic and results from excessive energy intake or inefficient energy *** is promising to utilize the thermogenic function of brown adipose tissue for obesity ***,the mechanisms controlling the efficacy of norepinephrine-induced thermogenesis in brown adipocytes remain *** we demonstrate that norepinephrine(NE)induces low-efficacy thermogenesis,evoking both heterogeneous changes(ΔΨm andΔpH)and homogenous responses,one of which is that NE stimulation causes large amounts of ATP consumption in brown *** reveal that the proton-ATPase activity of mitochondrial complex V is a key factor that antagonizes proton leakage by UCP1 and determines the efficacy of NE-induced thermogenesis in brown ***,to avoid unnecessary and undesired heat production,we reveal that ATP is a necessary sympathetic cotransmitter for the high efficacy and specificity of NE-induced thermogenesis in brown adipocytes as it increases intracellular calcium concentrations and upregulates the ATP synthase activity of complex ***,we demonstrate the modulation mechanism of thermogenic efficacy in brown *** findings imply new strategies to partially or fully utilize the thermogenic capacity of brown adipocytes to identify therapeutic targets for the treatment of obesity and diabetes.

关键词： utilize brown specificity

Experimental observations of ferroelectricity in double pyrochlore Dy2Ru2O7

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Frontiers of physics 2014年第1期9卷 82-89页

作者： Zai-chun Xu Mei-feng liu Lin Lin Huimei liu Zhi-Bo Yan Jun-Ming liu Laboratory of Solid State Microstructures Nanjing University Nanjing 210093 China

Double pyrochlore Dy2Ru207 is synthesized and its magnetism and ferroelectricity below the Ru4＋ spin ordering temperature （NI00 K） are investigated. The ferroelectric transition appears at -18 K, much higher than the Dy3＋ spin ordering point at -1.8 K and lower than the Ru4＋ spin ordering point at -100 K. The measured electric polarization at ,-2 K is as big as 145℃/m2 in the polycrystalline samples. It is argued that the ferroelectricity is possibly ascribed to the electric dipole ordering arising from the collective monopole excitations in the Dy3＋ tetrahedrons in prior to the Dy3＋ spin ordering into spin-ice like state below -1.8 K.

关键词： pyrochlore oxides multiferroics magnetically induced ferroelectricity

Multiple stress fractures of unilateral femur:A case report

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World Journal of Clinical Cases 2022年第13期10卷 4280-4287页

作者： Mao-Ting Tang chun-feng liu Jin-Lian liu Saijilafu Zhen Wang Department of Orthopaedics Suzhou Kowloon Hospital Shanghai Jiao Tong University School of MedicineSuzhou 215028Jiangsu ProvinceChina Orthopaedic Institute Medical CollegeSoochow UniversitySuzhou 215007Jiangsu ProvinceChina

BACKGROUND Stress fractures of the femoral neck are not common in clinical practice,and simultaneous stress fractures of the femoral neck and proximal femur of the unilateral femur are even more *** introduce a case of this type of fracture that was treated in our department,analyze the causes,and review similar stress fractures reported in the literature to provide references for the diagnosis and treatment of such *** SUMMARY A 62-year-old female,with a free medical history,was admitted to the hospital mainly due to pain in the right hip and worsening pain in the right *** patient had no obvious history of trauma.X-ray and computed tomography showed fracture of the femoral neck and proximal *** patient had undergone surgery 1 year prior to address a fracture of the left proximal femur that had occurred in a traffic *** first consideration was stress fracture of the femoral neck;however,simultaneous stress fractures of the femoral neck and proximal femur of the unilateral femur were *** femoral neck stress fracture was a tension fracture,with obvious displacement and varus deformity of the *** that the patient was an elderly female,we performed total hip ***-up X-rays showed that the stress fracture of the proximal femur had mostly healed after 3 *** Muscle fatigue and hip varus deformity provide an anatomical basis for the occurrence of femoral neck stress fractures.

关键词： Femoral neck fracture Femoral fracture Stress fracture Fatigue fracture Hip pain Case report

A New Perspective for Parkinson's Disease:Circadian Rhythm

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Neuroscience Bulletin 2017年第1期33卷 62-72页

作者： Siyue Li Yali Wang Fen Wang Li-Fang Hu chun-feng liu Department of Neurology and Suzhou Clinical Research Center of Neurological Disease The Second Affiliated Hospital of Soochow University Institutes of Neuroscience Soochow University

Circadian rhythm is manifested by the behavioral and physiological changes from day to night, which is controlled by the pacemaker and its regulator. The former is located at the suprachiasmatic nuclei （SCN） in the anterior hypothalamus, while the latter is composed of clock genes present in all tissues. Circadian desynchronization influences normal patterns of day-night rhythms such as sleep and alertness cycles, rest and activity cycles. Parkinson＇s disease （PD） exhibits diurnal fluctuations. Circadian dysfunction has been observed in PD patients and animal models, which may result in negative conse- quences to the homeostasis and even exacerbate the disease progression. Therefore, circadian therapies, including light stimulation, physical activity, dietary and social schedules, may be helpful for PD patients. However, the cellular and molecular mechanisms that underlie the circadian dysfunction in PD remain elusive. Further research on circadian patterns is needed. This article summarizes the existing research on the circadian rhythms in PD, focusing on the clinical symptom variations, molecular changes, as well as the available treatment options.

关键词： Parkinson's disease Circadian rhythm Sleep Dopamine