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复杂工况下选择性催化还原脱硝系统的迁移强化学习控制

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控制理论与应用 2024年第3期41卷 496-501页

作者：孙小明彭晨程传良上海大学机电工程与自动化学院上海200444

针对复杂工况下选择性催化还原(SCR)系统难以实现精确脱硝控制的问题,本文提出一种基于迁移强化学习的智能控制方法.首先根据机组负荷的变化将整体运行过程划分为不同阶段.然后训练了强化学习控制器以分别学习各个阶段的不同特征,从而... 详细信息

针对复杂工况下选择性催化还原(SCR)系统难以实现精确脱硝控制的问题,本文提出一种基于迁移强化学习的智能控制方法.首先根据机组负荷的变化将整体运行过程划分为不同阶段.然后训练了强化学习控制器以分别学习各个阶段的不同特征,从而实现了变工况下SCR脱硝系统的精确控制.此外,借鉴了迁移学习的思路以应对预料之外的未知工况,避免了因工况未知所造成的不利影响.最后将训练好的控制器用于实际SCR脱硝系统的控制中,实验结果表明所提方法可以有效地控制复杂工况下燃煤机组NOx的排放量,为复杂工况下SCR脱硝系统的智能控制提供了借鉴.

关键词： SCR脱硝系统变工况未知工况强化学习迁移学习

Generation of visible Raman operation laser by a fiber electro-optical modulator feedback loop

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Chinese Optics Letters 2024年第2期22卷 180-185页

作者：李睿睿叶蔚然陈一龙陈树谦亓文昊崔金明黄运锋李传锋郭光灿 CAS Key Laboratory of Quantum Information University of Science and Technology of ChinaHefei 230026China CAS Center for Excellence in Quantum Information and Quantum Physics University of Science and Technology of ChinaHefei 230026China Hefei National Laboratory University of Science and Technology of ChinaHefei 230088China

Phase-coherent multi-tone lasers play a critical role in atomic,molecular,and optical *** them,the Raman opeartion laser for manipulating atomic hyperfine qubits requires gigahertz bandwidth and low phase noise to retain long-term *** operation lasers generated by directly modulated and frequency-multipled infrared lasers are compact and stable but lack feedback control to actively suppress the phase noise,which limits their performance in practical *** this work,we employ a fiber electro-optical modulator driven by a voltage-controlled oscillator(VCO)to modulate a monochromatic laser and employ a second-harmonic generation process to convert it to the visible domain,where the beat note of the Raman operation laser is stabilized by controlling the output frequency of VCO with a digital phase-locked loop(PLL).The low-frequency phase noise is effectively suppressed compared to the scheme without active feedback and it reaches-80 d Bc/Hz@5 k Hz with a 20 k Hz loop ***,this compact and robust scheme effectively reduces the system's complexity and cost,which is promising for extensive application in atomic,molecular,and optical physics.

关键词： phase-coherent laser quantum information trapped ion stimulated Raman transition phase-locked loop

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基于注意力机制改进的无锚框舰船检测模型

吉林大学学报（工学版） 2024年第5期54卷 1407-1416页

作者：高云龙任明吴川高文中国科学院长春光学精密机械与物理研究所长春130033

为提升模型对合成孔径雷达(SAR)图像多尺度舰船目标的检测能力,保证检测网络的实时性,提出一个基于注意力机制改进的无锚框舰船检测模型。在YOLOX网络特征金字塔处嵌入空洞注意力模块,调节感受野与多尺度融合的关系,强化特征的表示能力... 详细信息

为提升模型对合成孔径雷达(SAR)图像多尺度舰船目标的检测能力,保证检测网络的实时性,提出一个基于注意力机制改进的无锚框舰船检测模型。在YOLOX网络特征金字塔处嵌入空洞注意力模块,调节感受野与多尺度融合的关系,强化特征的表示能力。在检测头部设计中心性预测分支,对锚点的分类得分进行加权处理,调整模型的损失函数,优化检测结果。在数据集SSDD上进行的对比实验结果表明:本文提出的模型优于主流的深度网络检测模型,精度达到94.73%,且在检测精度和检测速度中取得最佳平衡。

关键词：计算机视觉舰船目标检测空洞卷积注意力机制无锚框

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The FAST all sky HI survey(FASHI):The first release of catalog

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Science China(Physics,Mechanics & Astronomy) 2024年第1期67卷 112-133页

作者： chuan-Peng Zhang ming Zhu Peng Jiang Cheng Cheng Jing Wang Jie Wang Jin-Long Xu Xiao-Lan Liu Nai-Ping Yu Lei Qian Haiyang Yu Mei Ai Yingjie Jing Chen Xu Ziming Liu Xin Guan Chun Sun Qingliang Yang Menglin Huang Qiaoli Hao FAST Collaboration Guizhou Radio Astronomical Observatory Guizhou UniversityGuiyang 550000China National Astronomical Observatories Chinese Academy of Sciences(CAS)Beijing 100101China Chinese Academy of Sciences South America Center for Astronomy National Astronomical ObservatoriesCASBeijing 100101China Kavli Institute for Astronomy and Astrophysics Peking UniversityBeijing 100871China

The FAST All Sky HI survey(FASHI)was designed to cover the entire sky observable by the Five-hundred-meter Aperture Spherical radio Telescope(FAST),spanning approximately 22000 square degrees of declination between-14°and+66°,and in the frequency range of 1050-1450 MHz,with the expectation of eventually detecting more than 100000 HI *** August 2020 and June 2023,FASHI had covered more than 7600 square degrees,which is approximately 35%of the total sky observable by *** has a median detection sensitivity of around 0.76 m Jy beam-1and a spectral line velocity resolution of~6.4 km s-1at a frequency of~1.4 *** of now,a total of 41741 extragalactic HI sources have been detected in the frequency range 1305.5-1419.5 MHz,corresponding to a redshift limit of z■*** cross-matching FASHI sources with the Siena Galaxy Atlas(SGA)and the Sloan Digital Sky Survey(SDSS)catalogs,we found that 16972(40.7%)sources have spectroscopic redshifts and 10975(26.3%)sources have only photometric *** of the remaining 13794(33.0%)HI sources are located in the direction of the Galactic plane,making their optical counterparts difficult to identify due to high extinction or high contamination of Galactic stellar *** on current survey results,the FASHI survey is an unprecedented blind extragalactic H I *** has higher spectral and spatial resolution and broader coverage than the Arecibo Legacy Fast ALFA Survey(ALFALFA).When completed,FASHI will provide the largest extragalactic HI catalog and an objective view of HI content and large-scale structure in the local universe.

关键词： surveys redshifts galaxies telescope radio lines HI line

Efficacy and safety of Tianqi Pingchan Granule,a compound Chinese herbal medicine,for levodopa-induced dyskinesia in Parkinson’s disease:A randomized double-blind placebo-controlled trial

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Journal of Integrative Medicine 2024年第5期22卷 545-551页

作者： Yu Zhang Xiao-bo Zhu Yang Zhao Gui-yun cui Wen-tao Li Can-xing Yuan Jian-ping Huang Ying Wan Na Wu Lu Song Jia-hao Zhao Yan Liang chuan-ying Xu Mei-juan Liu Chen Gao Xin-xin Chen Zhen-guo Liu Department of Neurology Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai 200092China Department of Neurology Nanjing Hospital of Chinese Medicine Affiliated to Nanjing University of Chinese MedicineNanjing 210022Jiangsu ProvinceChina Parkinson’s Disease Center the Affiliated Hospital of Xuzhou Medical UniversityXuzhou 221004Jiangsu ProvinceChina Department of Neurology Shanghai Municipal Hospital of Traditional Chinese Medicine Affiliated to Shanghai University of Traditional Chinese MedicineShanghai 200071China Department of Neurology Longhua HospitalShanghai University of Traditional Chinese MedicineShanghai 200032China Department of Neurology Wenzhou Central HospitalWenzhou 325000Zhejiang ProvinceChina

Background Patients with Parkinson’s disease(PD)undergoing long-term levodopa therapy are prone to develop levodopa-induced dyskinesia(LID).Amantadine is the main drug recommended for the treatment of LID by current guidelines,but it is far from meeting clinical *** Pingchan Granule(TPG),a compound Chinese herbal medicine,has been developed to relieve symptom of *** This randomized controlled trial evaluated the efficacy and safety of the combination of TPG and amantadine for ***,setting,participants and interventions This is a randomized double-blind placebo-controlled trial,conducted from January 2020 to August 2021 at 6 sites in Jiangsu,Zhejiang and Shanghai,*** hundred PD patients with≥0.5 h of LID were randomly assigned to either the TPG plus amantadine group(TPG group)or the placebo plus amantadine group(placebo group),and treated for a period of 12 *** ensure unbiased results,all study participants,investigators and sponsors were unaware of group ***,the data analysts remained blinded until the analysis was *** outcome measures The primary outcome was assessed using the Unified Dyskinesia Rating Scale(UDysRS)(Range 0–104).The key secondary end point was improvement of motor and non-motor *** analyses included all enrolled *** One hundred patients were enrolled and randomized into the two treatment *** changes in UDysRS at week 12 were–11.02 for the TPG group and–4.19 for the placebo group(treatment difference–6.83[–10.53 to–3.12];P=0.0004).Adverse events were reported for 2 of 50 patients(4.0%)in each of the *** This study indicated that a 12-week treatment of amantadine plus TPG effectively reduced UDysRS scores and was well tolerated,demonstrating the efficacy and safety of TPG for the treatment of LID in PD.

关键词： Parkinson’s disease Tianqi Pingchan Granule Levodopa-induced dyskinesia

The Role of KDM2A and H3K36me2 Demethylation in Modulating MAPK Signaling During Neurodevelopment

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Neuroscience Bulletin 2024年第8期40卷 1076-1092页

作者： Zongyao Ren Haiyan Tang Wendiao Zhang minghui Guo Jingjie cui Hua Wang Bin Xie Jing Yu Yonghao Chen ming Zhang Cong Han Tianyao Chu Qiuman Liang Shunan Zhao Yingjie Huang Xuelian He Kefu Liu Chunyu Liu Chao Chen Center for Medical Genetics&Hunan Key Laboratory of Medical Genetics School of Life Sciencesand Department of PsychiatryThe Second Xiangya HospitalCentral South UniversityChangsha 410028China National Clinical Research Center on Mental Disorders The Second Xiangya HospitalCentral South UniversityChangsha 410028China National Clinical Research Center for Geriatric Disorders Xiangya HospitalCentral South UniversityChangsha 410011China Furong Laboratory Changsha 410000China Department of Psychiatry SUNY Upstate Medical UniversitySyracuseNY 13210USA Precision Medical Center Wuhan Children's Hospital(Wuhan Maternal and Child Healthcare Hospital)Tongji Medical CollegeHuazhong University of Science&TechnologyWuhan 430014China Department of Medical Genetics Hunan Children's HospitalChangsha 410007China

Intellectual disability(ID)is a condition characterized by cognitive impairment and difficulties in adaptive *** our research,we identified two de novo mutations(c.955C>T and c.732C>A)at the KDM2A locus in individuals with varying degrees of *** addition,by using the Gene4Denovo database,we discovered five additional cases of de novo mutations in *** mutations we identified significantly decreased the expression of the KDM2A *** investigate the role of KDM2A in neural development,we used both 2D neural stem cell models and 3D cerebral *** findings demonstrated that the reduced expression of KDM2A impairs the proliferation of neural progenitor cells(NPCs),increases apoptosis,induces premature neuronal differentiation,and affects synapse *** ChIP-Seq analysis,we found that KDM2A exhibited binding to the transcription start site regions of genes involved in *** addition,the knockdown of KDM2A hindered H3K36me2 binding to the downstream regulatory elements of *** integrating ChIP-Seq and RNA-Seq data,we made a significant discovery of the core genes'remarkable enrichment in the MAPK signaling ***,this enrichment was specifically linked to the p38 MAPK ***,disease enrichment analysis linked the differentially-expressed genes identified from RNA-Seq of NPCs and cerebral organoids to neurodevelopmental disorders such as ID,autism spectrum disorder,and ***,our findings suggest that KDM2A plays a crucial role in regulating the H3K36me2 modification of downstream genes,thereby modulating the MAPK signaling pathway and potentially impacting early brain development.

关键词： Intellectual disability KDM2A Neurodevelopmental disorder Cerebral organoids

C+L波段低弯曲损耗非耦合三模组渐变折射率光纤设计

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电子学报 2024年第8期52卷 2659-2667页

作者：王卓崔明杰余长源香港理工大学电机及电子工程学系中国香港999077 香港理工大学光子研究院中国香港999077 香港理工大学深圳研究院广东深圳518057

光纤是现代通信网络中最为稳定的信号传输媒介,提升光纤模式的数量是满足通信容量日益增加的有效方法.本文设计了低弯曲损耗的非耦合三模组(LP_(01),LP_(11),LP_(21))渐变折射率光纤,运用分层分析法给出了渐变折射率光纤中模组的严格截... 详细信息

光纤是现代通信网络中最为稳定的信号传输媒介,提升光纤模式的数量是满足通信容量日益增加的有效方法.本文设计了低弯曲损耗的非耦合三模组(LP_(01),LP_(11),LP_(21))渐变折射率光纤,运用分层分析法给出了渐变折射率光纤中模组的严格截止条件.此外,利用有限元仿真软件求解光纤模式的有效模场面积和弯曲损耗,得到低弯曲损耗条件下在C+L波段(1530~1625 nm)传输三模组的设计区间.揭示了纤芯中心折射率凹陷和沟槽层共同作用可促进光纤径向高阶模式的截止.模拟结果表明,所设计光纤的模组间有效折射率差大于等于3×10^(-3),弯曲半径为30 mm时的最大弯曲损耗为1.3 d B/km,符合ITU-T推荐的低弯曲损耗条件.而且,在1550 nm波长下,模组内简并模有较小的差分模式群时延(≈176 ps/km),可通过4×4多输入多输出技术补偿简并模之间的串扰.该光纤可适用于C+L波段上实现模组间非耦合的空分复用信号传输.

关键词：少模光纤渐变折射率低弯曲损耗空分复用光纤通信

基于动势能转换的虚拟编组列车动态最小安全间隔

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同济大学学报（自然科学版） 2024年第1期52卷 41-48页

作者：常鸣崔科王维旸汪小勇同济大学上海市轨道交通结构耐久与系统安全重点实验室上海201804 卡斯柯信号有限公司上海200072 上海轨道交通无人驾驶列控系统工程技术研究中心上海200072

根据安全制动模型,提出一种基于能量转换的虚拟编组列车安全防护方法。将实际项目数据作为前车的运行曲线,仿真计算了后车根据能量转换防护方法所能达到的最小安全间隔,并讨论了制动响应时间和制动能力对安全间隔的影响。结果表明,前后... 详细信息

根据安全制动模型,提出一种基于能量转换的虚拟编组列车安全防护方法。将实际项目数据作为前车的运行曲线,仿真计算了后车根据能量转换防护方法所能达到的最小安全间隔,并讨论了制动响应时间和制动能力对安全间隔的影响。结果表明,前后车的紧急制动率差异是决定安全间隔的关键因素。

关键词：城市轨道交通虚拟编组列车自动列车控制列车自动保护(ATP) 安全制动距离

Functional investigation and two-sample Mendelian randomization study of primary biliary cholangitis hub genes

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World Journal of Clinical Cases 2024年第30期12卷 6391-6406页

作者： Yun-chuan Yang Xiang Ma Chi Zhou Nan Xu Ding Ding Zhong-Zheng Ma Lei Zhou Pei-Yuan cui Department of Hepatobiliary Surgery The First Affiliated Hospital of Bengbu Medical UniversityBengbu 233000Anhui ProvinceChina Medical College Jinan UniversityGuangzhou 510000Guangdong ProvinceChina Department of General Surgery The First Affiliated Hospital of Bengbu Medical CollegeBengbu 233000Anhui ProvinceChina

BACKGROUND The identification of specific gene expression patterns is crucial for understanding the mechanisms underlying primary biliary cholangitis(PBC)and finding relevant biomarkers for diagnosis and therapeutic *** To determine PBC-associated hub genes and assess their clinical utility for disease *** PBC expression data were obtained from the Gene Expression Omnibus *** genes from differential expression analysis and weighted gene coexpression network analysis(WGCNA)were identified as key genes for *** Encyclopedia of Genes and Genomes and Gene Ontology analyses were performed to explore the potential roles of key *** genes were identified in protein-protein interaction(PPI)networks using the Degree algorithm in Cytoscape *** relationship between hub genes and immune cells was ***,a Mendelian randomization study was conducted to determine the causal effects of hub genes on *** We identified 71 overlapping key genes using differential expression analysis and *** genes were primarily enriched in pathways related to cytokinecytokine receptor interaction,and Th1,Th2,and Th17 cell *** utilized Cytoscape software and identified five hub genes(CD247,IL10,CCL5,CCL3,and STAT3)in PPI *** hub genes showed a strong correlation with immune cell infiltration in ***,inverse variance weighting analysis did not indicate the causal effects of hub genes on PBC *** Hub genes can potentially serve as valuable biomarkers for PBC prediction and treatment,thereby offering significant clinical utility.

关键词： Primary biliary cholangitis Weighted gene co-expression network analysis Hub genes Mendelian randomization Bioinformatic analysis