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General Psychiatry 2024年第1期37卷 73-82页

作者： Qian Lu Sisi Huang Tianjiao Zhang Jie Song Manyu Dong Yilun Qian Jing Teng Tong Wang chuan He Ying shen Department of Rehabilitation Medicine The Affiliated Jiangsu Shengze Hospital of Nanjing Medical UniversitySuzhouChina Rehabilitation Medicine Center The First Affiliated Hospital of Nanjing Medical UniversityNanjingChina

Background The neurophysiological differences in cortical plasticity and cholinergic system function due to ageing and their correlation with cognitive function remain poorly understood.Aims To reveal the differences in long-term potentiation(LTP)-like plasticity and short-latency afferent inhibition(SAl)between older and younger individuals,alongside their correlation with cognitive function using transcranial magnetic stimulation(TMS).Methods The cross-sectional study involved 31 younger adults aged 18-30 and 46 older adults aged 60-80.All participants underwent comprehensive cognitive assessments and a neurophysiological evaluation based on TMS.Cognitive function assessments included evaluations of global cognitive function,language,memory and executive function.The neurophysiological assessment included LTP-like plasticity and SAl.Results The findings of this study revealed a decline in LTP among the older adults compared with the younger adults(wald χ^(2)=3.98,p=0.046).Subgroup analysis further demonstrated a significant reduction in SAl level among individuals aged 70-80 years in comparison to both the younger adults(SAI(N20)):(t=-3.37,p=0.018);SAl(N20+4):(t=-3.13,p=0.038)and those aged 60-70(SAl(N20)):(t=3.26,p=0.025);SAl(N20+4):(t=-3.69,p=0.006).Conversely,there was no notable difference in SAl level between those aged 60-70 years and the younger group.Furthermore,after employing the Bonferroni correction,the correlation analysis revealed that only the positive correlation between LTP-like plasticity and language function(r=0.61,p<0.001)in the younger group remained statistically significant.Conclusions During the normal ageing process,a decline in synaptic plasticity may precede cholinergic system dysfunction.In individuals over 60 years of age,there is a reduction in LTP-like plasticity,while a decline in cholinergic system function is observed in those over 70.Thus,the cholinergic system may play a vital role in preventing cognitive decline during normal ageing.In younger individuals,LTP-like plasticit

关键词： function younger plasticity

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Plexin domain-containing 1 may be a biomarker of poor prognosis in hepatocellular carcinoma patients,may mediate immune evasion

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World Journal of Gastrointestinal Oncology 2024年第5期16卷 2091-2112页

作者： Ming-Yue Tang Xue shen Run-sheng Yuan Hui-Yuan Li Xin-Wei Li Yi-Ming Jing Yue Zhang Hong-Hong shen Zi-Shu Wang Lei Zhou Yun-chuan Yang He-Xin Wen Fang Su Department of Medical Oncology The First Affiliated Hospital of Bengbu Medical CollegeBengbu 233000Anhui ProvinceChina Otolaryngology and Head and Neck Surgery The First Affiliated Hospital of Bengbu Medical CollegeBengbu 233000Anhui ProvinceChina Department of Neurology The First Affiliated Hospital of Bengbu Medical CollegeBengbu 233000Anhui ProvinceChina Department of Hepatobiliary Surgery The First Affiliated Hospital of Bengbu Medical CollegeBengbu 233000Anhui ProvinceChina Department of Gastrointestinal Surgery The First Affiliated Hospital of Bengbu Medical CollegeBengbu 233000Anhui ProvinceChina

BACKGROUND For the first time,we investigated the oncological role of plexin domain-containing 1(PLXDC1),also known as tumor endothelial marker 7(TEM7),in hepatocellular carcinoma(HCC).AIM To investigate the oncological profile of PLXDC1 in HCC.METHODS Based on The Cancer Genome Atlas database,we analyzed the expression of PLXDC1 in HCC.Using immunohistochemistry,quantitative real-time polymerase chain reaction(qRT-PCR),and Western blotting,we validated our results.The prognostic value of PLXDC1 in HCC was analyzed by assessing its correlation with clinicopathological features,such as patient survival,methylation level,tumor immune microenvironment features,and immune cell surface checkpoint expression.Finally,to assess the immune evasion potential of PLXDC1 in HCC,we used the tumor immune dysfunction and exclusion(TIDE)website and immunohistochemical staining assays.RESULTS Based on immunohistochemistry,qRT-PCR,and Western blot assays,overexpression of PLXDC1 in HCC was associated with poor prognosis.Univariate and multivariate Cox analyses indicated that PLXDC1 might be an independent prognostic factor.In HCC patients with high methylation levels,the prognosis was worse than in patients with low methylation levels.Pathway enrichment analysis of HCC tissues indicated that genes upregulated in the high-PLXDC1 subgroup were enriched in mesenchymal and immune activation signaling,and TIDE assessment showed that the risk of immune evasion was significantly higher in the high-PLXDC1 subgroup compared to the low-PLXDC1 subgroup.The high-risk group had a significantly lower immune evasion rate as well as a poor prognosis,and PLXDC1-related risk scores were also associated with a poor prognosis.CONCLUSION As a result of this study analyzing PLXDC1 from multiple biological perspectives,it was revealed that it is a biomarker of poor prognosis for HCC patients,and that it plays a role in determining immune evasion status.

关键词： Plexin domain-containing 1 Biomarker Immune evasion Prognosis Immunotherapy Hepatocellular carcinoma

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Novel discovery of PDPN-positive CAFs contributing to tumor-associated lymphangiogenesis through mesenchymal to lymphatic endothelial transition in intrahepatic cholangiocarcinoma

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Genes & Diseases 2023年第6期10卷 2226-2228页

作者： Meng Sha chuan shen Seogsong Jeong Ning Xu Chen Chen Hua-lian Hang Ying Tong Jie Cao Department of Liver Surgery Renji HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai 200127China Department of Biomedical Informatics CHA University School of MedicineCHA UniversitySeongnam 13488Republic of Korea Institute of Basic Medical Sciences School of MedicineCHA UniversitySeongnam 13488Republic of Korea Institute for Biomedical Informatics School of MedicineCHA UniversitySeongnam 13488Republic of Korea

Tumor-associated lymphangiogenesis is thought to be an importantmetastaticstepin intrahepaticccholangiocarcinoma(ICC),while the origin of tumor-associated lymphatic vessels within tumors is little known.Cancerassociated fibroblasts(CAFs)enhance tumor progression through many aspects.2 CAFs have been discovered exhibiting cellular plasticity of phenotypic transition-such as epithelial-mesenchymal transition(EMT)which promotes increased migratory and invasive capabilities of cells.3However,mesenchymal-to-endothelial,(MEndT)transition is yet to be identified in tumor entities.

关键词： CAFs lymphatic mesenchymal

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Tumour response following preoperative chemotherapy is affected by body mass index in patients with colorectal liver metastases

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World Journal of Gastrointestinal Oncology 2024年第2期16卷 331-342页

作者： Hua-chuan Song Hang-Cheng Zhou Ping Gu Bing Bao Quan Sun Tian-Ming Mei Wei Cui Kang Yao Huan-Zhang Yao shen-Yu Zhang Yong-Shuai Wang Rui-Peng Song Ji-Zhou Wang Department of General Surgery Provincial Hospital Affiliated to Anhui Medical UniversityHefei 230001Anhui ProvinceChina Department of Hepatobiliary Surgery The First Affiliated Hospital of University of Science and Technology of ChinaDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefei 230001Anhui ProvinceChina Department of Pathology The First Affiliated Hospital of University of Science and Technology of ChinaDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefei 230001Anhui ProvinceChina Department of Gastrointestinal Surgery Tongcheng People’s HospitalTongcheng 231400Anhui ProvinceChina Department of Gastrointestinal Surgery Suzhou Hospital Affiliated to Anhui Medical UniversitySuzhou 234000Anhui ProvinceChina Department of General Surgery Xuancheng People’s HospitalXuancheng 242000Anhui ProvinceChina

BACKGROUND Colorectal cancer is the third most prevalent malignancy globally and ranks second in cancer-related mortality,with the liver being the primary organ of metastasis.Preoperative chemotherapy is widely recommended for initially or potentially resectable colorectal liver metastases(CRLMs).Tumour pathological response serves as the most important and intuitive indicator for assessing the efficacy of chemotherapy.However,the postoperative pathological results reveal that a considerable number of patients exhibit a poor response to preoperative chemotherapy.Body mass index(BMI)is one of the factors affecting the tumori-genesis and progression of colorectal cancer as well as prognosis after various antitumour therapies.Several studies have indicated that overweight and obese patients with metastatic colorectal cancer experience worse prognoses than those with normal weight,particularly when receiving first-line chemotherapy regimens in combination with bevacizumab.AIM To explore the predictive value of BMI regarding the pathologic response following preoperative chemotherapy for CRLMs.METHODS A retrospective analysis was performed in 126 consecutive patients with CRLM who underwent hepatectomy following preoperative chemotherapy at four different hospitals from October 2019 to July 2023.Univariate and multivariate logistic regression models were applied to analyse potential predictors of tumour pathological response.The Kaplan-Meier method with log rank test was used to compare progression-free survival(PFS)between patients with high and low BMI.BMI<24.0 kg/m^(2) was defined as low BMI,and tumour regression grade 1-2 was defined as complete tumour response.RESULTS Low BMI was observed in 74(58.7%)patients and complete tumour response was found in 27(21.4%)patients.The rate of complete tumour response was significantly higher in patients with low BMI(29.7%vs 9.6%,P=0.007).Multivariate analysis revealed that low BMI[odds ratio(OR)=4.56,95%confidence interval(CI):1.42-14.63,P=0.011],targeted therapy with bevaciz

关键词： Colorectal liver metastases Body mass index Tumour regression grade Preoperative chemotherapy Hepatectomy

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区块链安全问题研究综述

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计算机工程与科学 2024年第1期46卷 46-62页

作者：沈传年国家计算机网络应急技术处理协调中心上海分中心上海201315

区块链凭借其颠覆性的创新技术,正在不断改变数字金融、数字政务、物联网、智能制造等诸多行业的运行规则和应用场景,是构建未来社会全新信任体系和价值体系不可或缺的关键技术。然而,区块链自身技术的缺陷和应用场景的复杂多变导致的... 详细信息

区块链凭借其颠覆性的创新技术,正在不断改变数字金融、数字政务、物联网、智能制造等诸多行业的运行规则和应用场景,是构建未来社会全新信任体系和价值体系不可或缺的关键技术。然而,区块链自身技术的缺陷和应用场景的复杂多变导致的安全问题日趋严重,已成为制约区块链未来发展的主要瓶颈,区块链的监管之路任重道远。介绍了区块链的背景知识、基本概念和体系架构;从区块链的体系架构出发,分别从数据层、网络层、共识层、激励层、合约层、应用层以及跨链7个方面对区块链的安全问题和防范策略进行分析;在此基础上,从当前政策监管的情况及监管难点、技术监管的标准建立、创新方式及发展趋势对区块链的安全监管进行探讨。

关键词：区块链共识机制智能合约跨链监管

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Half-precessional cycle revealed by environment magnetism of stalagmite in Shizhu Cave from southwestern China during the Last Glacial

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Journal of Earth Science 2024年

作者： Huihui Yang Yu-Min Chou Xiuyang Jiang Wenyue Xia Hai Li Yi Zhong Jingyu Zhang Yaoqi He Tsai-Luen Yu Qingsong Liu chuan-Chou shen College of Tourism and Air Service Guizhou Minzu University Research Center for Future Earth Taiwan University Southern Marine Science and Engineering Guangdong Laboratory (Guangzhou) School of Environment Harbin Institute of Technology High-Precision Mass Spectrometry and Environment Change Laboratory (HISPEC) Department of Geosciences Taiwan University Key Laboratory of Humid Subtropical Eco-Geographical Processes College of Geography Science Fujian Normal University Center for Marine Magnetism (CM2) Department of Ocean Science and Engineering Southern University of Science and Technology

The environmental magnetic proxies of stalagmites hold significant potential for reconstructing regional hydroclimate changes by revealing the content and grain size of magnetic particles within stalagmites. In this study， we present the contents and grain sizes of magnetic particles within a stalagmite SZ-1， from Shizhu Cave in southwestern China from 70.4 to 22.3 thousand years ago (ka) during the last glacial period. Specifically， the parameters IRMsoft， soil-derived magnetic minerals， and ARM/SIRM (anhysteretic remanent magnetization/saturation isothermal remanent magnetization)， the ratio of fine magnetic particles to total ferrimagnetic particles preserved in stalagmite SZ-1， indicate the fluctuation of regional precipitation. Obvious half-precessional cycles are evident in these two proxies， indicating that hydroclimatic variations in southwestern China may predominantly arise from the heat and moisture transported from tropical oceans. These variations are likely influenced by shifts in the Intertropical Convergence Zone and fluctuations in the Asian summer monsoon.

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论民用机场内涝风险评估标准的特殊性——基于广州白云国际机场内涝风险评估工作

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给水排水 2024年第5期50卷 89-94页

作者：李琛申延波高川民航机场规划设计研究总院有限公司北京100029

民用机场占地面积广,用地属性庞杂,其既包含了航站区、工作区、货运区等“类城市”区域,也包含飞行区这样与城市在建设、运行、管理上截然不同的区域,因此城市内涝评价标准应用在民用机场时常存在一定不匹配的问题。广州白云国际机场总... 详细信息

民用机场占地面积广,用地属性庞杂,其既包含了航站区、工作区、货运区等“类城市”区域,也包含飞行区这样与城市在建设、运行、管理上截然不同的区域,因此城市内涝评价标准应用在民用机场时常存在一定不匹配的问题。广州白云国际机场总占地面积35 km^(2),降雨量大、降雨雨型呈单峰且集中、周边水文条件复杂,本期建成后共设5条跑道、2个航站区,复杂程度居国内枢纽机场之最,具有典型性。基于广州白云国际机场内涝风险评估工作,就民用机场内涝风险评估过程中暴露出的问题和与城市内涝评价标准的异同进行了深入的讨论。

关键词：民用机场 Infoworks ICM 内涝风险评估

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CYP2C19 Genotyping Plus Therapeutic Drug Monitoring Dependent Voriconazole Treatment for Invasive Pulmonary Aspergillosis in a Patient with Liver Failure

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Infectious Diseases & Immunity 2022年第2期2卷 125-128页

作者： chuan shen Qian Zhao Ziyue Li Wei Wang Yalin Zhao Lingya Kong Jing Xie Caiyan Zhao Department of Infectious Disease Third Affiliated Hospital of Hebei Medical UniversityShijiazhuang 050051China Clinical Research Center for Infectious Disease of Hebei Province Shijiazhuang 050051China Office of Quality Management and Control in Healthcare Third Affiliated Hospital of Hebei Medical UniversityShijiazhuang 050051China

Invasive pulmonary aspergillosis(IPA)is a lethal infectious disease with high mortality in patients with liver failure.Early recognition of the risk factors prompting earlier diagnosis and treatment may improve the outcomes.Voriconazole is recommended as the first-line drug for IPA,but hepatotoxicity limits its use in the context of liver diseases.We report a case of a 63-year-old female who was admitted to the Third Affiliated Hospital of Hebei Medical University due to IPA after glucocorticoid therapy for liver failure.The polymorphism of cytochrome P450(CYP)isoenzymes showed CYP2C19∗1/∗2 genotype associated with intermediate metabolism of voriconazole.However,the patient developed side effects such as skin rash,vomiting,hyperbilirubinemia,and alteration of consciousness,even if she received half of the recommended dosage for voriconazole.Therapeutic drug monitoring(TDM)was applied to guide the dosage adjustment of voriconazole in this patient,and consequently,the patient presented a favorable outcome.In conclusion,genotyping screening plus TDM dependent individualized treatment of voriconazole may improve the survival of liver failure patient with IPA.

关键词： Invasive pulmonary aspergillosis Liver failure Therapeutic drug monitoring Voriconazole

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Anisotropic spin transport and photoresponse characteristics detected by tip movement in magnetic single-molecule junction

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Chinese Physics B 2024年第4期33卷 640-648页

作者：陈登辉羊志付新宇秦申奥严岩王传奎李宗良邱帅 Shandong Key Laboratory of Medical Physics and Image Processing&Shandong Provincial Engineering and Technical Center of Light Manipulations School of Physics and ElectronicsShandong Normal UniversityJinan 250358China

Orientation-dependent transport properties induced by anisotropic molecules are enticing in single-molecule junctions.Here,using the first-principles method,we theoretically investigate spin transport properties and photoresponse characteristics in trimesic acid magnetic single-molecule junctions with different molecular adsorption orientations and electrode contact sites.The transport calculations indicate that a single-molecule switch and a significant enhancement of spin transport and photoresponse can be achieved when the molecular adsorption orientation changes from planar geometry to upright geometry.The maximum spin polarization of current and photocurrent in upright molecular junctions exceeds 90%.Moreover,as the Ni tip electrode moves,the tunneling magnetoresistance of upright molecular junctions can be increased to 70%.The analysis of the spin-dependent PDOS elucidates that the spinterfaces between organic molecule and ferromagnetic electrodes are modulated by molecular adsorption orientation,where the molecule in upright molecular junctions yields higher spin polarization.Our theoretical work paves the way for designing spintronic devices and optoelectronic devices with anisotropic functionality base on anisotropic molecules.

关键词： molecular spintronics spin polarization tunneling magnetoresistance photocurrent single-molecule junctions

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遗传算法在橡胶超弹性材料参数反求中的应用

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机械科学与技术 2024年第4期43卷 553-558页

作者：周兵袁昆明刘阳毅沈川湖南大学汽车车身先进设计制造国家重点实验室长沙410082 三一汽车起重机械有限公司长沙410600

将优化算法与有限元仿真分析相结合可以对橡胶的材料参数进行反求,该方法基于一款叠层橡胶弹簧的试验数据,并选用Mooney-Rivlin超弹性本构模型。在参数反求的过程中,为解决传统遗传算法出现的早熟、稳定性差以及收敛速度慢的问题,将编... 详细信息

将优化算法与有限元仿真分析相结合可以对橡胶的材料参数进行反求,该方法基于一款叠层橡胶弹簧的试验数据,并选用Mooney-Rivlin超弹性本构模型。在参数反求的过程中,为解决传统遗传算法出现的早熟、稳定性差以及收敛速度慢的问题,将编码方式改为实数编码,并在算法中引入精英保留策略和自适应的交叉与变异概率。将根据改进遗传算法反求得到的刚度特性曲线与试验结果进行对比,发现二者具有很好的一致性,表明通过反求得到的材料参数能准确地对橡胶材料的力学性能进行描述。

关键词：叠层橡胶弹簧超弹性本构模型参数反求遗传算法

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