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Facile synthesis of a tumor microenvironment-responsive nanomaterial with metallic polyphenol-encapsulated for enhanced synergistic therapy

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Journal of Rare Earths 2024年第10期42卷 1895-1902页

作者： Kaige Yu Nuo Kou Shouqiang Zhang Tianqi Cao Hanqing Wu Jing zhou Department of Chemistry Capital Normal University College of Teacher Education Capital Normal University

The tumor microenvironment（TME） differs from normal tissue cells in its physiological and biochemical *** construction of TME-responsive nanoplatforms requires a tedious preparation process and complex multicomponent *** this work,Er@EGCG-Cu,a TME-responsive nanoplatform,was simply and rapidly synthesized by combining rare earth-doped nanomaterials（NaLuF4:Yb,Er） with EGCG-Cu which is based on the ability of metal ions to coordinate with polyphenols to form a metal-phenolic network（MPN） *** MPN structure is then destroyed under an acidic TME,releasing the chemotherapy（CT） drug EGCG,which can cause apoptosis,CuxSyis generated by combining Cu2+with H2S overexpressed in human colorectal cancer cells and can be used for photothermal therapy（PTT）.Cell experiments show that laser irradiation improves the CT/PTT synergistic effect of Er@*** study has significance for the construction of TME-responsive nanomedicines with simple and rapid preparation for synergistic therapy.

关键词： Metal-polyphenol networks Nanomaterials Rare earths Synergistic therapy Tumor microenvironment

Security-constrained Transmission Maintenance Optimization Considering Generation and Operational Risk Costs

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Journal of Modern Power Systems and Clean Energy 2024年第3期12卷 767-781页

作者： Dan Xu Zhi Cai Qian Cheng Guodong Huang Jingyang zhou Junjie Tang Beijing Key Laboratory of Research and System Evaluation of Power Dispatching Automation Technology China Electric Power Research InstituteBeijing 100192China State Key Laboratory of Power Transmission Equipment&System Security and New Technology Chongqing UniversityChongqing 400044China

With the large-scale integration of renewable energy,the traditional maintenance arrangement during the load valley period cannot satisfy the transmission demand of renewable energy ***,in a market-oriented operation mode,the power dispatching control center aims to reduce the overall power purchase cost while ensuring the security of the power ***,a security-constrained transmission maintenance optimization model considering generation and operational risk costs is proposed *** model is built on double-layer optimization framework,where the upper-layer model is used for maintenance and generation planning,and the lowerlayer model is primarily used to address the operational security risk arising from the random prediction error and N-1 transmission ***,a generation-maintenance iterative algorithm based on a defined cost feedback is included to increase solution *** cost is determined using long-term security-constrained unit commitment,and the operational risk cost is obtained using a double-layer N-1 risk assessment *** electrical correlation coupling coefficient is proposed for the solution process to avoid maintenance of associated equipment simultaneously,thereby improving model convergence *** IEEE 118-bus system is used as a test case for illustration,and test results suggest that the proposed model and algorithm can reduce the total cost of transmission maintenance and system operation while effectively improving the solution efficiency of the joint optimization model.

关键词： Transmission maintenance security-constrained unit commitment iterative algorithm cost feedback N−1 risk assessment

Construction and properties of venlafaxine hydrochloride sustained release system based on hollow mesoporous silica microspheres

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Particuology 2024年第3期86卷 205-210页

作者： Chenjing Liang Lingling Shi Zhengguo Chen Lan zhou Zhaoxia Zhang Guoqing Zhang School of Materials Science and Engineering Zhejiang Sci-tech UniversityHangzhouChina College of Textile Science and Engineering Zhejiang Sci-tech UniversityHangzhouChina Zhejiang Provincial Innovation Center of Advanced Textile Technology ShaoxingChina

The aim of this work is to develop a venlafaxine hydrochloride sustained release system based on hollow mesoporous silica microspheres(HMSMs).HMSMs were innovatively prepared with tetraethyl silicate(TEOS)as the precursor and volatile n-heptane as a soft *** obtained HMSMs show a well-defined hollow structure with an average size of 967 nm and pore volume of 0.85 cm^(3)/g,implying it is a potential drug ***,venlafaxine hydrochloride(VF)was absorbed in the HMSMs with a content of 37.67% or *** sustained release effect is further measured by the dissolution in-strument at 37℃ and 50 rpm in ultrapure *** results showed that the HMSMs/VF system shows good sustained release properties compared with sustained release tablets with hydroxypropyl meth-ylcellulose as the main *** HMSMs sustained release system appears to be a promising candidate for a sustained drug release.

关键词： Hollowmesoporous silica microspheres(HMSMs) Venlafaxine hydrochloride Drug loading Sustained release

Separation density prediction of geldart A^(-)dense medium in gas-solid fluidized bed coal beneficiators

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Particuology 2024年第9期92卷 251-262页

作者： Chenyang zhou Chengguo Liu Yue Yuan Zhijie Fu Jesse Zhu Chenlong Duan School of Chemical Engineering and Technology China University of Mining and TechnologyXuzhou221116China Particle Technology Research Centre Western UniversityLondonOntarioN6A 5B9Canada

Gas-solid Fluidized Bed Coal Beneficiator(GFBCB)process is a crucial dry coal beneficiation fluidization *** work employs the GFBCB process alongside a novel Geldart A^(-)dense medium,consisting of Geldart A magnetite particles and Geldart C ultrafine coal,to separate small-size separated objects in the *** effects of various operational conditions,including the volume fraction of ultrafine coal,the gas velocity,the separated objects size,and the separation time,were investigated on the GFBCB's separation *** results indicated that the probable error for 6∼3 mm separated objects could be controlled within 0.10 g/cm^(3).Compared to the traditional Geldart B/D dense medium,the Geldart A/A^(-)dense medium exhibited better size-dependent separation performance with an overall probable error 0.04∼0.12 g/cm^(3).Moreover,it achieved a similar separation accuracy to the Geldart B/D dense medium fluidized bed with different external energy for the small-size object *** work furthermore validated a separation density prediction model based on theoretical derivation,available for both Geldart B/D dense medium and Geldart A/A^(-)dense medium at different operational conditions.

关键词： GFBCB Geldart A^(-)dense medium Separation density Separated objects size Prediction model

Geometric quality evaluation of three-dimensional printable concrete using computational fluid dynamics

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Frontiers of Structural and Civil Engineering 2024年第7期18卷 963-976页

作者： Weijiu CUI Haijun SUN Jiangang zhou Sheng WANG Xinyu SHI Yaxin TAO Department of Civil Engineering Qingdao University of TechnologyQingdao 266000China Innovation Institute for Sustainable Maritime Architecture Research and Technology Qingdao University of TechnologyQingdao 266000China Intelligent Construction Lab Qingdao University of TechnologyQingdao 266000China Shandong Zhaojin Industrial Development Co. Ltd.Yantai 264000China Architectural Engineering Institute Weifang Engineering Vocational CollegeWeifang 261000China Qingjian Group Co. Ltd.Qingdao 266000China College of Architecture and Urban Planning Qingdao University of TechnologyQingdao 266000China Department of Structural Engineering and Building Materials Ghent UniversityGhent 9000Belgium Institute of Building Materials ETH ZurichZurich 8064Switzerland

The importance of geometrical control of three dimensional(3D)printable concrete without the support of formwork is widely *** this study,a numerical model based on computational fluid dynamics was developed to evaluate the geometrical quality of a 3D printed *** numerical results were compared,using image analysis,with physical cross-sectional sawn *** influence of printing parameters(printing speed,nozzle height,and nozzle diameter)and the rheological behavior of printed materials(yield stress),on the geometrical quality of one printed layer was *** addition,the yield zone of the printed layer was analyzed,giving insights on the critical factors for geometrical control in 3D concrete *** indicated that the developed model can precisely describe the extrusion process,as well as the cross-sectional quality.

关键词： digital fabrication 3D concrete printing geometric quality computational fluid dynamics printing parameters yield stress

Impacts of multi-foulings on salinity gradient energy conversion process in negatively charged conical nanochannels

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Science China(Technological Sciences) 2024年第6期67卷 1714-1726页

作者： MAO RuiJie CHEN Xi zhou RuHong LONG Rui LIU ZhiChun LIU Wei School of Energy and Power Engineering Huazhong University of Science and TechnologyWuhan430074China China-EU Institute for Clean and Renewable Energy Huazhong University of Science and TechnologyWuhan430074China School of Mechanical Science and Engineering Huazhong University of Science and TechnologyWuhan430074China

Membrane fouling inevitably occurs during nanofluidic reverse ***,the impact of multi-fouling on the energy conversion performance of negatively charged conical nanochannels under asymmetrical configurations is systematically *** results reveal that in Configuration I,where a high-concentration solution is applied at the tip side,at small concentration ratios,multiple foulings reduce the electric *** Configuration II,where a low-concentration solution is applied at the tip side,multiple foulings near the base side contribute to the electric *** fouling that formed near the lowconcentration entrance diminished the electric power and energy conversion ***-fouling lowered the electrical power consumption by 69.27%and 99.94%in Configurations I and II,*** Configuration I,the electric power first increased with increasing fouling surface charge density,reached its maximum value,and thereafter *** Configuration II,the electric power first decreased with increasing fouling surface charge density,reached its minimum value,and thereafter *** negative or positive charge densities of fouling contribute to the electric power and energy conversion efficiency.

关键词： conical nanochannel fouling nanofluidic reverse electrodialysis salinity gradient energy

Digital Wealth Creation, Distribution and Common Prosperity

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Social Sciences in China 2024年第3期45卷 38-56页

作者： zhou Wen Han Wenlong Center for the Sinicization of Marxist Economics Fudan University School of Economics Southwest University of Finance and Economics

As a new form of social wealth,digital wealth is becoming an important force in the promotion of common *** the digital economy era,digital labor and data factors are important sources for creating digital *** creation of digital commodity wealth is reflected in the process of value formation and value appreciation of digital goods,as well as in the expansion and reproduction process of data production *** creation of digital non-commodity wealth needs to rely on the coordination of multiple supply systems including government,enterprises,society and *** the distribution of digital wealth in a socialist market economy,it is necessary to adhere to the basic distribution system with remuneration based on work as the main form and the coexistence of multiple distribution *** should fully reflect the value contribution of data factors while also addressing and resolving potential polarization effects caused by the distribution of digital *** the basis of the new development stage,China should steadily advance the creation and accumulation of digital wealth on the basis of constantly strengthening,improving and expanding the digital economy,and should pay attention to standardizing the distribution of digital wealth in order to achieve a solid advance in the common prosperity of all the people.

关键词： digital economy digital wealth common prosperity Marx's theory of wealth data factors

Rare earth fluorescent nanoprobes with minimal side effects enable tumor microenvironment activation for chemotherapy

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Journal of Rare Earths 2024年第2期42卷 256-262,I0001页

作者： Tianqi Cao Yuxin Liu Qi Jia Xiaolu Wang Shouqiang Zhang Jing zhou Department of Chemistry Capital Normal UniversityBeijing100048China

Chemotherapy,the use of antitumor drugs to kill cancer cells,is currently one of the most effective treatments for ***,serious toxic side effects caused by long-term drug accumulation can cause significant damage to the body,which limits the clinical application of antitumor *** this study,a novel RENPs@DOX-Fe nanoprobe(NP) was constructed by coating the surface of rare earth nanomaterials(NaLuF_(4):Yb,Er) with a complex formed by doxorubicin(DOX) and iron ion(Ⅲ).Due to the low toxicity of anthracycline-metal complexes,the damage to normal cells is *** unique acidic microenvironment in tumor cells facilitates the decomposition and gradual release of DOX from the DOX-Fe *** addition,the DOX-Fe complex can convert near-infrared(NIR) light into heat energy,which promotes the decomposition of the complex,further enhancing the release of DOX in the tumor *** change of ratio fluorescence of rare earth nanomaterials at 660 and 1550 nm after DOX release enables visual monitoring of drug release,which can potentially improve the chemotherapeutic *** vitro experiments established that RENPs@DOX-Fe NPs with NIR illumination had good therapeutic efficacy in *** work provides new insights into designing tumor microenvironment-responsive nanoprobes for chemotherapy with minimal side effects.

关键词： Rare earth nanoprobes Fluorescence Ratiometric imaging DOX Chemotherapy

An aqueous BiI_(3)-Zn battery with dual mechanisms of Zn^(2+)(de)intercalation and I^(-)/I_(2)redox

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Journal of Energy Chemistry 2024年第2期89卷 670-678,I0014页

作者： Qi Deng Fangzhong Liu Xiongwei Wu Changzhu Li Weibin zhou Bei Long State Key Laboratory of Utilization of Woody Oil Resource Key Laboratory of National Forestry and Grassland Administration on Utilization Science for Southern Woody Oil ResourcesHunan Provincial Key Laboratory of Oils&Fats Molecular Structure and FunctionHunan Academy of ForestryChangsha 410004HunanChina School of Chemistry Xiangtan UniversityXiangtan 411105HunanChina School of Chemistry and Materials Science Hunan Agricultural UniversityChangsha 410128HunanChina

The development of aqueous battery with dual mechanisms is now arousing more and more *** dual mechanisms of Zn^(2+)(de)intercalation and I^(-)/I_(2)redox bring unexpected ***,differing from previous studies using Zn I_(2)additive,this work designs an aqueous Bi I_(3)-Zn battery with selfsupplied I^(-).Ex situ tests reveal the conversion of Bi I_(3)into Bi(discharge)and Bi OI(charge)at the 1st cycle and the dissolved I^(-)in *** active I^(-)species enhances the specific capacity and discharge medium voltage of electrode as well as improves the generation of Zn dendrite and ***,the porous hard carbon is introduced to enhance the electronic/ionic conductivity and adsorb iodine species,proven by experimental and theoretical ***,the well-designed Bi I_(3)-Zn battery delivers a high reversible capacity of 182 m A h g^(-1)at 0.2 A g^(-1),an excellent rate capability with 88 m A h g^(-1)at 10 A g^(-1),and an impressive cyclability with 63%capacity retention over 20 K cycles at 10 A g^(-1).An excellent electrochemical performance is obtained even at a high mass loading of 6 mg cm^(-2).Moreover,a flexible quasi-solid-state Bi I_(3)-Zn battery exhibits satisfactory battery *** work provides a new idea for designing high-performance aqueous battery with dual mechanisms.

关键词： Aqueous BiI_(3)-Zn battery Dual mechanisms I^(-)-induced uniform zinc deposition Ultralong cyclic life Flexible quasi-solid-state battery