Novel discovery of PDPN-positive CAFs contributing to tumor-associated lymphangiogenesis through mesenchymal to lymphatic endothelial transition in intrahepatic cholangiocarcinoma

作     者：Meng Sha Chuan Shen Seogsong Jeong Ning Xu Chen Chen Hua-lian Hang Ying Tong Jie Cao Meng Sha;Chuan Shen;Seogsong Jeong;Ning Xu;Chen Chen;Hua-lian Hang;Ying Tong;Jie Cao

作者机构：Department of Liver SurgeryRenji HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai 200127China Department of Biomedical InformaticsCHA University School of MedicineCHA UniversitySeongnam 13488Republic of Korea Institute of Basic Medical SciencesSchool of MedicineCHA UniversitySeongnam 13488Republic of Korea Institute for Biomedical InformaticsSchool of MedicineCHA UniversitySeongnam 13488Republic of Korea 

出 版 物：《Genes & Diseases》 (基因与疾病（英文）)

年 卷 期：2023年第10卷第6期

页      面：2226-2228页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：supported by the National Natural Science Foundation of China(No.81902379) Cultivation Foundation of Renji Hospital,Shanghai,China(No.RJPY-LX-011) National Key Research on Precision Medicine of China(No.2018ZX10723204) 

主　　题：CAFs lymphatic mesenchymal 

摘      要：Tumor-associated lymphangiogenesis is thought to be an importantmetastaticstepin intrahepaticccholangiocarcinoma(ICC),while the origin of tumor-associated lymphatic vessels within tumors is little *** fibroblasts(CAFs)enhance tumor progression through many aspects.2 CAFs have been discovered exhibiting cellular plasticity of phenotypic transition-such as epithelial-mesenchymal transition(EMT)which promotes increased migratory and invasive capabilities of cells.3However,mesenchymal-to-endothelial,(MEndT)transition is yet to be identified in tumor entities.